Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23017
Gene name Gene Name - the full gene name approved by the HGNC.
Fas apoptotic inhibitory molecule 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FAIM2
Synonyms (NCBI Gene) Gene synonyms aliases
LFG, LFG2, NGP35, NMP35, TMBIM2
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT647646 hsa-miR-4267 HITS-CLIP 23824327
MIRT647645 hsa-miR-875-3p HITS-CLIP 23824327
MIRT647644 hsa-miR-6128 HITS-CLIP 23824327
MIRT647643 hsa-miR-3655 HITS-CLIP 23824327
MIRT647642 hsa-miR-6778-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 25764978
GO:0002931 Process Response to ischemia IEA
GO:0005262 Function Calcium channel activity IBA
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604306 17067 ENSG00000135472
Protein
UniProt ID Q9BWQ8
Protein name Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2)
Protein function Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, interna
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01027 Bax1-I 100 311 Inhibitor of apoptosis-promoting Bax1 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especial
Sequence
Sequence length 316
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes, Type 2 diabetes (PheCode 250.2) N/A N/A GWAS
Gout Gout N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 33193078
Breast Neoplasms Associate 20336406
Carcinogenesis Associate 26398169
Carcinoma Non Small Cell Lung Associate 29131440
Colorectal Neoplasms Associate 35999641
Diabetes Mellitus Type 1 Associate 33193078
Diabetes Mellitus Type 2 Associate 32228543
Gaucher Disease Associate 33193078
Graves Disease Associate 33193078
Hashimoto Disease Associate 33193078