GRAMD4 (GRAM domain containing 4)

Gene

• Entrez ID: 23151
• Gene name: GRAM domain containing 4
• Gene symbol: GRAMD4
• Synonyms (NCBI Gene): DIP
• Chromosome: 22
• Chromosome location: 22q13.31
• Summary: GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028317	hsa-miR-32-5p	Sequencing	20371350
MIRT045651	hsa-miR-149-5p	CLASH	23622248
MIRT537050	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT537049	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT537048	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT028317	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT537047	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT537046	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT537045	hsa-miR-137	PAR-CLIP	22012620
MIRT088225	hsa-miR-944	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT537044	hsa-miR-4257	PAR-CLIP	22012620
MIRT088238	hsa-miR-4768-3p	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT088224	hsa-miR-665	PAR-CLIP	22012620
MIRT088234	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT088227	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT088228	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT088230	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT537042	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT537041	hsa-miR-2467-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT088239	hsa-miR-548aw	PAR-CLIP	22012620
MIRT537039	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT537038	hsa-miR-527	PAR-CLIP	22012620
MIRT537050	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT537049	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT537048	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT028317	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT537047	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT537046	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT537045	hsa-miR-137	PAR-CLIP	22012620
MIRT088225	hsa-miR-944	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT537044	hsa-miR-4257	PAR-CLIP	22012620
MIRT088238	hsa-miR-4768-3p	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT088224	hsa-miR-665	PAR-CLIP	22012620
MIRT088234	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT088227	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT088228	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT088230	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT537042	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT537041	hsa-miR-2467-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT088239	hsa-miR-548aw	PAR-CLIP	22012620
MIRT537039	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT537038	hsa-miR-527	PAR-CLIP	22012620
MIRT1032890	hsa-miR-101	CLIP-seq
MIRT1032891	hsa-miR-1182	CLIP-seq
MIRT1032892	hsa-miR-1184	CLIP-seq
MIRT1032893	hsa-miR-1185	CLIP-seq
MIRT1032894	hsa-miR-1205	CLIP-seq
MIRT1032895	hsa-miR-1265	CLIP-seq
MIRT1032896	hsa-miR-1292	CLIP-seq
MIRT1032897	hsa-miR-1324	CLIP-seq
MIRT1032898	hsa-miR-144	CLIP-seq
MIRT1032899	hsa-miR-148a	CLIP-seq
MIRT1032900	hsa-miR-148b	CLIP-seq
MIRT1032901	hsa-miR-152	CLIP-seq
MIRT1032902	hsa-miR-2116	CLIP-seq
MIRT1032903	hsa-miR-224	CLIP-seq
MIRT1032904	hsa-miR-2355-5p	CLIP-seq
MIRT1032905	hsa-miR-25	CLIP-seq
MIRT1032906	hsa-miR-2682	CLIP-seq
MIRT1032907	hsa-miR-2964a-5p	CLIP-seq
MIRT1032908	hsa-miR-296-5p	CLIP-seq
MIRT1032909	hsa-miR-3064-3p	CLIP-seq
MIRT1032910	hsa-miR-3128	CLIP-seq
MIRT1032911	hsa-miR-3143	CLIP-seq
MIRT1032912	hsa-miR-3186-3p	CLIP-seq
MIRT1032913	hsa-miR-32	CLIP-seq
MIRT1032914	hsa-miR-3202	CLIP-seq
MIRT1032915	hsa-miR-34a	CLIP-seq
MIRT1032916	hsa-miR-34c-5p	CLIP-seq
MIRT1032917	hsa-miR-3605-5p	CLIP-seq
MIRT1032918	hsa-miR-3622a-5p	CLIP-seq
MIRT1032919	hsa-miR-363	CLIP-seq
MIRT1032920	hsa-miR-367	CLIP-seq
MIRT1032921	hsa-miR-3679-5p	CLIP-seq
MIRT1032922	hsa-miR-374c	CLIP-seq
MIRT1032923	hsa-miR-4282	CLIP-seq
MIRT1032924	hsa-miR-4423-3p	CLIP-seq
MIRT1032925	hsa-miR-4459	CLIP-seq
MIRT1032926	hsa-miR-4476	CLIP-seq
MIRT1032927	hsa-miR-449a	CLIP-seq
MIRT1032928	hsa-miR-449b	CLIP-seq
MIRT1032929	hsa-miR-449c	CLIP-seq
MIRT1032930	hsa-miR-4514	CLIP-seq
MIRT1032931	hsa-miR-4640-5p	CLIP-seq
MIRT1032932	hsa-miR-4650-5p	CLIP-seq
MIRT1032933	hsa-miR-4692	CLIP-seq
MIRT1032934	hsa-miR-4699-3p	CLIP-seq
MIRT1032935	hsa-miR-4723-5p	CLIP-seq
MIRT1032936	hsa-miR-4726-5p	CLIP-seq
MIRT1032937	hsa-miR-4728-5p	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT1032939	hsa-miR-4779	CLIP-seq
MIRT1032940	hsa-miR-500a	CLIP-seq
MIRT1032941	hsa-miR-501-5p	CLIP-seq
MIRT1032942	hsa-miR-543	CLIP-seq
MIRT1032943	hsa-miR-653	CLIP-seq
MIRT1032944	hsa-miR-655	CLIP-seq
MIRT1032945	hsa-miR-661	CLIP-seq
MIRT1032946	hsa-miR-92a	CLIP-seq
MIRT1032947	hsa-miR-92b	CLIP-seq
MIRT2006389	hsa-miR-1207-5p	CLIP-seq
MIRT2006390	hsa-miR-1343	CLIP-seq
MIRT2006391	hsa-miR-146b-3p	CLIP-seq
MIRT2006392	hsa-miR-1908	CLIP-seq
MIRT2006393	hsa-miR-1913	CLIP-seq
MIRT2006394	hsa-miR-1914	CLIP-seq
MIRT2006395	hsa-miR-1976	CLIP-seq
MIRT2006396	hsa-miR-198	CLIP-seq
MIRT2006397	hsa-miR-2117	CLIP-seq
MIRT1032904	hsa-miR-2355-5p	CLIP-seq
MIRT1032905	hsa-miR-25	CLIP-seq
MIRT2006398	hsa-miR-2861	CLIP-seq
MIRT1032908	hsa-miR-296-5p	CLIP-seq
MIRT2006399	hsa-miR-3065-3p	CLIP-seq
MIRT2006400	hsa-miR-3121-3p	CLIP-seq
MIRT2006401	hsa-miR-3126-5p	CLIP-seq
MIRT2006402	hsa-miR-3173-5p	CLIP-seq
MIRT2006403	hsa-miR-3197	CLIP-seq
MIRT1032913	hsa-miR-32	CLIP-seq
MIRT2006404	hsa-miR-324-3p	CLIP-seq
MIRT2006405	hsa-miR-3622a-3p	CLIP-seq
MIRT2006406	hsa-miR-3622b-3p	CLIP-seq
MIRT1032919	hsa-miR-363	CLIP-seq
MIRT2006407	hsa-miR-3664-3p	CLIP-seq
MIRT1032920	hsa-miR-367	CLIP-seq
MIRT2006408	hsa-miR-378g	CLIP-seq
MIRT2006409	hsa-miR-4273	CLIP-seq
MIRT2006410	hsa-miR-4279	CLIP-seq
MIRT2006411	hsa-miR-4281	CLIP-seq
MIRT2006412	hsa-miR-4284	CLIP-seq
MIRT2006413	hsa-miR-4297	CLIP-seq
MIRT2006414	hsa-miR-4300	CLIP-seq
MIRT2006415	hsa-miR-4419a	CLIP-seq
MIRT2006416	hsa-miR-4422	CLIP-seq
MIRT2006417	hsa-miR-4436a	CLIP-seq
MIRT2006418	hsa-miR-4437	CLIP-seq
MIRT1032925	hsa-miR-4459	CLIP-seq
MIRT2006419	hsa-miR-4475	CLIP-seq
MIRT1032926	hsa-miR-4476	CLIP-seq
MIRT2006420	hsa-miR-4492	CLIP-seq
MIRT2006421	hsa-miR-4498	CLIP-seq
MIRT2006422	hsa-miR-4505	CLIP-seq
MIRT2006423	hsa-miR-4510	CLIP-seq
MIRT2006424	hsa-miR-4530	CLIP-seq
MIRT2006425	hsa-miR-4638-5p	CLIP-seq
MIRT2006426	hsa-miR-4648	CLIP-seq
MIRT1032932	hsa-miR-4650-5p	CLIP-seq
MIRT2006427	hsa-miR-4651	CLIP-seq
MIRT2006428	hsa-miR-4652-3p	CLIP-seq
MIRT2006429	hsa-miR-4654	CLIP-seq
MIRT2006430	hsa-miR-4674	CLIP-seq
MIRT2006431	hsa-miR-4731-3p	CLIP-seq
MIRT2006432	hsa-miR-4731-5p	CLIP-seq
MIRT2006433	hsa-miR-4734	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT2006434	hsa-miR-4763-3p	CLIP-seq
MIRT2006435	hsa-miR-4769-5p	CLIP-seq
MIRT2006436	hsa-miR-4801	CLIP-seq
MIRT2006437	hsa-miR-510	CLIP-seq
MIRT2006438	hsa-miR-558	CLIP-seq
MIRT2006439	hsa-miR-608	CLIP-seq
MIRT2006440	hsa-miR-637	CLIP-seq
MIRT2006441	hsa-miR-663	CLIP-seq
MIRT2006442	hsa-miR-762	CLIP-seq
MIRT2006443	hsa-miR-874	CLIP-seq
MIRT2006444	hsa-miR-920	CLIP-seq
MIRT2006445	hsa-miR-922	CLIP-seq
MIRT1032946	hsa-miR-92a	CLIP-seq
MIRT1032947	hsa-miR-92b	CLIP-seq
MIRT2006446	hsa-miR-937	CLIP-seq
MIRT2006447	hsa-miR-942	CLIP-seq
MIRT1032890	hsa-miR-101	CLIP-seq
MIRT1032893	hsa-miR-1185	CLIP-seq
MIRT2238878	hsa-miR-1197	CLIP-seq
MIRT1032895	hsa-miR-1265	CLIP-seq
MIRT2238879	hsa-miR-1291	CLIP-seq
MIRT1032896	hsa-miR-1292	CLIP-seq
MIRT1032898	hsa-miR-144	CLIP-seq
MIRT1032899	hsa-miR-148a	CLIP-seq
MIRT1032900	hsa-miR-148b	CLIP-seq
MIRT1032901	hsa-miR-152	CLIP-seq
MIRT2238880	hsa-miR-190	CLIP-seq
MIRT2238881	hsa-miR-190b	CLIP-seq
MIRT2006393	hsa-miR-1913	CLIP-seq
MIRT2006396	hsa-miR-198	CLIP-seq
MIRT1032902	hsa-miR-2116	CLIP-seq
MIRT2238882	hsa-miR-218	CLIP-seq
MIRT1032903	hsa-miR-224	CLIP-seq
MIRT1032905	hsa-miR-25	CLIP-seq
MIRT1032907	hsa-miR-2964a-5p	CLIP-seq
MIRT2006400	hsa-miR-3121-3p	CLIP-seq
MIRT2006401	hsa-miR-3126-5p	CLIP-seq
MIRT1032910	hsa-miR-3128	CLIP-seq
MIRT1032912	hsa-miR-3186-3p	CLIP-seq
MIRT1032913	hsa-miR-32	CLIP-seq
MIRT2238883	hsa-miR-3201	CLIP-seq
MIRT2006404	hsa-miR-324-3p	CLIP-seq
MIRT2238884	hsa-miR-328	CLIP-seq
MIRT2238885	hsa-miR-330-3p	CLIP-seq
MIRT2238886	hsa-miR-331-3p	CLIP-seq
MIRT1032917	hsa-miR-3605-5p	CLIP-seq
MIRT1032918	hsa-miR-3622a-5p	CLIP-seq
MIRT1032919	hsa-miR-363	CLIP-seq
MIRT2238887	hsa-miR-3652	CLIP-seq
MIRT2006407	hsa-miR-3664-3p	CLIP-seq
MIRT2238888	hsa-miR-3667-3p	CLIP-seq
MIRT1032920	hsa-miR-367	CLIP-seq
MIRT1032921	hsa-miR-3679-5p	CLIP-seq
MIRT2238889	hsa-miR-3692	CLIP-seq
MIRT1032922	hsa-miR-374c	CLIP-seq
MIRT2238890	hsa-miR-3937	CLIP-seq
MIRT2238891	hsa-miR-4276	CLIP-seq
MIRT2238892	hsa-miR-4283	CLIP-seq
MIRT2238893	hsa-miR-4287	CLIP-seq
MIRT2238894	hsa-miR-4292	CLIP-seq
MIRT2006414	hsa-miR-4300	CLIP-seq
MIRT2006415	hsa-miR-4419a	CLIP-seq
MIRT1032924	hsa-miR-4423-3p	CLIP-seq
MIRT2238895	hsa-miR-4430	CLIP-seq
MIRT2006417	hsa-miR-4436a	CLIP-seq
MIRT2238896	hsa-miR-4436b-5p	CLIP-seq
MIRT2006419	hsa-miR-4475	CLIP-seq
MIRT2006422	hsa-miR-4505	CLIP-seq
MIRT2006423	hsa-miR-4510	CLIP-seq
MIRT2238897	hsa-miR-4512	CLIP-seq
MIRT2006424	hsa-miR-4530	CLIP-seq
MIRT2238898	hsa-miR-4645-5p	CLIP-seq
MIRT2006427	hsa-miR-4651	CLIP-seq
MIRT2238899	hsa-miR-4673	CLIP-seq
MIRT2238900	hsa-miR-4676-5p	CLIP-seq
MIRT2238901	hsa-miR-4685-3p	CLIP-seq
MIRT1032934	hsa-miR-4699-3p	CLIP-seq
MIRT2238902	hsa-miR-4713-3p	CLIP-seq
MIRT2238903	hsa-miR-4720-3p	CLIP-seq
MIRT1032935	hsa-miR-4723-5p	CLIP-seq
MIRT1032937	hsa-miR-4728-5p	CLIP-seq
MIRT2006431	hsa-miR-4731-3p	CLIP-seq
MIRT2006433	hsa-miR-4734	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT2238904	hsa-miR-4761-5p	CLIP-seq
MIRT2238905	hsa-miR-4791	CLIP-seq
MIRT2006436	hsa-miR-4801	CLIP-seq
MIRT2238906	hsa-miR-4804-3p	CLIP-seq
MIRT1032940	hsa-miR-500a	CLIP-seq
MIRT1032941	hsa-miR-501-5p	CLIP-seq
MIRT2006437	hsa-miR-510	CLIP-seq
MIRT2238907	hsa-miR-548q	CLIP-seq
MIRT2006438	hsa-miR-558	CLIP-seq
MIRT2238908	hsa-miR-572	CLIP-seq
MIRT2238909	hsa-miR-575	CLIP-seq
MIRT2006439	hsa-miR-608	CLIP-seq
MIRT2238910	hsa-miR-636	CLIP-seq
MIRT2006440	hsa-miR-637	CLIP-seq
MIRT1032943	hsa-miR-653	CLIP-seq
MIRT1032944	hsa-miR-655	CLIP-seq
MIRT1032945	hsa-miR-661	CLIP-seq
MIRT2238911	hsa-miR-663b	CLIP-seq
MIRT2006444	hsa-miR-920	CLIP-seq
MIRT2006445	hsa-miR-922	CLIP-seq
MIRT1032946	hsa-miR-92a	CLIP-seq
MIRT1032947	hsa-miR-92b	CLIP-seq
MIRT2006447	hsa-miR-942	CLIP-seq
MIRT2388748	hsa-miR-4436b-3p	CLIP-seq
MIRT2388749	hsa-miR-4532	CLIP-seq
MIRT2388750	hsa-miR-671-5p	CLIP-seq
MIRT2006393	hsa-miR-1913	CLIP-seq
MIRT2238882	hsa-miR-218	CLIP-seq
MIRT2450710	hsa-miR-3140-3p	CLIP-seq
MIRT2006404	hsa-miR-324-3p	CLIP-seq
MIRT2450711	hsa-miR-4313	CLIP-seq
MIRT2238897	hsa-miR-4512	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT2450712	hsa-miR-520g	CLIP-seq
MIRT2450713	hsa-miR-520h	CLIP-seq
MIRT2450714	hsa-miR-539	CLIP-seq
MIRT2450715	hsa-miR-576-3p	CLIP-seq
MIRT2450716	hsa-miR-595	CLIP-seq
MIRT2238910	hsa-miR-636	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	15565177
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0034164	Process	Negative regulation of toll-like receptor 9 signaling pathway	IBA
GO:0034164	Process	Negative regulation of toll-like receptor 9 signaling pathway	IEA
GO:0034164	Process	Negative regulation of toll-like receptor 9 signaling pathway	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IMP	15565177

Other IDs

• MIM: 613691
• HGNC: 29113
• e!Ensembl: ENSG00000075240

Protein

• UniProt ID: Q6IC98
• Protein name: GRAM domain-containing protein 4 (Death-inducing protein)
• Protein function: Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02893	GRAM	445 → 570	GRAM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in lung and in primary lung squamous cell carcinoma (LSCC). {ECO:0000269|PubMed:18302964}.
• Sequence:

  MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL
  IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR
  RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED
  FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV
  YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ
  LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA
  VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR
  SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT
  DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP
  STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS

• Sequence length: 578

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Melanoma	Uncertain significance	rs377286272	RCV005932490

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Inhibit	34841685
Neoplasm Metastasis	Inhibit	34841685