Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23365
Gene name Gene Name - the full gene name approved by the HGNC.	Rho guanine nucleotide exchange factor 12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARHGEF12
Synonyms (NCBI Gene) Gene synonyms aliases	LARG, PRO2792
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This pr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030993	hsa-miR-21-5p	Microarray	18591254
MIRT047997	hsa-miR-30c-5p	CLASH	23622248
MIRT036542	hsa-miR-1225-3p	CLASH	23622248
MIRT705580	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT705579	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT705578	hsa-miR-660-5p	HITS-CLIP	23313552
MIRT705577	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT705576	hsa-miR-7-5p	HITS-CLIP	23313552
MIRT705575	hsa-miR-6077	HITS-CLIP	23313552
MIRT705580	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT705579	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT705578	hsa-miR-660-5p	HITS-CLIP	23313552
MIRT705577	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT705576	hsa-miR-7-5p	HITS-CLIP	23313552
MIRT705575	hsa-miR-6077	HITS-CLIP	23313552
MIRT795356	hsa-miR-1183	CLIP-seq
MIRT795357	hsa-miR-1185	CLIP-seq
MIRT795358	hsa-miR-1224-3p	CLIP-seq
MIRT795359	hsa-miR-1224-5p	CLIP-seq
MIRT795360	hsa-miR-124	CLIP-seq
MIRT795361	hsa-miR-1243	CLIP-seq
MIRT795362	hsa-miR-1260	CLIP-seq
MIRT795363	hsa-miR-1260b	CLIP-seq
MIRT795364	hsa-miR-1261	CLIP-seq
MIRT795365	hsa-miR-1271	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT795367	hsa-miR-1280	CLIP-seq
MIRT795368	hsa-miR-1284	CLIP-seq
MIRT795369	hsa-miR-1297	CLIP-seq
MIRT795370	hsa-miR-1301	CLIP-seq
MIRT795371	hsa-miR-1305	CLIP-seq
MIRT795372	hsa-miR-130a	CLIP-seq
MIRT795373	hsa-miR-130b	CLIP-seq
MIRT795374	hsa-miR-15a	CLIP-seq
MIRT795375	hsa-miR-15b	CLIP-seq
MIRT795376	hsa-miR-16	CLIP-seq
MIRT795377	hsa-miR-182	CLIP-seq
MIRT795378	hsa-miR-195	CLIP-seq
MIRT795379	hsa-miR-200b	CLIP-seq
MIRT795380	hsa-miR-200c	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT795382	hsa-miR-22	CLIP-seq
MIRT795383	hsa-miR-26a	CLIP-seq
MIRT795384	hsa-miR-26b	CLIP-seq
MIRT795385	hsa-miR-301a	CLIP-seq
MIRT795386	hsa-miR-301b	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT795388	hsa-miR-3124-3p	CLIP-seq
MIRT795389	hsa-miR-337-3p	CLIP-seq
MIRT795390	hsa-miR-3605-5p	CLIP-seq
MIRT795391	hsa-miR-3606	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT795393	hsa-miR-3613-3p	CLIP-seq
MIRT795394	hsa-miR-361-5p	CLIP-seq
MIRT795395	hsa-miR-3654	CLIP-seq
MIRT795396	hsa-miR-3660	CLIP-seq
MIRT795397	hsa-miR-3662	CLIP-seq
MIRT795398	hsa-miR-3666	CLIP-seq
MIRT795399	hsa-miR-3673	CLIP-seq
MIRT795400	hsa-miR-3679-5p	CLIP-seq
MIRT795401	hsa-miR-3714	CLIP-seq
MIRT795402	hsa-miR-3910	CLIP-seq
MIRT795403	hsa-miR-3915	CLIP-seq
MIRT795404	hsa-miR-3919	CLIP-seq
MIRT795405	hsa-miR-3928	CLIP-seq
MIRT795406	hsa-miR-3941	CLIP-seq
MIRT795407	hsa-miR-3944-5p	CLIP-seq
MIRT795408	hsa-miR-424	CLIP-seq
MIRT795409	hsa-miR-4259	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT795411	hsa-miR-4274	CLIP-seq
MIRT795412	hsa-miR-429	CLIP-seq
MIRT795413	hsa-miR-4295	CLIP-seq
MIRT795414	hsa-miR-4420	CLIP-seq
MIRT795415	hsa-miR-4453	CLIP-seq
MIRT795416	hsa-miR-4465	CLIP-seq
MIRT795417	hsa-miR-4470	CLIP-seq
MIRT795418	hsa-miR-4473	CLIP-seq
MIRT795419	hsa-miR-4519	CLIP-seq
MIRT795420	hsa-miR-4520a-3p	CLIP-seq
MIRT795421	hsa-miR-4524	CLIP-seq
MIRT795422	hsa-miR-4526	CLIP-seq
MIRT795423	hsa-miR-4538	CLIP-seq
MIRT795424	hsa-miR-454	CLIP-seq
MIRT795425	hsa-miR-4638-3p	CLIP-seq
MIRT795426	hsa-miR-4645-3p	CLIP-seq
MIRT795427	hsa-miR-466	CLIP-seq
MIRT795428	hsa-miR-4660	CLIP-seq
MIRT795429	hsa-miR-4671-3p	CLIP-seq
MIRT795430	hsa-miR-4672	CLIP-seq
MIRT795431	hsa-miR-4677-3p	CLIP-seq
MIRT795432	hsa-miR-4686	CLIP-seq
MIRT795433	hsa-miR-4689	CLIP-seq
MIRT795434	hsa-miR-4704-3p	CLIP-seq
MIRT795435	hsa-miR-4715-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795437	hsa-miR-4731-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT795439	hsa-miR-4756-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT795441	hsa-miR-4763-5p	CLIP-seq
MIRT795442	hsa-miR-4766-3p	CLIP-seq
MIRT795443	hsa-miR-4781-3p	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT795445	hsa-miR-4801	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT795447	hsa-miR-497	CLIP-seq
MIRT795448	hsa-miR-498	CLIP-seq
MIRT795449	hsa-miR-503	CLIP-seq
MIRT795450	hsa-miR-5047	CLIP-seq
MIRT795451	hsa-miR-506	CLIP-seq
MIRT795452	hsa-miR-515-3p	CLIP-seq
MIRT795453	hsa-miR-519e	CLIP-seq
MIRT795454	hsa-miR-520d-5p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT795456	hsa-miR-524-5p	CLIP-seq
MIRT795457	hsa-miR-548m	CLIP-seq
MIRT795458	hsa-miR-550a	CLIP-seq
MIRT795459	hsa-miR-567	CLIP-seq
MIRT795460	hsa-miR-568	CLIP-seq
MIRT795461	hsa-miR-577	CLIP-seq
MIRT795462	hsa-miR-587	CLIP-seq
MIRT795463	hsa-miR-596	CLIP-seq
MIRT795464	hsa-miR-619	CLIP-seq
MIRT795465	hsa-miR-646	CLIP-seq
MIRT795466	hsa-miR-654-3p	CLIP-seq
MIRT795467	hsa-miR-659	CLIP-seq
MIRT795468	hsa-miR-875-3p	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT795470	hsa-miR-935	CLIP-seq
MIRT795471	hsa-miR-943	CLIP-seq
MIRT795472	hsa-miR-96	CLIP-seq
MIRT795473	hsa-miR-1255a	CLIP-seq
MIRT795474	hsa-miR-1255b	CLIP-seq
MIRT795364	hsa-miR-1261	CLIP-seq
MIRT795475	hsa-miR-1291	CLIP-seq
MIRT795476	hsa-miR-1294	CLIP-seq
MIRT795477	hsa-miR-142-5p	CLIP-seq
MIRT795478	hsa-miR-151-3p	CLIP-seq
MIRT795479	hsa-miR-3145-3p	CLIP-seq
MIRT795480	hsa-miR-3149	CLIP-seq
MIRT795481	hsa-miR-3173-5p	CLIP-seq
MIRT795482	hsa-miR-3180-5p	CLIP-seq
MIRT795483	hsa-miR-3647-3p	CLIP-seq
MIRT795484	hsa-miR-3942-3p	CLIP-seq
MIRT795485	hsa-miR-4260	CLIP-seq
MIRT795486	hsa-miR-4283	CLIP-seq
MIRT795487	hsa-miR-4316	CLIP-seq
MIRT795488	hsa-miR-4489	CLIP-seq
MIRT795489	hsa-miR-4514	CLIP-seq
MIRT795490	hsa-miR-4639-3p	CLIP-seq
MIRT795491	hsa-miR-4652-3p	CLIP-seq
MIRT795492	hsa-miR-4662a-3p	CLIP-seq
MIRT795431	hsa-miR-4677-3p	CLIP-seq
MIRT795493	hsa-miR-4692	CLIP-seq
MIRT795494	hsa-miR-4694-3p	CLIP-seq
MIRT795495	hsa-miR-4735-5p	CLIP-seq
MIRT795496	hsa-miR-4775	CLIP-seq
MIRT795497	hsa-miR-4777-5p	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT795498	hsa-miR-520a-5p	CLIP-seq
MIRT795454	hsa-miR-520d-5p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT795456	hsa-miR-524-5p	CLIP-seq
MIRT795499	hsa-miR-525-5p	CLIP-seq
MIRT795457	hsa-miR-548m	CLIP-seq
MIRT795500	hsa-miR-561	CLIP-seq
MIRT795501	hsa-miR-590-3p	CLIP-seq
MIRT795502	hsa-miR-635	CLIP-seq
MIRT795471	hsa-miR-943	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT1934819	hsa-miR-103b	CLIP-seq
MIRT1934820	hsa-miR-10a	CLIP-seq
MIRT1934821	hsa-miR-10b	CLIP-seq
MIRT1934822	hsa-miR-1184	CLIP-seq
MIRT795357	hsa-miR-1185	CLIP-seq
MIRT1934823	hsa-miR-1205	CLIP-seq
MIRT795359	hsa-miR-1224-5p	CLIP-seq
MIRT1934824	hsa-miR-1265	CLIP-seq
MIRT1934825	hsa-miR-1266	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT1934826	hsa-miR-142-3p	CLIP-seq
MIRT1934827	hsa-miR-145	CLIP-seq
MIRT1934828	hsa-miR-1909	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT1934829	hsa-miR-3064-5p	CLIP-seq
MIRT1934830	hsa-miR-3074-5p	CLIP-seq
MIRT1934831	hsa-miR-3123	CLIP-seq
MIRT1934832	hsa-miR-3127-5p	CLIP-seq
MIRT1934833	hsa-miR-3158-5p	CLIP-seq
MIRT1934834	hsa-miR-3160-5p	CLIP-seq
MIRT1934835	hsa-miR-3163	CLIP-seq
MIRT1934836	hsa-miR-3176	CLIP-seq
MIRT795482	hsa-miR-3180-5p	CLIP-seq
MIRT1934837	hsa-miR-324-5p	CLIP-seq
MIRT1934838	hsa-miR-325	CLIP-seq
MIRT795389	hsa-miR-337-3p	CLIP-seq
MIRT1934839	hsa-miR-3545-3p	CLIP-seq
MIRT795390	hsa-miR-3605-5p	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT795394	hsa-miR-361-5p	CLIP-seq
MIRT795397	hsa-miR-3662	CLIP-seq
MIRT1934840	hsa-miR-3671	CLIP-seq
MIRT795400	hsa-miR-3679-5p	CLIP-seq
MIRT1934841	hsa-miR-3682-5p	CLIP-seq
MIRT1934842	hsa-miR-3685	CLIP-seq
MIRT1934843	hsa-miR-370	CLIP-seq
MIRT1934844	hsa-miR-376a	CLIP-seq
MIRT1934845	hsa-miR-376b	CLIP-seq
MIRT1934846	hsa-miR-380	CLIP-seq
MIRT1934847	hsa-miR-384	CLIP-seq
MIRT1934848	hsa-miR-3914	CLIP-seq
MIRT795403	hsa-miR-3915	CLIP-seq
MIRT1934849	hsa-miR-3918	CLIP-seq
MIRT1934850	hsa-miR-3920	CLIP-seq
MIRT1934851	hsa-miR-3921	CLIP-seq
MIRT1934852	hsa-miR-3922-3p	CLIP-seq
MIRT1934853	hsa-miR-3925-5p	CLIP-seq
MIRT795405	hsa-miR-3928	CLIP-seq
MIRT795406	hsa-miR-3941	CLIP-seq
MIRT1934854	hsa-miR-4252	CLIP-seq
MIRT1934855	hsa-miR-4256	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT1934856	hsa-miR-4327	CLIP-seq
MIRT1934857	hsa-miR-4328	CLIP-seq
MIRT1934858	hsa-miR-4428	CLIP-seq
MIRT1934859	hsa-miR-4476	CLIP-seq
MIRT1934860	hsa-miR-4477a	CLIP-seq
MIRT1934861	hsa-miR-4502	CLIP-seq
MIRT1934862	hsa-miR-4518	CLIP-seq
MIRT795420	hsa-miR-4520a-3p	CLIP-seq
MIRT1934863	hsa-miR-4539	CLIP-seq
MIRT1934864	hsa-miR-4540	CLIP-seq
MIRT795490	hsa-miR-4639-3p	CLIP-seq
MIRT1934865	hsa-miR-4653-5p	CLIP-seq
MIRT795427	hsa-miR-466	CLIP-seq
MIRT795430	hsa-miR-4672	CLIP-seq
MIRT795431	hsa-miR-4677-3p	CLIP-seq
MIRT795433	hsa-miR-4689	CLIP-seq
MIRT1934866	hsa-miR-4699-3p	CLIP-seq
MIRT1934867	hsa-miR-4710	CLIP-seq
MIRT1934868	hsa-miR-4715-3p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795437	hsa-miR-4731-3p	CLIP-seq
MIRT1934869	hsa-miR-4738-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT1934870	hsa-miR-4753-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934871	hsa-miR-4764-5p	CLIP-seq
MIRT1934872	hsa-miR-4766-5p	CLIP-seq
MIRT1934873	hsa-miR-4768-5p	CLIP-seq
MIRT1934874	hsa-miR-4776-3p	CLIP-seq
MIRT795443	hsa-miR-4781-3p	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT1934875	hsa-miR-4792	CLIP-seq
MIRT1934876	hsa-miR-4795-3p	CLIP-seq
MIRT1934877	hsa-miR-4797-3p	CLIP-seq
MIRT795445	hsa-miR-4801	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT1934878	hsa-miR-494	CLIP-seq
MIRT795448	hsa-miR-498	CLIP-seq
MIRT795498	hsa-miR-520a-5p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT795499	hsa-miR-525-5p	CLIP-seq
MIRT1934879	hsa-miR-539	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT1934881	hsa-miR-548ae	CLIP-seq
MIRT1934882	hsa-miR-548aj	CLIP-seq
MIRT1934883	hsa-miR-548am	CLIP-seq
MIRT1934884	hsa-miR-548c-3p	CLIP-seq
MIRT1934885	hsa-miR-548p	CLIP-seq
MIRT1934886	hsa-miR-548x	CLIP-seq
MIRT795500	hsa-miR-561	CLIP-seq
MIRT795459	hsa-miR-567	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT1934888	hsa-miR-628-3p	CLIP-seq
MIRT1934889	hsa-miR-636	CLIP-seq
MIRT1934890	hsa-miR-640	CLIP-seq
MIRT1934891	hsa-miR-648	CLIP-seq
MIRT1934892	hsa-miR-671-5p	CLIP-seq
MIRT1934893	hsa-miR-767-3p	CLIP-seq
MIRT1934894	hsa-miR-892b	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT1934860	hsa-miR-4477a	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT1934877	hsa-miR-4797-3p	CLIP-seq
MIRT2174608	hsa-miR-513a-5p	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT1934822	hsa-miR-1184	CLIP-seq
MIRT1934823	hsa-miR-1205	CLIP-seq
MIRT2174609	hsa-miR-1237	CLIP-seq
MIRT2174610	hsa-miR-1248	CLIP-seq
MIRT1934824	hsa-miR-1265	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT2174611	hsa-miR-1285	CLIP-seq
MIRT2174612	hsa-miR-1299	CLIP-seq
MIRT2174613	hsa-miR-1302	CLIP-seq
MIRT795371	hsa-miR-1305	CLIP-seq
MIRT795372	hsa-miR-130a	CLIP-seq
MIRT795373	hsa-miR-130b	CLIP-seq
MIRT2174614	hsa-miR-138	CLIP-seq
MIRT795374	hsa-miR-15a	CLIP-seq
MIRT795375	hsa-miR-15b	CLIP-seq
MIRT795376	hsa-miR-16	CLIP-seq
MIRT1934828	hsa-miR-1909	CLIP-seq
MIRT795378	hsa-miR-195	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT2174615	hsa-miR-2114	CLIP-seq
MIRT2174616	hsa-miR-214	CLIP-seq
MIRT2174617	hsa-miR-2278	CLIP-seq
MIRT2174618	hsa-miR-2682	CLIP-seq
MIRT2174619	hsa-miR-27a	CLIP-seq
MIRT2174620	hsa-miR-27b	CLIP-seq
MIRT795385	hsa-miR-301a	CLIP-seq
MIRT795386	hsa-miR-301b	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT2174621	hsa-miR-3122	CLIP-seq
MIRT1934831	hsa-miR-3123	CLIP-seq
MIRT2174622	hsa-miR-3152-5p	CLIP-seq
MIRT2174623	hsa-miR-3156-3p	CLIP-seq
MIRT1934833	hsa-miR-3158-5p	CLIP-seq
MIRT1934835	hsa-miR-3163	CLIP-seq
MIRT2174624	hsa-miR-3185	CLIP-seq
MIRT2174625	hsa-miR-3187-5p	CLIP-seq
MIRT2174626	hsa-miR-3189-3p	CLIP-seq
MIRT2174627	hsa-miR-3192	CLIP-seq
MIRT2174628	hsa-miR-3194-3p	CLIP-seq
MIRT2174629	hsa-miR-3199	CLIP-seq
MIRT1934837	hsa-miR-324-5p	CLIP-seq
MIRT2174630	hsa-miR-326	CLIP-seq
MIRT2174631	hsa-miR-330-5p	CLIP-seq
MIRT2174632	hsa-miR-34a	CLIP-seq
MIRT2174633	hsa-miR-34c-5p	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT2174634	hsa-miR-3619-5p	CLIP-seq
MIRT2174635	hsa-miR-3650	CLIP-seq
MIRT795397	hsa-miR-3662	CLIP-seq
MIRT795398	hsa-miR-3666	CLIP-seq
MIRT1934841	hsa-miR-3682-5p	CLIP-seq
MIRT2174636	hsa-miR-378g	CLIP-seq
MIRT1934846	hsa-miR-380	CLIP-seq
MIRT2174637	hsa-miR-3913-5p	CLIP-seq
MIRT1934853	hsa-miR-3925-5p	CLIP-seq
MIRT795406	hsa-miR-3941	CLIP-seq
MIRT795408	hsa-miR-424	CLIP-seq
MIRT1934854	hsa-miR-4252	CLIP-seq
MIRT2174638	hsa-miR-4257	CLIP-seq
MIRT2174639	hsa-miR-4266	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT2174640	hsa-miR-4277	CLIP-seq
MIRT2174641	hsa-miR-4282	CLIP-seq
MIRT795413	hsa-miR-4295	CLIP-seq
MIRT2174642	hsa-miR-4298	CLIP-seq
MIRT2174643	hsa-miR-4301	CLIP-seq
MIRT2174644	hsa-miR-4314	CLIP-seq
MIRT1934856	hsa-miR-4327	CLIP-seq
MIRT1934857	hsa-miR-4328	CLIP-seq
MIRT2174645	hsa-miR-4468	CLIP-seq
MIRT2174646	hsa-miR-4486	CLIP-seq
MIRT2174647	hsa-miR-4487	CLIP-seq
MIRT2174648	hsa-miR-449a	CLIP-seq
MIRT2174649	hsa-miR-449b	CLIP-seq
MIRT2174650	hsa-miR-449c	CLIP-seq
MIRT2174651	hsa-miR-4511	CLIP-seq
MIRT795489	hsa-miR-4514	CLIP-seq
MIRT795421	hsa-miR-4524	CLIP-seq
MIRT795424	hsa-miR-454	CLIP-seq
MIRT2174652	hsa-miR-4633-3p	CLIP-seq
MIRT795490	hsa-miR-4639-3p	CLIP-seq
MIRT2174653	hsa-miR-4646-5p	CLIP-seq
MIRT795427	hsa-miR-466	CLIP-seq
MIRT2174654	hsa-miR-4671-5p	CLIP-seq
MIRT795430	hsa-miR-4672	CLIP-seq
MIRT2174655	hsa-miR-4690-5p	CLIP-seq
MIRT795493	hsa-miR-4692	CLIP-seq
MIRT2174656	hsa-miR-4695-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT2174657	hsa-miR-4726-3p	CLIP-seq
MIRT795437	hsa-miR-4731-3p	CLIP-seq
MIRT1934869	hsa-miR-4738-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934871	hsa-miR-4764-5p	CLIP-seq
MIRT2174658	hsa-miR-4779	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT2174659	hsa-miR-4793-5p	CLIP-seq
MIRT1934877	hsa-miR-4797-3p	CLIP-seq
MIRT795445	hsa-miR-4801	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT795447	hsa-miR-497	CLIP-seq
MIRT795448	hsa-miR-498	CLIP-seq
MIRT795449	hsa-miR-503	CLIP-seq
MIRT2174608	hsa-miR-513a-5p	CLIP-seq
MIRT2174660	hsa-miR-516a-3p	CLIP-seq
MIRT2174661	hsa-miR-516b	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT2174662	hsa-miR-541	CLIP-seq
MIRT2174663	hsa-miR-554	CLIP-seq
MIRT2174664	hsa-miR-558	CLIP-seq
MIRT795462	hsa-miR-587	CLIP-seq
MIRT795463	hsa-miR-596	CLIP-seq
MIRT2174665	hsa-miR-612	CLIP-seq
MIRT795464	hsa-miR-619	CLIP-seq
MIRT795465	hsa-miR-646	CLIP-seq
MIRT2174666	hsa-miR-654-5p	CLIP-seq
MIRT2174667	hsa-miR-664	CLIP-seq
MIRT2174668	hsa-miR-761	CLIP-seq
MIRT795468	hsa-miR-875-3p	CLIP-seq
MIRT2174669	hsa-miR-876-3p	CLIP-seq
MIRT1934894	hsa-miR-892b	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT795470	hsa-miR-935	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT2384431	hsa-miR-203	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2174663	hsa-miR-554	CLIP-seq
MIRT795467	hsa-miR-659	CLIP-seq
MIRT2174611	hsa-miR-1285	CLIP-seq
MIRT2174613	hsa-miR-1302	CLIP-seq
MIRT2174615	hsa-miR-2114	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT2174621	hsa-miR-3122	CLIP-seq
MIRT2174623	hsa-miR-3156-3p	CLIP-seq
MIRT2174624	hsa-miR-3185	CLIP-seq
MIRT2174625	hsa-miR-3187-5p	CLIP-seq
MIRT2174626	hsa-miR-3189-3p	CLIP-seq
MIRT2174629	hsa-miR-3199	CLIP-seq
MIRT2174630	hsa-miR-326	CLIP-seq
MIRT2174631	hsa-miR-330-5p	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT2174636	hsa-miR-378g	CLIP-seq
MIRT2174637	hsa-miR-3913-5p	CLIP-seq
MIRT2174642	hsa-miR-4298	CLIP-seq
MIRT2174643	hsa-miR-4301	CLIP-seq
MIRT2174646	hsa-miR-4486	CLIP-seq
MIRT2174651	hsa-miR-4511	CLIP-seq
MIRT2174663	hsa-miR-554	CLIP-seq
MIRT2174665	hsa-miR-612	CLIP-seq
MIRT2443938	hsa-miR-1323	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2443939	hsa-miR-548o	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT2478118	hsa-miR-1253	CLIP-seq
MIRT2443938	hsa-miR-1323	CLIP-seq
MIRT2478119	hsa-miR-2115	CLIP-seq
MIRT1934838	hsa-miR-325	CLIP-seq
MIRT795404	hsa-miR-3919	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT2478120	hsa-miR-4436b-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795439	hsa-miR-4756-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2443939	hsa-miR-548o	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT1934888	hsa-miR-628-3p	CLIP-seq
MIRT2174609	hsa-miR-1237	CLIP-seq
MIRT2174610	hsa-miR-1248	CLIP-seq
MIRT2478118	hsa-miR-1253	CLIP-seq
MIRT2443938	hsa-miR-1323	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT1934838	hsa-miR-325	CLIP-seq
MIRT1934842	hsa-miR-3685	CLIP-seq
MIRT1934847	hsa-miR-384	CLIP-seq
MIRT795404	hsa-miR-3919	CLIP-seq
MIRT2174639	hsa-miR-4266	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT2174656	hsa-miR-4695-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT795439	hsa-miR-4756-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT2174658	hsa-miR-4779	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT2174660	hsa-miR-516a-3p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT2174662	hsa-miR-541	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2443939	hsa-miR-548o	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT795464	hsa-miR-619	CLIP-seq
MIRT1934888	hsa-miR-628-3p	CLIP-seq
MIRT2174666	hsa-miR-654-5p	CLIP-seq
MIRT795468	hsa-miR-875-3p	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001664	Function	G protein-coupled receptor binding	IDA	15755723
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	11724822, 15364580, 15755723, 20300064, 20844236
GO:0005737	Component	Cytoplasm	IDA	15755723
GO:0005829	Component	Cytosol	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	15755723
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007266	Process	Rho protein signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
604763	14193	ENSG00000196914

Protein

UniProt ID

Q9NZN5

Protein name

Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)

Protein function

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and G

PDB

1TXD , 1X86 , 2OMJ , 2OS6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	73 → 145	PDZ domain	Domain
PF09128	RGS-like	368 → 558	Regulator of G protein signalling-like domain	Domain
PF00621	RhoGEF	791 → 975	RhoGEF domain	Domain
PF17838	PH_16	1004 → 1132	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Isoform 2 is found in jejunum and testis.

Sequence

MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDAS
RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR
IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK
SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI
LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY
LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ
VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK
PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS
GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK
QLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG
DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH
FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ
PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ
SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS

Sequence length

1544

Interactions

View interactions

	KEGG		Reactome
	Vascular smooth muscle contraction Axon guidance Platelet activation C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Yersinia infection Tuberculosis Human cytomegalovirus infection Pathways in cancer Proteoglycans in cancer		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	30104761
Glaucoma	Glaucoma, Glaucoma, Open-Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328 View all (29 more)	30054594, 29891935

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Hypertension	Hypertension		GWAS
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	19734946
Cell Transformation Neoplastic	Associate	30217930
Colorectal Neoplasms	Associate	19734946, 26258642
Congenital Abnormalities	Associate	33084842
Glaucoma	Associate	25637523
Glaucoma Open Angle	Associate	25637523, 38242088
Glioblastoma	Associate	32693062
Glioma	Associate	32693062
Heart Defects Congenital	Associate	33084842
Heart Diseases	Associate	26483157
Hypersensitivity Delayed	Associate	33084842
Immunoglobulin Light chain Amyloidosis	Associate	32922167
Intraocular Lymphoma	Associate	25637523
Leukemia	Associate	11373293, 32693062, 33419897
Leukemia Biphenotypic Acute	Associate	11373293
Leukemia Myeloid Acute	Associate	10681437, 11094164, 11373293, 19196702, 33419897
Leukemia T Cell	Stimulate	17539775
Leukemia T Cell	Associate	34304710
Low Tension Glaucoma	Associate	25637523
Malformations of Cortical Development Group I	Associate	23885121
Multiple Myeloma	Associate	32922167
Neoplasms	Associate	11373293, 26483157, 33084842, 35238908
Neoplasms	Inhibit	19734946
Pituitary dwarfism 1	Associate	25485589
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	33419897
Prostatic Neoplasms	Associate	21147910
Pulmonary Disease Chronic Obstructive	Associate	34675500
Shwachman Diamond Syndrome	Stimulate	17539775

ARHGEF12 (Rho guanine nucleotide exchange factor 12)