DAGLB (diacylglycerol lipase beta)

Gene

• Entrez ID: 221955
• Gene name: Diacylglycerol lipase beta
• Gene symbol: DAGLB
• Synonyms (NCBI Gene): DAGLBETA, KCCR13L
• Chromosome: 7
• Chromosome location: 7p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016573	hsa-miR-193b-3p	Proteomics	21512034
MIRT045074	hsa-miR-186-5p	CLASH	23622248
MIRT922883	hsa-miR-1324	CLIP-seq
MIRT922884	hsa-miR-1910	CLIP-seq
MIRT922885	hsa-miR-4713-3p	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq
MIRT922887	hsa-miR-671-5p	CLIP-seq
MIRT922888	hsa-miR-140-3p	CLIP-seq
MIRT922889	hsa-miR-451b	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq
MIRT2512851	hsa-miR-1193	CLIP-seq
MIRT2512852	hsa-miR-1267	CLIP-seq
MIRT2512853	hsa-miR-1292	CLIP-seq
MIRT922888	hsa-miR-140-3p	CLIP-seq
MIRT2512854	hsa-miR-197	CLIP-seq
MIRT2512855	hsa-miR-2052	CLIP-seq
MIRT2512856	hsa-miR-223	CLIP-seq
MIRT2512857	hsa-miR-224	CLIP-seq
MIRT2512858	hsa-miR-3134	CLIP-seq
MIRT2512859	hsa-miR-4328	CLIP-seq
MIRT2512860	hsa-miR-4471	CLIP-seq
MIRT2512861	hsa-miR-4477b	CLIP-seq
MIRT2512862	hsa-miR-4534	CLIP-seq
MIRT2512863	hsa-miR-4652-3p	CLIP-seq
MIRT2512864	hsa-miR-4768-3p	CLIP-seq
MIRT2512865	hsa-miR-4778-5p	CLIP-seq
MIRT2512866	hsa-miR-4786-5p	CLIP-seq
MIRT2512867	hsa-miR-591	CLIP-seq
MIRT2512868	hsa-miR-639	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq
MIRT922887	hsa-miR-671-5p	CLIP-seq
MIRT2512869	hsa-miR-769-5p	CLIP-seq
MIRT922888	hsa-miR-140-3p	CLIP-seq
MIRT2512854	hsa-miR-197	CLIP-seq
MIRT2512864	hsa-miR-4768-3p	CLIP-seq
MIRT922886	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001516	Process	Prostaglandin biosynthetic process	IEA
GO:0001516	Process	Prostaglandin biosynthetic process	ISS
GO:0004806	Function	Triacylglycerol lipase activity	IBA
GO:0004806	Function	Triacylglycerol lipase activity	IEA
GO:0004806	Function	Triacylglycerol lipase activity	ISS	31991095
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14610053
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006640	Process	Monoacylglycerol biosynthetic process	IEA
GO:0006690	Process	Icosanoid metabolic process	IEA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0010898	Process	Positive regulation of triglyceride catabolic process	IEA
GO:0010898	Process	Positive regulation of triglyceride catabolic process	ISS	31991095
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016298	Function	Lipase activity	IDA	14610053
GO:0016298	Function	Lipase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019369	Process	Arachidonate metabolic process	IBA
GO:0019369	Process	Arachidonate metabolic process	IDA	14610053
GO:0019369	Process	Arachidonate metabolic process	IEA
GO:0019369	Process	Arachidonate metabolic process	TAS
GO:0022008	Process	Neurogenesis	IBA
GO:0022008	Process	Neurogenesis	IEA
GO:0046340	Process	Diacylglycerol catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0047372	Function	Monoacylglycerol lipase activity	IEA
GO:0047372	Function	Monoacylglycerol lipase activity	TAS
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:1901696	Process	Cannabinoid biosynthetic process	IEA

Other IDs

• MIM: 614016
• HGNC: 28923
• e!Ensembl: ENSG00000164535

Protein

• UniProt ID: Q8NCG7
• Protein name: Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
• Protein function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic aci
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01764	Lipase_3	370 → 505	Lipase (class 3)	Family

• Sequence:

  MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
  VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
  DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
  LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
  LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
  TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
  ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
  NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
  EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
  NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
  EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
  CPAQGVSSVDVA

• Sequence length: 672

Pathways

KEGG:

Retrograde endocannabinoid signaling
Aldosterone synthesis and secretion

Reactome:

Arachidonate production from DAG