TCF25 (TCF25 ribosome quality control complex subunit)

Gene

• Entrez ID: 22980
• Gene name: TCF25 ribosome quality control complex subunit
• Gene symbol: TCF25
• Synonyms (NCBI Gene): FKSG26, Hulp1, NULP1, PRO2620, hKIAA1049
• Chromosome: 16
• Chromosome location: 16q24.3
• Summary: TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050402	hsa-miR-23a-3p	CLASH	23622248
MIRT046271	hsa-miR-23b-3p	CLASH	23622248
MIRT037265	hsa-miR-877-5p	CLASH	23622248
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq
MIRT2124822	hsa-miR-193a-3p	CLIP-seq
MIRT2124823	hsa-miR-193b	CLIP-seq
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT2124824	hsa-miR-3619-3p	CLIP-seq
MIRT2124825	hsa-miR-3919	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT2124826	hsa-miR-4729	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT2124827	hsa-miR-4776-5p	CLIP-seq
MIRT2124828	hsa-miR-4800-5p	CLIP-seq
MIRT2124829	hsa-miR-487a	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT2124830	hsa-miR-539	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq
MIRT2124822	hsa-miR-193a-3p	CLIP-seq
MIRT2124823	hsa-miR-193b	CLIP-seq
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT2124825	hsa-miR-3919	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT2124829	hsa-miR-487a	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT2124830	hsa-miR-539	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq
MIRT1416170	hsa-miR-3162-3p	CLIP-seq
MIRT1416171	hsa-miR-4269	CLIP-seq
MIRT1416172	hsa-miR-4514	CLIP-seq
MIRT1416173	hsa-miR-4692	CLIP-seq
MIRT1416174	hsa-miR-4742-5p	CLIP-seq
MIRT1416175	hsa-miR-512-5p	CLIP-seq
MIRT1416176	hsa-miR-603	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	16574069
GO:0003677	Function	DNA binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	16574069
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 21516116, 24947832, 25416956, 28514442, 31046837, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	16574069
GO:0007507	Process	Heart development	NAS	16574069
GO:1990112	Component	RQC complex	IBA	21873635

Other IDs

• MIM: 612326
• HGNC: 29181
• e!Ensembl: ENSG00000141002

Protein

• UniProt ID: Q9BQ70
• Protein name: Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25)
• Protein function: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, requ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04910	Tcf25	248 → 588	Transcriptional repressor TCF25	Family

• Tissue specificity: TISSUE SPECIFICITY: In the embryo, widely expressed with highest levels in brain (PubMed:16574069). In the adult, highest expression is found in the heart (PubMed:16574069, PubMed:32805187). Repressed in cardiac tissue of patients with heart failure (at p
• Sequence:

  MSRRALRRLRGEQRGQEPLGPGALHFDLRDDDDAEEEGPKRELGVRRPGGAGKEGVRVNN
  RFELINIDDLEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTETVPSEQSH
  ASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIEDSTGLNRPGPAPLSSRKHVLYV
  EHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLE
  SKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQE
  DQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPENRSFYLALYKQMSFLEKRGCP
  RTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAF
  SVPLAYFLLSQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSH
  RFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEAC
  ENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPER
  LSPISHGNTIALFFRSLLPNYTMEGERPEEGVAGGLNRNQGLNRLMLAVRDMMANFHLND
  LEAPHEDDAEGEGEWD

• Sequence length: 676

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Myocardial infarction	Myocardial Infarction		21211798	ClinVar
Carcinoma	Carcinoma			GWAS
Alzheimer disease	Alzheimer disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Arrhythmogenic Right Ventricular Dysplasia	Associate	29221435