Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23197
Gene name Gene Name - the full gene name approved by the HGNC.
Fas associated factor family member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FAF2
Synonyms (NCBI Gene) Gene synonyms aliases
ETEA, UBXD8, UBXN3B
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q35.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of A
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028605 hsa-miR-30a-5p Proteomics 18668040
MIRT045457 hsa-miR-149-5p CLASH 23622248
MIRT041330 hsa-miR-193b-3p CLASH 23622248
MIRT166066 hsa-miR-106b-5p HITS-CLIP 22473208
MIRT166062 hsa-miR-20a-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18711132, 18775313, 19818707, 22119785, 24215460, 28514442, 29997244, 31073040
GO:0005576 Component Extracellular region TAS
GO:0005783 Component Endoplasmic reticulum IDA 23297223
GO:0005811 Component Lipid droplet IDA 14741744, 23297223
GO:0006986 Process Response to unfolded protein IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616935 24666 ENSG00000113194
Protein
UniProt ID Q96CS3
Protein name FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Protein function Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expressi
PDB 2DAM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14555 UBA_4 14 57 Domain
PF00789 UBX 357 441 UBX domain Domain
Tissue specificity TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain. {ECO:0000269|PubMed:12372427}.
Sequence
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSV
FNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRF
IRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGD
DHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKD
RRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLAS
LRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPE
SVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEW
PNPPTLQEAGLSHTEVLFVQD
LTDE
Sequence length 445
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17199135
Associations from Text Mining
Disease Name Relationship Type References
Leukemia Lymphocytic Chronic B Cell Associate 26556860