Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22881
Gene name Gene Name - the full gene name approved by the HGNC.	Ankyrin repeat domain 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANKRD6
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q15

Show/Hide all(115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024472	hsa-miR-215-5p	Microarray	19074876
MIRT026861	hsa-miR-192-5p	Microarray	19074876
MIRT722418	hsa-miR-1264	HITS-CLIP	19536157
MIRT722417	hsa-miR-3616-5p	HITS-CLIP	19536157
MIRT722416	hsa-miR-573	HITS-CLIP	19536157
MIRT722415	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT722418	hsa-miR-1264	HITS-CLIP	19536157
MIRT722417	hsa-miR-3616-5p	HITS-CLIP	19536157
MIRT722416	hsa-miR-573	HITS-CLIP	19536157
MIRT722415	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT785246	hsa-miR-1236	CLIP-seq
MIRT785247	hsa-miR-134	CLIP-seq
MIRT785248	hsa-miR-3118	CLIP-seq
MIRT785249	hsa-miR-3164	CLIP-seq
MIRT785250	hsa-miR-339-5p	CLIP-seq
MIRT785251	hsa-miR-3613-3p	CLIP-seq
MIRT785252	hsa-miR-4474-5p	CLIP-seq
MIRT785253	hsa-miR-4480	CLIP-seq
MIRT785254	hsa-miR-514	CLIP-seq
MIRT785255	hsa-miR-514b-3p	CLIP-seq
MIRT785256	hsa-miR-670	CLIP-seq
MIRT785257	hsa-miR-10a	CLIP-seq
MIRT785258	hsa-miR-10b	CLIP-seq
MIRT785259	hsa-miR-1275	CLIP-seq
MIRT785260	hsa-miR-1303	CLIP-seq
MIRT785261	hsa-miR-203	CLIP-seq
MIRT785262	hsa-miR-3065-5p	CLIP-seq
MIRT785263	hsa-miR-3140-3p	CLIP-seq
MIRT785264	hsa-miR-3200-3p	CLIP-seq
MIRT785265	hsa-miR-326	CLIP-seq
MIRT785266	hsa-miR-330-5p	CLIP-seq
MIRT785250	hsa-miR-339-5p	CLIP-seq
MIRT785267	hsa-miR-3618	CLIP-seq
MIRT785268	hsa-miR-3647-3p	CLIP-seq
MIRT785269	hsa-miR-3667-5p	CLIP-seq
MIRT785270	hsa-miR-4271	CLIP-seq
MIRT785271	hsa-miR-4421	CLIP-seq
MIRT785272	hsa-miR-4452	CLIP-seq
MIRT785273	hsa-miR-451b	CLIP-seq
MIRT785274	hsa-miR-4525	CLIP-seq
MIRT785275	hsa-miR-4635	CLIP-seq
MIRT785276	hsa-miR-4643	CLIP-seq
MIRT785277	hsa-miR-4652-3p	CLIP-seq
MIRT785278	hsa-miR-4665-5p	CLIP-seq
MIRT785279	hsa-miR-4667-5p	CLIP-seq
MIRT785280	hsa-miR-4670-3p	CLIP-seq
MIRT785281	hsa-miR-4696	CLIP-seq
MIRT785282	hsa-miR-4700-5p	CLIP-seq
MIRT785283	hsa-miR-4723-5p	CLIP-seq
MIRT785284	hsa-miR-4725-3p	CLIP-seq
MIRT785285	hsa-miR-4725-5p	CLIP-seq
MIRT785286	hsa-miR-4795-3p	CLIP-seq
MIRT785287	hsa-miR-504	CLIP-seq
MIRT785288	hsa-miR-578	CLIP-seq
MIRT785289	hsa-miR-590-3p	CLIP-seq
MIRT785290	hsa-miR-593	CLIP-seq
MIRT785291	hsa-miR-625	CLIP-seq
MIRT785292	hsa-miR-637	CLIP-seq
MIRT785293	hsa-miR-645	CLIP-seq
MIRT785294	hsa-miR-656	CLIP-seq
MIRT785295	hsa-miR-7	CLIP-seq
MIRT785296	hsa-miR-934	CLIP-seq
MIRT785263	hsa-miR-3140-3p	CLIP-seq
MIRT1931561	hsa-miR-4711-3p	CLIP-seq
MIRT1931561	hsa-miR-4711-3p	CLIP-seq
MIRT2435350	hsa-miR-4666-5p	CLIP-seq
MIRT2443704	hsa-miR-24	CLIP-seq
MIRT2443705	hsa-miR-3163	CLIP-seq
MIRT2443706	hsa-miR-4284	CLIP-seq
MIRT2443707	hsa-miR-4659a-3p	CLIP-seq
MIRT2443708	hsa-miR-4659b-3p	CLIP-seq
MIRT1931561	hsa-miR-4711-3p	CLIP-seq
MIRT2443709	hsa-miR-4716-5p	CLIP-seq
MIRT2443710	hsa-miR-4753-3p	CLIP-seq
MIRT2443711	hsa-miR-4778-3p	CLIP-seq
MIRT2443712	hsa-miR-548ac	CLIP-seq
MIRT2443713	hsa-miR-548d-3p	CLIP-seq
MIRT2443714	hsa-miR-548z	CLIP-seq
MIRT2443715	hsa-miR-668	CLIP-seq
MIRT2443716	hsa-miR-9	CLIP-seq
MIRT2443717	hsa-miR-942	CLIP-seq
MIRT785257	hsa-miR-10a	CLIP-seq
MIRT785258	hsa-miR-10b	CLIP-seq
MIRT2475051	hsa-miR-1179	CLIP-seq
MIRT785262	hsa-miR-3065-5p	CLIP-seq
MIRT785250	hsa-miR-339-5p	CLIP-seq
MIRT785269	hsa-miR-3667-5p	CLIP-seq
MIRT2475052	hsa-miR-4282	CLIP-seq
MIRT2475053	hsa-miR-4291	CLIP-seq
MIRT2475054	hsa-miR-4310	CLIP-seq
MIRT785271	hsa-miR-4421	CLIP-seq
MIRT785273	hsa-miR-451b	CLIP-seq
MIRT2443707	hsa-miR-4659a-3p	CLIP-seq
MIRT2443708	hsa-miR-4659b-3p	CLIP-seq
MIRT785281	hsa-miR-4696	CLIP-seq
MIRT2475055	hsa-miR-4704-5p	CLIP-seq
MIRT1931561	hsa-miR-4711-3p	CLIP-seq
MIRT2443709	hsa-miR-4716-5p	CLIP-seq
MIRT785285	hsa-miR-4725-5p	CLIP-seq
MIRT2443711	hsa-miR-4778-3p	CLIP-seq
MIRT785287	hsa-miR-504	CLIP-seq
MIRT785257	hsa-miR-10a	CLIP-seq
MIRT785258	hsa-miR-10b	CLIP-seq
MIRT785262	hsa-miR-3065-5p	CLIP-seq
MIRT785250	hsa-miR-339-5p	CLIP-seq
MIRT785269	hsa-miR-3667-5p	CLIP-seq
MIRT785271	hsa-miR-4421	CLIP-seq
MIRT785273	hsa-miR-451b	CLIP-seq
MIRT2443707	hsa-miR-4659a-3p	CLIP-seq
MIRT2443708	hsa-miR-4659b-3p	CLIP-seq
MIRT785281	hsa-miR-4696	CLIP-seq
MIRT1931561	hsa-miR-4711-3p	CLIP-seq
MIRT785285	hsa-miR-4725-5p	CLIP-seq
MIRT2443711	hsa-miR-4778-3p	CLIP-seq
MIRT785287	hsa-miR-504	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0046330	Process	Positive regulation of JNK cascade	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:2000096	Process	Positive regulation of Wnt signaling pathway, planar cell polarity pathway	IEA

MIM	HGNC	e!Ensembl
610583	17280	ENSG00000135299

Protein

UniProt ID

Q9Y2G4

Protein name

Ankyrin repeat domain-containing protein 6 (Diversin)

Protein function

Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13857	Ank_5	29 → 82		Repeat
PF13857	Ank_5	94 → 148		Repeat
PF12796	Ank_2	198 → 267	Ankyrin repeats (3 copies)	Repeat

Sequence

MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI
LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF
SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV
AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG
QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG
SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG
HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK
LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL
QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD
QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM
NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD
TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR
TRVQKEN

Sequence length

727

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Metabolic Syndrome	Metabolic Syndrome	GWAS
Coronary artery disease	Coronary artery disease	GWAS
Bipolar Disorder	Bipolar Disorder	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Stimulate	24858714
Colorectal Neoplasms	Stimulate	36623636
Glioma	Associate	24833088
Lymphatic Metastasis	Stimulate	36623636
Melanoma	Associate	31338875
Neoplasm Metastasis	Stimulate	24858714
Neoplasms	Stimulate	24833088, 36623636

ANKRD6 (ankyrin repeat domain 6)