UBXN4 (UBX domain protein 4)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23190 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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UBX domain protein 4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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UBXN4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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UBXD2, UBXDC1, erasin |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q21.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q92575 | ||||||||||
| Protein name | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | ||||||||||
| Protein function | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). | ||||||||||
| PDB | 2KXJ | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level). {ECO:0000269|PubMed:16968747}. | ||||||||||
| Sequence |
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| Sequence length | 508 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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