FAM171A1 (family with sequence similarity 171 member A1)

Gene

• Entrez ID: 221061
• Gene name: Family with sequence similarity 171 member A1
• Gene symbol: FAM171A1
• Synonyms (NCBI Gene): APCN, C10orf38
• Chromosome: 10
• Chromosome location: 10p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022483	hsa-miR-124-3p	Microarray	18668037
MIRT027016	hsa-miR-103a-3p	Sequencing	20371350
MIRT027931	hsa-miR-96-5p	Sequencing	20371350
MIRT037282	hsa-miR-877-5p	CLASH	23622248
MIRT981948	hsa-miR-139-3p	CLIP-seq
MIRT981949	hsa-miR-2115	CLIP-seq
MIRT981950	hsa-miR-3121-5p	CLIP-seq
MIRT981951	hsa-miR-3124-3p	CLIP-seq
MIRT981952	hsa-miR-3145-3p	CLIP-seq
MIRT981953	hsa-miR-3200-3p	CLIP-seq
MIRT981954	hsa-miR-3672	CLIP-seq
MIRT981955	hsa-miR-3912	CLIP-seq
MIRT981956	hsa-miR-3925-5p	CLIP-seq
MIRT981957	hsa-miR-539	CLIP-seq
MIRT2225159	hsa-miR-1208	CLIP-seq
MIRT2225160	hsa-miR-1267	CLIP-seq
MIRT2225161	hsa-miR-128	CLIP-seq
MIRT2225162	hsa-miR-27a	CLIP-seq
MIRT2225163	hsa-miR-27b	CLIP-seq
MIRT2225164	hsa-miR-3120-5p	CLIP-seq
MIRT2225165	hsa-miR-3159	CLIP-seq
MIRT2225166	hsa-miR-501-5p	CLIP-seq
MIRT2225167	hsa-miR-513a-5p	CLIP-seq
MIRT2225168	hsa-miR-513c	CLIP-seq
MIRT2225169	hsa-miR-514b-5p	CLIP-seq
MIRT2225170	hsa-miR-668	CLIP-seq
MIRT2387755	hsa-miR-1261	CLIP-seq
MIRT2225161	hsa-miR-128	CLIP-seq
MIRT2225162	hsa-miR-27a	CLIP-seq
MIRT2225163	hsa-miR-27b	CLIP-seq
MIRT2225165	hsa-miR-3159	CLIP-seq
MIRT2387756	hsa-miR-3614-5p	CLIP-seq
MIRT2387757	hsa-miR-3689a-5p	CLIP-seq
MIRT2387758	hsa-miR-3689b	CLIP-seq
MIRT2387759	hsa-miR-3689e	CLIP-seq
MIRT2387760	hsa-miR-3689f	CLIP-seq
MIRT2387761	hsa-miR-432	CLIP-seq
MIRT2387762	hsa-miR-4424	CLIP-seq
MIRT2225167	hsa-miR-513a-5p	CLIP-seq
MIRT2225168	hsa-miR-513c	CLIP-seq
MIRT2225169	hsa-miR-514b-5p	CLIP-seq
MIRT2387763	hsa-miR-890	CLIP-seq
MIRT2528663	hsa-miR-103a	CLIP-seq
MIRT2528664	hsa-miR-107	CLIP-seq
MIRT2528665	hsa-miR-183	CLIP-seq
MIRT2387756	hsa-miR-3614-5p	CLIP-seq
MIRT2528666	hsa-miR-4422	CLIP-seq
MIRT2528667	hsa-miR-548p	CLIP-seq
MIRT2528668	hsa-miR-885-3p	CLIP-seq
MIRT2528663	hsa-miR-103a	CLIP-seq
MIRT2528664	hsa-miR-107	CLIP-seq
MIRT2528665	hsa-miR-183	CLIP-seq
MIRT2387756	hsa-miR-3614-5p	CLIP-seq
MIRT2680582	hsa-miR-4311	CLIP-seq
MIRT2528666	hsa-miR-4422	CLIP-seq
MIRT2528667	hsa-miR-548p	CLIP-seq
MIRT2528668	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30312582, 32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	30312582
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IMP	30312582
GO:0016021	Component	Integral component of membrane	IEA
GO:0043149	Process	Stress fiber assembly	IBA	21873635
GO:0043149	Process	Stress fiber assembly	IMP	30312582

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5VUB5
• Protein name: Protein FAM171A1 (Astroprincin) (APCN)
• Protein function: Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10577	UPF0560	34 → 888	Uncharacterised protein family UPF0560	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, brain, liver, skeletal muscle, kidney and pancreas (PubMed:30312582). In brain, expressed by glia, pyramidal neurons and astrocytes (at protein level) (PubMed:30312582). Highly expressed in placental trophoblasts (P
• Sequence:

  MSRSATLLLCLLGCHVWKAVTKTLREPGAGAQEVTLKVHISDASTHQPVADALIEIFTNQ
  ASIASGTSGTDGVAFIKFQYKLGSQLIVTASKHAYVPNSAPWKPIRLPVFSSLSLGLLPE
  RSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDS
  FPYLRGLDGNGTGNSTRHDLTPVTAVSVHLLSSNGTPVLVDGPIYVTVPLATQSSLRHNA
  YVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPIPGPVVTQDITT
  YHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPAGLESSKRDQSTSMS
  HINLLFSRRASEFPGPLSVTSHGRPEAPGTKELMSGVHLEMMSPGGEGDLHTPMLKLSYS
  TSQEFSSREELLSCKEEDKSQISFDNLTPSGTLGKDYHKSVEVFPLKARKSMEREGYESS
  GNDDYRGSYNTVLSQPLFEKQDREGPASTGSKLTIQEHLYPAPSSPEKEQLLDRRPTECM
  MSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQP
  LVVPADQQLEIERLQAELSNPHAGIFPHPSSQIQPQPLSSQAISQQHLQDAGTREWSPQN
  ASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHV
  RHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAP
  DSTAYTQLVYLDDVEQSGSECGTTVCTPEDSALRCLLEGSSRRSGGQLPSLQEETTRRTA
  DAPSEPAASPHQRRSAHEEEEDDDDDDQGEDKKSPWQKREERPLMAFNIK

• Sequence length: 890

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Unknown
Disease term	Disease name	Evidence	References	Source
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	34481452
Neoplasms	Associate	18783612
Neoplasms	Stimulate	34481452
Sarcopenia	Associate	36050999, 36147639
Triple Negative Breast Neoplasms	Associate	31649243