Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22913
Gene name Gene Name - the full gene name approved by the HGNC.	RALY heterogeneous nuclear ribonucleoprotein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RALY
Synonyms (NCBI Gene) Gene synonyms aliases	HNRPCL2, P542
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q11.22
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq,

Show/Hide all(167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044575	hsa-miR-320a	CLASH	23622248
MIRT666746	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT666747	hsa-miR-654-3p	HITS-CLIP	23824327
MIRT666744	hsa-miR-3183	HITS-CLIP	23824327
MIRT666745	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT666743	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT666742	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT666741	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT666740	hsa-miR-6730-3p	HITS-CLIP	23824327
MIRT666739	hsa-miR-3660	HITS-CLIP	23824327
MIRT666738	hsa-miR-4526	HITS-CLIP	23824327
MIRT666737	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT666736	hsa-miR-4635	HITS-CLIP	23824327
MIRT666735	hsa-miR-4786-3p	HITS-CLIP	23824327
MIRT666734	hsa-miR-4297	HITS-CLIP	23824327
MIRT666733	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT666732	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT666731	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT666730	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT666729	hsa-miR-7843-3p	HITS-CLIP	23824327
MIRT666728	hsa-miR-127-5p	HITS-CLIP	23824327
MIRT497396	hsa-miR-3622a-3p	PAR-CLIP	22291592
MIRT497395	hsa-miR-3622b-3p	PAR-CLIP	22291592
MIRT497394	hsa-miR-6765-3p	PAR-CLIP	22291592
MIRT497393	hsa-miR-412-3p	PAR-CLIP	22291592
MIRT497392	hsa-miR-6754-3p	PAR-CLIP	22291592
MIRT497391	hsa-miR-938	PAR-CLIP	22291592
MIRT497390	hsa-miR-6886-3p	PAR-CLIP	22291592
MIRT497389	hsa-miR-885-3p	PAR-CLIP	22291592
MIRT497388	hsa-miR-486-3p	PAR-CLIP	22291592
MIRT666746	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT666747	hsa-miR-654-3p	HITS-CLIP	23824327
MIRT666744	hsa-miR-3183	HITS-CLIP	23824327
MIRT666745	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT666743	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT666742	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT666741	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT666740	hsa-miR-6730-3p	HITS-CLIP	23824327
MIRT666739	hsa-miR-3660	HITS-CLIP	23824327
MIRT666738	hsa-miR-4526	HITS-CLIP	23824327
MIRT666737	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT666736	hsa-miR-4635	HITS-CLIP	23824327
MIRT666735	hsa-miR-4786-3p	HITS-CLIP	23824327
MIRT666734	hsa-miR-4297	HITS-CLIP	23824327
MIRT666733	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT666732	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT666731	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT666730	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT666729	hsa-miR-7843-3p	HITS-CLIP	23824327
MIRT666728	hsa-miR-127-5p	HITS-CLIP	23824327
MIRT497396	hsa-miR-3622a-3p	PAR-CLIP	22291592
MIRT497395	hsa-miR-3622b-3p	PAR-CLIP	22291592
MIRT497394	hsa-miR-6765-3p	PAR-CLIP	22291592
MIRT497393	hsa-miR-412-3p	PAR-CLIP	22291592
MIRT497392	hsa-miR-6754-3p	PAR-CLIP	22291592
MIRT497391	hsa-miR-938	PAR-CLIP	22291592
MIRT497390	hsa-miR-6886-3p	PAR-CLIP	22291592
MIRT497389	hsa-miR-885-3p	PAR-CLIP	22291592
MIRT497388	hsa-miR-486-3p	PAR-CLIP	22291592
MIRT2085925	hsa-miR-216b	CLIP-seq
MIRT2085926	hsa-miR-339-5p	CLIP-seq
MIRT2085927	hsa-miR-4258	CLIP-seq
MIRT2085928	hsa-miR-4753-3p	CLIP-seq
MIRT2085929	hsa-miR-663b	CLIP-seq
MIRT2311176	hsa-let-7a	CLIP-seq
MIRT2311177	hsa-let-7b	CLIP-seq
MIRT2311178	hsa-let-7c	CLIP-seq
MIRT2311179	hsa-let-7d	CLIP-seq
MIRT2311180	hsa-let-7e	CLIP-seq
MIRT2311181	hsa-let-7f	CLIP-seq
MIRT2311182	hsa-let-7g	CLIP-seq
MIRT2311183	hsa-let-7i	CLIP-seq
MIRT2311184	hsa-miR-122	CLIP-seq
MIRT2311185	hsa-miR-1304	CLIP-seq
MIRT2311186	hsa-miR-1343	CLIP-seq
MIRT2311187	hsa-miR-196a	CLIP-seq
MIRT2311188	hsa-miR-196b	CLIP-seq
MIRT2311189	hsa-miR-3150a-3p	CLIP-seq
MIRT2311190	hsa-miR-3175	CLIP-seq
MIRT2311191	hsa-miR-3192	CLIP-seq
MIRT2085926	hsa-miR-339-5p	CLIP-seq
MIRT2311192	hsa-miR-3675-5p	CLIP-seq
MIRT2085927	hsa-miR-4258	CLIP-seq
MIRT2311193	hsa-miR-4458	CLIP-seq
MIRT2311194	hsa-miR-4500	CLIP-seq
MIRT2311195	hsa-miR-4667-5p	CLIP-seq
MIRT2311196	hsa-miR-4700-5p	CLIP-seq
MIRT2311197	hsa-miR-548ac	CLIP-seq
MIRT2311198	hsa-miR-548d-3p	CLIP-seq
MIRT2311199	hsa-miR-548z	CLIP-seq
MIRT2311200	hsa-miR-661	CLIP-seq
MIRT2085929	hsa-miR-663b	CLIP-seq
MIRT2311201	hsa-miR-939	CLIP-seq
MIRT2311202	hsa-miR-98	CLIP-seq
MIRT2085925	hsa-miR-216b	CLIP-seq
MIRT2393455	hsa-miR-450b-3p	CLIP-seq
MIRT2393456	hsa-miR-4713-3p	CLIP-seq
MIRT2085928	hsa-miR-4753-3p	CLIP-seq
MIRT2393457	hsa-miR-638	CLIP-seq
MIRT2393458	hsa-miR-769-3p	CLIP-seq
MIRT2607516	hsa-miR-1202	CLIP-seq
MIRT2607517	hsa-miR-1238	CLIP-seq
MIRT2607518	hsa-miR-1262	CLIP-seq
MIRT2607519	hsa-miR-1263	CLIP-seq
MIRT2607520	hsa-miR-1275	CLIP-seq
MIRT2311185	hsa-miR-1304	CLIP-seq
MIRT2607521	hsa-miR-296-3p	CLIP-seq
MIRT2607522	hsa-miR-3064-5p	CLIP-seq
MIRT2607523	hsa-miR-3124-3p	CLIP-seq
MIRT2607524	hsa-miR-3194-5p	CLIP-seq
MIRT2607525	hsa-miR-3197	CLIP-seq
MIRT2607526	hsa-miR-3652	CLIP-seq
MIRT2607527	hsa-miR-370	CLIP-seq
MIRT2607528	hsa-miR-3972	CLIP-seq
MIRT2607529	hsa-miR-4430	CLIP-seq
MIRT2607530	hsa-miR-4490	CLIP-seq
MIRT2607531	hsa-miR-4505	CLIP-seq
MIRT2607532	hsa-miR-4525	CLIP-seq
MIRT2607533	hsa-miR-4642	CLIP-seq
MIRT2607534	hsa-miR-4651	CLIP-seq
MIRT2607535	hsa-miR-4665-5p	CLIP-seq
MIRT2607536	hsa-miR-4685-5p	CLIP-seq
MIRT2607537	hsa-miR-4695-5p	CLIP-seq
MIRT2607538	hsa-miR-4701-3p	CLIP-seq
MIRT2607539	hsa-miR-4723-5p	CLIP-seq
MIRT2607540	hsa-miR-4731-5p	CLIP-seq
MIRT2607541	hsa-miR-4774-5p	CLIP-seq
MIRT2607542	hsa-miR-566	CLIP-seq
MIRT2607543	hsa-miR-608	CLIP-seq
MIRT2607544	hsa-miR-625	CLIP-seq
MIRT2607545	hsa-miR-637	CLIP-seq
MIRT2311200	hsa-miR-661	CLIP-seq
MIRT2607546	hsa-miR-765	CLIP-seq
MIRT2607547	hsa-miR-892b	CLIP-seq
MIRT2607516	hsa-miR-1202	CLIP-seq
MIRT2607517	hsa-miR-1238	CLIP-seq
MIRT2607518	hsa-miR-1262	CLIP-seq
MIRT2607519	hsa-miR-1263	CLIP-seq
MIRT2607520	hsa-miR-1275	CLIP-seq
MIRT2311185	hsa-miR-1304	CLIP-seq
MIRT2607521	hsa-miR-296-3p	CLIP-seq
MIRT2607522	hsa-miR-3064-5p	CLIP-seq
MIRT2607523	hsa-miR-3124-3p	CLIP-seq
MIRT2607524	hsa-miR-3194-5p	CLIP-seq
MIRT2607525	hsa-miR-3197	CLIP-seq
MIRT2607526	hsa-miR-3652	CLIP-seq
MIRT2607527	hsa-miR-370	CLIP-seq
MIRT2607528	hsa-miR-3972	CLIP-seq
MIRT2607529	hsa-miR-4430	CLIP-seq
MIRT2607530	hsa-miR-4490	CLIP-seq
MIRT2607531	hsa-miR-4505	CLIP-seq
MIRT2607532	hsa-miR-4525	CLIP-seq
MIRT2607533	hsa-miR-4642	CLIP-seq
MIRT2607534	hsa-miR-4651	CLIP-seq
MIRT2607535	hsa-miR-4665-5p	CLIP-seq
MIRT2607536	hsa-miR-4685-5p	CLIP-seq
MIRT2607537	hsa-miR-4695-5p	CLIP-seq
MIRT2607538	hsa-miR-4701-3p	CLIP-seq
MIRT2607539	hsa-miR-4723-5p	CLIP-seq
MIRT2607540	hsa-miR-4731-5p	CLIP-seq
MIRT2607541	hsa-miR-4774-5p	CLIP-seq
MIRT2607542	hsa-miR-566	CLIP-seq
MIRT2607543	hsa-miR-608	CLIP-seq
MIRT2607544	hsa-miR-625	CLIP-seq
MIRT2607545	hsa-miR-637	CLIP-seq
MIRT2607546	hsa-miR-765	CLIP-seq
MIRT2607547	hsa-miR-892b	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003712	Function	Transcription coregulator activity	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	9376072
GO:0005515	Function	Protein binding	IPI	22365833, 22720776, 30021884, 30354839, 33961781, 35271311, 37207277, 39251607
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	22720776
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9376072
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0042632	Process	Cholesterol homeostasis	IEA
GO:0042632	Process	Cholesterol homeostasis	ISS
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
614663	15921	ENSG00000125970

Protein

UniProt ID

Q9UKM9

Protein name

RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)

Protein function

RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a

PDB

1WF1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	23 → 86	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta. {ECO:0000269|PubMed:10500250}.

Sequence

MSLKLQASNVTNKNDPKSINSRVFIGNLNTALVKKSDVETIFSKYGRVAGCSVHKGYAFV
QYSNERHARAAVLGENGRVLAGQTLDINMAGEPKPDRPKGLKRAASAIYSGYIFDYDYYR
DDFYDRLFDYRGRLSPVPVPRAVPVKRPRVTVPLVRRVKTNVPVKLFARSTAVTTSSAKI
KLKSSELQAIKTELTQIKSNIDALLSRLEQIAAEQKANPDGKKKGDGGGAGGGGGGGGSG
GGGSGGGGGGGSSRPPAPQENTTSEAGLPQGEARTRDDGDEEGLLTHSEEELEHSQDTDA
DDGALQ

Sequence length

306

Interactions

View interactions

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Actinic keratosis	Actinic keratosis	N/A	N/A	GWAS
Breast cancer	Breast cancer	N/A	N/A	GWAS
Carcinoma	Squamous cell carcinoma, Basal cell carcinoma	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Melanoma	Melanoma	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Vitiligo	Vitiligo	N/A	N/A	GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Autoimmune Diseases	Associate	7533789
Barrett Esophagus	Associate	33491460
Carcinogenesis	Stimulate	36952348
Colitis Ulcerative	Associate	7533789
Colonic Neoplasms	Associate	22118625
Colorectal Neoplasms	Associate	22118625
Infectious Mononucleosis	Associate	7533789
Inflammation	Associate	35941292
Lung Neoplasms	Stimulate	36952348
Lupus Erythematosus Systemic	Associate	7533789
Metrorrhagia	Associate	25705849
Nasopharyngeal Carcinoma	Associate	16308470
Neoplasms	Associate	35941292
Neoplasms	Inhibit	36952348
Osteoporosis	Associate	34743649
Primary Immunodeficiency Diseases	Associate	35941292
Scleroderma Systemic	Associate	7533789
Skin Neoplasms	Associate	25705849
Triple Negative Breast Neoplasms	Associate	24325915

RALY (RALY heterogeneous nuclear ribonucleoprotein)