DOK6 (docking protein 6)

Gene

• Entrez ID: 220164
• Gene name: Docking protein 6
• Gene symbol: DOK6
• Synonyms (NCBI Gene): DOK5L, HsT3226
• Chromosome: 18
• Chromosome location: 18q22.2
• Summary: DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018286	hsa-miR-335-5p	Microarray	18185580
MIRT023914	hsa-miR-1-3p	Microarray	18668037
MIRT721835	hsa-miR-410-3p	HITS-CLIP	19536157
MIRT721834	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT721833	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT721832	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT658947	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT658946	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT658945	hsa-miR-3161	HITS-CLIP	23824327
MIRT658944	hsa-miR-653-5p	HITS-CLIP	23824327
MIRT658943	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT658942	hsa-miR-578	HITS-CLIP	23824327
MIRT658941	hsa-miR-599	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT721835	hsa-miR-410-3p	HITS-CLIP	19536157
MIRT721834	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT721833	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT721832	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT658947	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT658946	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT658945	hsa-miR-3161	HITS-CLIP	23824327
MIRT658944	hsa-miR-653-5p	HITS-CLIP	23824327
MIRT658943	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT658942	hsa-miR-578	HITS-CLIP	23824327
MIRT658941	hsa-miR-599	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT943143	hsa-miR-105	CLIP-seq
MIRT943144	hsa-miR-10a	CLIP-seq
MIRT943145	hsa-miR-10b	CLIP-seq
MIRT943146	hsa-miR-1237	CLIP-seq
MIRT943147	hsa-miR-1248	CLIP-seq
MIRT943148	hsa-miR-1253	CLIP-seq
MIRT943149	hsa-miR-145	CLIP-seq
MIRT943150	hsa-miR-188-5p	CLIP-seq
MIRT943151	hsa-miR-1914	CLIP-seq
MIRT943152	hsa-miR-19a	CLIP-seq
MIRT943153	hsa-miR-19b	CLIP-seq
MIRT943154	hsa-miR-203	CLIP-seq
MIRT943155	hsa-miR-2053	CLIP-seq
MIRT943156	hsa-miR-219-2-3p	CLIP-seq
MIRT943157	hsa-miR-2276	CLIP-seq
MIRT943158	hsa-miR-23a	CLIP-seq
MIRT943159	hsa-miR-23b	CLIP-seq
MIRT943160	hsa-miR-23c	CLIP-seq
MIRT943161	hsa-miR-2467-5p	CLIP-seq
MIRT943162	hsa-miR-3120-3p	CLIP-seq
MIRT943163	hsa-miR-3123	CLIP-seq
MIRT943164	hsa-miR-3129-3p	CLIP-seq
MIRT943165	hsa-miR-3143	CLIP-seq
MIRT943166	hsa-miR-3148	CLIP-seq
MIRT943167	hsa-miR-3152-5p	CLIP-seq
MIRT943168	hsa-miR-3164	CLIP-seq
MIRT943169	hsa-miR-3173-5p	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943171	hsa-miR-339-5p	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT943173	hsa-miR-3671	CLIP-seq
MIRT943174	hsa-miR-382	CLIP-seq
MIRT943175	hsa-miR-3919	CLIP-seq
MIRT943176	hsa-miR-3924	CLIP-seq
MIRT943177	hsa-miR-3925-3p	CLIP-seq
MIRT943178	hsa-miR-3925-5p	CLIP-seq
MIRT943179	hsa-miR-3976	CLIP-seq
MIRT943180	hsa-miR-4252	CLIP-seq
MIRT943181	hsa-miR-4284	CLIP-seq
MIRT943182	hsa-miR-4327	CLIP-seq
MIRT943183	hsa-miR-4328	CLIP-seq
MIRT943184	hsa-miR-4521	CLIP-seq
MIRT943185	hsa-miR-4524	CLIP-seq
MIRT943186	hsa-miR-4659a-5p	CLIP-seq
MIRT943187	hsa-miR-4659b-5p	CLIP-seq
MIRT943188	hsa-miR-4662a-5p	CLIP-seq
MIRT943189	hsa-miR-4668-5p	CLIP-seq
MIRT943190	hsa-miR-4678	CLIP-seq
MIRT943191	hsa-miR-4699-3p	CLIP-seq
MIRT943192	hsa-miR-4708-3p	CLIP-seq
MIRT943193	hsa-miR-4717-3p	CLIP-seq
MIRT943194	hsa-miR-4725-5p	CLIP-seq
MIRT943195	hsa-miR-4774-3p	CLIP-seq
MIRT943196	hsa-miR-504	CLIP-seq
MIRT943197	hsa-miR-508-5p	CLIP-seq
MIRT943198	hsa-miR-539	CLIP-seq
MIRT943199	hsa-miR-543	CLIP-seq
MIRT943200	hsa-miR-548c-3p	CLIP-seq
MIRT943201	hsa-miR-548k	CLIP-seq
MIRT943202	hsa-miR-569	CLIP-seq
MIRT943203	hsa-miR-633	CLIP-seq
MIRT943204	hsa-miR-654-3p	CLIP-seq
MIRT943205	hsa-miR-802	CLIP-seq
MIRT943206	hsa-miR-889	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT1979263	hsa-miR-1207-3p	CLIP-seq
MIRT1979264	hsa-miR-1245b-3p	CLIP-seq
MIRT1979265	hsa-miR-1270	CLIP-seq
MIRT943155	hsa-miR-2053	CLIP-seq
MIRT1979266	hsa-miR-219-5p	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT1979267	hsa-miR-4268	CLIP-seq
MIRT1979268	hsa-miR-4299	CLIP-seq
MIRT1979269	hsa-miR-4330	CLIP-seq
MIRT1979270	hsa-miR-4421	CLIP-seq
MIRT1979271	hsa-miR-4445	CLIP-seq
MIRT1979272	hsa-miR-4448	CLIP-seq
MIRT1979273	hsa-miR-4464	CLIP-seq
MIRT1979274	hsa-miR-4494	CLIP-seq
MIRT1979275	hsa-miR-4531	CLIP-seq
MIRT1979276	hsa-miR-4686	CLIP-seq
MIRT1979277	hsa-miR-4748	CLIP-seq
MIRT1979278	hsa-miR-4762-3p	CLIP-seq
MIRT1979279	hsa-miR-4765	CLIP-seq
MIRT1979280	hsa-miR-4782-3p	CLIP-seq
MIRT1979281	hsa-miR-508-3p	CLIP-seq
MIRT1979282	hsa-miR-620	CLIP-seq
MIRT1979283	hsa-miR-767-3p	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT1979264	hsa-miR-1245b-3p	CLIP-seq
MIRT2214469	hsa-miR-129-5p	CLIP-seq
MIRT2214470	hsa-miR-1301	CLIP-seq
MIRT2214471	hsa-miR-1304	CLIP-seq
MIRT2214472	hsa-miR-3153	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT2214473	hsa-miR-369-3p	CLIP-seq
MIRT2214474	hsa-miR-374a	CLIP-seq
MIRT2214475	hsa-miR-374b	CLIP-seq
MIRT2214476	hsa-miR-375	CLIP-seq
MIRT2214477	hsa-miR-3914	CLIP-seq
MIRT943180	hsa-miR-4252	CLIP-seq
MIRT2214478	hsa-miR-4261	CLIP-seq
MIRT2214479	hsa-miR-450b-5p	CLIP-seq
MIRT2214480	hsa-miR-4646-5p	CLIP-seq
MIRT943188	hsa-miR-4662a-5p	CLIP-seq
MIRT943189	hsa-miR-4668-5p	CLIP-seq
MIRT2214481	hsa-miR-4691-3p	CLIP-seq
MIRT2214482	hsa-miR-4795-3p	CLIP-seq
MIRT2214483	hsa-miR-494	CLIP-seq
MIRT2214484	hsa-miR-5047	CLIP-seq
MIRT2214485	hsa-miR-507	CLIP-seq
MIRT2214486	hsa-miR-522	CLIP-seq
MIRT2214487	hsa-miR-555	CLIP-seq
MIRT2214488	hsa-miR-557	CLIP-seq
MIRT2214489	hsa-miR-589	CLIP-seq
MIRT2214490	hsa-miR-590-3p	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT2214491	hsa-miR-944	CLIP-seq
MIRT1979266	hsa-miR-219-5p	CLIP-seq
MIRT2387082	hsa-miR-3117-3p	CLIP-seq
MIRT2387083	hsa-miR-3169	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT943180	hsa-miR-4252	CLIP-seq
MIRT1979267	hsa-miR-4268	CLIP-seq
MIRT1979271	hsa-miR-4445	CLIP-seq
MIRT1979272	hsa-miR-4448	CLIP-seq
MIRT943188	hsa-miR-4662a-5p	CLIP-seq
MIRT1979276	hsa-miR-4686	CLIP-seq
MIRT2387084	hsa-miR-4759	CLIP-seq
MIRT1979280	hsa-miR-4782-3p	CLIP-seq
MIRT1979281	hsa-miR-508-3p	CLIP-seq
MIRT2387085	hsa-miR-592	CLIP-seq
MIRT2387086	hsa-miR-597	CLIP-seq
MIRT1979283	hsa-miR-767-3p	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT2518717	hsa-miR-624	CLIP-seq
MIRT2518718	hsa-miR-629	CLIP-seq
MIRT2518717	hsa-miR-624	CLIP-seq
MIRT2518718	hsa-miR-629	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 20565848, 25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA

Other IDs

• MIM: 611402
• HGNC: 28301
• e!Ensembl: ENSG00000206052

Protein

• UniProt ID: Q6PKX4
• Protein name: Docking protein 6 (Downstream of tyrosine kinase 6)
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02174	IRS	135 → 232	PTB domain (IRS-1 type)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. {ECO:0000269|PubMed:15286081}.
• Sequence:

  MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVT
  ELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDIS
  LGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWP
  LSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLE
  MEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTF
  PSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ

• Sequence length: 331

Pathways

Reactome:

RET signaling