Gene Gene information from NCBI Gene database.
Entrez ID 23197
Gene name Fas associated factor family member 2
Gene symbol FAF2
Synonyms (NCBI Gene)
ETEAUBXD8UBXN3B
Chromosome 5
Chromosome location 5q35.2
Summary The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of A
miRNA miRNA information provided by mirtarbase database.
854
miRTarBase ID miRNA Experiments Reference
MIRT028605 hsa-miR-30a-5p Proteomics 18668040
MIRT045457 hsa-miR-149-5p CLASH 23622248
MIRT041330 hsa-miR-193b-3p CLASH 23622248
MIRT166066 hsa-miR-106b-5p HITS-CLIP 22473208
MIRT166062 hsa-miR-20a-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18711132, 18775313, 19818707, 22119785, 24215460, 28514442, 29997244, 31073040, 35044719, 35271311, 37776851
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IEA
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IDA 34739333
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616935 24666 ENSG00000113194
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96CS3
Protein name FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Protein function Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expressi
PDB 2DAM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14555 UBA_4 14 57 Domain
PF00789 UBX 357 441 UBX domain Domain
Tissue specificity TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain. {ECO:0000269|PubMed:12372427}.
Sequence
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSV
FNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRF
IRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGD
DHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKD
RRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLAS
LRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPE
SVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEW
PNPPTLQEAGLSHTEVLFVQD
LTDE
Sequence length 445
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation