DAGLB (diacylglycerol lipase beta)

Gene

• Entrez ID: 221955
• Gene name: Diacylglycerol lipase beta
• Gene symbol: DAGLB
• Synonyms (NCBI Gene): DAGLBETA, KCCR13L
• Chromosome: 7
• Chromosome location: 7p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016573	hsa-miR-193b-3p	Proteomics	21512034
MIRT045074	hsa-miR-186-5p	CLASH	23622248
MIRT922883	hsa-miR-1324	CLIP-seq
MIRT922884	hsa-miR-1910	CLIP-seq
MIRT922885	hsa-miR-4713-3p	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq
MIRT922887	hsa-miR-671-5p	CLIP-seq
MIRT922888	hsa-miR-140-3p	CLIP-seq
MIRT922889	hsa-miR-451b	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq
MIRT2512851	hsa-miR-1193	CLIP-seq
MIRT2512852	hsa-miR-1267	CLIP-seq
MIRT2512853	hsa-miR-1292	CLIP-seq
MIRT922888	hsa-miR-140-3p	CLIP-seq
MIRT2512854	hsa-miR-197	CLIP-seq
MIRT2512855	hsa-miR-2052	CLIP-seq
MIRT2512856	hsa-miR-223	CLIP-seq
MIRT2512857	hsa-miR-224	CLIP-seq
MIRT2512858	hsa-miR-3134	CLIP-seq
MIRT2512859	hsa-miR-4328	CLIP-seq
MIRT2512860	hsa-miR-4471	CLIP-seq
MIRT2512861	hsa-miR-4477b	CLIP-seq
MIRT2512862	hsa-miR-4534	CLIP-seq
MIRT2512863	hsa-miR-4652-3p	CLIP-seq
MIRT2512864	hsa-miR-4768-3p	CLIP-seq
MIRT2512865	hsa-miR-4778-5p	CLIP-seq
MIRT2512866	hsa-miR-4786-5p	CLIP-seq
MIRT2512867	hsa-miR-591	CLIP-seq
MIRT2512868	hsa-miR-639	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq
MIRT922887	hsa-miR-671-5p	CLIP-seq
MIRT2512869	hsa-miR-769-5p	CLIP-seq
MIRT922888	hsa-miR-140-3p	CLIP-seq
MIRT2512854	hsa-miR-197	CLIP-seq
MIRT2512864	hsa-miR-4768-3p	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001516	Process	Prostaglandin biosynthetic process	ISS
GO:0004806	Function	Triglyceride lipase activity	ISS	31991095
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IDA	14610053
GO:0005886	Component	Plasma membrane	TAS
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0010898	Process	Positive regulation of triglyceride catabolic process	ISS	31991095
GO:0016021	Component	Integral component of membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016298	Function	Lipase activity	IDA	14610053
GO:0019369	Process	Arachidonic acid metabolic process	IDA	14610053
GO:0022008	Process	Neurogenesis	IBA	21873635
GO:0042136	Process	Neurotransmitter biosynthetic process	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0071926	Process	Endocannabinoid signaling pathway	IBA	21873635
GO:0098921	Process	Retrograde trans-synaptic signaling by endocannabinoid	IBA	21873635

Other IDs

• MIM: 614016
• HGNC: 28923
• e!Ensembl: ENSG00000164535

Protein

• UniProt ID: Q8NCG7
• Protein name: Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
• Protein function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic aci
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01764	Lipase_3	370 → 505	Lipase (class 3)	Family

• Sequence:

  MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
  VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
  DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
  LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
  LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
  TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
  ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
  NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
  EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
  NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
  EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
  CPAQGVSSVDVA

• Sequence length: 672

Pathways

KEGG:

Retrograde endocannabinoid signaling
Aldosterone synthesis and secretion

Reactome:

Arachidonate production from DAG

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	29212778

Unknown
Disease term	Disease name	Evidence	References	Source
Irritable Bowel Syndrome	Irritable Bowel Syndrome			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Cholelithiasis	Cholelithiasis			GWAS
Dermatitis	Dermatitis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	35589867
Neuroblastoma	Associate	21493725
Uterine Cervical Neoplasms	Associate	35924232