Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23170
Gene name Gene Name - the full gene name approved by the HGNC.	Tubulin tyrosine ligase like 12
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TTLL12
Synonyms (NCBI Gene) Gene synonyms aliases	dJ526I14.2
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.2

Show/Hide all(319)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025542	hsa-miR-34a-5p	Proteomics	21566225
MIRT025922	hsa-miR-7-5p	Microarray	19073608
MIRT031972	hsa-miR-16-5p	Proteomics	18668040
MIRT032468	hsa-let-7b-5p	Proteomics	18668040
MIRT051428	hsa-let-7e-5p	CLASH	23622248
MIRT031972	hsa-miR-16-5p	CLASH	23622248
MIRT031972	hsa-miR-16-5p	CLASH	23622248
MIRT048325	hsa-miR-106a-5p	CLASH	23622248
MIRT046157	hsa-miR-30b-5p	CLASH	23622248
MIRT042997	hsa-miR-324-3p	CLASH	23622248
MIRT041561	hsa-miR-193b-3p	CLASH	23622248
MIRT040865	hsa-miR-18a-3p	CLASH	23622248
MIRT038373	hsa-miR-296-3p	CLASH	23622248
MIRT712016	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT712015	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT712014	hsa-miR-501-5p	HITS-CLIP	19536157
MIRT712013	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT712012	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712011	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT712010	hsa-miR-6505-5p	HITS-CLIP	19536157
MIRT712009	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT712008	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT712016	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT712015	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT712014	hsa-miR-501-5p	HITS-CLIP	19536157
MIRT712013	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT712012	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712011	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT712010	hsa-miR-6505-5p	HITS-CLIP	19536157
MIRT712009	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT712008	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT712016	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT712015	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT712014	hsa-miR-501-5p	HITS-CLIP	19536157
MIRT712013	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT712012	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712011	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT712010	hsa-miR-6505-5p	HITS-CLIP	19536157
MIRT712009	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT712008	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT678915	hsa-miR-8062	HITS-CLIP	23824327
MIRT678914	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678913	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT678912	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT678911	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT678910	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT678909	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT678908	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678907	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT678906	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT678905	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678904	hsa-miR-1976	HITS-CLIP	23824327
MIRT678903	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678902	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678901	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678900	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT678899	hsa-miR-1297	HITS-CLIP	23824327
MIRT678898	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT678897	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT678896	hsa-miR-4465	HITS-CLIP	23824327
MIRT678895	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT678894	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT678893	hsa-miR-4279	HITS-CLIP	23824327
MIRT678892	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT678891	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT678890	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT564521	hsa-miR-2392	PAR-CLIP	20371350
MIRT564520	hsa-miR-1265	PAR-CLIP	20371350
MIRT564519	hsa-miR-3167	PAR-CLIP	20371350
MIRT564518	hsa-miR-876-5p	PAR-CLIP	20371350
MIRT564517	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT520430	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT564516	hsa-miR-3149	PAR-CLIP	20371350
MIRT520440	hsa-miR-3186-5p	PAR-CLIP	23446348
MIRT520439	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT520438	hsa-miR-4698	PAR-CLIP	23446348
MIRT520437	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT520436	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT520435	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT520434	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT520433	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT520432	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT520431	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT520430	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT462649	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT462648	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT462647	hsa-miR-1180-5p	PAR-CLIP	23592263
MIRT462646	hsa-miR-7114-3p	PAR-CLIP	23592263
MIRT462645	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT462644	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT462647	hsa-miR-1180-5p	PAR-CLIP	26701625
MIRT462648	hsa-miR-140-3p	PAR-CLIP	26701625
MIRT462645	hsa-miR-3605-5p	PAR-CLIP	26701625
MIRT462649	hsa-miR-552-3p	PAR-CLIP	26701625
MIRT462644	hsa-miR-6894-5p	PAR-CLIP	26701625
MIRT462646	hsa-miR-7114-3p	PAR-CLIP	26701625
MIRT712016	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT712015	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT712014	hsa-miR-501-5p	HITS-CLIP	19536157
MIRT712013	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT712012	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712011	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT712010	hsa-miR-6505-5p	HITS-CLIP	19536157
MIRT712009	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT712008	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT712016	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT712015	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT712014	hsa-miR-501-5p	HITS-CLIP	19536157
MIRT712013	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT712012	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712011	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT712010	hsa-miR-6505-5p	HITS-CLIP	19536157
MIRT712009	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT712008	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT712016	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT712015	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT712014	hsa-miR-501-5p	HITS-CLIP	19536157
MIRT712013	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT712012	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712011	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT712010	hsa-miR-6505-5p	HITS-CLIP	19536157
MIRT712009	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT712008	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT678915	hsa-miR-8062	HITS-CLIP	23824327
MIRT678914	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678913	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT678912	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT678911	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT678910	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT678909	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT678908	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678907	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT678906	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT678905	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678904	hsa-miR-1976	HITS-CLIP	23824327
MIRT678903	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678902	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678901	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678900	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT678899	hsa-miR-1297	HITS-CLIP	23824327
MIRT678898	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT678897	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT678896	hsa-miR-4465	HITS-CLIP	23824327
MIRT678895	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT678894	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT678893	hsa-miR-4279	HITS-CLIP	23824327
MIRT678892	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT678891	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT678890	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT564521	hsa-miR-2392	PAR-CLIP	20371350
MIRT564520	hsa-miR-1265	PAR-CLIP	20371350
MIRT564519	hsa-miR-3167	PAR-CLIP	20371350
MIRT564518	hsa-miR-876-5p	PAR-CLIP	20371350
MIRT564517	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT520430	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT564516	hsa-miR-3149	PAR-CLIP	20371350
MIRT520440	hsa-miR-3186-5p	PAR-CLIP	23446348
MIRT520439	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT520438	hsa-miR-4698	PAR-CLIP	23446348
MIRT520437	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT520436	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT520435	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT520434	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT520433	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT520432	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT520431	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT520430	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT462649	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT462648	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT462647	hsa-miR-1180-5p	PAR-CLIP	23592263
MIRT462646	hsa-miR-7114-3p	PAR-CLIP	23592263
MIRT462645	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT462644	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT1462340	hsa-miR-1262	CLIP-seq
MIRT1462341	hsa-miR-136	CLIP-seq
MIRT1462342	hsa-miR-138	CLIP-seq
MIRT1462343	hsa-miR-2116	CLIP-seq
MIRT1462344	hsa-miR-2278	CLIP-seq
MIRT1462345	hsa-miR-296-5p	CLIP-seq
MIRT1462346	hsa-miR-3144-5p	CLIP-seq
MIRT1462347	hsa-miR-3160-3p	CLIP-seq
MIRT1462348	hsa-miR-3168	CLIP-seq
MIRT1462349	hsa-miR-3191	CLIP-seq
MIRT1462350	hsa-miR-3202	CLIP-seq
MIRT1462351	hsa-miR-3664-3p	CLIP-seq
MIRT1462352	hsa-miR-3907	CLIP-seq
MIRT1462353	hsa-miR-4292	CLIP-seq
MIRT1462354	hsa-miR-4299	CLIP-seq
MIRT1462355	hsa-miR-4314	CLIP-seq
MIRT1462356	hsa-miR-4449	CLIP-seq
MIRT1462357	hsa-miR-4464	CLIP-seq
MIRT1462358	hsa-miR-4468	CLIP-seq
MIRT1462359	hsa-miR-4476	CLIP-seq
MIRT1462360	hsa-miR-4487	CLIP-seq
MIRT1462361	hsa-miR-4532	CLIP-seq
MIRT1462362	hsa-miR-4652-5p	CLIP-seq
MIRT1462363	hsa-miR-4662a-3p	CLIP-seq
MIRT1462364	hsa-miR-4667-5p	CLIP-seq
MIRT1462365	hsa-miR-4690-3p	CLIP-seq
MIRT1462366	hsa-miR-4700-5p	CLIP-seq
MIRT1462367	hsa-miR-4701-3p	CLIP-seq
MIRT1462368	hsa-miR-4748	CLIP-seq
MIRT1462369	hsa-miR-4755-3p	CLIP-seq
MIRT1462370	hsa-miR-4758-3p	CLIP-seq
MIRT1462371	hsa-miR-4775	CLIP-seq
MIRT1462372	hsa-miR-493	CLIP-seq
MIRT1462373	hsa-miR-515-5p	CLIP-seq
MIRT1462374	hsa-miR-523	CLIP-seq
MIRT1462375	hsa-miR-558	CLIP-seq
MIRT1462376	hsa-miR-607	CLIP-seq
MIRT1462377	hsa-miR-636	CLIP-seq
MIRT1462378	hsa-miR-873	CLIP-seq
MIRT2139054	hsa-miR-1184	CLIP-seq
MIRT2139055	hsa-miR-150	CLIP-seq
MIRT1462345	hsa-miR-296-5p	CLIP-seq
MIRT2139056	hsa-miR-30a	CLIP-seq
MIRT2139057	hsa-miR-30b	CLIP-seq
MIRT2139058	hsa-miR-30c	CLIP-seq
MIRT2139059	hsa-miR-30d	CLIP-seq
MIRT2139060	hsa-miR-30e	CLIP-seq
MIRT2139061	hsa-miR-3133	CLIP-seq
MIRT1462346	hsa-miR-3144-5p	CLIP-seq
MIRT1462347	hsa-miR-3160-3p	CLIP-seq
MIRT1462349	hsa-miR-3191	CLIP-seq
MIRT2139062	hsa-miR-3194-3p	CLIP-seq
MIRT2139063	hsa-miR-323-3p	CLIP-seq
MIRT2139064	hsa-miR-345	CLIP-seq
MIRT2139065	hsa-miR-370	CLIP-seq
MIRT1462352	hsa-miR-3907	CLIP-seq
MIRT2139066	hsa-miR-3942-3p	CLIP-seq
MIRT2139067	hsa-miR-4256	CLIP-seq
MIRT2139068	hsa-miR-4269	CLIP-seq
MIRT1462353	hsa-miR-4292	CLIP-seq
MIRT2139069	hsa-miR-4418	CLIP-seq
MIRT1462360	hsa-miR-4487	CLIP-seq
MIRT2139070	hsa-miR-4511	CLIP-seq
MIRT2139071	hsa-miR-4645-5p	CLIP-seq
MIRT1462362	hsa-miR-4652-5p	CLIP-seq
MIRT1462364	hsa-miR-4667-5p	CLIP-seq
MIRT2139072	hsa-miR-4673	CLIP-seq
MIRT1462365	hsa-miR-4690-3p	CLIP-seq
MIRT2139073	hsa-miR-4691-3p	CLIP-seq
MIRT1462366	hsa-miR-4700-5p	CLIP-seq
MIRT2139074	hsa-miR-4713-5p	CLIP-seq
MIRT2139075	hsa-miR-4735-5p	CLIP-seq
MIRT2139076	hsa-miR-509-3-5p	CLIP-seq
MIRT2139077	hsa-miR-509-5p	CLIP-seq
MIRT2139078	hsa-miR-532-3p	CLIP-seq
MIRT2139079	hsa-miR-552	CLIP-seq
MIRT1462375	hsa-miR-558	CLIP-seq
MIRT2139080	hsa-miR-590-3p	CLIP-seq
MIRT1462377	hsa-miR-636	CLIP-seq
MIRT2359765	hsa-miR-103a	CLIP-seq
MIRT2359766	hsa-miR-107	CLIP-seq
MIRT2139054	hsa-miR-1184	CLIP-seq
MIRT2359767	hsa-miR-1231	CLIP-seq
MIRT2359768	hsa-miR-1301	CLIP-seq
MIRT1462342	hsa-miR-138	CLIP-seq
MIRT2359769	hsa-miR-146a	CLIP-seq
MIRT2359770	hsa-miR-146b-5p	CLIP-seq
MIRT2359771	hsa-miR-148a	CLIP-seq
MIRT2359772	hsa-miR-148b	CLIP-seq
MIRT2359773	hsa-miR-152	CLIP-seq
MIRT1462344	hsa-miR-2278	CLIP-seq
MIRT2359774	hsa-miR-28-5p	CLIP-seq
MIRT2139056	hsa-miR-30a	CLIP-seq
MIRT2139057	hsa-miR-30b	CLIP-seq
MIRT2139058	hsa-miR-30c	CLIP-seq
MIRT2139059	hsa-miR-30d	CLIP-seq
MIRT2139060	hsa-miR-30e	CLIP-seq
MIRT2359775	hsa-miR-3120-5p	CLIP-seq
MIRT2359776	hsa-miR-3139	CLIP-seq
MIRT1462346	hsa-miR-3144-5p	CLIP-seq
MIRT1462347	hsa-miR-3160-3p	CLIP-seq
MIRT2359777	hsa-miR-3184	CLIP-seq
MIRT1462349	hsa-miR-3191	CLIP-seq
MIRT2359778	hsa-miR-323-5p	CLIP-seq
MIRT2359779	hsa-miR-3673	CLIP-seq
MIRT1462352	hsa-miR-3907	CLIP-seq
MIRT2359780	hsa-miR-3919	CLIP-seq
MIRT2359781	hsa-miR-3925-3p	CLIP-seq
MIRT2359782	hsa-miR-3925-5p	CLIP-seq
MIRT2139068	hsa-miR-4269	CLIP-seq
MIRT2359783	hsa-miR-4290	CLIP-seq
MIRT1462353	hsa-miR-4292	CLIP-seq
MIRT1462354	hsa-miR-4299	CLIP-seq
MIRT2139069	hsa-miR-4418	CLIP-seq
MIRT2359784	hsa-miR-4459	CLIP-seq
MIRT1462357	hsa-miR-4464	CLIP-seq
MIRT1462360	hsa-miR-4487	CLIP-seq
MIRT2359785	hsa-miR-4489	CLIP-seq
MIRT2139071	hsa-miR-4645-5p	CLIP-seq
MIRT1462362	hsa-miR-4652-5p	CLIP-seq
MIRT2359786	hsa-miR-4660	CLIP-seq
MIRT1462364	hsa-miR-4667-5p	CLIP-seq
MIRT2139072	hsa-miR-4673	CLIP-seq
MIRT2359787	hsa-miR-4685-5p	CLIP-seq
MIRT1462365	hsa-miR-4690-3p	CLIP-seq
MIRT2139073	hsa-miR-4691-3p	CLIP-seq
MIRT1462366	hsa-miR-4700-5p	CLIP-seq
MIRT2359788	hsa-miR-4722-5p	CLIP-seq
MIRT1462368	hsa-miR-4748	CLIP-seq
MIRT2359789	hsa-miR-4756-3p	CLIP-seq
MIRT1462372	hsa-miR-493	CLIP-seq
MIRT2359790	hsa-miR-500a	CLIP-seq
MIRT2359791	hsa-miR-5047	CLIP-seq
MIRT2139076	hsa-miR-509-3-5p	CLIP-seq
MIRT2139077	hsa-miR-509-5p	CLIP-seq
MIRT1462374	hsa-miR-523	CLIP-seq
MIRT1462375	hsa-miR-558	CLIP-seq
MIRT1462377	hsa-miR-636	CLIP-seq
MIRT2359792	hsa-miR-646	CLIP-seq
MIRT2359793	hsa-miR-665	CLIP-seq
MIRT2359794	hsa-miR-708	CLIP-seq
MIRT2359795	hsa-miR-766	CLIP-seq
MIRT2139080	hsa-miR-590-3p	CLIP-seq
MIRT2462638	hsa-miR-4646-5p	CLIP-seq
MIRT2462639	hsa-miR-4747-5p	CLIP-seq
MIRT2462640	hsa-miR-7	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004835	Function	Tubulin-tyrosine ligase activity	IDA	23251473
GO:0005515	Function	Protein binding	IPI	23251473, 28011935, 28514442, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	28011935
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005819	Component	Spindle	IEA
GO:0007346	Process	Regulation of mitotic cell cycle	IMP	23251473
GO:0015631	Function	Tubulin binding	IDA	23251473
GO:0018024	Function	Histone-lysine N-methyltransferase activity	IDA	23251473
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0030496	Component	Midbody	IEA
GO:0034968	Process	Histone lysine methylation	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IMP	28011935
GO:0070510	Process	Regulation of histone H4-K20 methylation	IDA	23251473
GO:1990889	Function	H4K20me3 modified histone binding	IDA	23251473

MIM	HGNC	e!Ensembl
619410	28974	ENSG00000100304

Protein

UniProt ID

Q14166

Protein name

Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12)

Protein function

Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at '

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03133	TTL	346 → 642	Tubulin-tyrosine ligase family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions. {ECO:0000269|PubMed:20162578}.

Sequence

MEAERGPERRPAERSSPGQTPEEGAQALAEFAALHGPALRASGVPERYWGRLLHKLEHEV
FDAGEVFGIMQVEEVEEEEDEAAREVRKQQPNPGNELCYKVIVTRESGLQAAHPNSIFLI
DHAWTCRVEHARQQLQQVPGLLHRMANLMGIEFHGELPSTEAVALVLEEMWKFNQTYQLA
HGTAEEKMPVWYIMDEFGSRIQHADVPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTR
DFAYGETDPLIRKCMLLPWAPTDMLDLSSCTPEPPAEHYQAILEENKEKLPLDINPVVHP
HGHIFKVYTDVQQVASSLTHPRFTLTQSEADADILFNFSHFKDYRKLSQERPGVLLNQFP
CENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQQRERWGEDNHWICKP
WNLARSLDTHVTKSLHSIIRHRESTPKVVSKYIESPVLFLREDVGKVKFDIRYIVLLRSV
RPLRLFVYDVFWLRFSNRAFALNDLDDYEKHFTVMNYDPDVVLKQVHCEEFIPEFEKQYP
EFPWTDVQAEIFRAFTELFQVACAKPPPLGLCDYPSSRAMYAVDLMLKWDNGPDGRRVMQ
PQILEVNFNPDCERACRYHPTFFNDVFSTLFLDQPGGCHVTCLV

Sequence length

644

Interactions

View interactions

	Reactome
			Carboxyterminal post-translational modifications of tubulin

TTLL12 (tubulin tyrosine ligase like 12)