SWAP70 (switching B cell complex subunit SWAP70)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23075 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Switching B cell complex subunit SWAP70 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SWAP70 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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HSPC321, SWAP-70 |
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Chromosome
Chromosome number
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11 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11p15.4 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q9UH65 | ||||||||||
| Protein name | Switch-associated protein 70 (SWAP-70) | ||||||||||
| Protein function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the act | ||||||||||
| PDB | 2DN6 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found | ||||||||||
| Sequence |
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| Sequence length | 585 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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