Gene Gene information from NCBI Gene database.
Entrez ID 23017
Gene name Fas apoptotic inhibitory molecule 2
Gene symbol FAIM2
Synonyms (NCBI Gene)
LFGLFG2NGP35NMP35TMBIM2
Chromosome 12
Chromosome location 12q13.12
miRNA miRNA information provided by mirtarbase database.
292
miRTarBase ID miRNA Experiments Reference
MIRT647646 hsa-miR-4267 HITS-CLIP 23824327
MIRT647645 hsa-miR-875-3p HITS-CLIP 23824327
MIRT647644 hsa-miR-6128 HITS-CLIP 23824327
MIRT647643 hsa-miR-3655 HITS-CLIP 23824327
MIRT647642 hsa-miR-6778-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 25764978
GO:0002931 Process Response to ischemia IEA
GO:0005262 Function Calcium channel activity IBA
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604306 17067 ENSG00000135472
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BWQ8
Protein name Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2)
Protein function Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, interna
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01027 Bax1-I 100 311 Inhibitor of apoptosis-promoting Bax1 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especial
Sequence
Sequence length 316
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GOUT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERPITUITARISM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MORBID OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Arthritis Rheumatoid Associate 33193078
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 20336406
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 26398169
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 29131440
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 35999641
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 1 Associate 33193078
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 32228543
★☆☆☆☆
Found in Text Mining only
Gaucher Disease Associate 33193078
★☆☆☆☆
Found in Text Mining only
Graves Disease Associate 33193078
★☆☆☆☆
Found in Text Mining only
Hashimoto Disease Associate 33193078
★☆☆☆☆
Found in Text Mining only