RUFY3 (RUN and FYVE domain containing 3)

Gene

• Entrez ID: 22902
• Gene name: RUN and FYVE domain containing 3
• Gene symbol: RUFY3
• Synonyms (NCBI Gene): RIPX, SINGAR1, ZFYVE30
• Chromosome: 4
• Chromosome location: 4q13.3
• Summary: This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022964	hsa-miR-124-3p	Microarray	18668037
MIRT024652	hsa-miR-215-5p	Microarray	19074876
MIRT026779	hsa-miR-192-5p	Microarray	19074876
MIRT030979	hsa-miR-21-5p	Microarray	18591254
MIRT041031	hsa-miR-505-3p	CLASH	23622248
MIRT1322489	hsa-miR-125a-5p	CLIP-seq
MIRT1322490	hsa-miR-125b	CLIP-seq
MIRT1322491	hsa-miR-1273e	CLIP-seq
MIRT1322492	hsa-miR-1304	CLIP-seq
MIRT1322493	hsa-miR-145	CLIP-seq
MIRT1322494	hsa-miR-1538	CLIP-seq
MIRT1322495	hsa-miR-18a	CLIP-seq
MIRT1322496	hsa-miR-18b	CLIP-seq
MIRT1322497	hsa-miR-24	CLIP-seq
MIRT1322498	hsa-miR-3180-5p	CLIP-seq
MIRT1322499	hsa-miR-3187-3p	CLIP-seq
MIRT1322500	hsa-miR-3662	CLIP-seq
MIRT1322501	hsa-miR-3690	CLIP-seq
MIRT1322502	hsa-miR-3934	CLIP-seq
MIRT1322503	hsa-miR-3940-5p	CLIP-seq
MIRT1322504	hsa-miR-4282	CLIP-seq
MIRT1322505	hsa-miR-4284	CLIP-seq
MIRT1322506	hsa-miR-4287	CLIP-seq
MIRT1322507	hsa-miR-4292	CLIP-seq
MIRT1322508	hsa-miR-4308	CLIP-seq
MIRT1322509	hsa-miR-4319	CLIP-seq
MIRT1322510	hsa-miR-4324	CLIP-seq
MIRT1322511	hsa-miR-4435	CLIP-seq
MIRT1322512	hsa-miR-4446-5p	CLIP-seq
MIRT1322513	hsa-miR-4469	CLIP-seq
MIRT1322514	hsa-miR-4507	CLIP-seq
MIRT1322515	hsa-miR-4685-3p	CLIP-seq
MIRT1322516	hsa-miR-4699-5p	CLIP-seq
MIRT1322517	hsa-miR-4701-5p	CLIP-seq
MIRT1322518	hsa-miR-4712-5p	CLIP-seq
MIRT1322519	hsa-miR-4713-5p	CLIP-seq
MIRT1322520	hsa-miR-4732-3p	CLIP-seq
MIRT1322521	hsa-miR-4735-3p	CLIP-seq
MIRT1322522	hsa-miR-4745-3p	CLIP-seq
MIRT1322523	hsa-miR-4747-3p	CLIP-seq
MIRT1322524	hsa-miR-4747-5p	CLIP-seq
MIRT1322525	hsa-miR-4755-5p	CLIP-seq
MIRT1322526	hsa-miR-4775	CLIP-seq
MIRT1322527	hsa-miR-513a-3p	CLIP-seq
MIRT1322528	hsa-miR-548p	CLIP-seq
MIRT1322529	hsa-miR-548s	CLIP-seq
MIRT1322530	hsa-miR-570	CLIP-seq
MIRT1322531	hsa-miR-588	CLIP-seq
MIRT1322532	hsa-miR-670	CLIP-seq
MIRT1322533	hsa-miR-770-5p	CLIP-seq
MIRT1322534	hsa-miR-4484	CLIP-seq
MIRT1322535	hsa-miR-548an	CLIP-seq
MIRT1322536	hsa-miR-1278	CLIP-seq
MIRT1322537	hsa-miR-139-5p	CLIP-seq
MIRT1322538	hsa-miR-3123	CLIP-seq
MIRT1322539	hsa-miR-3154	CLIP-seq
MIRT1322540	hsa-miR-325	CLIP-seq
MIRT1322541	hsa-miR-3925-5p	CLIP-seq
MIRT1322542	hsa-miR-3976	CLIP-seq
MIRT1322543	hsa-miR-4307	CLIP-seq
MIRT1322544	hsa-miR-582-5p	CLIP-seq
MIRT1322545	hsa-miR-628-3p	CLIP-seq
MIRT1322489	hsa-miR-125a-5p	CLIP-seq
MIRT1322490	hsa-miR-125b	CLIP-seq
MIRT1553203	hsa-miR-128	CLIP-seq
MIRT1553204	hsa-miR-27a	CLIP-seq
MIRT1553205	hsa-miR-27b	CLIP-seq
MIRT1322503	hsa-miR-3940-5p	CLIP-seq
MIRT1322509	hsa-miR-4319	CLIP-seq
MIRT1322510	hsa-miR-4324	CLIP-seq
MIRT1322512	hsa-miR-4446-5p	CLIP-seq
MIRT1322514	hsa-miR-4507	CLIP-seq
MIRT1322520	hsa-miR-4732-3p	CLIP-seq
MIRT1322525	hsa-miR-4755-5p	CLIP-seq
MIRT1553206	hsa-miR-513a-5p	CLIP-seq
MIRT1322532	hsa-miR-670	CLIP-seq
MIRT2320136	hsa-miR-1248	CLIP-seq
MIRT1322489	hsa-miR-125a-5p	CLIP-seq
MIRT1322490	hsa-miR-125b	CLIP-seq
MIRT1322495	hsa-miR-18a	CLIP-seq
MIRT1322496	hsa-miR-18b	CLIP-seq
MIRT2320137	hsa-miR-3689a-3p	CLIP-seq
MIRT2320138	hsa-miR-3689c	CLIP-seq
MIRT1322503	hsa-miR-3940-5p	CLIP-seq
MIRT2320139	hsa-miR-3975	CLIP-seq
MIRT1322509	hsa-miR-4319	CLIP-seq
MIRT1322510	hsa-miR-4324	CLIP-seq
MIRT2320140	hsa-miR-4428	CLIP-seq
MIRT1322512	hsa-miR-4446-5p	CLIP-seq
MIRT1322514	hsa-miR-4507	CLIP-seq
MIRT2320141	hsa-miR-4676-5p	CLIP-seq
MIRT2320142	hsa-miR-4724-3p	CLIP-seq
MIRT2320143	hsa-miR-4728-5p	CLIP-seq
MIRT1322520	hsa-miR-4732-3p	CLIP-seq
MIRT1322521	hsa-miR-4735-3p	CLIP-seq
MIRT1322524	hsa-miR-4747-5p	CLIP-seq
MIRT1322525	hsa-miR-4755-5p	CLIP-seq
MIRT2320144	hsa-miR-4786-5p	CLIP-seq
MIRT2320145	hsa-miR-485-3p	CLIP-seq
MIRT2320146	hsa-miR-487a	CLIP-seq
MIRT2320147	hsa-miR-575	CLIP-seq
MIRT2320148	hsa-miR-664	CLIP-seq
MIRT1322532	hsa-miR-670	CLIP-seq
MIRT2320149	hsa-miR-769-5p	CLIP-seq
MIRT2320150	hsa-miR-890	CLIP-seq
MIRT1322534	hsa-miR-4484	CLIP-seq
MIRT2393953	hsa-miR-489	CLIP-seq
MIRT1322535	hsa-miR-548an	CLIP-seq
MIRT2320140	hsa-miR-4428	CLIP-seq
MIRT2458696	hsa-miR-4436b-3p	CLIP-seq
MIRT2458697	hsa-miR-4533	CLIP-seq
MIRT2458698	hsa-miR-4766-5p	CLIP-seq
MIRT2320140	hsa-miR-4428	CLIP-seq
MIRT2458696	hsa-miR-4436b-3p	CLIP-seq
MIRT2458697	hsa-miR-4533	CLIP-seq
MIRT2458698	hsa-miR-4766-5p	CLIP-seq
MIRT2615958	hsa-miR-105	CLIP-seq
MIRT2615959	hsa-miR-1245b-3p	CLIP-seq
MIRT2615960	hsa-miR-1265	CLIP-seq
MIRT2615961	hsa-miR-1273d	CLIP-seq
MIRT2615962	hsa-miR-1307	CLIP-seq
MIRT2615963	hsa-miR-1323	CLIP-seq
MIRT2615964	hsa-miR-154	CLIP-seq
MIRT2615965	hsa-miR-2117	CLIP-seq
MIRT2615966	hsa-miR-216a	CLIP-seq
MIRT2615967	hsa-miR-216b	CLIP-seq
MIRT2615968	hsa-miR-2276	CLIP-seq
MIRT2615969	hsa-miR-2277-3p	CLIP-seq
MIRT1322497	hsa-miR-24	CLIP-seq
MIRT2615970	hsa-miR-297	CLIP-seq
MIRT2615971	hsa-miR-3157-5p	CLIP-seq
MIRT2615972	hsa-miR-3171	CLIP-seq
MIRT1322499	hsa-miR-3187-3p	CLIP-seq
MIRT2615973	hsa-miR-3190	CLIP-seq
MIRT2615974	hsa-miR-331-5p	CLIP-seq
MIRT2615975	hsa-miR-3591-3p	CLIP-seq
MIRT2615976	hsa-miR-3605-5p	CLIP-seq
MIRT2615977	hsa-miR-3613-3p	CLIP-seq
MIRT2615978	hsa-miR-3616-5p	CLIP-seq
MIRT2615979	hsa-miR-3646	CLIP-seq
MIRT2615980	hsa-miR-3647-5p	CLIP-seq
MIRT2615981	hsa-miR-3668	CLIP-seq
MIRT2615982	hsa-miR-3692	CLIP-seq
MIRT1322502	hsa-miR-3934	CLIP-seq
MIRT2615983	hsa-miR-3942-3p	CLIP-seq
MIRT2615984	hsa-miR-410	CLIP-seq
MIRT2615985	hsa-miR-4272	CLIP-seq
MIRT2615986	hsa-miR-4273	CLIP-seq
MIRT1322505	hsa-miR-4284	CLIP-seq
MIRT2615987	hsa-miR-4310	CLIP-seq
MIRT2615988	hsa-miR-4318	CLIP-seq
MIRT1322511	hsa-miR-4435	CLIP-seq
MIRT2615989	hsa-miR-4452	CLIP-seq
MIRT2615990	hsa-miR-4459	CLIP-seq
MIRT2615991	hsa-miR-4638-5p	CLIP-seq
MIRT2615992	hsa-miR-4672	CLIP-seq
MIRT2615993	hsa-miR-4678	CLIP-seq
MIRT2615994	hsa-miR-4684-5p	CLIP-seq
MIRT2615995	hsa-miR-4691-3p	CLIP-seq
MIRT2615996	hsa-miR-4695-3p	CLIP-seq
MIRT1322517	hsa-miR-4701-5p	CLIP-seq
MIRT2615997	hsa-miR-4761-5p	CLIP-seq
MIRT2615998	hsa-miR-4772-3p	CLIP-seq
MIRT2615999	hsa-miR-4780	CLIP-seq
MIRT2616000	hsa-miR-4781-3p	CLIP-seq
MIRT2616001	hsa-miR-4795-5p	CLIP-seq
MIRT2616002	hsa-miR-4797-5p	CLIP-seq
MIRT2616003	hsa-miR-548a-5p	CLIP-seq
MIRT2616004	hsa-miR-548ab	CLIP-seq
MIRT2616005	hsa-miR-548ak	CLIP-seq
MIRT2616006	hsa-miR-548b-5p	CLIP-seq
MIRT2616007	hsa-miR-548c-5p	CLIP-seq
MIRT2616008	hsa-miR-548d-5p	CLIP-seq
MIRT2616009	hsa-miR-548h	CLIP-seq
MIRT2616010	hsa-miR-548i	CLIP-seq
MIRT2616011	hsa-miR-548j	CLIP-seq
MIRT2616012	hsa-miR-548k	CLIP-seq
MIRT2616013	hsa-miR-548l	CLIP-seq
MIRT2616014	hsa-miR-548o	CLIP-seq
MIRT1322528	hsa-miR-548p	CLIP-seq
MIRT1322529	hsa-miR-548s	CLIP-seq
MIRT2616015	hsa-miR-548w	CLIP-seq
MIRT2616016	hsa-miR-548y	CLIP-seq
MIRT2616017	hsa-miR-559	CLIP-seq
MIRT2616018	hsa-miR-567	CLIP-seq
MIRT2616019	hsa-miR-573	CLIP-seq
MIRT1322531	hsa-miR-588	CLIP-seq
MIRT2616020	hsa-miR-596	CLIP-seq
MIRT2616021	hsa-miR-610	CLIP-seq
MIRT2616022	hsa-miR-615-3p	CLIP-seq
MIRT2616023	hsa-miR-616	CLIP-seq
MIRT2616024	hsa-miR-653	CLIP-seq
MIRT2616025	hsa-miR-660	CLIP-seq
MIRT2615959	hsa-miR-1245b-3p	CLIP-seq
MIRT2615960	hsa-miR-1265	CLIP-seq
MIRT2615961	hsa-miR-1273d	CLIP-seq
MIRT2615962	hsa-miR-1307	CLIP-seq
MIRT2615963	hsa-miR-1323	CLIP-seq
MIRT2615964	hsa-miR-154	CLIP-seq
MIRT2615965	hsa-miR-2117	CLIP-seq
MIRT2615966	hsa-miR-216a	CLIP-seq
MIRT2615967	hsa-miR-216b	CLIP-seq
MIRT2615969	hsa-miR-2277-3p	CLIP-seq
MIRT1322497	hsa-miR-24	CLIP-seq
MIRT2615970	hsa-miR-297	CLIP-seq
MIRT2615971	hsa-miR-3157-5p	CLIP-seq
MIRT2615972	hsa-miR-3171	CLIP-seq
MIRT1322499	hsa-miR-3187-3p	CLIP-seq
MIRT2615973	hsa-miR-3190	CLIP-seq
MIRT2615974	hsa-miR-331-5p	CLIP-seq
MIRT2615975	hsa-miR-3591-3p	CLIP-seq
MIRT2615976	hsa-miR-3605-5p	CLIP-seq
MIRT2615977	hsa-miR-3613-3p	CLIP-seq
MIRT2615978	hsa-miR-3616-5p	CLIP-seq
MIRT2615979	hsa-miR-3646	CLIP-seq
MIRT2615980	hsa-miR-3647-5p	CLIP-seq
MIRT2615981	hsa-miR-3668	CLIP-seq
MIRT2615982	hsa-miR-3692	CLIP-seq
MIRT1322502	hsa-miR-3934	CLIP-seq
MIRT2615983	hsa-miR-3942-3p	CLIP-seq
MIRT2615984	hsa-miR-410	CLIP-seq
MIRT2615985	hsa-miR-4272	CLIP-seq
MIRT2615986	hsa-miR-4273	CLIP-seq
MIRT1322505	hsa-miR-4284	CLIP-seq
MIRT2615987	hsa-miR-4310	CLIP-seq
MIRT2615988	hsa-miR-4318	CLIP-seq
MIRT1322511	hsa-miR-4435	CLIP-seq
MIRT2615990	hsa-miR-4459	CLIP-seq
MIRT2615991	hsa-miR-4638-5p	CLIP-seq
MIRT2615992	hsa-miR-4672	CLIP-seq
MIRT2615993	hsa-miR-4678	CLIP-seq
MIRT2615995	hsa-miR-4691-3p	CLIP-seq
MIRT2615996	hsa-miR-4695-3p	CLIP-seq
MIRT1322517	hsa-miR-4701-5p	CLIP-seq
MIRT2615997	hsa-miR-4761-5p	CLIP-seq
MIRT2615999	hsa-miR-4780	CLIP-seq
MIRT2616000	hsa-miR-4781-3p	CLIP-seq
MIRT2616001	hsa-miR-4795-5p	CLIP-seq
MIRT2616002	hsa-miR-4797-5p	CLIP-seq
MIRT2616003	hsa-miR-548a-5p	CLIP-seq
MIRT2616004	hsa-miR-548ab	CLIP-seq
MIRT2616005	hsa-miR-548ak	CLIP-seq
MIRT2616006	hsa-miR-548b-5p	CLIP-seq
MIRT2616007	hsa-miR-548c-5p	CLIP-seq
MIRT2616008	hsa-miR-548d-5p	CLIP-seq
MIRT2616009	hsa-miR-548h	CLIP-seq
MIRT2616010	hsa-miR-548i	CLIP-seq
MIRT2616011	hsa-miR-548j	CLIP-seq
MIRT2616012	hsa-miR-548k	CLIP-seq
MIRT2616013	hsa-miR-548l	CLIP-seq
MIRT2616014	hsa-miR-548o	CLIP-seq
MIRT1322528	hsa-miR-548p	CLIP-seq
MIRT1322529	hsa-miR-548s	CLIP-seq
MIRT2616015	hsa-miR-548w	CLIP-seq
MIRT2616016	hsa-miR-548y	CLIP-seq
MIRT2616017	hsa-miR-559	CLIP-seq
MIRT2616018	hsa-miR-567	CLIP-seq
MIRT2616019	hsa-miR-573	CLIP-seq
MIRT1322531	hsa-miR-588	CLIP-seq
MIRT2616020	hsa-miR-596	CLIP-seq
MIRT2616021	hsa-miR-610	CLIP-seq
MIRT2616022	hsa-miR-615-3p	CLIP-seq
MIRT2616023	hsa-miR-616	CLIP-seq
MIRT2616024	hsa-miR-653	CLIP-seq
MIRT2616025	hsa-miR-660	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25766321, 32296183, 35314674
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	25766321
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007015	Process	Actin filament organization	ISS
GO:0007399	Process	Nervous system development	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0030175	Component	Filopodium	IEA
GO:0030175	Component	Filopodium	ISS
GO:0030335	Process	Positive regulation of cell migration	IDA	25766321
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	ISS
GO:0030426	Component	Growth cone	IEA
GO:0030426	Component	Growth cone	ISS
GO:0034452	Function	Dynactin binding	IDA	35314674
GO:0036019	Component	Endolysosome	IDA	35314674
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043204	Component	Perikaryon	IEA
GO:0043204	Component	Perikaryon	ISS
GO:0045773	Process	Positive regulation of axon extension	ISS
GO:0050770	Process	Regulation of axonogenesis	IBA
GO:0050771	Process	Negative regulation of axonogenesis	ISS
GO:0070161	Component	Anchoring junction	IEA
GO:0090316	Process	Positive regulation of intracellular protein transport	ISS
GO:2000114	Process	Regulation of establishment of cell polarity	ISS
GO:2001019	Process	Positive regulation of retrograde axon cargo transport	IDA	35314674

Other IDs

• MIM: 611194
• HGNC: 30285
• e!Ensembl: ENSG00000018189

Protein

• UniProt ID: Q7L099
• Protein name: Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)
• Protein function: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in t
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02759	RUN	103 → 226	RUN domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321). {ECO:0000269|PubMed:25766321}.
• Sequence:

  MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED
  PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
  TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
  KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
  YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
  VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
  KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
  QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH

• Sequence length: 469