Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22900
Gene name Gene Name - the full gene name approved by the HGNC.	Caspase recruitment domain family member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CARD8
Synonyms (NCBI Gene) Gene synonyms aliases	CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the infl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000825	hsa-miR-15a-5p	Microarray	18362358
MIRT000824	hsa-miR-16-5p	Microarray	18362358
MIRT019890	hsa-miR-375	Microarray	20215506
MIRT053405	hsa-miR-629-5p	Microarray	23807165
MIRT683581	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT683580	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT683579	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT683578	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT683577	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT683576	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT683575	hsa-miR-4698	HITS-CLIP	23313552
MIRT235391	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT683574	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT683573	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT683572	hsa-miR-8073	HITS-CLIP	23313552
MIRT683571	hsa-miR-4421	HITS-CLIP	23313552
MIRT683570	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT683569	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT683568	hsa-miR-3926	HITS-CLIP	23313552
MIRT683567	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT683566	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT683565	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT683564	hsa-miR-548s	HITS-CLIP	23313552
MIRT683563	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT690178	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT690177	hsa-miR-4493	HITS-CLIP	23313552
MIRT690176	hsa-miR-6087	HITS-CLIP	23313552
MIRT690175	hsa-miR-3656	HITS-CLIP	23313552
MIRT690174	hsa-miR-4533	HITS-CLIP	23313552
MIRT690173	hsa-miR-3202	HITS-CLIP	23313552
MIRT690172	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT690171	hsa-miR-6745	HITS-CLIP	23313552
MIRT690170	hsa-miR-3165	HITS-CLIP	23313552
MIRT690169	hsa-miR-7977	HITS-CLIP	23313552
MIRT690168	hsa-miR-6079	HITS-CLIP	23313552
MIRT683581	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT683580	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT683579	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT683578	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT683577	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT683576	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT683575	hsa-miR-4698	HITS-CLIP	23313552
MIRT683574	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT683573	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT683572	hsa-miR-8073	HITS-CLIP	23313552
MIRT683571	hsa-miR-4421	HITS-CLIP	23313552
MIRT683570	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT683569	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT683568	hsa-miR-3926	HITS-CLIP	23313552
MIRT683567	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT683566	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT683565	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT683564	hsa-miR-548s	HITS-CLIP	23313552
MIRT683563	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT452290	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT452289	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT452288	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT452286	hsa-miR-4257	PAR-CLIP	23592263
MIRT452287	hsa-miR-4459	PAR-CLIP	23592263
MIRT452285	hsa-miR-665	PAR-CLIP	23592263
MIRT452284	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT452283	hsa-miR-558	PAR-CLIP	23592263
MIRT452281	hsa-miR-4487	PAR-CLIP	23592263
MIRT452282	hsa-miR-1827	PAR-CLIP	23592263
MIRT452280	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT452278	hsa-miR-6086	PAR-CLIP	23592263
MIRT452279	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT452277	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT452276	hsa-miR-3612	PAR-CLIP	23592263
MIRT452275	hsa-miR-650	PAR-CLIP	23592263
MIRT452274	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT452273	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT452272	hsa-miR-4724-5p	PAR-CLIP	23592263
MIRT683577	hsa-miR-10a-5p	PAR-CLIP	27292025
MIRT683576	hsa-miR-10b-5p	PAR-CLIP	27292025
MIRT683574	hsa-miR-339-5p	PAR-CLIP	27292025
MIRT683581	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT683580	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT683579	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT683578	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT683577	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT683576	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT683575	hsa-miR-4698	HITS-CLIP	23313552
MIRT235391	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT683574	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT683573	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT683572	hsa-miR-8073	HITS-CLIP	23313552
MIRT683571	hsa-miR-4421	HITS-CLIP	23313552
MIRT683570	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT683569	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT683568	hsa-miR-3926	HITS-CLIP	23313552
MIRT683567	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT683566	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT683565	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT683564	hsa-miR-548s	HITS-CLIP	23313552
MIRT683563	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT690178	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT690177	hsa-miR-4493	HITS-CLIP	23313552
MIRT690176	hsa-miR-6087	HITS-CLIP	23313552
MIRT690175	hsa-miR-3656	HITS-CLIP	23313552
MIRT690174	hsa-miR-4533	HITS-CLIP	23313552
MIRT690173	hsa-miR-3202	HITS-CLIP	23313552
MIRT690172	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT690171	hsa-miR-6745	HITS-CLIP	23313552
MIRT690170	hsa-miR-3165	HITS-CLIP	23313552
MIRT690169	hsa-miR-7977	HITS-CLIP	23313552
MIRT690168	hsa-miR-6079	HITS-CLIP	23313552
MIRT683581	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT683580	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT683579	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT683578	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT683577	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT683576	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT683575	hsa-miR-4698	HITS-CLIP	23313552
MIRT683574	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT683573	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT683572	hsa-miR-8073	HITS-CLIP	23313552
MIRT683571	hsa-miR-4421	HITS-CLIP	23313552
MIRT683570	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT683569	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT683568	hsa-miR-3926	HITS-CLIP	23313552
MIRT683567	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT683566	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT683565	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT683564	hsa-miR-548s	HITS-CLIP	23313552
MIRT683563	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT452290	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT452289	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT452288	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT452286	hsa-miR-4257	PAR-CLIP	23592263
MIRT452287	hsa-miR-4459	PAR-CLIP	23592263
MIRT452285	hsa-miR-665	PAR-CLIP	23592263
MIRT452284	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT452283	hsa-miR-558	PAR-CLIP	23592263
MIRT452281	hsa-miR-4487	PAR-CLIP	23592263
MIRT452282	hsa-miR-1827	PAR-CLIP	23592263
MIRT452280	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT452278	hsa-miR-6086	PAR-CLIP	23592263
MIRT452279	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT452277	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT452276	hsa-miR-3612	PAR-CLIP	23592263
MIRT452275	hsa-miR-650	PAR-CLIP	23592263
MIRT452274	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT452273	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT452272	hsa-miR-4724-5p	PAR-CLIP	23592263
MIRT862801	hsa-miR-1185	CLIP-seq
MIRT862802	hsa-miR-145	CLIP-seq
MIRT862803	hsa-miR-203	CLIP-seq
MIRT862804	hsa-miR-3143	CLIP-seq
MIRT862805	hsa-miR-323-3p	CLIP-seq
MIRT862806	hsa-miR-3605-5p	CLIP-seq
MIRT862807	hsa-miR-3679-5p	CLIP-seq
MIRT862808	hsa-miR-3692	CLIP-seq
MIRT862809	hsa-miR-4803	CLIP-seq
MIRT862810	hsa-miR-543	CLIP-seq
MIRT862811	hsa-miR-605	CLIP-seq
MIRT862801	hsa-miR-1185	CLIP-seq
MIRT862812	hsa-miR-1237	CLIP-seq
MIRT862813	hsa-miR-1245b-5p	CLIP-seq
MIRT862814	hsa-miR-1285	CLIP-seq
MIRT862815	hsa-miR-1293	CLIP-seq
MIRT862816	hsa-miR-1304	CLIP-seq
MIRT862817	hsa-miR-1343	CLIP-seq
MIRT862818	hsa-miR-141	CLIP-seq
MIRT862802	hsa-miR-145	CLIP-seq
MIRT862819	hsa-miR-193a-5p	CLIP-seq
MIRT862820	hsa-miR-200a	CLIP-seq
MIRT862803	hsa-miR-203	CLIP-seq
MIRT862821	hsa-miR-3122	CLIP-seq
MIRT862822	hsa-miR-3142	CLIP-seq
MIRT862823	hsa-miR-3187-5p	CLIP-seq
MIRT862824	hsa-miR-3200-5p	CLIP-seq
MIRT862805	hsa-miR-323-3p	CLIP-seq
MIRT862806	hsa-miR-3605-5p	CLIP-seq
MIRT862825	hsa-miR-3614-5p	CLIP-seq
MIRT862826	hsa-miR-361-5p	CLIP-seq
MIRT862827	hsa-miR-3660	CLIP-seq
MIRT862828	hsa-miR-3664-3p	CLIP-seq
MIRT862829	hsa-miR-3664-5p	CLIP-seq
MIRT862807	hsa-miR-3679-5p	CLIP-seq
MIRT862830	hsa-miR-3689a-3p	CLIP-seq
MIRT862831	hsa-miR-3689a-5p	CLIP-seq
MIRT862832	hsa-miR-3689b	CLIP-seq
MIRT862833	hsa-miR-3689c	CLIP-seq
MIRT862834	hsa-miR-3689e	CLIP-seq
MIRT862835	hsa-miR-3689f	CLIP-seq
MIRT862836	hsa-miR-378g	CLIP-seq
MIRT862837	hsa-miR-3913-5p	CLIP-seq
MIRT862838	hsa-miR-3929	CLIP-seq
MIRT862839	hsa-miR-3945	CLIP-seq
MIRT862840	hsa-miR-4253	CLIP-seq
MIRT862841	hsa-miR-4311	CLIP-seq
MIRT862842	hsa-miR-4314	CLIP-seq
MIRT862843	hsa-miR-4419b	CLIP-seq
MIRT862844	hsa-miR-4427	CLIP-seq
MIRT862845	hsa-miR-4433	CLIP-seq
MIRT862846	hsa-miR-4436b-5p	CLIP-seq
MIRT862847	hsa-miR-4443	CLIP-seq
MIRT862848	hsa-miR-4478	CLIP-seq
MIRT862849	hsa-miR-4483	CLIP-seq
MIRT862850	hsa-miR-4486	CLIP-seq
MIRT862851	hsa-miR-4506	CLIP-seq
MIRT862852	hsa-miR-4526	CLIP-seq
MIRT862853	hsa-miR-4540	CLIP-seq
MIRT862854	hsa-miR-4714-5p	CLIP-seq
MIRT862855	hsa-miR-4728-5p	CLIP-seq
MIRT862856	hsa-miR-4768-3p	CLIP-seq
MIRT862857	hsa-miR-4793-3p	CLIP-seq
MIRT862809	hsa-miR-4803	CLIP-seq
MIRT862858	hsa-miR-485-5p	CLIP-seq
MIRT862859	hsa-miR-508-5p	CLIP-seq
MIRT862860	hsa-miR-510	CLIP-seq
MIRT862861	hsa-miR-512-5p	CLIP-seq
MIRT862862	hsa-miR-516b	CLIP-seq
MIRT862863	hsa-miR-548u	CLIP-seq
MIRT862811	hsa-miR-605	CLIP-seq
MIRT862864	hsa-miR-612	CLIP-seq
MIRT862865	hsa-miR-766	CLIP-seq
MIRT862801	hsa-miR-1185	CLIP-seq
MIRT862866	hsa-miR-122	CLIP-seq
MIRT862867	hsa-miR-1228	CLIP-seq
MIRT862868	hsa-miR-1253	CLIP-seq
MIRT862815	hsa-miR-1293	CLIP-seq
MIRT862816	hsa-miR-1304	CLIP-seq
MIRT862869	hsa-miR-150	CLIP-seq
MIRT862803	hsa-miR-203	CLIP-seq
MIRT862870	hsa-miR-208a	CLIP-seq
MIRT862871	hsa-miR-208b	CLIP-seq
MIRT862872	hsa-miR-27a	CLIP-seq
MIRT862873	hsa-miR-27b	CLIP-seq
MIRT862874	hsa-miR-2964a-5p	CLIP-seq
MIRT862875	hsa-miR-3064-5p	CLIP-seq
MIRT862821	hsa-miR-3122	CLIP-seq
MIRT862876	hsa-miR-3125	CLIP-seq
MIRT862877	hsa-miR-3136-5p	CLIP-seq
MIRT862804	hsa-miR-3143	CLIP-seq
MIRT862824	hsa-miR-3200-5p	CLIP-seq
MIRT862805	hsa-miR-323-3p	CLIP-seq
MIRT862878	hsa-miR-33a	CLIP-seq
MIRT862879	hsa-miR-33b	CLIP-seq
MIRT862806	hsa-miR-3605-5p	CLIP-seq
MIRT862825	hsa-miR-3614-5p	CLIP-seq
MIRT862827	hsa-miR-3660	CLIP-seq
MIRT862880	hsa-miR-3667-5p	CLIP-seq
MIRT862807	hsa-miR-3679-5p	CLIP-seq
MIRT862830	hsa-miR-3689a-3p	CLIP-seq
MIRT862833	hsa-miR-3689c	CLIP-seq
MIRT862881	hsa-miR-3909	CLIP-seq
MIRT862837	hsa-miR-3913-5p	CLIP-seq
MIRT862882	hsa-miR-3916	CLIP-seq
MIRT862838	hsa-miR-3929	CLIP-seq
MIRT862883	hsa-miR-3940-3p	CLIP-seq
MIRT862884	hsa-miR-4277	CLIP-seq
MIRT862843	hsa-miR-4419b	CLIP-seq
MIRT862885	hsa-miR-4439	CLIP-seq
MIRT862886	hsa-miR-4477a	CLIP-seq
MIRT862848	hsa-miR-4478	CLIP-seq
MIRT862849	hsa-miR-4483	CLIP-seq
MIRT862887	hsa-miR-4496	CLIP-seq
MIRT862888	hsa-miR-4513	CLIP-seq
MIRT862852	hsa-miR-4526	CLIP-seq
MIRT862889	hsa-miR-4662a-3p	CLIP-seq
MIRT862890	hsa-miR-4712-3p	CLIP-seq
MIRT862891	hsa-miR-4713-5p	CLIP-seq
MIRT862855	hsa-miR-4728-5p	CLIP-seq
MIRT862892	hsa-miR-4738-3p	CLIP-seq
MIRT862857	hsa-miR-4793-3p	CLIP-seq
MIRT862809	hsa-miR-4803	CLIP-seq
MIRT862858	hsa-miR-485-5p	CLIP-seq
MIRT862893	hsa-miR-499-5p	CLIP-seq
MIRT862859	hsa-miR-508-5p	CLIP-seq
MIRT862894	hsa-miR-513a-5p	CLIP-seq
MIRT862895	hsa-miR-532-3p	CLIP-seq
MIRT862810	hsa-miR-543	CLIP-seq
MIRT862896	hsa-miR-548p	CLIP-seq
MIRT862863	hsa-miR-548u	CLIP-seq
MIRT862811	hsa-miR-605	CLIP-seq
MIRT862865	hsa-miR-766	CLIP-seq
MIRT862897	hsa-miR-767-3p	CLIP-seq
MIRT862898	hsa-miR-892b	CLIP-seq
MIRT862899	hsa-miR-944	CLIP-seq
MIRT862866	hsa-miR-122	CLIP-seq
MIRT862867	hsa-miR-1228	CLIP-seq
MIRT2193508	hsa-miR-1286	CLIP-seq
MIRT862815	hsa-miR-1293	CLIP-seq
MIRT862816	hsa-miR-1304	CLIP-seq
MIRT2193509	hsa-miR-1323	CLIP-seq
MIRT862818	hsa-miR-141	CLIP-seq
MIRT2193510	hsa-miR-142-3p	CLIP-seq
MIRT862802	hsa-miR-145	CLIP-seq
MIRT2193511	hsa-miR-194	CLIP-seq
MIRT862820	hsa-miR-200a	CLIP-seq
MIRT2193512	hsa-miR-205	CLIP-seq
MIRT2193513	hsa-miR-216a	CLIP-seq
MIRT2193514	hsa-miR-23a	CLIP-seq
MIRT2193515	hsa-miR-23b	CLIP-seq
MIRT2193516	hsa-miR-23c	CLIP-seq
MIRT2193517	hsa-miR-3120-5p	CLIP-seq
MIRT862821	hsa-miR-3122	CLIP-seq
MIRT2193518	hsa-miR-3123	CLIP-seq
MIRT862804	hsa-miR-3143	CLIP-seq
MIRT2193519	hsa-miR-329	CLIP-seq
MIRT862825	hsa-miR-3614-5p	CLIP-seq
MIRT862826	hsa-miR-361-5p	CLIP-seq
MIRT2193520	hsa-miR-3622a-5p	CLIP-seq
MIRT2193521	hsa-miR-362-3p	CLIP-seq
MIRT2193522	hsa-miR-3662	CLIP-seq
MIRT862828	hsa-miR-3664-3p	CLIP-seq
MIRT862829	hsa-miR-3664-5p	CLIP-seq
MIRT2193523	hsa-miR-3677-5p	CLIP-seq
MIRT862830	hsa-miR-3689a-3p	CLIP-seq
MIRT862831	hsa-miR-3689a-5p	CLIP-seq
MIRT862832	hsa-miR-3689b	CLIP-seq
MIRT862833	hsa-miR-3689c	CLIP-seq
MIRT862834	hsa-miR-3689e	CLIP-seq
MIRT862835	hsa-miR-3689f	CLIP-seq
MIRT862808	hsa-miR-3692	CLIP-seq
MIRT862836	hsa-miR-378g	CLIP-seq
MIRT862837	hsa-miR-3913-5p	CLIP-seq
MIRT862838	hsa-miR-3929	CLIP-seq
MIRT2193524	hsa-miR-3941	CLIP-seq
MIRT2193525	hsa-miR-425	CLIP-seq
MIRT2193526	hsa-miR-431	CLIP-seq
MIRT862841	hsa-miR-4311	CLIP-seq
MIRT2193527	hsa-miR-4330	CLIP-seq
MIRT862843	hsa-miR-4419b	CLIP-seq
MIRT2193528	hsa-miR-4423-3p	CLIP-seq
MIRT862845	hsa-miR-4433	CLIP-seq
MIRT862847	hsa-miR-4443	CLIP-seq
MIRT862848	hsa-miR-4478	CLIP-seq
MIRT862849	hsa-miR-4483	CLIP-seq
MIRT862853	hsa-miR-4540	CLIP-seq
MIRT2193529	hsa-miR-4645-5p	CLIP-seq
MIRT2193530	hsa-miR-4649-3p	CLIP-seq
MIRT2193531	hsa-miR-4673	CLIP-seq
MIRT2193532	hsa-miR-4683	CLIP-seq
MIRT2193533	hsa-miR-4690-5p	CLIP-seq
MIRT862854	hsa-miR-4714-5p	CLIP-seq
MIRT2193534	hsa-miR-4722-5p	CLIP-seq
MIRT862855	hsa-miR-4728-5p	CLIP-seq
MIRT862856	hsa-miR-4768-3p	CLIP-seq
MIRT862857	hsa-miR-4793-3p	CLIP-seq
MIRT862858	hsa-miR-485-5p	CLIP-seq
MIRT2193535	hsa-miR-501-3p	CLIP-seq
MIRT2193536	hsa-miR-502-3p	CLIP-seq
MIRT862859	hsa-miR-508-5p	CLIP-seq
MIRT862860	hsa-miR-510	CLIP-seq
MIRT862861	hsa-miR-512-5p	CLIP-seq
MIRT862862	hsa-miR-516b	CLIP-seq
MIRT862810	hsa-miR-543	CLIP-seq
MIRT2193537	hsa-miR-544	CLIP-seq
MIRT2193538	hsa-miR-548aa	CLIP-seq
MIRT2193539	hsa-miR-548o	CLIP-seq
MIRT862896	hsa-miR-548p	CLIP-seq
MIRT2193540	hsa-miR-603	CLIP-seq
MIRT2193541	hsa-miR-642b	CLIP-seq
MIRT862865	hsa-miR-766	CLIP-seq
MIRT862897	hsa-miR-767-3p	CLIP-seq
MIRT2193542	hsa-miR-873	CLIP-seq
MIRT2193543	hsa-miR-936	CLIP-seq
MIRT862899	hsa-miR-944	CLIP-seq
MIRT862867	hsa-miR-1228	CLIP-seq
MIRT862853	hsa-miR-4540	CLIP-seq
MIRT862857	hsa-miR-4793-3p	CLIP-seq
MIRT862859	hsa-miR-508-5p	CLIP-seq
MIRT862865	hsa-miR-766	CLIP-seq
MIRT2427039	hsa-miR-1267	CLIP-seq
MIRT2427040	hsa-miR-4282	CLIP-seq
MIRT862846	hsa-miR-4436b-5p	CLIP-seq
MIRT2427041	hsa-miR-513c	CLIP-seq
MIRT2427042	hsa-miR-514b-5p	CLIP-seq
MIRT2427043	hsa-miR-607	CLIP-seq
MIRT2427044	hsa-miR-664	CLIP-seq
MIRT862815	hsa-miR-1293	CLIP-seq
MIRT862816	hsa-miR-1304	CLIP-seq
MIRT862821	hsa-miR-3122	CLIP-seq
MIRT2446167	hsa-miR-3148	CLIP-seq
MIRT862825	hsa-miR-3614-5p	CLIP-seq
MIRT862829	hsa-miR-3664-5p	CLIP-seq
MIRT2193523	hsa-miR-3677-5p	CLIP-seq
MIRT862830	hsa-miR-3689a-3p	CLIP-seq
MIRT862833	hsa-miR-3689c	CLIP-seq
MIRT862837	hsa-miR-3913-5p	CLIP-seq
MIRT862838	hsa-miR-3929	CLIP-seq
MIRT2193527	hsa-miR-4330	CLIP-seq
MIRT862843	hsa-miR-4419b	CLIP-seq
MIRT862847	hsa-miR-4443	CLIP-seq
MIRT862848	hsa-miR-4478	CLIP-seq
MIRT862849	hsa-miR-4483	CLIP-seq
MIRT862854	hsa-miR-4714-5p	CLIP-seq
MIRT862855	hsa-miR-4728-5p	CLIP-seq
MIRT862858	hsa-miR-485-5p	CLIP-seq
MIRT862862	hsa-miR-516b	CLIP-seq
MIRT862815	hsa-miR-1293	CLIP-seq
MIRT862816	hsa-miR-1304	CLIP-seq
MIRT862821	hsa-miR-3122	CLIP-seq
MIRT862825	hsa-miR-3614-5p	CLIP-seq
MIRT2193523	hsa-miR-3677-5p	CLIP-seq
MIRT862830	hsa-miR-3689a-3p	CLIP-seq
MIRT862833	hsa-miR-3689c	CLIP-seq
MIRT862837	hsa-miR-3913-5p	CLIP-seq
MIRT862838	hsa-miR-3929	CLIP-seq
MIRT862843	hsa-miR-4419b	CLIP-seq
MIRT862848	hsa-miR-4478	CLIP-seq
MIRT862849	hsa-miR-4483	CLIP-seq
MIRT862855	hsa-miR-4728-5p	CLIP-seq
MIRT862858	hsa-miR-485-5p	CLIP-seq
MIRT2496646	hsa-miR-10a	CLIP-seq
MIRT2496647	hsa-miR-10b	CLIP-seq
MIRT862815	hsa-miR-1293	CLIP-seq
MIRT862816	hsa-miR-1304	CLIP-seq
MIRT2193509	hsa-miR-1323	CLIP-seq
MIRT2496648	hsa-miR-1587	CLIP-seq
MIRT2496649	hsa-miR-2392	CLIP-seq
MIRT2496650	hsa-miR-24	CLIP-seq
MIRT862874	hsa-miR-2964a-5p	CLIP-seq
MIRT2193517	hsa-miR-3120-5p	CLIP-seq
MIRT862821	hsa-miR-3122	CLIP-seq
MIRT862876	hsa-miR-3125	CLIP-seq
MIRT2496651	hsa-miR-3158-5p	CLIP-seq
MIRT862825	hsa-miR-3614-5p	CLIP-seq
MIRT2496652	hsa-miR-3618	CLIP-seq
MIRT2193520	hsa-miR-3622a-5p	CLIP-seq
MIRT862829	hsa-miR-3664-5p	CLIP-seq
MIRT2193523	hsa-miR-3677-5p	CLIP-seq
MIRT2496653	hsa-miR-3688-3p	CLIP-seq
MIRT862830	hsa-miR-3689a-3p	CLIP-seq
MIRT862833	hsa-miR-3689c	CLIP-seq
MIRT862836	hsa-miR-378g	CLIP-seq
MIRT862881	hsa-miR-3909	CLIP-seq
MIRT862837	hsa-miR-3913-5p	CLIP-seq
MIRT2496654	hsa-miR-3914	CLIP-seq
MIRT862882	hsa-miR-3916	CLIP-seq
MIRT862838	hsa-miR-3929	CLIP-seq
MIRT2496655	hsa-miR-4251	CLIP-seq
MIRT2496656	hsa-miR-4261	CLIP-seq
MIRT2496657	hsa-miR-4269	CLIP-seq
MIRT2496658	hsa-miR-4284	CLIP-seq
MIRT2496659	hsa-miR-4418	CLIP-seq
MIRT862843	hsa-miR-4419b	CLIP-seq
MIRT862845	hsa-miR-4433	CLIP-seq
MIRT862847	hsa-miR-4443	CLIP-seq
MIRT862848	hsa-miR-4478	CLIP-seq
MIRT862849	hsa-miR-4483	CLIP-seq
MIRT2496660	hsa-miR-4492	CLIP-seq
MIRT862887	hsa-miR-4496	CLIP-seq
MIRT2496661	hsa-miR-4498	CLIP-seq
MIRT2193529	hsa-miR-4645-5p	CLIP-seq
MIRT2193530	hsa-miR-4649-3p	CLIP-seq
MIRT2496662	hsa-miR-4656	CLIP-seq
MIRT2193531	hsa-miR-4673	CLIP-seq
MIRT2496663	hsa-miR-4675	CLIP-seq
MIRT862854	hsa-miR-4714-5p	CLIP-seq
MIRT862855	hsa-miR-4728-5p	CLIP-seq
MIRT862892	hsa-miR-4738-3p	CLIP-seq
MIRT2496664	hsa-miR-4741	CLIP-seq
MIRT2496665	hsa-miR-4755-3p	CLIP-seq
MIRT862809	hsa-miR-4803	CLIP-seq
MIRT862858	hsa-miR-485-5p	CLIP-seq
MIRT2496666	hsa-miR-493	CLIP-seq
MIRT2496667	hsa-miR-509-3-5p	CLIP-seq
MIRT2496668	hsa-miR-509-5p	CLIP-seq
MIRT862862	hsa-miR-516b	CLIP-seq
MIRT2496669	hsa-miR-522	CLIP-seq
MIRT2496670	hsa-miR-539	CLIP-seq
MIRT2193539	hsa-miR-548o	CLIP-seq
MIRT862896	hsa-miR-548p	CLIP-seq
MIRT2496671	hsa-miR-564	CLIP-seq
MIRT2496672	hsa-miR-570	CLIP-seq
MIRT2496673	hsa-miR-580	CLIP-seq
MIRT2496674	hsa-miR-593	CLIP-seq
MIRT2193540	hsa-miR-603	CLIP-seq
MIRT2193541	hsa-miR-642b	CLIP-seq
MIRT2496675	hsa-miR-762	CLIP-seq
MIRT2193542	hsa-miR-873	CLIP-seq
MIRT2496676	hsa-miR-934	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
NFKB1	Unknown	17878386
RELA	Unknown	17878386

Show/Hide all(51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002218	Process	Activation of innate immune response	IBA
GO:0002376	Process	Immune system process	IEA
GO:0004175	Function	Endopeptidase activity	IDA	22087307, 34019797
GO:0005515	Function	Protein binding	IPI	11551959, 15030775, 31525884, 33542150
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11551959
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	24517500
GO:0005737	Component	Cytoplasm	IDA	15030775
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	11821383
GO:0012501	Process	Programmed cell death	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031665	Process	Negative regulation of lipopolysaccharide-mediated signaling pathway	IDA	11821383
GO:0032089	Function	NACHT domain binding	IPI	15030775
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IDA	11821383
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IDA	15030775
GO:0032991	Component	Protein-containing complex	IDA	11821383
GO:0038187	Function	Pattern recognition receptor activity	IBA
GO:0038187	Function	Pattern recognition receptor activity	IDA	33542150
GO:0042803	Function	Protein homodimerization activity	IDA	15030775
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IDA	11551959
GO:0045087	Process	Innate immune response	IEA
GO:0050700	Function	CARD domain binding	IPI	11821383
GO:0050729	Process	Positive regulation of inflammatory response	IDA	32109412
GO:0051260	Process	Protein homooligomerization	IDA	33420028, 33420033, 34019797
GO:0051604	Process	Protein maturation	IDA	32109412
GO:0051607	Process	Defense response to virus	IDA	33542150
GO:0061702	Component	Canonical inflammasome complex	IDA	34019797
GO:0061702	Component	Canonical inflammasome complex	IEA
GO:0070269	Process	Pyroptotic inflammatory response	IDA	32840892, 33542150, 34019797
GO:0072559	Component	NLRP3 inflammasome complex	IBA
GO:0072559	Component	NLRP3 inflammasome complex	IDA	15030775
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IBA
GO:0097264	Process	Self proteolysis	IDA	33542150
GO:0140374	Process	Antiviral innate immune response	IDA	33542150
GO:0140608	Function	Cysteine-type endopeptidase activator activity	IBA
GO:0140608	Function	Cysteine-type endopeptidase activator activity	IDA	15030775, 31525884, 32840892, 33542150
GO:0140633	Process	CARD8 inflammasome complex assembly	IDA	31525884, 33053349
GO:0140633	Process	CARD8 inflammasome complex assembly	IDA	31525884, 33053349, 33420028, 33420033
GO:0140634	Component	CARD8 inflammasome complex	IDA	15030775, 32840892, 33420028, 33420033, 33542150
GO:0140693	Function	Molecular condensate scaffold activity	IDA	33053349
GO:0141201	Process	Pyroptotic cell death	IDA	32109412
GO:1900226	Process	Negative regulation of NLRP3 inflammasome complex assembly	IDA	24517500

MIM	HGNC	e!Ensembl
609051	17057	ENSG00000105483

Protein

UniProt ID

Q9Y2G2

Protein name

Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-ter

Protein function

Inflammasome sensor, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis of CD4(+) T-cells and macrophages (PubMed:11408476, PubMed:11821383, PubMed:15030775, PubMed:3205125

PDB

4IKM , 6K9F , 6XKJ , 7JKQ , 7JN7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13553	FIIND	77 → 330	Function to find	Family
PF00619	CARD	345 → 429	Caspase recruitment domain	Domain

Tissue specificity

TISSUE SPECIFICITY: High expression in lung, ovary, testis and placenta (PubMed:11551959). Lower expression in heart, kidney and liver (PubMed:11551959). Also expressed in spleen, lymph node and bone marrow (PubMed:11821383). {ECO:0000269|PubMed:11551959,

Sequence

MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPE
GNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHH
EQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEP
FYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKA
IDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFY
AGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMG
DLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDP
YLVSYLRQQNL

Sequence length

431

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway		Formation of apoptosome Regulation of the apoptosome activity

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Inflammatory Bowel Disease	Inflammatory bowel disease 30, inflammatory bowel disease 30	N/A	N/A	ClinVar, GenCC

Show/Hide Text Mining Associations (54)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	35476781
Adenocarcinoma of Lung	Inhibit	35996500, 38166691
Alcoholism	Associate	34587665
Anxiety	Associate	34587665
Aortic Aneurysm Abdominal	Associate	27157464
Arteriosclerosis Obliterans	Associate	28135700
Arthritis Gouty	Associate	26462562
Arthritis Psoriatic	Associate	33300400
Arthritis Rheumatoid	Associate	23088220
Atherosclerosis	Associate	33154409
Autoimmune Diseases	Associate	36835594
Carcinoma Hepatocellular	Associate	26147888
Carcinoma Non Small Cell Lung	Associate	16796750, 17094407
Cerebral Infarction	Inhibit	24385277
Cerebral Infarction	Associate	24385277
Cholesteatoma	Associate	32396255
Colorectal Neoplasms	Associate	11408476, 19843337
COVID 19	Associate	37289745
Crohn Disease	Associate	23506543, 29408806
Death	Associate	36870425
Diabetes Mellitus	Associate	33164551
Diabetes Mellitus Type 2	Associate	26273672, 33164551
Diabetic Nephropathies	Associate	33164551
Dyskinesias	Associate	28137891
Gout	Associate	25790751, 26462562, 27550484
Helicobacter Infections	Associate	24901306
Hereditary Autoinflammatory Diseases	Associate	28137891, 37544411
HIV Infections	Associate	33542150
Hypertension	Associate	30530896
Infections	Associate	36129453
Inflammation	Associate	11551959, 28135700, 28137891, 33154409, 33164551, 36129453, 37289745, 39354402
Inflammatory Bowel Diseases	Associate	17595233
Iridogoniodysgenesis type1	Associate	36204643
Kidney Calculi	Associate	25790751
Lymphatic Metastasis	Inhibit	35996500
Lymphohistiocytosis Hemophagocytic	Associate	37544411
Meningism	Associate	39354402
Meningitis Bacterial	Associate	39354402
Mental Disorders	Associate	34587665
Multiple Myeloma	Associate	30211233
Myocarditis	Associate	36129453
Neoplasms	Associate	11408476, 17094407, 26147888, 38166691
Obsessive Compulsive Disorder	Associate	34587665
Pleural Diseases	Associate	24142982
Renal Insufficiency Chronic	Associate	36835594
Skin Diseases	Associate	33300400
Spondylitis Ankylosing	Associate	32080163
Stomach Neoplasms	Associate	24901306
Stomatitis Aphthous	Associate	28137891
Tooth Erosion	Associate	32396255
Tuberculosis	Associate	36204643
Tuberculosis Extrapulmonary	Associate	33868225
Uterine Cervical Neoplasms	Associate	26147888
Virus Diseases	Stimulate	36129453

CARD8 (caspase recruitment domain family member 8)