Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22985
Gene name Gene Name - the full gene name approved by the HGNC.	Apoptotic chromatin condensation inducer 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ACIN1
Synonyms (NCBI Gene) Gene synonyms aliases	ACINUS, ACN, fSAP152
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA

Show/Hide all(130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019549	hsa-miR-340-5p	Sequencing	20371350
MIRT027955	hsa-miR-93-5p	Sequencing	20371350
MIRT031335	hsa-miR-18a-5p	Sequencing	20371350
MIRT046954	hsa-miR-221-3p	CLASH	23622248
MIRT044279	hsa-miR-106b-5p	CLASH	23622248
MIRT043129	hsa-miR-324-5p	CLASH	23622248
MIRT038741	hsa-miR-93-3p	CLASH	23622248
MIRT036443	hsa-miR-1226-3p	CLASH	23622248
MIRT715885	hsa-miR-4640-3p	HITS-CLIP	19536157
MIRT715884	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT715883	hsa-miR-4292	HITS-CLIP	19536157
MIRT715882	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT715881	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT715880	hsa-miR-7114-5p	HITS-CLIP	19536157
MIRT715879	hsa-miR-134-3p	HITS-CLIP	19536157
MIRT715878	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT715877	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT715876	hsa-miR-6762-5p	HITS-CLIP	19536157
MIRT715875	hsa-miR-6845-5p	HITS-CLIP	19536157
MIRT715874	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT715873	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT715872	hsa-miR-663b	HITS-CLIP	19536157
MIRT715871	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT715870	hsa-miR-1227-5p	HITS-CLIP	19536157
MIRT715869	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT441292	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441292	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT715885	hsa-miR-4640-3p	HITS-CLIP	19536157
MIRT715884	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT715883	hsa-miR-4292	HITS-CLIP	19536157
MIRT715882	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT715881	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT715880	hsa-miR-7114-5p	HITS-CLIP	19536157
MIRT715879	hsa-miR-134-3p	HITS-CLIP	19536157
MIRT715878	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT715877	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT715876	hsa-miR-6762-5p	HITS-CLIP	19536157
MIRT715875	hsa-miR-6845-5p	HITS-CLIP	19536157
MIRT715874	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT715873	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT715872	hsa-miR-663b	HITS-CLIP	19536157
MIRT715871	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT715870	hsa-miR-1227-5p	HITS-CLIP	19536157
MIRT715869	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT762685	hsa-miR-4729	CLIP-seq
MIRT762686	hsa-miR-587	CLIP-seq
MIRT762687	hsa-miR-224	CLIP-seq
MIRT762688	hsa-miR-548a-3p	CLIP-seq
MIRT762689	hsa-miR-548e	CLIP-seq
MIRT762690	hsa-miR-548f	CLIP-seq
MIRT1924839	hsa-miR-154	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2166054	hsa-miR-1205	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2166054	hsa-miR-1205	CLIP-seq
MIRT2383818	hsa-miR-1291	CLIP-seq
MIRT2383819	hsa-miR-1292	CLIP-seq
MIRT2383820	hsa-miR-1909	CLIP-seq
MIRT2383821	hsa-miR-3199	CLIP-seq
MIRT2383822	hsa-miR-4418	CLIP-seq
MIRT2383823	hsa-miR-4471	CLIP-seq
MIRT2383824	hsa-miR-509-3-5p	CLIP-seq
MIRT2383825	hsa-miR-509-5p	CLIP-seq
MIRT2166054	hsa-miR-1205	CLIP-seq
MIRT2468554	hsa-miR-1286	CLIP-seq
MIRT2468555	hsa-miR-1321	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT2468556	hsa-miR-1912	CLIP-seq
MIRT2468557	hsa-miR-1915	CLIP-seq
MIRT2468558	hsa-miR-2355-5p	CLIP-seq
MIRT2468559	hsa-miR-2392	CLIP-seq
MIRT2468560	hsa-miR-3064-5p	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT2468561	hsa-miR-3148	CLIP-seq
MIRT2468562	hsa-miR-3169	CLIP-seq
MIRT2468563	hsa-miR-3176	CLIP-seq
MIRT2468564	hsa-miR-326	CLIP-seq
MIRT2468565	hsa-miR-330-5p	CLIP-seq
MIRT2468566	hsa-miR-3689d	CLIP-seq
MIRT2468567	hsa-miR-3922-3p	CLIP-seq
MIRT2468568	hsa-miR-3926	CLIP-seq
MIRT2468569	hsa-miR-4257	CLIP-seq
MIRT2468570	hsa-miR-4270	CLIP-seq
MIRT2468571	hsa-miR-4436a	CLIP-seq
MIRT2468572	hsa-miR-4441	CLIP-seq
MIRT2468573	hsa-miR-4446-3p	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT2468574	hsa-miR-4515	CLIP-seq
MIRT2468575	hsa-miR-4534	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2468576	hsa-miR-4722-5p	CLIP-seq
MIRT2468577	hsa-miR-4739	CLIP-seq
MIRT2468578	hsa-miR-4756-5p	CLIP-seq
MIRT2468579	hsa-miR-4802-5p	CLIP-seq
MIRT2468580	hsa-miR-486-3p	CLIP-seq
MIRT2468581	hsa-miR-548c-3p	CLIP-seq
MIRT2468582	hsa-miR-548s	CLIP-seq
MIRT2468583	hsa-miR-765	CLIP-seq
MIRT2468555	hsa-miR-1321	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT2468556	hsa-miR-1912	CLIP-seq
MIRT2468557	hsa-miR-1915	CLIP-seq
MIRT2468559	hsa-miR-2392	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT2468561	hsa-miR-3148	CLIP-seq
MIRT2468562	hsa-miR-3169	CLIP-seq
MIRT2468566	hsa-miR-3689d	CLIP-seq
MIRT2468569	hsa-miR-4257	CLIP-seq
MIRT2468570	hsa-miR-4270	CLIP-seq
MIRT2468572	hsa-miR-4441	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT2468574	hsa-miR-4515	CLIP-seq
MIRT2468575	hsa-miR-4534	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2468577	hsa-miR-4739	CLIP-seq
MIRT2468578	hsa-miR-4756-5p	CLIP-seq
MIRT2468579	hsa-miR-4802-5p	CLIP-seq
MIRT2468580	hsa-miR-486-3p	CLIP-seq
MIRT2468581	hsa-miR-548c-3p	CLIP-seq
MIRT2468583	hsa-miR-765	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003676	Function	Nucleic acid binding	NAS	10490026
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 18951082, 19387494, 20195357, 22365833, 22388736, 23602568, 28514442, 30021884, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	10490026
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008380	Process	RNA splicing	IBA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IDA	20966198
GO:0016607	Component	Nuclear speck	IEA
GO:0016887	Function	ATP hydrolysis activity	NAS	10490026
GO:0019899	Function	Enzyme binding	NAS	10490026
GO:0030218	Process	Erythrocyte differentiation	IEP	11208865
GO:0030263	Process	Apoptotic chromosome condensation	IDA	10490026
GO:0031981	Component	Nuclear lumen	IEA
GO:0035145	Component	Exon-exon junction complex	IDA	16314458
GO:0043065	Process	Positive regulation of apoptotic process	IDA	12665594
GO:0045657	Process	Positive regulation of monocyte differentiation	IEP	12393560
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IDA	12665594
GO:0061574	Component	ASAP complex	IBA
GO:0061574	Component	ASAP complex	IDA	12665594

MIM	HGNC	e!Ensembl
604562	17066	ENSG00000100813

Protein

UniProt ID

Q9UKV3

Protein name

Apoptotic chromatin condensation inducer in the nucleus (Acinus)

Protein function

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated fa

PDB

6G6S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02037	SAP	72 → 106	SAP domain	Family
PF16294	RSB_motif	1129 → 1247	RNSP1-SAP18 binding (RSB) motif	Motif

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Sequence

MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMA
ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA
FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA
SLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS
EGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI
LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE
MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT
KEASSPPPHPQLHSEEEIEPMEGPAPAVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL
SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK
GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG
SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGV
SRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT
QRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR
PENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT
EGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED
ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVAL
PPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLV
RPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK
FLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER
AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE
KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ
KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD
TKRHSRSRSRSTPVRDRGGRR

Sequence length

1341

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport mRNA surveillance pathway Spliceosome		Apoptotic cleavage of cellular proteins

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Postmenopausal breast cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	17409846
Adenocarcinoma Bronchiolo Alveolar	Associate	17409846
Adenocarcinoma of Lung	Associate	17409846
Colorectal Neoplasms	Associate	33142236
general anxiety disorder	Associate	36344488
Leukemia	Associate	18559500
Leukemia Myeloid Acute	Associate	18559500
Neoplasms	Inhibit	22629410
Neoplasms	Associate	30784602, 39201394
Obsessive Compulsive Disorder	Associate	36344488
Pancreatic Neoplasms	Associate	22629410
Personality Disorders	Associate	35255776
Prostatic Neoplasms	Associate	37143720
Uterine Cervical Neoplasms	Associate	35255776

ACIN1 (apoptotic chromatin condensation inducer 1)