Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23047
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Gene name
Gene Name - the full gene name approved by the HGNC.
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PDS5 cohesin associated factor B |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PDS5B |
Synonyms (NCBI Gene)
Gene synonyms aliases
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APRIN, AS3, CG008 |
Chromosome
Chromosome number
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13 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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13q13.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Breast carcinoma |
Breast Carcinoma |
rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038 View all (71 more) |
29059683 |
Coronary artery disease |
Coronary Artery Disease |
rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 |
29212778 |
Lung carcinoma |
Squamous cell carcinoma of lung, Carcinoma of lung |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
28604730 |
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Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Asthma |
Asthma |
|
|
GWAS |
Breast Cancer |
Breast Cancer |
Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients |
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GWAS, CBGDA |
Metabolic Syndrome |
Metabolic Syndrome |
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|
GWAS |
Myocardial Infarction |
Myocardial Infarction |
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|
GWAS |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Anemia Sickle Cell |
Associate
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34418541 |
Asthma |
Associate
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31924195 |
Breast Neoplasms |
Associate
|
22293751, 31081100, 32143617 |
Breast Neoplasms |
Inhibit
|
30883342 |
Carcinogenesis |
Stimulate
|
35031324 |
Carcinoma Basal Cell |
Associate
|
31047981 |
Carcinoma Hepatocellular |
Inhibit
|
32546442 |
Carcinoma Hepatocellular |
Associate
|
36359865, 36852700 |
Carcinoma Non Small Cell Lung |
Inhibit
|
31539127, 32138716 |
Carcinoma Ovarian Epithelial |
Associate
|
39519394 |
Carcinoma Squamous Cell |
Associate
|
36139456 |
Colorectal Neoplasms |
Associate
|
32533587 |
Fibrocartilaginous embolism |
Associate
|
32143617, 37102649 |
Glioma |
Associate
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31081100 |
Inflammation |
Inhibit
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37102649 |
Intervertebral Disc Degeneration |
Inhibit
|
32143617 |
Intervertebral Disc Degeneration |
Associate
|
37102649 |
Leukemia Myeloid Acute |
Associate
|
26492932 |
Leukemia Promyelocytic Acute |
Inhibit
|
26110921 |
Lung Neoplasms |
Associate
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36852700 |
Lymphatic Metastasis |
Inhibit
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31539127, 36852700 |
Myoclonic Epilepsies Progressive |
Associate
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32174258 |
Neoplasm Metastasis |
Inhibit
|
31539127 |
Neoplasm Metastasis |
Associate
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36852700 |
Neoplasms |
Associate
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26492932, 35253323 |
Neoplasms |
Inhibit
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31539127, 32533587, 32681706, 35043728 |
Neoplasms |
Stimulate
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35031324 |
Ovarian Neoplasms |
Inhibit
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32681706 |
Pancreatic Neoplasms |
Associate
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35043728 |
Precursor T Cell Lymphoblastic Leukemia Lymphoma |
Associate
|
32174258 |
Prostatic Neoplasms |
Associate
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10963680, 32953881 |
Prostatic Neoplasms |
Stimulate
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35031324 |
Renal Insufficiency |
Associate
|
34308739 |
Squamous Cell Carcinoma of Head and Neck |
Inhibit
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36852700 |
Stomach Neoplasms |
Associate
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35814566, 37457685 |
Urinary Bladder Neoplasms |
Associate
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30170380, 31081100 |
Urinary Bladder Neoplasms |
Inhibit
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33231563 |
Uterine Cervical Neoplasms |
Inhibit
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35126958 |
Wounds and Injuries |
Inhibit
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37102649 |
X Linked Combined Immunodeficiency Diseases |
Associate
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32174258 |
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