Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2314
Gene name Gene Name - the full gene name approved by the HGNC.	FLII actin remodeling protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FLII
Synonyms (NCBI Gene) Gene synonyms aliases	CMD2J, FLI, FLIL, Fli1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization

Show/Hide all(117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022789	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT052017	hsa-let-7b-5p	CLASH	23622248
MIRT048726	hsa-miR-96-5p	CLASH	23622248
MIRT043515	hsa-miR-331-3p	CLASH	23622248
MIRT042489	hsa-miR-423-3p	CLASH	23622248
MIRT041743	hsa-miR-484	CLASH	23622248
MIRT998340	hsa-miR-125a-5p	CLIP-seq
MIRT998341	hsa-miR-125b	CLIP-seq
MIRT998342	hsa-miR-1273e	CLIP-seq
MIRT998343	hsa-miR-1290	CLIP-seq
MIRT998344	hsa-miR-1304	CLIP-seq
MIRT998345	hsa-miR-185	CLIP-seq
MIRT998346	hsa-miR-2467-5p	CLIP-seq
MIRT998347	hsa-miR-3144-5p	CLIP-seq
MIRT998348	hsa-miR-3167	CLIP-seq
MIRT998349	hsa-miR-3188	CLIP-seq
MIRT998350	hsa-miR-3191	CLIP-seq
MIRT998351	hsa-miR-3199	CLIP-seq
MIRT998352	hsa-miR-3616-3p	CLIP-seq
MIRT998353	hsa-miR-3688-5p	CLIP-seq
MIRT998354	hsa-miR-3907	CLIP-seq
MIRT998355	hsa-miR-3975	CLIP-seq
MIRT998356	hsa-miR-4306	CLIP-seq
MIRT998357	hsa-miR-4318	CLIP-seq
MIRT998358	hsa-miR-4319	CLIP-seq
MIRT998359	hsa-miR-4644	CLIP-seq
MIRT998360	hsa-miR-4652-5p	CLIP-seq
MIRT998361	hsa-miR-4667-5p	CLIP-seq
MIRT998362	hsa-miR-4700-5p	CLIP-seq
MIRT998363	hsa-miR-4721	CLIP-seq
MIRT998364	hsa-miR-485-5p	CLIP-seq
MIRT998365	hsa-miR-544b	CLIP-seq
MIRT998366	hsa-miR-571	CLIP-seq
MIRT998367	hsa-miR-876-5p	CLIP-seq
MIRT1995892	hsa-miR-1324	CLIP-seq
MIRT1995893	hsa-miR-181a	CLIP-seq
MIRT1995894	hsa-miR-181b	CLIP-seq
MIRT1995895	hsa-miR-181c	CLIP-seq
MIRT1995896	hsa-miR-181d	CLIP-seq
MIRT1995897	hsa-miR-188-5p	CLIP-seq
MIRT1995898	hsa-miR-1911	CLIP-seq
MIRT1995899	hsa-miR-3166	CLIP-seq
MIRT1995900	hsa-miR-3622a-3p	CLIP-seq
MIRT1995901	hsa-miR-3622b-3p	CLIP-seq
MIRT1995902	hsa-miR-3665	CLIP-seq
MIRT1995903	hsa-miR-4262	CLIP-seq
MIRT1995904	hsa-miR-597	CLIP-seq
MIRT1995905	hsa-miR-621	CLIP-seq
MIRT2229929	hsa-miR-1236	CLIP-seq
MIRT2229930	hsa-miR-3127-3p	CLIP-seq
MIRT2229931	hsa-miR-3667-3p	CLIP-seq
MIRT2229932	hsa-miR-4686	CLIP-seq
MIRT998357	hsa-miR-4318	CLIP-seq
MIRT998340	hsa-miR-125a-5p	CLIP-seq
MIRT998341	hsa-miR-125b	CLIP-seq
MIRT998343	hsa-miR-1290	CLIP-seq
MIRT998348	hsa-miR-3167	CLIP-seq
MIRT998352	hsa-miR-3616-3p	CLIP-seq
MIRT998358	hsa-miR-4319	CLIP-seq
MIRT998363	hsa-miR-4721	CLIP-seq
MIRT998365	hsa-miR-544b	CLIP-seq
MIRT998367	hsa-miR-876-5p	CLIP-seq
MIRT998340	hsa-miR-125a-5p	CLIP-seq
MIRT998341	hsa-miR-125b	CLIP-seq
MIRT998342	hsa-miR-1273e	CLIP-seq
MIRT998343	hsa-miR-1290	CLIP-seq
MIRT998344	hsa-miR-1304	CLIP-seq
MIRT998345	hsa-miR-185	CLIP-seq
MIRT998346	hsa-miR-2467-5p	CLIP-seq
MIRT998347	hsa-miR-3144-5p	CLIP-seq
MIRT998348	hsa-miR-3167	CLIP-seq
MIRT998349	hsa-miR-3188	CLIP-seq
MIRT998350	hsa-miR-3191	CLIP-seq
MIRT998351	hsa-miR-3199	CLIP-seq
MIRT998352	hsa-miR-3616-3p	CLIP-seq
MIRT998353	hsa-miR-3688-5p	CLIP-seq
MIRT998354	hsa-miR-3907	CLIP-seq
MIRT998355	hsa-miR-3975	CLIP-seq
MIRT998356	hsa-miR-4306	CLIP-seq
MIRT998357	hsa-miR-4318	CLIP-seq
MIRT998358	hsa-miR-4319	CLIP-seq
MIRT998359	hsa-miR-4644	CLIP-seq
MIRT998360	hsa-miR-4652-5p	CLIP-seq
MIRT998361	hsa-miR-4667-5p	CLIP-seq
MIRT998362	hsa-miR-4700-5p	CLIP-seq
MIRT998363	hsa-miR-4721	CLIP-seq
MIRT998364	hsa-miR-485-5p	CLIP-seq
MIRT998365	hsa-miR-544b	CLIP-seq
MIRT998366	hsa-miR-571	CLIP-seq
MIRT998367	hsa-miR-876-5p	CLIP-seq
MIRT998340	hsa-miR-125a-5p	CLIP-seq
MIRT998341	hsa-miR-125b	CLIP-seq
MIRT998342	hsa-miR-1273e	CLIP-seq
MIRT998343	hsa-miR-1290	CLIP-seq
MIRT998344	hsa-miR-1304	CLIP-seq
MIRT998345	hsa-miR-185	CLIP-seq
MIRT998346	hsa-miR-2467-5p	CLIP-seq
MIRT998347	hsa-miR-3144-5p	CLIP-seq
MIRT998348	hsa-miR-3167	CLIP-seq
MIRT998349	hsa-miR-3188	CLIP-seq
MIRT998350	hsa-miR-3191	CLIP-seq
MIRT998351	hsa-miR-3199	CLIP-seq
MIRT998352	hsa-miR-3616-3p	CLIP-seq
MIRT998354	hsa-miR-3907	CLIP-seq
MIRT998355	hsa-miR-3975	CLIP-seq
MIRT998356	hsa-miR-4306	CLIP-seq
MIRT998357	hsa-miR-4318	CLIP-seq
MIRT998358	hsa-miR-4319	CLIP-seq
MIRT998359	hsa-miR-4644	CLIP-seq
MIRT998360	hsa-miR-4652-5p	CLIP-seq
MIRT998361	hsa-miR-4667-5p	CLIP-seq
MIRT998362	hsa-miR-4700-5p	CLIP-seq
MIRT998363	hsa-miR-4721	CLIP-seq
MIRT998364	hsa-miR-485-5p	CLIP-seq
MIRT998365	hsa-miR-544b	CLIP-seq
MIRT998366	hsa-miR-571	CLIP-seq
MIRT998367	hsa-miR-876-5p	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002102	Component	Podosome	IEA
GO:0002102	Component	Podosome	ISS
GO:0003779	Function	Actin binding	IDA	9525888
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	9671805, 10366446, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005903	Component	Brush border	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0008154	Process	Actin polymerization or depolymerization	IBA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0030239	Process	Myofibril assembly	IBA
GO:0034451	Component	Centriolar satellite	IDA
GO:0042995	Component	Cell projection	IEA
GO:0045214	Process	Sarcomere organization	IEA
GO:0051014	Process	Actin filament severing	IBA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051016	Process	Barbed-end actin filament capping	IBA
GO:0070161	Component	Anchoring junction	IEA

MIM	HGNC	e!Ensembl
600362	3750	ENSG00000177731

Protein

UniProt ID

Q13045

Protein name

Protein flightless-1 homolog

Protein function

Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By simil

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	33 → 91	Leucine rich repeat	Repeat
PF13855	LRR_8	127 → 186	Leucine rich repeat	Repeat
PF00626	Gelsolin	508 → 591	Gelsolin repeat	Domain
PF00626	Gelsolin	628 → 703	Gelsolin repeat	Domain
PF00626	Gelsolin	756 → 832	Gelsolin repeat	Domain
PF00626	Gelsolin	1177 → 1255	Gelsolin repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: Strongest expression in skeletal muscle with high expression also in the heart and lung. {ECO:0000269|PubMed:9525888}.

Sequence

MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
WSAFCKALA

Sequence length

1269

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Cardiomyopathy	cardiomyopathy, dilated, 2j	N/A	N/A	GenCC
Congenital finger flexion contractures	Flexion contracture	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenomatous Polyposis Coli	Associate	23106643
Breast Neoplasms	Inhibit	17172821
Carcinogenesis	Associate	12086853, 23527175
Disease	Inhibit	37033921
Melanoma	Associate	29048432
Menkes Kinky Hair Syndrome	Associate	7703487
Neoplasms	Associate	35298000, 36615603
Sarcoma	Associate	35238118
Sarcoma Ewing	Associate	12086853, 18626011, 19920188, 22749036, 23527175, 24812032, 25025207, 27792997, 28720588, 28847958, 29091716, 29358035, 32658189, 32842875, 34145397, 35298000, 36124657, 36615603 View all (3 more)
Thrombocytopenia	Associate	7703487

FLII (FLII actin remodeling protein)