SWAP70 (switching B cell complex subunit SWAP70)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23075 |
| Gene name | Switching B cell complex subunit SWAP70 |
| Gene symbol | SWAP70 |
| Synonyms (NCBI Gene) |
HSPC321SWAP-70
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| Chromosome | 11 |
| Chromosome location | 11p15.4 |
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miRNA
miRNA information provided by mirtarbase database.
477
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UH65 | ||||||||||
| Protein name | Switch-associated protein 70 (SWAP-70) | ||||||||||
| Protein function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the act | ||||||||||
| PDB | 2DN6 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found | ||||||||||
| Sequence |
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| Sequence length | 585 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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