Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	22955
Gene name	Scm polycomb group protein homolog 1
Gene symbol	SCMH1
Synonyms (NCBI Gene)	Scml3
Chromosome	1
Chromosome location	1p34.2

133

Show/Hide all (133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024711	hsa-miR-215-5p	Microarray	19074876
MIRT026128	hsa-miR-192-5p	Microarray	19074876
MIRT051461	hsa-let-7e-5p	CLASH	23622248
MIRT047441	hsa-miR-10b-5p	CLASH	23622248
MIRT037923	hsa-miR-532-3p	CLASH	23622248
MIRT2097695	hsa-miR-3176	CLIP-seq
MIRT2097696	hsa-miR-3194-5p	CLIP-seq
MIRT2097697	hsa-miR-3922-3p	CLIP-seq
MIRT2097698	hsa-miR-4277	CLIP-seq
MIRT2097699	hsa-miR-4435	CLIP-seq
MIRT2097700	hsa-miR-4685-5p	CLIP-seq
MIRT2321959	hsa-miR-28-5p	CLIP-seq
MIRT2321960	hsa-miR-3139	CLIP-seq
MIRT2097695	hsa-miR-3176	CLIP-seq
MIRT2097696	hsa-miR-3194-5p	CLIP-seq
MIRT2097697	hsa-miR-3922-3p	CLIP-seq
MIRT2097698	hsa-miR-4277	CLIP-seq
MIRT2097699	hsa-miR-4435	CLIP-seq
MIRT2321961	hsa-miR-4447	CLIP-seq
MIRT2321962	hsa-miR-4472	CLIP-seq
MIRT2321963	hsa-miR-4488	CLIP-seq
MIRT2097700	hsa-miR-4685-5p	CLIP-seq
MIRT2321964	hsa-miR-4697-5p	CLIP-seq
MIRT2321965	hsa-miR-486-3p	CLIP-seq
MIRT2321966	hsa-miR-541	CLIP-seq
MIRT2321967	hsa-miR-654-5p	CLIP-seq
MIRT2321968	hsa-miR-708	CLIP-seq
MIRT2458909	hsa-miR-296-3p	CLIP-seq
MIRT2458910	hsa-miR-3121-3p	CLIP-seq
MIRT2458911	hsa-miR-3126-5p	CLIP-seq
MIRT2458912	hsa-miR-3649	CLIP-seq
MIRT2458913	hsa-miR-539	CLIP-seq
MIRT2458914	hsa-miR-580	CLIP-seq
MIRT2458909	hsa-miR-296-3p	CLIP-seq
MIRT2458910	hsa-miR-3121-3p	CLIP-seq
MIRT2458911	hsa-miR-3126-5p	CLIP-seq
MIRT2458912	hsa-miR-3649	CLIP-seq
MIRT2458913	hsa-miR-539	CLIP-seq
MIRT2458914	hsa-miR-580	CLIP-seq
MIRT2618386	hsa-miR-1180	CLIP-seq
MIRT2618387	hsa-miR-1234	CLIP-seq
MIRT2618388	hsa-miR-1248	CLIP-seq
MIRT2618389	hsa-miR-1254	CLIP-seq
MIRT2618390	hsa-miR-198	CLIP-seq
MIRT2618391	hsa-miR-199a-5p	CLIP-seq
MIRT2618392	hsa-miR-199b-5p	CLIP-seq
MIRT2321959	hsa-miR-28-5p	CLIP-seq
MIRT2618393	hsa-miR-3116	CLIP-seq
MIRT2618394	hsa-miR-3127-5p	CLIP-seq
MIRT2618395	hsa-miR-3130-5p	CLIP-seq
MIRT2618396	hsa-miR-3138	CLIP-seq
MIRT2321960	hsa-miR-3139	CLIP-seq
MIRT2618397	hsa-miR-3148	CLIP-seq
MIRT2618398	hsa-miR-3156-5p	CLIP-seq
MIRT2618399	hsa-miR-3163	CLIP-seq
MIRT2097695	hsa-miR-3176	CLIP-seq
MIRT2618400	hsa-miR-3689a-3p	CLIP-seq
MIRT2618401	hsa-miR-3689c	CLIP-seq
MIRT2097697	hsa-miR-3922-3p	CLIP-seq
MIRT2618402	hsa-miR-3927	CLIP-seq
MIRT2097698	hsa-miR-4277	CLIP-seq
MIRT2618403	hsa-miR-4290	CLIP-seq
MIRT2618404	hsa-miR-4297	CLIP-seq
MIRT2618405	hsa-miR-4299	CLIP-seq
MIRT2618406	hsa-miR-4320	CLIP-seq
MIRT2097699	hsa-miR-4435	CLIP-seq
MIRT2618407	hsa-miR-4451	CLIP-seq
MIRT2618408	hsa-miR-4456	CLIP-seq
MIRT2618409	hsa-miR-4464	CLIP-seq
MIRT2618410	hsa-miR-4481	CLIP-seq
MIRT2618411	hsa-miR-4482	CLIP-seq
MIRT2618412	hsa-miR-4520a-3p	CLIP-seq
MIRT2618413	hsa-miR-4648	CLIP-seq
MIRT2618414	hsa-miR-4654	CLIP-seq
MIRT2618415	hsa-miR-4659a-3p	CLIP-seq
MIRT2618416	hsa-miR-4659b-3p	CLIP-seq
MIRT2097700	hsa-miR-4685-5p	CLIP-seq
MIRT2618417	hsa-miR-4710	CLIP-seq
MIRT2618418	hsa-miR-4728-5p	CLIP-seq
MIRT2618419	hsa-miR-4745-5p	CLIP-seq
MIRT2618420	hsa-miR-4748	CLIP-seq
MIRT2618421	hsa-miR-4769-5p	CLIP-seq
MIRT2618422	hsa-miR-4792	CLIP-seq
MIRT2618423	hsa-miR-4800-5p	CLIP-seq
MIRT2618424	hsa-miR-496	CLIP-seq
MIRT2618425	hsa-miR-507	CLIP-seq
MIRT2618426	hsa-miR-508-5p	CLIP-seq
MIRT2321966	hsa-miR-541	CLIP-seq
MIRT2618427	hsa-miR-548m	CLIP-seq
MIRT2618428	hsa-miR-548q	CLIP-seq
MIRT2618429	hsa-miR-557	CLIP-seq
MIRT2618430	hsa-miR-606	CLIP-seq
MIRT2618431	hsa-miR-624	CLIP-seq
MIRT2618432	hsa-miR-628-5p	CLIP-seq
MIRT2618433	hsa-miR-648	CLIP-seq
MIRT2321967	hsa-miR-654-5p	CLIP-seq
MIRT2618434	hsa-miR-671-5p	CLIP-seq
MIRT2321968	hsa-miR-708	CLIP-seq
MIRT2618435	hsa-miR-765	CLIP-seq
MIRT2618436	hsa-miR-766	CLIP-seq
MIRT2618437	hsa-miR-767-5p	CLIP-seq
MIRT2618438	hsa-miR-875-3p	CLIP-seq
MIRT2618439	hsa-miR-885-3p	CLIP-seq
MIRT2618386	hsa-miR-1180	CLIP-seq
MIRT2618387	hsa-miR-1234	CLIP-seq
MIRT2618388	hsa-miR-1248	CLIP-seq
MIRT2618389	hsa-miR-1254	CLIP-seq
MIRT2321959	hsa-miR-28-5p	CLIP-seq
MIRT2618393	hsa-miR-3116	CLIP-seq
MIRT2321960	hsa-miR-3139	CLIP-seq
MIRT2618397	hsa-miR-3148	CLIP-seq
MIRT2618398	hsa-miR-3156-5p	CLIP-seq
MIRT2097695	hsa-miR-3176	CLIP-seq
MIRT2097697	hsa-miR-3922-3p	CLIP-seq
MIRT2618402	hsa-miR-3927	CLIP-seq
MIRT2097698	hsa-miR-4277	CLIP-seq
MIRT2618403	hsa-miR-4290	CLIP-seq
MIRT2618404	hsa-miR-4297	CLIP-seq
MIRT2097699	hsa-miR-4435	CLIP-seq
MIRT2618407	hsa-miR-4451	CLIP-seq
MIRT2618409	hsa-miR-4464	CLIP-seq
MIRT2618415	hsa-miR-4659a-3p	CLIP-seq
MIRT2618416	hsa-miR-4659b-3p	CLIP-seq
MIRT2097700	hsa-miR-4685-5p	CLIP-seq
MIRT2618420	hsa-miR-4748	CLIP-seq
MIRT2618425	hsa-miR-507	CLIP-seq
MIRT2618426	hsa-miR-508-5p	CLIP-seq
MIRT2618427	hsa-miR-548m	CLIP-seq
MIRT2618429	hsa-miR-557	CLIP-seq
MIRT2321968	hsa-miR-708	CLIP-seq
MIRT2618436	hsa-miR-766	CLIP-seq
MIRT2618437	hsa-miR-767-5p	CLIP-seq
MIRT2618438	hsa-miR-875-3p	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0031507	Process	Heterochromatin formation	ISS
GO:0042393	Function	Histone binding	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	NAS	10524249

MIM	HGNC	e!Ensembl
616396	19003	ENSG00000010803

Q96GD3

Protein name

Polycomb protein SCMH1 (Sex comb on midleg homolog 1)

Protein function

Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.

PDB

2P0K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02820	MBT	62 → 130	mbt repeat	Domain
PF02820	MBT	171 → 238	mbt repeat	Domain
PF17208	RBR	271 → 324	RNA binding Region	Family
PF12140	SLED	358 → 466	SLED domain	Domain
PF00536	SAM_1	591 → 656	SAM domain (Sterile alpha motif)	Domain

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney. {ECO:0000269|PubMed:10524249}.

Sequence

MLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKI
SMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNG
GMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKN
PHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVV
IPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKTLISHPISAPSKTA
EPLKFPKKRGPKPGSKRKPRTLLNPPPASPTTSTPEPDTSTVPQDAATIPSSAMQAPTVC
IYLNKNGSTGPHLDKKKVQQLPDHFGPARASVVLQQAVQACIDCAYHQKTVFSFLKQGHG
GEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTAIEY
SHSHDRYLPGETFVLGNSLARSLEPHSDSMDSASNPTNLVSTSQRHRPLLSSCGLPPSTA
SAVRRLCSRGVLKGSNERRDMESFWKLNRSPGSDRYLESRDASRLSGRDPSSWTVEDVMQ
FVREADPQLGPHADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSYHIDRLKQGKF

Sequence length

660

Interactions

View interactions

	KEGG		Reactome
	Polycomb repressive complex		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription

SCMH1 (Scm polycomb group protein homolog 1)