Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23284
Gene name Gene Name - the full gene name approved by the HGNC.	Adhesion G protein-coupled receptor L3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADGRL3
Synonyms (NCBI Gene) Gene synonyms aliases	CIRL3, CL3, LEC3, LPHN3
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cystein

Show/Hide all(59)

miRTarBase ID	miRNA	Experiments	Reference
MIRT740396	hsa-miR-7844-5p	HITS-CLIP	19536157
MIRT740397	hsa-miR-5683	HITS-CLIP	19536157
MIRT740398	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT740399	hsa-miR-3682-3p	HITS-CLIP	19536157
MIRT740400	hsa-miR-4775	HITS-CLIP	19536157
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT741957	hsa-miR-3133	HITS-CLIP	23824327
MIRT741958	hsa-miR-4511	HITS-CLIP	23824327
MIRT741959	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT741960	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT741961	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT741962	hsa-miR-3976	HITS-CLIP	23824327
MIRT741963	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT741964	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT741965	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT741966	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT741967	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT741968	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741969	hsa-miR-578	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT742294	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT742295	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT742296	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT742294	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT742295	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT742296	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT755246	hsa-miR-3668	PAR-CLIP	22100165
MIRT755247	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT755248	hsa-miR-1253	PAR-CLIP	22100165
MIRT755249	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT755250	hsa-miR-601	PAR-CLIP	22100165
MIRT755251	hsa-miR-6832-5p	PAR-CLIP	22100165
MIRT755252	hsa-miR-4732-5p	PAR-CLIP	22100165
MIRT755253	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT755254	hsa-miR-6843-3p	PAR-CLIP	22100165
MIRT755255	hsa-miR-6848-3p	PAR-CLIP	22100165
MIRT755256	hsa-miR-133a-3p	PAR-CLIP	22100165
MIRT755257	hsa-miR-133b	PAR-CLIP	22100165
MIRT755246	hsa-miR-3668	PAR-CLIP	22100165
MIRT755247	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT755248	hsa-miR-1253	PAR-CLIP	22100165
MIRT755249	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT755250	hsa-miR-601	PAR-CLIP	22100165
MIRT755251	hsa-miR-6832-5p	PAR-CLIP	22100165
MIRT755252	hsa-miR-4732-5p	PAR-CLIP	22100165
MIRT755253	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT755254	hsa-miR-6843-3p	PAR-CLIP	22100165
MIRT755255	hsa-miR-6848-3p	PAR-CLIP	22100165
MIRT755256	hsa-miR-133a-3p	PAR-CLIP	22100165
MIRT755257	hsa-miR-133b	PAR-CLIP	22100165

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	35418682
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0004930	Function	G protein-coupled receptor activity	NAS	10994649
GO:0004930	Function	G protein-coupled receptor activity	TAS	15203201
GO:0005509	Function	Calcium ion binding	IDA	26235030
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	26235030
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	26235030
GO:0005886	Component	Plasma membrane	IEA
GO:0005911	Component	Cell-cell junction	IBA
GO:0005911	Component	Cell-cell junction	ISS
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	10994649
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	15203201
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0007416	Process	Synapse assembly	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10994649
GO:0016020	Component	Membrane	TAS	15203201
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0098631	Function	Cell adhesion mediator activity	ISS
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IDA	26235030
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0140693	Function	Molecular condensate scaffold activity	ISS
GO:0160221	Process	Rho-activating G protein-coupled receptor signaling pathway	IDA	35418682
GO:1904861	Process	Excitatory synapse assembly	ISS

MIM	HGNC	e!Ensembl
616417	20974	ENSG00000150471

Protein

UniProt ID

Q9HAR2

Protein name

Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)

Protein function

Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:35418682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the

PDB

5CMN , 6VHH , 7SF7 , 8DJG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02140	Gal_Lectin	43 → 123	Galactose binding lectin domain	Domain
PF02191	OLF	139 → 391	Olfactomedin-like domain	Family
PF16489	GAIN	567 → 775	GPCR-Autoproteolysis INducing (GAIN) domain	Domain
PF01825	GPS	803 → 847	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	861 → 1097	7 transmembrane receptor (Secretin family)	Family
PF02354	Latrophilin	1117 → 1184	Latrophilin Cytoplasmic C-terminal region	Family
PF02354	Latrophilin	1181 → 1447	Latrophilin Cytoplasmic C-terminal region	Family

Sequence

MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGR
TDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQ
YECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTD
TLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSG
EAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGT
WDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNS
YQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELE
RPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDM
TTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIW
DPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVG
LLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTV
EESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLK
QNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNK
VYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNH
LTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIH
KNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVF
ESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIM
LNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTV
IMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRT
PGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLN
GNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQN
RNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQP
HHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEP
PPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGP
AHLVTSL

Sequence length

1447

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Eosinophilia	Eosinophilic esophagitis	N/A	N/A	GWAS
Epilepsy	Epilepsy	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Ischemic Stroke	Ischemic stroke	N/A	N/A	GWAS
Kidney Disease	Chronic kidney disease	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Astrocytoma	Associate	27692237
Attention Deficit and Disruptive Behavior Disorders	Associate	30696812
Attention Deficit Disorder with Hyperactivity	Associate	20157310, 21040458, 21606926, 22832519, 23190410, 23245769, 25989180, 26598068, 26746237, 27692237, 28624582, 28871191, 30696812, 31426340, 33504901, 35393556, 36151371 View all (2 more)
Bicuspid Aortic Valve Disease	Associate	21309044
Breast Neoplasms	Associate	23317273, 39948777
Breast Neoplasms	Inhibit	33247693
Carcinoma Intraductal Noninfiltrating	Associate	26718977
Cutis Laxa Autosomal Dominant	Associate	21309044
Disruptive Impulse Control and Conduct Disorders	Associate	28624582
Dyslexia	Associate	23190410
Ependymoma	Associate	35013530
Inflammatory Bowel Diseases	Associate	16007110
Leukemia Lymphocytic Chronic B Cell	Associate	21911837
Lymphatic Metastasis	Stimulate	23317273
Neoplasm Metastasis	Inhibit	33247693
Neoplasm Metastasis	Associate	39948777
Neuroblastoma	Associate	27692237
Personality Disorders	Associate	21911837
Renal Insufficiency Chronic	Associate	30226566
Substance Related Disorders	Associate	30696812

ADGRL3 (adhesion G protein-coupled receptor L3)