Gene Gene information from NCBI Gene database.
Entrez ID 226
Gene name Aldolase, fructose-bisphosphate A
Gene symbol ALDOA
Synonyms (NCBI Gene)
ALDAGSD12HEL-S-87p
Chromosome 16
Chromosome location 16p11.2
Summary This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone ph
miRNA miRNA information provided by mirtarbase database.
557
miRTarBase ID miRNA Experiments Reference
MIRT003085 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT003085 hsa-miR-122-5p Northern blot 18073344
MIRT046363 hsa-miR-23b-3p CLASH 23622248
MIRT043086 hsa-miR-324-5p CLASH 23622248
MIRT042956 hsa-miR-324-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
HIF1A Activation 8955077
ZNF224 Repression 17900823
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0003779 Function Actin binding TAS 1008835
GO:0004332 Function Fructose-bisphosphate aldolase activity IBA
GO:0004332 Function Fructose-bisphosphate aldolase activity IDA 9244396, 14766013
GO:0004332 Function Fructose-bisphosphate aldolase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
103850 414 ENSG00000149925
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P04075
Protein name Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)
Protein function Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarit
PDB 1ALD , 2ALD , 4ALD , 5KY6 , 6XMH , 6XML , 6XMM , 6XMO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00274 Glycolytic 15 364 Fructose-bisphosphate aldolase class-I Domain
Sequence
Sequence length 364
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
HIF-1 signaling pathway
  Platelet degranulation
Neutrophil degranulation
Glycolysis
Gluconeogenesis
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
254
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
HNSHA due to aldolase A deficiency Likely pathogenic; Pathogenic rs2151019809, rs2151019295, rs773601711, rs762619360, rs892947296, rs1340894214, rs121909533, rs121909534 RCV001730019
RCV001730028
RCV002972689
RCV003634528
RCV003816497
RCV003870388
RCV000019808
RCV000019809
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs78124282 RCV005897991
ALDOA-related disorder Likely benign; Conflicting classifications of pathogenicity; Uncertain significance; Benign rs573479181, rs142957871, rs1182078816, rs769800173, rs753739488, rs780378047, rs138824667, rs142315181, rs111252736, rs767840312, rs76767223, rs200278984, rs565013143 RCV003976251
RCV003968843
RCV004747208
RCV003399521
RCV003956545
RCV003927095
RCV003940251
RCV003940250
RCV003959892
RCV003899888
RCV003922759
RCV003905561
RCV003953229
Cervical cancer Uncertain significance; Benign rs774939475, rs78124282 RCV005911173
RCV005897992
Gastric cancer Conflicting classifications of pathogenicity rs142315181 RCV005894445
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Disease Associate 32362107
Adenocarcinoma Associate 32530543
Adenocarcinoma of Lung Associate 35404841, 36564744, 37626419, 39267056
Adenocarcinoma of Lung Stimulate 35804089
Anemia Hemolytic Associate 14615364, 25392908
Arrhythmogenic Right Ventricular Dysplasia Associate 33904367
Carcinogenesis Associate 29992789, 32362107
Carcinoma Hepatocellular Associate 24452951, 30482855, 33994862, 35028121, 35404841
Carcinoma Hepatocellular Stimulate 35804089
Carcinoma Pancreatic Ductal Associate 37990271