Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
22800
Gene name Gene Name - the full gene name approved by the HGNC.
RAS related 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RRAS2
Synonyms (NCBI Gene) Gene synonyms aliases
NS12, TC21
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NS12
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathway
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs113954997 T>A,C Pathogenic Missense variant, 5 prime UTR variant, coding sequence variant
rs782457908 C>T Pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
rs1591495767 ->ACGCCGCCC Pathogenic Genic upstream transcript variant, coding sequence variant, inframe insertion, upstream transcript variant, intron variant
rs1591495776 ->CCCCCGCCG Pathogenic Genic upstream transcript variant, coding sequence variant, inframe insertion, upstream transcript variant, intron variant
rs1591495779 C>A Pathogenic Genic upstream transcript variant, coding sequence variant, upstream transcript variant, missense variant, intron variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022861 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT025875 hsa-miR-7-5p Sequencing 20371350
MIRT028141 hsa-miR-93-5p Sequencing 20371350
MIRT029816 hsa-miR-26b-5p Microarray 19088304
MIRT031260 hsa-miR-19b-3p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
BTF3 Repression 17312387
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001649 Process Osteoblast differentiation HDA 16210410
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 12620389, 19060904, 28514442, 31515488, 32296183
GO:0005525 Function GTP binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600098 17271 ENSG00000133818
Protein
UniProt ID P62070
Protein name Ras-related protein R-Ras2 (EC 3.6.5.2) (Ras-like protein TC21) (Teratocarcinoma oncogene)
Protein function GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:31130282, PubMed:31130285, PubMed:39809765). Regulates craniofacial development (PubMed:31
PDB 2ERY , 9B4Q , 9B4S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 16 177 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. {ECO:0000269|PubMed:8052619}.
Sequence
Sequence length 204
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  MAPK signaling pathway
Ras signaling pathway
cAMP signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Apelin signaling pathway
C-type lectin receptor signaling pathway
Regulation of actin cytoskeleton
Proteoglycans in cancer
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Myelomonocytic leukemia Juvenile Myelomonocytic Leukemia rs137854555, rs267606602, rs267606604, rs137854562, rs267606607, rs121918546, rs112445441, rs121913529, rs121913530, rs121918465, rs267606708, rs267606706, rs121434596, rs121913237, rs397514641
View all (68 more)
26457647
Noonan syndrome Noonan Syndrome, Noonan Syndrome 1, Noonan syndrome rs121434312, rs267607048, rs121434499, rs113954997, rs104894359, rs104894360, rs104894364, rs104894365, rs104894366, rs104894367, rs193929331, rs28933406, rs104894230, rs104894226, rs104894228
View all (240 more)
31130282, 31130285, 24705357
Ovarian cancer Malignant neoplasm of ovary rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828
View all (31 more)
Ovarian carcinoma Ovarian Carcinoma rs62625308, rs137886232, rs397507192, rs80357609, rs397508926, rs80357223, rs80357678, rs587779243, rs587782861, rs747539984, rs876658381
Unknown
Disease term Disease name Evidence References Source
Noonan Syndrome Noonan syndrome GenCC
Multiple Sclerosis Multiple Sclerosis GWAS
Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy GWAS
Associations from Text Mining
Disease Name Relationship Type References
Astrocytoma Stimulate 24148564
Breast Neoplasms Stimulate 24148564
Developmental Disabilities Associate 37942564
Epstein Barr Virus Infections Associate 37434198
Esophageal Neoplasms Associate 22919244
Esophageal Squamous Cell Carcinoma Associate 22919244
Genetic Diseases Inborn Associate 33686258
Glioblastoma Stimulate 24148564
Hydrops Fetalis Associate 33686258
Hyperplasia Stimulate 24148564