TCF25 (TCF25 ribosome quality control complex subunit)

Gene

• Entrez ID: 22980
• Gene name: TCF25 ribosome quality control complex subunit
• Gene symbol: TCF25
• Synonyms (NCBI Gene): FKSG26, Hulp1, NULP1, PRO2620, hKIAA1049
• Chromosome: 16
• Chromosome location: 16q24.3
• Summary: TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050402	hsa-miR-23a-3p	CLASH	23622248
MIRT046271	hsa-miR-23b-3p	CLASH	23622248
MIRT037265	hsa-miR-877-5p	CLASH	23622248
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq
MIRT2124822	hsa-miR-193a-3p	CLIP-seq
MIRT2124823	hsa-miR-193b	CLIP-seq
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT2124824	hsa-miR-3619-3p	CLIP-seq
MIRT2124825	hsa-miR-3919	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT2124826	hsa-miR-4729	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT2124827	hsa-miR-4776-5p	CLIP-seq
MIRT2124828	hsa-miR-4800-5p	CLIP-seq
MIRT2124829	hsa-miR-487a	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT2124830	hsa-miR-539	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq
MIRT2124822	hsa-miR-193a-3p	CLIP-seq
MIRT2124823	hsa-miR-193b	CLIP-seq
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT2124825	hsa-miR-3919	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT2124829	hsa-miR-487a	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT2124830	hsa-miR-539	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 21516116, 24947832, 25416956, 28514442, 31046837, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0061945	Process	Regulation of protein K48-linked ubiquitination	IDA	30244831
GO:0072344	Process	Rescue of stalled ribosome	IDA	30244831
GO:1990112	Component	RQC complex	IBA
GO:1990112	Component	RQC complex	IDA	30244831

Other IDs

• MIM: 612326
• HGNC: 29181
• e!Ensembl: ENSG00000141002

Protein

• UniProt ID: Q9BQ70
• Protein name: Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25)
• Protein function: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, requ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04910	Tcf25	248 → 588	Transcriptional repressor TCF25	Family

• Tissue specificity: TISSUE SPECIFICITY: In the embryo, widely expressed with highest levels in brain (PubMed:16574069). In the adult, highest expression is found in the heart (PubMed:16574069, PubMed:32805187). Repressed in cardiac tissue of patients with heart failure (at p
• Sequence:

  MSRRALRRLRGEQRGQEPLGPGALHFDLRDDDDAEEEGPKRELGVRRPGGAGKEGVRVNN
  RFELINIDDLEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTETVPSEQSH
  ASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIEDSTGLNRPGPAPLSSRKHVLYV
  EHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLE
  SKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQE
  DQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPENRSFYLALYKQMSFLEKRGCP
  RTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAF
  SVPLAYFLLSQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSH
  RFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEAC
  ENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPER
  LSPISHGNTIALFFRSLLPNYTMEGERPEEGVAGGLNRNQGLNRLMLAVRDMMANFHLND
  LEAPHEDDAEGEGEWD

• Sequence length: 676

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	rs778208667	RCV005927139

Associations from Text Mining
Disease Name	Relationship Type	References
Arrhythmogenic Right Ventricular Dysplasia	Associate	29221435