Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	23284
Gene name	Adhesion G protein-coupled receptor L3
Gene symbol	ADGRL3
Synonyms (NCBI Gene)	CIRL3CL3LEC3LPHN3
Chromosome	4
Chromosome location	4q13.1
Summary	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cystein

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miRTarBase ID	miRNA	Experiments	Reference
MIRT740396	hsa-miR-7844-5p	HITS-CLIP	19536157
MIRT740397	hsa-miR-5683	HITS-CLIP	19536157
MIRT740398	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT740399	hsa-miR-3682-3p	HITS-CLIP	19536157
MIRT740400	hsa-miR-4775	HITS-CLIP	19536157
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT741957	hsa-miR-3133	HITS-CLIP	23824327
MIRT741958	hsa-miR-4511	HITS-CLIP	23824327
MIRT741959	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT741960	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT741961	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT741962	hsa-miR-3976	HITS-CLIP	23824327
MIRT741963	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT741964	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT741965	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT741966	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT741967	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT741968	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741969	hsa-miR-578	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT742294	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT742295	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT742296	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT742294	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT742295	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT742296	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT742273	hsa-miR-4282	HITS-CLIP	23824327
MIRT741705	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT755246	hsa-miR-3668	PAR-CLIP	22100165
MIRT755247	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT755248	hsa-miR-1253	PAR-CLIP	22100165
MIRT755249	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT755250	hsa-miR-601	PAR-CLIP	22100165
MIRT755251	hsa-miR-6832-5p	PAR-CLIP	22100165
MIRT755252	hsa-miR-4732-5p	PAR-CLIP	22100165
MIRT755253	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT755254	hsa-miR-6843-3p	PAR-CLIP	22100165
MIRT755255	hsa-miR-6848-3p	PAR-CLIP	22100165
MIRT755256	hsa-miR-133a-3p	PAR-CLIP	22100165
MIRT755257	hsa-miR-133b	PAR-CLIP	22100165
MIRT755246	hsa-miR-3668	PAR-CLIP	22100165
MIRT755247	hsa-miR-7852-3p	PAR-CLIP	22100165
MIRT755248	hsa-miR-1253	PAR-CLIP	22100165
MIRT755249	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT755250	hsa-miR-601	PAR-CLIP	22100165
MIRT755251	hsa-miR-6832-5p	PAR-CLIP	22100165
MIRT755252	hsa-miR-4732-5p	PAR-CLIP	22100165
MIRT755253	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT755254	hsa-miR-6843-3p	PAR-CLIP	22100165
MIRT755255	hsa-miR-6848-3p	PAR-CLIP	22100165
MIRT755256	hsa-miR-133a-3p	PAR-CLIP	22100165
MIRT755257	hsa-miR-133b	PAR-CLIP	22100165

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	35418682
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0004930	Function	G protein-coupled receptor activity	NAS	10994649
GO:0004930	Function	G protein-coupled receptor activity	TAS	15203201
GO:0005509	Function	Calcium ion binding	IDA	26235030
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	26235030
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	26235030
GO:0005886	Component	Plasma membrane	IEA
GO:0005911	Component	Cell-cell junction	IBA
GO:0005911	Component	Cell-cell junction	ISS
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	10994649
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	15203201
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0007416	Process	Synapse assembly	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10994649
GO:0016020	Component	Membrane	TAS	15203201
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0098631	Function	Cell adhesion mediator activity	ISS
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IDA	26235030
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0140693	Function	Molecular condensate scaffold activity	ISS
GO:0160221	Process	Rho-activating G protein-coupled receptor signaling pathway	IDA	35418682
GO:1904861	Process	Excitatory synapse assembly	ISS

MIM	HGNC	e!Ensembl
616417	20974	ENSG00000150471

Q9HAR2

Protein name

Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)

Protein function

Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:35418682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the

PDB

5CMN , 6VHH , 7SF7 , 8DJG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02140	Gal_Lectin	43 → 123	Galactose binding lectin domain	Domain
PF02191	OLF	139 → 391	Olfactomedin-like domain	Family
PF16489	GAIN	567 → 775	GPCR-Autoproteolysis INducing (GAIN) domain	Domain
PF01825	GPS	803 → 847	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	861 → 1097	7 transmembrane receptor (Secretin family)	Family
PF02354	Latrophilin	1117 → 1184	Latrophilin Cytoplasmic C-terminal region	Family
PF02354	Latrophilin	1181 → 1447	Latrophilin Cytoplasmic C-terminal region	Family

Sequence

MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGR
TDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQ
YECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTD
TLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSG
EAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGT
WDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNS
YQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELE
RPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDM
TTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIW
DPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVG
LLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTV
EESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLK
QNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNK
VYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNH
LTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIH
KNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVF
ESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIM
LNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTV
IMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRT
PGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLN
GNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQN
RNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQP
HHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEP
PPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGP
AHLVTSL

Sequence length

1447

Interactions

View interactions

ADGRL3 (adhesion G protein-coupled receptor L3)