SULF1 (sulfatase 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
23213 |
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Sulfatase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
SULF1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
SULF-1 |
Chromosome
Chromosome number
|
8 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
8q13.2-q13.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently |
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
Protein | ||||||||||||||||
UniProt ID | Q8IWU6 | |||||||||||||||
Protein name | Extracellular sulfatase Sulf-1 (hSulf-1) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form] | |||||||||||||||
Protein function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295 | |||||||||||||||
Family and domains |
Pfam
|
|||||||||||||||
Tissue specificity | TISSUE SPECIFICITY: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, o | |||||||||||||||
Sequence |
|
|||||||||||||||
Sequence length | 871 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|