Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
22936
Gene name Gene Name - the full gene name approved by the HGNC.
Elongation factor for RNA polymerase II 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ELL2
Synonyms (NCBI Gene) Gene synonyms aliases
MRCCAT1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q15
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020029 hsa-miR-375 Microarray 20215506
MIRT024649 hsa-miR-215-5p Microarray 19074876
MIRT026909 hsa-miR-192-5p Microarray 19074876
MIRT537708 hsa-miR-548n PAR-CLIP 20371350
MIRT537707 hsa-miR-548az-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21729782, 28514442, 32296183, 32814053
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
GO:0006368 Process Transcription elongation from RNA polymerase II promoter IEA
GO:0008023 Component Transcription elongation factor complex IDA 22195968
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601874 17064 ENSG00000118985
Protein
UniProt ID O00472
Protein name RNA polymerase II elongation factor ELL2
Protein function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component
PDB 2E5N , 5JW9 , 7OKX , 7OKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10390 ELL 11 291 RNA polymerase II elongation factor ELL Family
PF07303 Occludin_ELL 532 633 Occludin homology domain Domain
Sequence
MAAGGTGGLREEQRYGLSCGRLGQDNITVLHVKLTETAIRALETYQSHKNLIPFRPSIQF
QGLHGLVKIPKNDPLNEVHNFNFYLSNVGKDNPQGSFDCIQQTFSSSGASQLNCLGFIQD
KITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAVSDTVPER
KRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNS
LGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKL
NPSQNAAGT
SRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSA
AGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDS
IYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDI
ETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAIELPDYLIKYIAIVSYEQ
RQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKI
KQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQ
QQAESWS
Sequence length 640
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1   RNA polymerase II transcribes snRNA genes
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Multiple myeloma Multiple Myeloma rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962
View all (38 more)
27363682, 28112199, 26007630
Associations from Text Mining
Disease Name Relationship Type References
Galactosemias Associate 31275443
Glioma Associate 30556882
Glomerulonephritis IGA Associate 31275443
Glycogen Storage Disease Type II Associate 28386079
Multiple Myeloma Inhibit 28903037
Multiple Myeloma Associate 28903037, 29695719, 35013207
Neoplasms Associate 29150481
Neoplasms Inhibit 30009504
Prostatic Hyperplasia Associate 19676094
Prostatic Intraepithelial Neoplasia Inhibit 29179998