Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23039
Gene name Gene Name - the full gene name approved by the HGNC.
Exportin 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
XPO7
Synonyms (NCBI Gene) Gene synonyms aliases
EXP7, RANBP16
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027121 hsa-miR-103a-3p Sequencing 20371350
MIRT027326 hsa-miR-101-3p Sequencing 20371350
MIRT031797 hsa-miR-16-5p Sequencing 20371350
MIRT031797 hsa-miR-16-5p Proteomics 18668040
MIRT032321 hsa-let-7b-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005049 Function Nuclear export signal receptor activity IBA 21873635
GO:0005049 Function Nuclear export signal receptor activity IDA 11024021
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005634 Component Nucleus IDA 11071879
GO:0005643 Component Nuclear pore IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606140 14108 ENSG00000130227
Protein
UniProt ID Q9UIA9
Protein name Exportin-7 (Exp7) (Ran-binding protein 16)
Protein function Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03810 IBN_N 30 96 Importin-beta N-terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in re
Sequence
MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQ
LLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLAT
RPKLATFVTQALIQLYARITKLGW
FDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASS
FRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESS
DDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAER
AKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIA
NFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLES
VHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSAS
ASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQ
AGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNL
KYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLT
DMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLV
GLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVH
NRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLK
AALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQD
HMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTP
LNQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLR
NSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGV
NSNDMMS
Sequence length 1087
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Nucleocytoplasmic transport  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
29892015, 30061737
Unknown
Disease term Disease name Evidence References Source
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 29892015, 30061737 ClinVar
Prostate cancer prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GenCC, CBGDA
Atrial Fibrillation Atrial Fibrillation GWAS
Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alcoholism Associate 21876473
Carcinoma Ovarian Epithelial Associate 24625450
Prostatic Neoplasms Associate 32800727