Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	221935
Gene name	Sidekick cell adhesion molecule 1
Gene symbol	SDK1
Synonyms (NCBI Gene)	-
Chromosome	7
Chromosome location	7p22.2
Summary	The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellula

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Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040164	hsa-miR-615-3p	CLASH	23622248
MIRT492410	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT492408	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT492409	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT492407	hsa-miR-6892-3p	PAR-CLIP	23592263
MIRT492406	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT492405	hsa-miR-4533	PAR-CLIP	23592263
MIRT492404	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT492403	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT492402	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT492400	hsa-miR-4271	PAR-CLIP	23592263
MIRT492401	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT492399	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT492398	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT492397	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT492396	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT453852	hsa-miR-4476	PAR-CLIP	23592263
MIRT453851	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT453850	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT453849	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT453848	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT453847	hsa-miR-764	PAR-CLIP	23592263
MIRT453846	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT453845	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT453844	hsa-miR-3179	PAR-CLIP	23592263
MIRT453843	hsa-miR-1253	PAR-CLIP	23592263
MIRT453842	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT453841	hsa-miR-3202	PAR-CLIP	23592263
MIRT453840	hsa-miR-3153	PAR-CLIP	23592263
MIRT453839	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT453838	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT453837	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT492410	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT492408	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT492409	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT492407	hsa-miR-6892-3p	PAR-CLIP	23592263
MIRT492406	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT492405	hsa-miR-4533	PAR-CLIP	23592263
MIRT492404	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT492403	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT492402	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT492400	hsa-miR-4271	PAR-CLIP	23592263
MIRT492401	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT492399	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT492398	hsa-miR-128-1-5p	PAR-CLIP	23592263
MIRT492397	hsa-miR-128-2-5p	PAR-CLIP	23592263
MIRT492396	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT453852	hsa-miR-4476	PAR-CLIP	23592263
MIRT453851	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT453850	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT453849	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT453848	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT453847	hsa-miR-764	PAR-CLIP	23592263
MIRT453846	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT453845	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT453844	hsa-miR-3179	PAR-CLIP	23592263
MIRT453843	hsa-miR-1253	PAR-CLIP	23592263
MIRT453842	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT453841	hsa-miR-3202	PAR-CLIP	23592263
MIRT453840	hsa-miR-3153	PAR-CLIP	23592263
MIRT453839	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT453838	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT453837	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT1331918	hsa-miR-1228	CLIP-seq
MIRT1331919	hsa-miR-1303	CLIP-seq
MIRT1331920	hsa-miR-1324	CLIP-seq
MIRT1331921	hsa-miR-2115	CLIP-seq
MIRT1331922	hsa-miR-2355-3p	CLIP-seq
MIRT1331923	hsa-miR-3124-3p	CLIP-seq
MIRT1331924	hsa-miR-3140-3p	CLIP-seq
MIRT1331925	hsa-miR-3162-3p	CLIP-seq
MIRT1331926	hsa-miR-361-5p	CLIP-seq
MIRT1331927	hsa-miR-3657	CLIP-seq
MIRT1331928	hsa-miR-4428	CLIP-seq
MIRT1331929	hsa-miR-4514	CLIP-seq
MIRT1331930	hsa-miR-4640-5p	CLIP-seq
MIRT1331931	hsa-miR-4646-3p	CLIP-seq
MIRT1331932	hsa-miR-4663	CLIP-seq
MIRT1331933	hsa-miR-4692	CLIP-seq
MIRT1331934	hsa-miR-4726-5p	CLIP-seq
MIRT1331935	hsa-miR-625	CLIP-seq
MIRT1331936	hsa-miR-767-3p	CLIP-seq
MIRT2098083	hsa-miR-1293	CLIP-seq
MIRT2098084	hsa-miR-1343	CLIP-seq
MIRT2098085	hsa-miR-146a	CLIP-seq
MIRT2098086	hsa-miR-146b-5p	CLIP-seq
MIRT2098087	hsa-miR-298	CLIP-seq
MIRT2098088	hsa-miR-3120-3p	CLIP-seq
MIRT2098089	hsa-miR-3150a-3p	CLIP-seq
MIRT2098090	hsa-miR-3157-5p	CLIP-seq
MIRT2098091	hsa-miR-3175	CLIP-seq
MIRT2098092	hsa-miR-326	CLIP-seq
MIRT2098093	hsa-miR-330-5p	CLIP-seq
MIRT2098094	hsa-miR-3942-3p	CLIP-seq
MIRT2098095	hsa-miR-4254	CLIP-seq
MIRT2098096	hsa-miR-4418	CLIP-seq
MIRT2098097	hsa-miR-4483	CLIP-seq
MIRT2098098	hsa-miR-4530	CLIP-seq
MIRT2098099	hsa-miR-503	CLIP-seq
MIRT2098100	hsa-miR-509-3-5p	CLIP-seq
MIRT2098101	hsa-miR-509-5p	CLIP-seq
MIRT2098102	hsa-miR-545	CLIP-seq
MIRT2098103	hsa-miR-589	CLIP-seq
MIRT2098104	hsa-miR-619	CLIP-seq
MIRT2098105	hsa-miR-642b	CLIP-seq
MIRT2098106	hsa-miR-922	CLIP-seq
MIRT2098107	hsa-miR-939	CLIP-seq
MIRT2322808	hsa-miR-124	CLIP-seq
MIRT2098084	hsa-miR-1343	CLIP-seq
MIRT2322809	hsa-miR-15a	CLIP-seq
MIRT2322810	hsa-miR-15b	CLIP-seq
MIRT2322811	hsa-miR-16	CLIP-seq
MIRT2322812	hsa-miR-1909	CLIP-seq
MIRT2322813	hsa-miR-195	CLIP-seq
MIRT2322814	hsa-miR-1976	CLIP-seq
MIRT2098088	hsa-miR-3120-3p	CLIP-seq
MIRT2098094	hsa-miR-3942-3p	CLIP-seq
MIRT2322815	hsa-miR-424	CLIP-seq
MIRT2098095	hsa-miR-4254	CLIP-seq
MIRT2322816	hsa-miR-4419a	CLIP-seq
MIRT2322817	hsa-miR-4459	CLIP-seq
MIRT2322818	hsa-miR-4469	CLIP-seq
MIRT2322819	hsa-miR-4510	CLIP-seq
MIRT2098098	hsa-miR-4530	CLIP-seq
MIRT2322820	hsa-miR-455-3p	CLIP-seq
MIRT2322821	hsa-miR-4779	CLIP-seq
MIRT2322822	hsa-miR-486-3p	CLIP-seq
MIRT2322823	hsa-miR-497	CLIP-seq
MIRT2322824	hsa-miR-506	CLIP-seq
MIRT2322825	hsa-miR-544	CLIP-seq
MIRT2098102	hsa-miR-545	CLIP-seq
MIRT2322826	hsa-miR-548an	CLIP-seq
MIRT2098104	hsa-miR-619	CLIP-seq
MIRT2322827	hsa-miR-642a	CLIP-seq
MIRT2322828	hsa-miR-665	CLIP-seq
MIRT1331922	hsa-miR-2355-3p	CLIP-seq
MIRT2394138	hsa-miR-3909	CLIP-seq
MIRT2322816	hsa-miR-4419a	CLIP-seq
MIRT2322819	hsa-miR-4510	CLIP-seq
MIRT1331931	hsa-miR-4646-3p	CLIP-seq
MIRT2394139	hsa-miR-548aa	CLIP-seq
MIRT2394140	hsa-miR-676	CLIP-seq
MIRT1331918	hsa-miR-1228	CLIP-seq
MIRT2466014	hsa-miR-324-5p	CLIP-seq
MIRT1331932	hsa-miR-4663	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0007416	Process	Synapse assembly	ISS
GO:0010842	Process	Retina layer formation	ISS
GO:0016020	Component	Membrane	IEA
GO:0042802	Function	Identical protein binding	ISS
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0048148	Process	Behavioral response to cocaine	IEA
GO:0060998	Process	Regulation of dendritic spine development	IEA

MIM	HGNC	e!Ensembl
607216	19307	ENSG00000146555

Q7Z5N4

Protein name

Protein sidekick-1

Protein function

Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13927	Ig_3	104 → 173		Domain
PF07679	I-set	192 → 278	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	292 → 365		Domain
PF07679	I-set	386 → 475	Immunoglobulin I-set domain	Domain
PF07679	I-set	480 → 570	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	575 → 650		Domain
PF00041	fn3	669 → 755	Fibronectin type III domain	Domain
PF00041	fn3	770 → 857	Fibronectin type III domain	Domain
PF00041	fn3	871 → 960	Fibronectin type III domain	Domain
PF00041	fn3	973 → 1057	Fibronectin type III domain	Domain
PF00041	fn3	1071 → 1160	Fibronectin type III domain	Domain
PF00041	fn3	1175 → 1264	Fibronectin type III domain	Domain
PF00041	fn3	1278 → 1365	Fibronectin type III domain	Domain
PF00041	fn3	1379 → 1463	Fibronectin type III domain	Domain
PF00041	fn3	1478 → 1565	Fibronectin type III domain	Domain
PF00041	fn3	1580 → 1689	Fibronectin type III domain	Domain
PF00041	fn3	1703 → 1790	Fibronectin type III domain	Domain
PF00041	fn3	1803 → 1889	Fibronectin type III domain	Domain
PF00041	fn3	1904 → 1990	Fibronectin type III domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells (PubMed:1521

Sequence

MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGG
DTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGN
RLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQ
RKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAI
TLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPG
NRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPY
VCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQW
YKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP
VFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI
APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD
PRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA
RLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSN
VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR
TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ
YEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFING
INQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS
TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLT
HTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISN
ISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTP
YTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS
QYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGA
GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD
LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGP
PVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTAT
DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV
PGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG
DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE
LEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAY
NIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIY
YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQA
APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW
QRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTL
QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA
VNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKN
CSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDED
ICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRA
QGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV

Sequence length

2213

Interactions

View interactions

	Reactome
			SDK interactions

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autism spectrum disorder	association	rs779551787	RCV001291322
Cervical cancer	Likely benign	rs76259242	RCV005936670
Cholangiocarcinoma	Benign	rs34775958	RCV005905261
Clear cell carcinoma of kidney	Likely benign	rs76259242	RCV005936671
Colon adenocarcinoma	Likely benign	rs76259242	RCV005936668
Hepatocellular carcinoma	Likely benign	rs76259242	RCV005936669
Lung cancer	Likely benign; Benign	rs76259242, rs34775958	RCV005936673 RCV005905262
Ovarian serous cystadenocarcinoma	Likely benign	rs76259242	RCV005936672
Prostate cancer	Uncertain significance	rs193920905	RCV000149352
Uterine corpus endometrial carcinoma	Likely benign	rs76259242	RCV005936674

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	35441736, 35733175
Adrenocortical Carcinoma	Associate	25490274
Alzheimer Disease	Associate	36928034
Autism Spectrum Disorder	Associate	32807774
Autistic Disorder	Associate	24204716
Bipolar Disorder	Associate	34341362
Cap Myopathy	Associate	23576568
Carcinogenesis	Associate	25490274
Carcinoma Hepatocellular	Associate	28514750
Cardiovascular Diseases	Associate	34895303
Cognition Disorders	Associate	30867049
COVID 19	Associate	35733175
Depressive Disorder Major	Associate	36928034
Fibrosis	Associate	37684433
Marfan Syndrome	Associate	34895303
Neoplasms	Associate	31341365
Technophobia	Associate	33941792

SDK1 (sidekick cell adhesion molecule 1)