Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23213
Gene name Gene Name - the full gene name approved by the HGNC.
Sulfatase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SULF1
Synonyms (NCBI Gene) Gene synonyms aliases
SULF-1
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q13.2-q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005970 hsa-miR-516a-3p Northern blot, qRT-PCR, Western blot 21169410
MIRT005970 hsa-miR-516a-3p Northern blot, qRT-PCR, Western blot 21169410
MIRT022965 hsa-miR-124-3p Microarray 18668037
MIRT734636 hsa-miR-378a-3p Luciferase reporter assay, Microarray, qRT-PCR 32866261
MIRT1402616 hsa-miR-548p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001822 Process Kidney development ISS
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 16778174
GO:0002063 Process Chondrocyte development ISS
GO:0003094 Process Glomerular filtration ISS
GO:0004065 Function Arylsulfatase activity IDA 12368295
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610012 20391 ENSG00000137573
Protein
UniProt ID Q8IWU6
Protein name Extracellular sulfatase Sulf-1 (hSulf-1) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]
Protein function Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00884 Sulfatase 43 374 Sulfatase Family
PF12548 DUF3740 534 679 Sulfatase protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, o
Sequence
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
NIDLAPTILDIAGL
DTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
REVRGHLKRRKPEECSCSK
QSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
Sequence length 871
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Ovarian cancer Malignant neoplasm of ovary rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828
View all (31 more)
17310998
Unknown
Disease term Disease name Evidence References Source
Cervical Cancer Cervical Cancer Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2). GWAS, CBGDA
Crohn Disease Crohn Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 24322345
Adenocarcinoma Associate 38250763
Adenocarcinoma of Lung Associate 21599997
Adenoma Associate 30175151
Alveolitis Extrinsic Allergic Associate 37800807
Bone Diseases Inhibit 32413029
Brain Neoplasms Stimulate 28525382
Breast Neoplasms Stimulate 21599997
Breast Neoplasms Associate 24911625, 30236106, 32377705
Carcinogenesis Associate 29991755