UBXN4 (UBX domain protein 4)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23190 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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UBX domain protein 4 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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UBXN4 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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UBXD2, UBXDC1, erasin |
Chromosome
Chromosome number
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2 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q21.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008] |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q92575 | ||||||||||
Protein name | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | ||||||||||
Protein function | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). | ||||||||||
PDB | 2KXJ | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level). {ECO:0000269|PubMed:16968747}. | ||||||||||
Sequence |
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Sequence length | 508 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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