FBXL7 (F-box and leucine rich repeat protein 7)

Gene

• Entrez ID: 23194
• Gene name: F-box and leucine rich repeat protein 7
• Gene symbol: FBXL7
• Synonyms (NCBI Gene): FBL6, FBL7
• Chromosome: 5
• Chromosome location: 5p15.1
• Summary: This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiqu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT537453	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT537452	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT537451	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT537450	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT537449	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT537448	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT537447	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT537446	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT537445	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT537444	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT537443	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT537442	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT537441	hsa-miR-302e	PAR-CLIP	22012620
MIRT537440	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT537439	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT537438	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT537437	hsa-miR-520b	PAR-CLIP	22012620
MIRT537436	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT537435	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT537434	hsa-miR-520e	PAR-CLIP	22012620
MIRT537433	hsa-miR-5579-5p	PAR-CLIP	22012620
MIRT537432	hsa-miR-4461	PAR-CLIP	22012620
MIRT537431	hsa-miR-520g-3p	PAR-CLIP	22012620
MIRT537430	hsa-miR-520h	PAR-CLIP	22012620
MIRT537429	hsa-miR-219a-1-3p	PAR-CLIP	22012620
MIRT537428	hsa-miR-571	PAR-CLIP	22012620
MIRT537427	hsa-miR-31-3p	PAR-CLIP	22012620
MIRT537426	hsa-miR-5681b	PAR-CLIP	22012620
MIRT537425	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT537424	hsa-miR-527	PAR-CLIP	22012620
MIRT537423	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT537453	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT537452	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT537451	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT537450	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT537449	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT537448	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT537447	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT537446	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT537445	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT537444	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT537443	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT537442	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT537441	hsa-miR-302e	PAR-CLIP	22012620
MIRT537440	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT537439	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT537438	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT537437	hsa-miR-520b	PAR-CLIP	22012620
MIRT537436	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT537435	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT537434	hsa-miR-520e	PAR-CLIP	22012620
MIRT537433	hsa-miR-5579-5p	PAR-CLIP	22012620
MIRT537432	hsa-miR-4461	PAR-CLIP	22012620
MIRT537431	hsa-miR-520g-3p	PAR-CLIP	22012620
MIRT537430	hsa-miR-520h	PAR-CLIP	22012620
MIRT537429	hsa-miR-219a-1-3p	PAR-CLIP	22012620
MIRT537428	hsa-miR-571	PAR-CLIP	22012620
MIRT537427	hsa-miR-31-3p	PAR-CLIP	22012620
MIRT537426	hsa-miR-5681b	PAR-CLIP	22012620
MIRT537425	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT537424	hsa-miR-527	PAR-CLIP	22012620
MIRT537423	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT991167	hsa-miR-1184	CLIP-seq
MIRT991168	hsa-miR-1193	CLIP-seq
MIRT991169	hsa-miR-1285	CLIP-seq
MIRT991170	hsa-miR-1287	CLIP-seq
MIRT991171	hsa-miR-132	CLIP-seq
MIRT991172	hsa-miR-1343	CLIP-seq
MIRT991173	hsa-miR-141	CLIP-seq
MIRT991174	hsa-miR-148a	CLIP-seq
MIRT991175	hsa-miR-148b	CLIP-seq
MIRT991176	hsa-miR-152	CLIP-seq
MIRT991177	hsa-miR-200a	CLIP-seq
MIRT991178	hsa-miR-212	CLIP-seq
MIRT991179	hsa-miR-3135b	CLIP-seq
MIRT991180	hsa-miR-3160-3p	CLIP-seq
MIRT991181	hsa-miR-3187-5p	CLIP-seq
MIRT991182	hsa-miR-3689a-3p	CLIP-seq
MIRT991183	hsa-miR-3689c	CLIP-seq
MIRT991184	hsa-miR-3915	CLIP-seq
MIRT991185	hsa-miR-3928	CLIP-seq
MIRT991186	hsa-miR-4276	CLIP-seq
MIRT991187	hsa-miR-4297	CLIP-seq
MIRT991188	hsa-miR-4302	CLIP-seq
MIRT991189	hsa-miR-4455	CLIP-seq
MIRT991190	hsa-miR-4648	CLIP-seq
MIRT991191	hsa-miR-4654	CLIP-seq
MIRT991192	hsa-miR-4690-3p	CLIP-seq
MIRT991193	hsa-miR-4718	CLIP-seq
MIRT991194	hsa-miR-4728-5p	CLIP-seq
MIRT991195	hsa-miR-4731-5p	CLIP-seq
MIRT991196	hsa-miR-4769-5p	CLIP-seq
MIRT991197	hsa-miR-488	CLIP-seq
MIRT991198	hsa-miR-509-3p	CLIP-seq
MIRT991199	hsa-miR-512-3p	CLIP-seq
MIRT991200	hsa-miR-570	CLIP-seq
MIRT991201	hsa-miR-609	CLIP-seq
MIRT991202	hsa-miR-612	CLIP-seq
MIRT991203	hsa-miR-671-5p	CLIP-seq
MIRT991204	hsa-miR-7	CLIP-seq
MIRT991167	hsa-miR-1184	CLIP-seq
MIRT1993913	hsa-miR-1253	CLIP-seq
MIRT1993914	hsa-miR-1976	CLIP-seq
MIRT1993915	hsa-miR-2355-5p	CLIP-seq
MIRT1993916	hsa-miR-3151	CLIP-seq
MIRT1993917	hsa-miR-3165	CLIP-seq
MIRT991192	hsa-miR-4690-3p	CLIP-seq
MIRT991204	hsa-miR-7	CLIP-seq
MIRT1993918	hsa-miR-9	CLIP-seq
MIRT2227955	hsa-miR-1182	CLIP-seq
MIRT991167	hsa-miR-1184	CLIP-seq
MIRT991170	hsa-miR-1287	CLIP-seq
MIRT991174	hsa-miR-148a	CLIP-seq
MIRT991175	hsa-miR-148b	CLIP-seq
MIRT991176	hsa-miR-152	CLIP-seq
MIRT1993914	hsa-miR-1976	CLIP-seq
MIRT1993915	hsa-miR-2355-5p	CLIP-seq
MIRT991179	hsa-miR-3135b	CLIP-seq
MIRT2227956	hsa-miR-3140-5p	CLIP-seq
MIRT991186	hsa-miR-4276	CLIP-seq
MIRT991192	hsa-miR-4690-3p	CLIP-seq
MIRT991199	hsa-miR-512-3p	CLIP-seq
MIRT991203	hsa-miR-671-5p	CLIP-seq
MIRT991167	hsa-miR-1184	CLIP-seq
MIRT991170	hsa-miR-1287	CLIP-seq
MIRT991174	hsa-miR-148a	CLIP-seq
MIRT991175	hsa-miR-148b	CLIP-seq
MIRT991176	hsa-miR-152	CLIP-seq
MIRT991179	hsa-miR-3135b	CLIP-seq
MIRT991186	hsa-miR-4276	CLIP-seq
MIRT991192	hsa-miR-4690-3p	CLIP-seq
MIRT991199	hsa-miR-512-3p	CLIP-seq
MIRT991203	hsa-miR-671-5p	CLIP-seq
MIRT2428846	hsa-miR-1915	CLIP-seq
MIRT2428847	hsa-miR-3159	CLIP-seq
MIRT2428848	hsa-miR-3162-5p	CLIP-seq
MIRT2428849	hsa-miR-3667-5p	CLIP-seq
MIRT2428850	hsa-miR-3918	CLIP-seq
MIRT2428851	hsa-miR-4685-5p	CLIP-seq
MIRT991167	hsa-miR-1184	CLIP-seq
MIRT991170	hsa-miR-1287	CLIP-seq
MIRT991174	hsa-miR-148a	CLIP-seq
MIRT991175	hsa-miR-148b	CLIP-seq
MIRT991176	hsa-miR-152	CLIP-seq
MIRT991179	hsa-miR-3135b	CLIP-seq
MIRT991186	hsa-miR-4276	CLIP-seq
MIRT991192	hsa-miR-4690-3p	CLIP-seq
MIRT991199	hsa-miR-512-3p	CLIP-seq
MIRT991203	hsa-miR-671-5p	CLIP-seq
MIRT2449504	hsa-miR-19a	CLIP-seq
MIRT2449505	hsa-miR-19b	CLIP-seq
MIRT2449506	hsa-miR-3934	CLIP-seq
MIRT2449507	hsa-miR-4708-3p	CLIP-seq
MIRT2449508	hsa-miR-4755-3p	CLIP-seq
MIRT2449504	hsa-miR-19a	CLIP-seq
MIRT2449505	hsa-miR-19b	CLIP-seq
MIRT2449506	hsa-miR-3934	CLIP-seq
MIRT2449507	hsa-miR-4708-3p	CLIP-seq
MIRT2449508	hsa-miR-4755-3p	CLIP-seq
MIRT2227955	hsa-miR-1182	CLIP-seq
MIRT2531467	hsa-miR-224	CLIP-seq
MIRT2531468	hsa-miR-3134	CLIP-seq
MIRT2227956	hsa-miR-3140-5p	CLIP-seq
MIRT991180	hsa-miR-3160-3p	CLIP-seq
MIRT2531469	hsa-miR-3671	CLIP-seq
MIRT2531470	hsa-miR-3682-3p	CLIP-seq
MIRT2531471	hsa-miR-4457	CLIP-seq
MIRT2531472	hsa-miR-4502	CLIP-seq
MIRT2531473	hsa-miR-4534	CLIP-seq
MIRT2531474	hsa-miR-4679	CLIP-seq
MIRT2531475	hsa-miR-4738-3p	CLIP-seq
MIRT2531476	hsa-miR-4762-3p	CLIP-seq
MIRT2531477	hsa-miR-513b	CLIP-seq
MIRT2531478	hsa-miR-607	CLIP-seq
MIRT2227955	hsa-miR-1182	CLIP-seq
MIRT2680857	hsa-miR-133a	CLIP-seq
MIRT2680858	hsa-miR-133b	CLIP-seq
MIRT2531467	hsa-miR-224	CLIP-seq
MIRT1993915	hsa-miR-2355-5p	CLIP-seq
MIRT2531468	hsa-miR-3134	CLIP-seq
MIRT2227956	hsa-miR-3140-5p	CLIP-seq
MIRT991180	hsa-miR-3160-3p	CLIP-seq
MIRT2531469	hsa-miR-3671	CLIP-seq
MIRT2680859	hsa-miR-3679-3p	CLIP-seq
MIRT2531470	hsa-miR-3682-3p	CLIP-seq
MIRT991184	hsa-miR-3915	CLIP-seq
MIRT991185	hsa-miR-3928	CLIP-seq
MIRT2531471	hsa-miR-4457	CLIP-seq
MIRT2680860	hsa-miR-4487	CLIP-seq
MIRT2531472	hsa-miR-4502	CLIP-seq
MIRT2531473	hsa-miR-4534	CLIP-seq
MIRT2680861	hsa-miR-4663	CLIP-seq
MIRT2531474	hsa-miR-4679	CLIP-seq
MIRT2680862	hsa-miR-4686	CLIP-seq
MIRT2531475	hsa-miR-4738-3p	CLIP-seq
MIRT2531476	hsa-miR-4762-3p	CLIP-seq
MIRT2680863	hsa-miR-4786-5p	CLIP-seq
MIRT2531477	hsa-miR-513b	CLIP-seq
MIRT2680864	hsa-miR-515-5p	CLIP-seq
MIRT2680865	hsa-miR-548c-3p	CLIP-seq
MIRT2680866	hsa-miR-558	CLIP-seq
MIRT2531478	hsa-miR-607	CLIP-seq
MIRT2680867	hsa-miR-659	CLIP-seq
MIRT2680868	hsa-miR-769-5p	CLIP-seq
MIRT1993918	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	ISS
GO:0000151	Component	Ubiquitin ligase complex	NAS	10531035
GO:0000209	Process	Protein polyubiquitination	IDA	25778398
GO:0000209	Process	Protein polyubiquitination	IMP	28218735
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0000278	Process	Mitotic cell cycle	ISS
GO:0005515	Function	Protein binding	IPI	25778398, 28218735, 32296183
GO:0005813	Component	Centrosome	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	NAS	10531035
GO:0010265	Process	SCF complex assembly	TAS
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016567	Process	Protein ubiquitination	ISS
GO:0019005	Component	SCF ubiquitin ligase complex	IBA	21873635
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	25778398
GO:0019005	Component	SCF ubiquitin ligase complex	ISS
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	25778398
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP	28218735
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0051301	Process	Cell division	IEA

Other IDs

• MIM: 605656
• HGNC: 13604
• e!Ensembl: ENSG00000183580

Protein

• UniProt ID: Q9UJT9
• Protein name: F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)
• Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00646	F-box	112 → 159	F-box domain	Domain
  PF13516	LRR_6	296 → 320	Leucine Rich repeat	Repeat
  PF13516	LRR_6	400 → 424	Leucine Rich repeat	Repeat
  PF13516	LRR_6	426 → 447	Leucine Rich repeat	Repeat

• Sequence:

  MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALIC
  PPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDH
  SMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQD
  TPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNL
  EHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQL
  THLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHC
  GRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGL
  ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKR
  CVIEHTNPAFF

• Sequence length: 491

Pathways

Reactome:

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	26339675
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28736931

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma		25918132, 24486069	ClinVar, GWAS
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		26634245	ClinVar
Lung adenocarcinoma	Lung adenocarcinoma	Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors		GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Asthma	Associate	24486069, 31095684, 32119686
Breast Neoplasms	Associate	20418484
Carcinoma Non Small Cell Lung	Associate	37179372
Esophageal Neoplasms	Associate	35887149
Hemangioma capillary infantile	Associate	36181115
Hereditary Breast and Ovarian Cancer Syndrome	Associate	22759382
Hypoxia	Associate	37179372
Ige Responsiveness Atopic	Associate	30584054
Insulin Resistance	Associate	23628382
Neoplasm Metastasis	Associate	37179372
Neoplasms	Associate	22759382, 28472177, 37179372
Neoplasms	Inhibit	35887149
Neoplasms Adipose Tissue	Associate	23628382
Pancreatic Neoplasms	Associate	35887149