Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23151
Gene name Gene Name - the full gene name approved by the HGNC.	GRAM domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRAMD4
Synonyms (NCBI Gene) Gene synonyms aliases	DIP
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.31
Summary Summary of gene provided in NCBI Entrez Gene.	GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]

Show/Hide all(286)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028317	hsa-miR-32-5p	Sequencing	20371350
MIRT045651	hsa-miR-149-5p	CLASH	23622248
MIRT537050	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT537049	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT537048	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT028317	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT537047	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT537046	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT537045	hsa-miR-137	PAR-CLIP	22012620
MIRT088225	hsa-miR-944	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT537044	hsa-miR-4257	PAR-CLIP	22012620
MIRT088238	hsa-miR-4768-3p	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT088224	hsa-miR-665	PAR-CLIP	22012620
MIRT088234	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT088227	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT088228	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT088230	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT537042	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT537041	hsa-miR-2467-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT088239	hsa-miR-548aw	PAR-CLIP	22012620
MIRT537039	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT537038	hsa-miR-527	PAR-CLIP	22012620
MIRT537050	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT537049	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT537048	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT028317	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT537047	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT537046	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT537045	hsa-miR-137	PAR-CLIP	22012620
MIRT088225	hsa-miR-944	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT537044	hsa-miR-4257	PAR-CLIP	22012620
MIRT088238	hsa-miR-4768-3p	PAR-CLIP	22012620
MIRT537043	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT088224	hsa-miR-665	PAR-CLIP	22012620
MIRT088234	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT088227	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT088228	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT088230	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT537042	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT537041	hsa-miR-2467-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT537040	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT088239	hsa-miR-548aw	PAR-CLIP	22012620
MIRT537039	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT537038	hsa-miR-527	PAR-CLIP	22012620
MIRT1032890	hsa-miR-101	CLIP-seq
MIRT1032891	hsa-miR-1182	CLIP-seq
MIRT1032892	hsa-miR-1184	CLIP-seq
MIRT1032893	hsa-miR-1185	CLIP-seq
MIRT1032894	hsa-miR-1205	CLIP-seq
MIRT1032895	hsa-miR-1265	CLIP-seq
MIRT1032896	hsa-miR-1292	CLIP-seq
MIRT1032897	hsa-miR-1324	CLIP-seq
MIRT1032898	hsa-miR-144	CLIP-seq
MIRT1032899	hsa-miR-148a	CLIP-seq
MIRT1032900	hsa-miR-148b	CLIP-seq
MIRT1032901	hsa-miR-152	CLIP-seq
MIRT1032902	hsa-miR-2116	CLIP-seq
MIRT1032903	hsa-miR-224	CLIP-seq
MIRT1032904	hsa-miR-2355-5p	CLIP-seq
MIRT1032905	hsa-miR-25	CLIP-seq
MIRT1032906	hsa-miR-2682	CLIP-seq
MIRT1032907	hsa-miR-2964a-5p	CLIP-seq
MIRT1032908	hsa-miR-296-5p	CLIP-seq
MIRT1032909	hsa-miR-3064-3p	CLIP-seq
MIRT1032910	hsa-miR-3128	CLIP-seq
MIRT1032911	hsa-miR-3143	CLIP-seq
MIRT1032912	hsa-miR-3186-3p	CLIP-seq
MIRT1032913	hsa-miR-32	CLIP-seq
MIRT1032914	hsa-miR-3202	CLIP-seq
MIRT1032915	hsa-miR-34a	CLIP-seq
MIRT1032916	hsa-miR-34c-5p	CLIP-seq
MIRT1032917	hsa-miR-3605-5p	CLIP-seq
MIRT1032918	hsa-miR-3622a-5p	CLIP-seq
MIRT1032919	hsa-miR-363	CLIP-seq
MIRT1032920	hsa-miR-367	CLIP-seq
MIRT1032921	hsa-miR-3679-5p	CLIP-seq
MIRT1032922	hsa-miR-374c	CLIP-seq
MIRT1032923	hsa-miR-4282	CLIP-seq
MIRT1032924	hsa-miR-4423-3p	CLIP-seq
MIRT1032925	hsa-miR-4459	CLIP-seq
MIRT1032926	hsa-miR-4476	CLIP-seq
MIRT1032927	hsa-miR-449a	CLIP-seq
MIRT1032928	hsa-miR-449b	CLIP-seq
MIRT1032929	hsa-miR-449c	CLIP-seq
MIRT1032930	hsa-miR-4514	CLIP-seq
MIRT1032931	hsa-miR-4640-5p	CLIP-seq
MIRT1032932	hsa-miR-4650-5p	CLIP-seq
MIRT1032933	hsa-miR-4692	CLIP-seq
MIRT1032934	hsa-miR-4699-3p	CLIP-seq
MIRT1032935	hsa-miR-4723-5p	CLIP-seq
MIRT1032936	hsa-miR-4726-5p	CLIP-seq
MIRT1032937	hsa-miR-4728-5p	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT1032939	hsa-miR-4779	CLIP-seq
MIRT1032940	hsa-miR-500a	CLIP-seq
MIRT1032941	hsa-miR-501-5p	CLIP-seq
MIRT1032942	hsa-miR-543	CLIP-seq
MIRT1032943	hsa-miR-653	CLIP-seq
MIRT1032944	hsa-miR-655	CLIP-seq
MIRT1032945	hsa-miR-661	CLIP-seq
MIRT1032946	hsa-miR-92a	CLIP-seq
MIRT1032947	hsa-miR-92b	CLIP-seq
MIRT2006389	hsa-miR-1207-5p	CLIP-seq
MIRT2006390	hsa-miR-1343	CLIP-seq
MIRT2006391	hsa-miR-146b-3p	CLIP-seq
MIRT2006392	hsa-miR-1908	CLIP-seq
MIRT2006393	hsa-miR-1913	CLIP-seq
MIRT2006394	hsa-miR-1914	CLIP-seq
MIRT2006395	hsa-miR-1976	CLIP-seq
MIRT2006396	hsa-miR-198	CLIP-seq
MIRT2006397	hsa-miR-2117	CLIP-seq
MIRT1032904	hsa-miR-2355-5p	CLIP-seq
MIRT1032905	hsa-miR-25	CLIP-seq
MIRT2006398	hsa-miR-2861	CLIP-seq
MIRT1032908	hsa-miR-296-5p	CLIP-seq
MIRT2006399	hsa-miR-3065-3p	CLIP-seq
MIRT2006400	hsa-miR-3121-3p	CLIP-seq
MIRT2006401	hsa-miR-3126-5p	CLIP-seq
MIRT2006402	hsa-miR-3173-5p	CLIP-seq
MIRT2006403	hsa-miR-3197	CLIP-seq
MIRT1032913	hsa-miR-32	CLIP-seq
MIRT2006404	hsa-miR-324-3p	CLIP-seq
MIRT2006405	hsa-miR-3622a-3p	CLIP-seq
MIRT2006406	hsa-miR-3622b-3p	CLIP-seq
MIRT1032919	hsa-miR-363	CLIP-seq
MIRT2006407	hsa-miR-3664-3p	CLIP-seq
MIRT1032920	hsa-miR-367	CLIP-seq
MIRT2006408	hsa-miR-378g	CLIP-seq
MIRT2006409	hsa-miR-4273	CLIP-seq
MIRT2006410	hsa-miR-4279	CLIP-seq
MIRT2006411	hsa-miR-4281	CLIP-seq
MIRT2006412	hsa-miR-4284	CLIP-seq
MIRT2006413	hsa-miR-4297	CLIP-seq
MIRT2006414	hsa-miR-4300	CLIP-seq
MIRT2006415	hsa-miR-4419a	CLIP-seq
MIRT2006416	hsa-miR-4422	CLIP-seq
MIRT2006417	hsa-miR-4436a	CLIP-seq
MIRT2006418	hsa-miR-4437	CLIP-seq
MIRT1032925	hsa-miR-4459	CLIP-seq
MIRT2006419	hsa-miR-4475	CLIP-seq
MIRT1032926	hsa-miR-4476	CLIP-seq
MIRT2006420	hsa-miR-4492	CLIP-seq
MIRT2006421	hsa-miR-4498	CLIP-seq
MIRT2006422	hsa-miR-4505	CLIP-seq
MIRT2006423	hsa-miR-4510	CLIP-seq
MIRT2006424	hsa-miR-4530	CLIP-seq
MIRT2006425	hsa-miR-4638-5p	CLIP-seq
MIRT2006426	hsa-miR-4648	CLIP-seq
MIRT1032932	hsa-miR-4650-5p	CLIP-seq
MIRT2006427	hsa-miR-4651	CLIP-seq
MIRT2006428	hsa-miR-4652-3p	CLIP-seq
MIRT2006429	hsa-miR-4654	CLIP-seq
MIRT2006430	hsa-miR-4674	CLIP-seq
MIRT2006431	hsa-miR-4731-3p	CLIP-seq
MIRT2006432	hsa-miR-4731-5p	CLIP-seq
MIRT2006433	hsa-miR-4734	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT2006434	hsa-miR-4763-3p	CLIP-seq
MIRT2006435	hsa-miR-4769-5p	CLIP-seq
MIRT2006436	hsa-miR-4801	CLIP-seq
MIRT2006437	hsa-miR-510	CLIP-seq
MIRT2006438	hsa-miR-558	CLIP-seq
MIRT2006439	hsa-miR-608	CLIP-seq
MIRT2006440	hsa-miR-637	CLIP-seq
MIRT2006441	hsa-miR-663	CLIP-seq
MIRT2006442	hsa-miR-762	CLIP-seq
MIRT2006443	hsa-miR-874	CLIP-seq
MIRT2006444	hsa-miR-920	CLIP-seq
MIRT2006445	hsa-miR-922	CLIP-seq
MIRT1032946	hsa-miR-92a	CLIP-seq
MIRT1032947	hsa-miR-92b	CLIP-seq
MIRT2006446	hsa-miR-937	CLIP-seq
MIRT2006447	hsa-miR-942	CLIP-seq
MIRT1032890	hsa-miR-101	CLIP-seq
MIRT1032893	hsa-miR-1185	CLIP-seq
MIRT2238878	hsa-miR-1197	CLIP-seq
MIRT1032895	hsa-miR-1265	CLIP-seq
MIRT2238879	hsa-miR-1291	CLIP-seq
MIRT1032896	hsa-miR-1292	CLIP-seq
MIRT1032898	hsa-miR-144	CLIP-seq
MIRT1032899	hsa-miR-148a	CLIP-seq
MIRT1032900	hsa-miR-148b	CLIP-seq
MIRT1032901	hsa-miR-152	CLIP-seq
MIRT2238880	hsa-miR-190	CLIP-seq
MIRT2238881	hsa-miR-190b	CLIP-seq
MIRT2006393	hsa-miR-1913	CLIP-seq
MIRT2006396	hsa-miR-198	CLIP-seq
MIRT1032902	hsa-miR-2116	CLIP-seq
MIRT2238882	hsa-miR-218	CLIP-seq
MIRT1032903	hsa-miR-224	CLIP-seq
MIRT1032905	hsa-miR-25	CLIP-seq
MIRT1032907	hsa-miR-2964a-5p	CLIP-seq
MIRT2006400	hsa-miR-3121-3p	CLIP-seq
MIRT2006401	hsa-miR-3126-5p	CLIP-seq
MIRT1032910	hsa-miR-3128	CLIP-seq
MIRT1032912	hsa-miR-3186-3p	CLIP-seq
MIRT1032913	hsa-miR-32	CLIP-seq
MIRT2238883	hsa-miR-3201	CLIP-seq
MIRT2006404	hsa-miR-324-3p	CLIP-seq
MIRT2238884	hsa-miR-328	CLIP-seq
MIRT2238885	hsa-miR-330-3p	CLIP-seq
MIRT2238886	hsa-miR-331-3p	CLIP-seq
MIRT1032917	hsa-miR-3605-5p	CLIP-seq
MIRT1032918	hsa-miR-3622a-5p	CLIP-seq
MIRT1032919	hsa-miR-363	CLIP-seq
MIRT2238887	hsa-miR-3652	CLIP-seq
MIRT2006407	hsa-miR-3664-3p	CLIP-seq
MIRT2238888	hsa-miR-3667-3p	CLIP-seq
MIRT1032920	hsa-miR-367	CLIP-seq
MIRT1032921	hsa-miR-3679-5p	CLIP-seq
MIRT2238889	hsa-miR-3692	CLIP-seq
MIRT1032922	hsa-miR-374c	CLIP-seq
MIRT2238890	hsa-miR-3937	CLIP-seq
MIRT2238891	hsa-miR-4276	CLIP-seq
MIRT2238892	hsa-miR-4283	CLIP-seq
MIRT2238893	hsa-miR-4287	CLIP-seq
MIRT2238894	hsa-miR-4292	CLIP-seq
MIRT2006414	hsa-miR-4300	CLIP-seq
MIRT2006415	hsa-miR-4419a	CLIP-seq
MIRT1032924	hsa-miR-4423-3p	CLIP-seq
MIRT2238895	hsa-miR-4430	CLIP-seq
MIRT2006417	hsa-miR-4436a	CLIP-seq
MIRT2238896	hsa-miR-4436b-5p	CLIP-seq
MIRT2006419	hsa-miR-4475	CLIP-seq
MIRT2006422	hsa-miR-4505	CLIP-seq
MIRT2006423	hsa-miR-4510	CLIP-seq
MIRT2238897	hsa-miR-4512	CLIP-seq
MIRT2006424	hsa-miR-4530	CLIP-seq
MIRT2238898	hsa-miR-4645-5p	CLIP-seq
MIRT2006427	hsa-miR-4651	CLIP-seq
MIRT2238899	hsa-miR-4673	CLIP-seq
MIRT2238900	hsa-miR-4676-5p	CLIP-seq
MIRT2238901	hsa-miR-4685-3p	CLIP-seq
MIRT1032934	hsa-miR-4699-3p	CLIP-seq
MIRT2238902	hsa-miR-4713-3p	CLIP-seq
MIRT2238903	hsa-miR-4720-3p	CLIP-seq
MIRT1032935	hsa-miR-4723-5p	CLIP-seq
MIRT1032937	hsa-miR-4728-5p	CLIP-seq
MIRT2006431	hsa-miR-4731-3p	CLIP-seq
MIRT2006433	hsa-miR-4734	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT2238904	hsa-miR-4761-5p	CLIP-seq
MIRT2238905	hsa-miR-4791	CLIP-seq
MIRT2006436	hsa-miR-4801	CLIP-seq
MIRT2238906	hsa-miR-4804-3p	CLIP-seq
MIRT1032940	hsa-miR-500a	CLIP-seq
MIRT1032941	hsa-miR-501-5p	CLIP-seq
MIRT2006437	hsa-miR-510	CLIP-seq
MIRT2238907	hsa-miR-548q	CLIP-seq
MIRT2006438	hsa-miR-558	CLIP-seq
MIRT2238908	hsa-miR-572	CLIP-seq
MIRT2238909	hsa-miR-575	CLIP-seq
MIRT2006439	hsa-miR-608	CLIP-seq
MIRT2238910	hsa-miR-636	CLIP-seq
MIRT2006440	hsa-miR-637	CLIP-seq
MIRT1032943	hsa-miR-653	CLIP-seq
MIRT1032944	hsa-miR-655	CLIP-seq
MIRT1032945	hsa-miR-661	CLIP-seq
MIRT2238911	hsa-miR-663b	CLIP-seq
MIRT2006444	hsa-miR-920	CLIP-seq
MIRT2006445	hsa-miR-922	CLIP-seq
MIRT1032946	hsa-miR-92a	CLIP-seq
MIRT1032947	hsa-miR-92b	CLIP-seq
MIRT2006447	hsa-miR-942	CLIP-seq
MIRT2388748	hsa-miR-4436b-3p	CLIP-seq
MIRT2388749	hsa-miR-4532	CLIP-seq
MIRT2388750	hsa-miR-671-5p	CLIP-seq
MIRT2006393	hsa-miR-1913	CLIP-seq
MIRT2238882	hsa-miR-218	CLIP-seq
MIRT2450710	hsa-miR-3140-3p	CLIP-seq
MIRT2006404	hsa-miR-324-3p	CLIP-seq
MIRT2450711	hsa-miR-4313	CLIP-seq
MIRT2238897	hsa-miR-4512	CLIP-seq
MIRT1032938	hsa-miR-4757-5p	CLIP-seq
MIRT2450712	hsa-miR-520g	CLIP-seq
MIRT2450713	hsa-miR-520h	CLIP-seq
MIRT2450714	hsa-miR-539	CLIP-seq
MIRT2450715	hsa-miR-576-3p	CLIP-seq
MIRT2450716	hsa-miR-595	CLIP-seq
MIRT2238910	hsa-miR-636	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	15565177
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0034164	Process	Negative regulation of toll-like receptor 9 signaling pathway	IBA	21873635
GO:0034164	Process	Negative regulation of toll-like receptor 9 signaling pathway	ISS
GO:0043280	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	21873635
GO:0043280	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	15565177

MIM	HGNC	e!Ensembl
613691	29113	ENSG00000075240

Protein

UniProt ID

Q6IC98

Protein name

GRAM domain-containing protein 4 (Death-inducing protein)

Protein function

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02893	GRAM	445 → 570	GRAM domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in lung and in primary lung squamous cell carcinoma (LSCC). {ECO:0000269|PubMed:18302964}.

Sequence

MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTL
IMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQR
RMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVED
FRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTV
YMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQ
LVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLA
VGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSR
SYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPT
DYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTP
STQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS

Sequence length

578

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Inhibit	34841685
Neoplasm Metastasis	Inhibit	34841685

GRAMD4 (GRAM domain containing 4)