Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
226
Gene name Gene Name - the full gene name approved by the HGNC.
Aldolase, fructose-bisphosphate A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ALDOA
Synonyms (NCBI Gene) Gene synonyms aliases
ALDA, GSD12, HEL-S-87p
Disease Acronyms (UniProt) Disease acronyms from UniProt database
GSD12
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone ph
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003085 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003085 hsa-miR-122-5p Northern blot 18073344
MIRT046363 hsa-miR-23b-3p CLASH 23622248
MIRT043086 hsa-miR-324-5p CLASH 23622248
MIRT042956 hsa-miR-324-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
HIF1A Activation 8955077
ZNF224 Repression 17900823
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002576 Process Platelet degranulation TAS
GO:0003723 Function RNA binding HDA 22681889
GO:0003779 Function Actin binding TAS 1008835
GO:0004332 Function Fructose-bisphosphate aldolase activity IBA 21873635
GO:0004332 Function Fructose-bisphosphate aldolase activity IDA 9244396, 14766013
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
103850 414 ENSG00000149925
Protein
UniProt ID P04075
Protein name Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)
Protein function Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarit
PDB 1ALD , 2ALD , 4ALD , 5KY6 , 6XMH , 6XML , 6XMM , 6XMO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00274 Glycolytic 15 364 Fructose-bisphosphate aldolase class-I Domain
Sequence
Sequence length 364
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
HIF-1 signaling pathway
  Platelet degranulation
Neutrophil degranulation
Glycolysis
Gluconeogenesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Anemia Normocytic anemia rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
20562527
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
20562527
Cholelithiasis Cholelithiasis rs121918440, rs72552778, rs387906528, rs759202962, rs377160065, rs1051861187, rs757693457, rs752563752
Unknown
Disease term Disease name Evidence References Source
Ptosis Blepharoptosis, Ptosis ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Acute Disease Associate 32362107
Adenocarcinoma Associate 32530543
Adenocarcinoma of Lung Associate 35404841, 36564744, 37626419, 39267056
Adenocarcinoma of Lung Stimulate 35804089
Anemia Hemolytic Associate 14615364, 25392908
Arrhythmogenic Right Ventricular Dysplasia Associate 33904367
Carcinogenesis Associate 29992789, 32362107
Carcinoma Hepatocellular Associate 24452951, 30482855, 33994862, 35028121, 35404841
Carcinoma Hepatocellular Stimulate 35804089
Carcinoma Pancreatic Ductal Associate 37990271