Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	221
Gene name	Aldehyde dehydrogenase 3 family member B1
Gene symbol	ALDH3B1
Synonyms (NCBI Gene)	ALDH4ALDH7
Chromosome	11
Chromosome location	11q13.2
Summary	This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT451839	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT451838	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT451837	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT451836	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT451835	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT451834	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT451833	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT451832	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451831	hsa-miR-4468	PAR-CLIP	23592263
MIRT451830	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT451829	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT451828	hsa-miR-107	PAR-CLIP	23592263
MIRT451827	hsa-miR-6077	PAR-CLIP	23592263
MIRT451826	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT451825	hsa-miR-1255a	PAR-CLIP	23592263
MIRT451824	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT451823	hsa-miR-4271	PAR-CLIP	23592263
MIRT451822	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451821	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451820	hsa-miR-2110	PAR-CLIP	23592263
MIRT451839	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT451838	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT451837	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT451836	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT451835	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT451834	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT451833	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT451832	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451831	hsa-miR-4468	PAR-CLIP	23592263
MIRT451830	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT451829	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT451828	hsa-miR-107	PAR-CLIP	23592263
MIRT451827	hsa-miR-6077	PAR-CLIP	23592263
MIRT451826	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT451825	hsa-miR-1255a	PAR-CLIP	23592263
MIRT451824	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT451823	hsa-miR-4271	PAR-CLIP	23592263
MIRT451822	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451821	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451820	hsa-miR-2110	PAR-CLIP	23592263
MIRT777292	hsa-miR-1193	CLIP-seq
MIRT777293	hsa-miR-1207-5p	CLIP-seq
MIRT777294	hsa-miR-1238	CLIP-seq
MIRT777295	hsa-miR-182	CLIP-seq
MIRT777296	hsa-miR-1909	CLIP-seq
MIRT777297	hsa-miR-3681	CLIP-seq
MIRT777298	hsa-miR-3691-5p	CLIP-seq
MIRT777299	hsa-miR-4466	CLIP-seq
MIRT777300	hsa-miR-4481	CLIP-seq
MIRT777301	hsa-miR-4691-5p	CLIP-seq
MIRT777302	hsa-miR-4706	CLIP-seq
MIRT777303	hsa-miR-4745-5p	CLIP-seq
MIRT777304	hsa-miR-4749-5p	CLIP-seq
MIRT777305	hsa-miR-4758-5p	CLIP-seq
MIRT777306	hsa-miR-4763-3p	CLIP-seq
MIRT777307	hsa-miR-4793-3p	CLIP-seq
MIRT777308	hsa-miR-486-3p	CLIP-seq
MIRT777309	hsa-miR-500a	CLIP-seq
MIRT777310	hsa-miR-501-5p	CLIP-seq
MIRT777311	hsa-miR-647	CLIP-seq
MIRT777312	hsa-miR-675	CLIP-seq
MIRT777313	hsa-miR-744	CLIP-seq
MIRT777314	hsa-miR-216a	CLIP-seq
MIRT777315	hsa-miR-4722-5p	CLIP-seq
MIRT777316	hsa-miR-548al	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT1929516	hsa-miR-4694-3p	CLIP-seq
MIRT1929517	hsa-miR-4724-5p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT1929521	hsa-miR-5095	CLIP-seq
MIRT1929522	hsa-miR-552	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2170182	hsa-miR-106a	CLIP-seq
MIRT2170183	hsa-miR-106b	CLIP-seq
MIRT2170184	hsa-miR-1200	CLIP-seq
MIRT2170185	hsa-miR-17	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170187	hsa-miR-20a	CLIP-seq
MIRT2170188	hsa-miR-20b	CLIP-seq
MIRT777314	hsa-miR-216a	CLIP-seq
MIRT2170189	hsa-miR-302a	CLIP-seq
MIRT2170190	hsa-miR-302b	CLIP-seq
MIRT2170191	hsa-miR-302c	CLIP-seq
MIRT2170192	hsa-miR-302d	CLIP-seq
MIRT2170193	hsa-miR-302e	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT2170194	hsa-miR-372	CLIP-seq
MIRT2170195	hsa-miR-373	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT2170196	hsa-miR-411	CLIP-seq
MIRT2170197	hsa-miR-4276	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2170199	hsa-miR-4324	CLIP-seq
MIRT2170200	hsa-miR-4438	CLIP-seq
MIRT2170201	hsa-miR-4537	CLIP-seq
MIRT2170202	hsa-miR-4716-5p	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT2170204	hsa-miR-4731-5p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT2170205	hsa-miR-4743	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT2170206	hsa-miR-4787-3p	CLIP-seq
MIRT2170207	hsa-miR-483-5p	CLIP-seq
MIRT2170208	hsa-miR-498	CLIP-seq
MIRT1929521	hsa-miR-5095	CLIP-seq
MIRT2170209	hsa-miR-512-3p	CLIP-seq
MIRT2170210	hsa-miR-519d	CLIP-seq
MIRT2170211	hsa-miR-520a-3p	CLIP-seq
MIRT2170212	hsa-miR-520b	CLIP-seq
MIRT2170213	hsa-miR-520c-3p	CLIP-seq
MIRT2170214	hsa-miR-520d-3p	CLIP-seq
MIRT2170215	hsa-miR-520e	CLIP-seq
MIRT2170216	hsa-miR-520g	CLIP-seq
MIRT2170217	hsa-miR-520h	CLIP-seq
MIRT2170218	hsa-miR-544b	CLIP-seq
MIRT777316	hsa-miR-548al	CLIP-seq
MIRT1929522	hsa-miR-552	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2170219	hsa-miR-93	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2384068	hsa-miR-4532	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT2170208	hsa-miR-498	CLIP-seq
MIRT2170182	hsa-miR-106a	CLIP-seq
MIRT2170183	hsa-miR-106b	CLIP-seq
MIRT2170184	hsa-miR-1200	CLIP-seq
MIRT2473062	hsa-miR-1234	CLIP-seq
MIRT2473063	hsa-miR-125a-3p	CLIP-seq
MIRT2473064	hsa-miR-150	CLIP-seq
MIRT2170185	hsa-miR-17	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170187	hsa-miR-20a	CLIP-seq
MIRT2170188	hsa-miR-20b	CLIP-seq
MIRT2170189	hsa-miR-302a	CLIP-seq
MIRT2170190	hsa-miR-302b	CLIP-seq
MIRT2170191	hsa-miR-302c	CLIP-seq
MIRT2170192	hsa-miR-302d	CLIP-seq
MIRT2170193	hsa-miR-302e	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT2170194	hsa-miR-372	CLIP-seq
MIRT2170195	hsa-miR-373	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT2170196	hsa-miR-411	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2170199	hsa-miR-4324	CLIP-seq
MIRT2473065	hsa-miR-4454	CLIP-seq
MIRT2384068	hsa-miR-4532	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT2473066	hsa-miR-4763-5p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT2170208	hsa-miR-498	CLIP-seq
MIRT2170209	hsa-miR-512-3p	CLIP-seq
MIRT2170210	hsa-miR-519d	CLIP-seq
MIRT2170211	hsa-miR-520a-3p	CLIP-seq
MIRT2170212	hsa-miR-520b	CLIP-seq
MIRT2170213	hsa-miR-520c-3p	CLIP-seq
MIRT2170214	hsa-miR-520d-3p	CLIP-seq
MIRT2170215	hsa-miR-520e	CLIP-seq
MIRT2170216	hsa-miR-520g	CLIP-seq
MIRT2170217	hsa-miR-520h	CLIP-seq
MIRT2170218	hsa-miR-544b	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2473067	hsa-miR-764	CLIP-seq
MIRT2170219	hsa-miR-93	CLIP-seq
MIRT2170182	hsa-miR-106a	CLIP-seq
MIRT2170183	hsa-miR-106b	CLIP-seq
MIRT2170184	hsa-miR-1200	CLIP-seq
MIRT2473062	hsa-miR-1234	CLIP-seq
MIRT2473063	hsa-miR-125a-3p	CLIP-seq
MIRT2473064	hsa-miR-150	CLIP-seq
MIRT2170185	hsa-miR-17	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170187	hsa-miR-20a	CLIP-seq
MIRT2170188	hsa-miR-20b	CLIP-seq
MIRT2170189	hsa-miR-302a	CLIP-seq
MIRT2170190	hsa-miR-302b	CLIP-seq
MIRT2170191	hsa-miR-302c	CLIP-seq
MIRT2170192	hsa-miR-302d	CLIP-seq
MIRT2170193	hsa-miR-302e	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT2170194	hsa-miR-372	CLIP-seq
MIRT2170195	hsa-miR-373	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2170199	hsa-miR-4324	CLIP-seq
MIRT2473065	hsa-miR-4454	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT2473066	hsa-miR-4763-5p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT2170209	hsa-miR-512-3p	CLIP-seq
MIRT2170210	hsa-miR-519d	CLIP-seq
MIRT2170211	hsa-miR-520a-3p	CLIP-seq
MIRT2170212	hsa-miR-520b	CLIP-seq
MIRT2170213	hsa-miR-520c-3p	CLIP-seq
MIRT2170214	hsa-miR-520d-3p	CLIP-seq
MIRT2170215	hsa-miR-520e	CLIP-seq
MIRT2170216	hsa-miR-520g	CLIP-seq
MIRT2170217	hsa-miR-520h	CLIP-seq
MIRT2170218	hsa-miR-544b	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2473067	hsa-miR-764	CLIP-seq
MIRT2170219	hsa-miR-93	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004028	Function	3-chloroallyl aldehyde dehydrogenase activity	IBA
GO:0004028	Function	3-chloroallyl aldehyde dehydrogenase activity	TAS	7828891
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IBA
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IEA
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	IDA	20699116
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	IEA
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	20699116
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006066	Process	Alcohol metabolic process	TAS	7828891
GO:0006068	Process	Ethanol catabolic process	IEA
GO:0006081	Process	Aldehyde metabolic process	IBA
GO:0006081	Process	Aldehyde metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	TAS	7828891
GO:0006979	Process	Response to oxidative stress	IDA	20699116
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA
GO:0018477	Function	Benzaldehyde dehydrogenase (NADP+) activity	IEA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IEA
GO:0030149	Process	Sphingolipid catabolic process	TAS
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031982	Component	Vesicle	HDA	19190083
GO:0033721	Function	Aldehyde dehydrogenase (NADP+) activity	IEA
GO:0034599	Process	Cellular response to oxidative stress	IDA	20699116
GO:0035579	Component	Specific granule membrane	TAS
GO:0046185	Process	Aldehyde catabolic process	IDA	20699116
GO:0050061	Function	Long-chain fatty aldehyde dehydrogenase (NAD+) activity	IEA
GO:0052814	Function	Medium-chain fatty aldehyde dehydrogenase (NAD+) activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
600466	410	ENSG00000006534

P43353

Protein name

Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.28) (EC 1.2.1.5) (EC 1.2.1.7) (Aldehyde dehydrogenase 7) (Long-chain fatty aldehyde dehydrogenase) (EC 1.2.1.48) (Medium-chain fatty aldehyde dehydrogenase)

Protein function

Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxid

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00171	Aldedh	5 → 428	Aldehyde dehydrogenase family	Family

Tissue specificity

TISSUE SPECIFICITY: Highest expression in kidney and lung.

Sequence

MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

Sequence length

468

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Histidine metabolism Tyrosine metabolism Phenylalanine metabolism beta-Alanine metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation

ALDH3B1 (aldehyde dehydrogenase 3 family member B1)