Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23299
Gene name Gene Name - the full gene name approved by the HGNC.
BICD cargo adaptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BICD2
Synonyms (NCBI Gene) Gene synonyms aliases
SMALED2, SMALED2A, SMALED2B, bA526D8.1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SMALED2A, SMALED2B
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q22.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs141414055 G>A,C Conflicting-interpretations-of-pathogenicity Coding sequence variant, synonymous variant, missense variant
rs192669216 G>A,T Conflicting-interpretations-of-pathogenicity, uncertain-significance Missense variant, coding sequence variant
rs371707778 G>A Pathogenic, likely-pathogenic Missense variant, coding sequence variant
rs398123028 G>A Pathogenic, not-provided Missense variant, coding sequence variant
rs398123029 T>G Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023191 hsa-miR-124-3p Microarray 18668037
MIRT028312 hsa-miR-32-5p Sequencing 20371350
MIRT041505 hsa-miR-193b-3p CLASH 23622248
MIRT039848 hsa-miR-615-3p CLASH 23622248
MIRT039040 hsa-miR-766-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16417406, 20386726, 23664119, 24482476
GO:0005635 Component Nuclear envelope IDA 20386726
GO:0005642 Component Annulate lamellae IDA 20386726
GO:0005643 Component Nuclear pore IDA 20386726
GO:0005737 Component Cytoplasm IMP 17139249
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609797 17208 ENSG00000185963
Protein
UniProt ID Q8TD16
Protein name Protein bicaudal D homolog 2 (Bic-D 2)
Protein function Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynac
PDB 6OFP , 6PSE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09730 BicD 83 801 Microtubule-associated protein Bicaudal-D Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH
VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG
GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE
LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA
MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS
LLRMAIQQKLALTQRLELLEL
DHEQTRRGRAKAAPKTKPATPSL
Sequence length 824
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1   COPI-independent Golgi-to-ER retrograde traffic
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthrogryposis multiplex congenita Arthrogryposis rs1586285494, rs80358233, rs137853305, rs1559154278, rs398124167, rs398124172, rs587780399, rs786204576, rs786204430, rs769345284, rs749355583, rs793888524, rs793888525, rs878854368, rs555445835
View all (138 more)
30054298
Hydrocephalus Hydrocephalus rs387907320, rs369384363, rs387907321, rs372127610, rs770273135, rs797045095, rs797045707, rs769795916, rs781251438, rs922703465, rs376078512, rs1567043467, rs1587149916, rs1586841546
Hydrops fetalis Hydrops Fetalis rs28935477, rs1131691986 30054298
Macrocephaly Macrocephaly rs786204854, rs764333096, rs1557739557
Unknown
Disease term Disease name Evidence References Source
Spinal Muscular Atrophy autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures GenCC
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32360590
Allergic Fungal Sinusitis Associate 29253858
Amyotrophic Lateral Sclerosis Associate 37849306
Arthrogryposis Associate 25497877, 28635954, 30054298
Atrophy Associate 30054298
Brain Diseases Associate 36930595
Breast Neoplasms Associate 31965981
Cardiomegaly Associate 33122805
Central Nervous System Vascular Malformations Associate 35896821, 36930595
Cerebellar Hypoplasia Associate 35896821