Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23014
Gene name Gene Name - the full gene name approved by the HGNC.
F-box protein 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FBXO21
Synonyms (NCBI Gene) Gene synonyms aliases
FBX21
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), w
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019578 hsa-miR-340-5p Sequencing 20371350
MIRT027913 hsa-miR-96-5p Sequencing 20371350
MIRT046784 hsa-miR-222-3p CLASH 23622248
MIRT040547 hsa-miR-92b-3p CLASH 23622248
MIRT658215 hsa-miR-605-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex NAS 10531035
GO:0000209 Process Protein polyubiquitination TAS
GO:0003677 Function DNA binding IEA
GO:0004842 Function Ubiquitin-protein transferase activity NAS 10531035
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609095 13592 ENSG00000135108
Protein
UniProt ID O94952
Protein name F-box only protein 21
Protein function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13369 Transglut_core2 215 390 Transglutaminase-like superfamily Family
PF08755 YccV-like 501 593 Hemimethylated DNA-binding protein YccV like Domain
Sequence
MAAAAVDSAMEVVPALAEEAAPEVAGLSCLVNLPGEVLEYILCCGSLTAADIGRVSSTCR
RLRELCQSSGKVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKR
FFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILN
NLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQAQIDSIVELVCKTLRGINSRHP
SLAFKAGESSMIMEIELQSQVLDAMNYVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGI
PISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGATLDIFDYIYIDAFGKGKQLTV
KECEYLIGQHVTAALYGVVNVKKVLQRMVG
NLLSLGKREGIDQSYQLLRDSLDLYLAMYP
DQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIE
RKKEEVGVEVKLRSDEKHRDVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVH
SLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTH
YIPNAEL
EIRYPEDLEFVYETVQNIYSAKKENIDE
Sequence length 628
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Leukemia Myeloid Acute Associate 37689825
Neoplasms Inhibit 37689825
Osteoarthritis Associate 36278814
Ovarian Neoplasms Inhibit 34660776