Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	220164
Gene name Gene Name - the full gene name approved by the HGNC.	Docking protein 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DOK6
Synonyms (NCBI Gene) Gene synonyms aliases	DOK5L, HsT3226
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

Show/Hide all(242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018286	hsa-miR-335-5p	Microarray	18185580
MIRT023914	hsa-miR-1-3p	Microarray	18668037
MIRT721835	hsa-miR-410-3p	HITS-CLIP	19536157
MIRT721834	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT721833	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT721832	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT658947	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT658946	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT658945	hsa-miR-3161	HITS-CLIP	23824327
MIRT658944	hsa-miR-653-5p	HITS-CLIP	23824327
MIRT658943	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT658942	hsa-miR-578	HITS-CLIP	23824327
MIRT658941	hsa-miR-599	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT721835	hsa-miR-410-3p	HITS-CLIP	19536157
MIRT721834	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT721833	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT721832	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT658947	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT658946	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT658945	hsa-miR-3161	HITS-CLIP	23824327
MIRT658944	hsa-miR-653-5p	HITS-CLIP	23824327
MIRT658943	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT658942	hsa-miR-578	HITS-CLIP	23824327
MIRT658941	hsa-miR-599	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT638801	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT638800	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT638799	hsa-miR-603	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT638798	hsa-miR-3941	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT628263	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT610148	hsa-miR-8485	HITS-CLIP	23824327
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT508909	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT508909	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT508910	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT508908	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT508909	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT943143	hsa-miR-105	CLIP-seq
MIRT943144	hsa-miR-10a	CLIP-seq
MIRT943145	hsa-miR-10b	CLIP-seq
MIRT943146	hsa-miR-1237	CLIP-seq
MIRT943147	hsa-miR-1248	CLIP-seq
MIRT943148	hsa-miR-1253	CLIP-seq
MIRT943149	hsa-miR-145	CLIP-seq
MIRT943150	hsa-miR-188-5p	CLIP-seq
MIRT943151	hsa-miR-1914	CLIP-seq
MIRT943152	hsa-miR-19a	CLIP-seq
MIRT943153	hsa-miR-19b	CLIP-seq
MIRT943154	hsa-miR-203	CLIP-seq
MIRT943155	hsa-miR-2053	CLIP-seq
MIRT943156	hsa-miR-219-2-3p	CLIP-seq
MIRT943157	hsa-miR-2276	CLIP-seq
MIRT943158	hsa-miR-23a	CLIP-seq
MIRT943159	hsa-miR-23b	CLIP-seq
MIRT943160	hsa-miR-23c	CLIP-seq
MIRT943161	hsa-miR-2467-5p	CLIP-seq
MIRT943162	hsa-miR-3120-3p	CLIP-seq
MIRT943163	hsa-miR-3123	CLIP-seq
MIRT943164	hsa-miR-3129-3p	CLIP-seq
MIRT943165	hsa-miR-3143	CLIP-seq
MIRT943166	hsa-miR-3148	CLIP-seq
MIRT943167	hsa-miR-3152-5p	CLIP-seq
MIRT943168	hsa-miR-3164	CLIP-seq
MIRT943169	hsa-miR-3173-5p	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943171	hsa-miR-339-5p	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT943173	hsa-miR-3671	CLIP-seq
MIRT943174	hsa-miR-382	CLIP-seq
MIRT943175	hsa-miR-3919	CLIP-seq
MIRT943176	hsa-miR-3924	CLIP-seq
MIRT943177	hsa-miR-3925-3p	CLIP-seq
MIRT943178	hsa-miR-3925-5p	CLIP-seq
MIRT943179	hsa-miR-3976	CLIP-seq
MIRT943180	hsa-miR-4252	CLIP-seq
MIRT943181	hsa-miR-4284	CLIP-seq
MIRT943182	hsa-miR-4327	CLIP-seq
MIRT943183	hsa-miR-4328	CLIP-seq
MIRT943184	hsa-miR-4521	CLIP-seq
MIRT943185	hsa-miR-4524	CLIP-seq
MIRT943186	hsa-miR-4659a-5p	CLIP-seq
MIRT943187	hsa-miR-4659b-5p	CLIP-seq
MIRT943188	hsa-miR-4662a-5p	CLIP-seq
MIRT943189	hsa-miR-4668-5p	CLIP-seq
MIRT943190	hsa-miR-4678	CLIP-seq
MIRT943191	hsa-miR-4699-3p	CLIP-seq
MIRT943192	hsa-miR-4708-3p	CLIP-seq
MIRT943193	hsa-miR-4717-3p	CLIP-seq
MIRT943194	hsa-miR-4725-5p	CLIP-seq
MIRT943195	hsa-miR-4774-3p	CLIP-seq
MIRT943196	hsa-miR-504	CLIP-seq
MIRT943197	hsa-miR-508-5p	CLIP-seq
MIRT943198	hsa-miR-539	CLIP-seq
MIRT943199	hsa-miR-543	CLIP-seq
MIRT943200	hsa-miR-548c-3p	CLIP-seq
MIRT943201	hsa-miR-548k	CLIP-seq
MIRT943202	hsa-miR-569	CLIP-seq
MIRT943203	hsa-miR-633	CLIP-seq
MIRT943204	hsa-miR-654-3p	CLIP-seq
MIRT943205	hsa-miR-802	CLIP-seq
MIRT943206	hsa-miR-889	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT1979263	hsa-miR-1207-3p	CLIP-seq
MIRT1979264	hsa-miR-1245b-3p	CLIP-seq
MIRT1979265	hsa-miR-1270	CLIP-seq
MIRT943155	hsa-miR-2053	CLIP-seq
MIRT1979266	hsa-miR-219-5p	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT1979267	hsa-miR-4268	CLIP-seq
MIRT1979268	hsa-miR-4299	CLIP-seq
MIRT1979269	hsa-miR-4330	CLIP-seq
MIRT1979270	hsa-miR-4421	CLIP-seq
MIRT1979271	hsa-miR-4445	CLIP-seq
MIRT1979272	hsa-miR-4448	CLIP-seq
MIRT1979273	hsa-miR-4464	CLIP-seq
MIRT1979274	hsa-miR-4494	CLIP-seq
MIRT1979275	hsa-miR-4531	CLIP-seq
MIRT1979276	hsa-miR-4686	CLIP-seq
MIRT1979277	hsa-miR-4748	CLIP-seq
MIRT1979278	hsa-miR-4762-3p	CLIP-seq
MIRT1979279	hsa-miR-4765	CLIP-seq
MIRT1979280	hsa-miR-4782-3p	CLIP-seq
MIRT1979281	hsa-miR-508-3p	CLIP-seq
MIRT1979282	hsa-miR-620	CLIP-seq
MIRT1979283	hsa-miR-767-3p	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT1979264	hsa-miR-1245b-3p	CLIP-seq
MIRT2214469	hsa-miR-129-5p	CLIP-seq
MIRT2214470	hsa-miR-1301	CLIP-seq
MIRT2214471	hsa-miR-1304	CLIP-seq
MIRT2214472	hsa-miR-3153	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT2214473	hsa-miR-369-3p	CLIP-seq
MIRT2214474	hsa-miR-374a	CLIP-seq
MIRT2214475	hsa-miR-374b	CLIP-seq
MIRT2214476	hsa-miR-375	CLIP-seq
MIRT2214477	hsa-miR-3914	CLIP-seq
MIRT943180	hsa-miR-4252	CLIP-seq
MIRT2214478	hsa-miR-4261	CLIP-seq
MIRT2214479	hsa-miR-450b-5p	CLIP-seq
MIRT2214480	hsa-miR-4646-5p	CLIP-seq
MIRT943188	hsa-miR-4662a-5p	CLIP-seq
MIRT943189	hsa-miR-4668-5p	CLIP-seq
MIRT2214481	hsa-miR-4691-3p	CLIP-seq
MIRT2214482	hsa-miR-4795-3p	CLIP-seq
MIRT2214483	hsa-miR-494	CLIP-seq
MIRT2214484	hsa-miR-5047	CLIP-seq
MIRT2214485	hsa-miR-507	CLIP-seq
MIRT2214486	hsa-miR-522	CLIP-seq
MIRT2214487	hsa-miR-555	CLIP-seq
MIRT2214488	hsa-miR-557	CLIP-seq
MIRT2214489	hsa-miR-589	CLIP-seq
MIRT2214490	hsa-miR-590-3p	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT2214491	hsa-miR-944	CLIP-seq
MIRT1979266	hsa-miR-219-5p	CLIP-seq
MIRT2387082	hsa-miR-3117-3p	CLIP-seq
MIRT2387083	hsa-miR-3169	CLIP-seq
MIRT943170	hsa-miR-329	CLIP-seq
MIRT943172	hsa-miR-3618	CLIP-seq
MIRT943180	hsa-miR-4252	CLIP-seq
MIRT1979267	hsa-miR-4268	CLIP-seq
MIRT1979271	hsa-miR-4445	CLIP-seq
MIRT1979272	hsa-miR-4448	CLIP-seq
MIRT943188	hsa-miR-4662a-5p	CLIP-seq
MIRT1979276	hsa-miR-4686	CLIP-seq
MIRT2387084	hsa-miR-4759	CLIP-seq
MIRT1979280	hsa-miR-4782-3p	CLIP-seq
MIRT1979281	hsa-miR-508-3p	CLIP-seq
MIRT2387085	hsa-miR-592	CLIP-seq
MIRT2387086	hsa-miR-597	CLIP-seq
MIRT1979283	hsa-miR-767-3p	CLIP-seq
MIRT943207	hsa-miR-934	CLIP-seq
MIRT2518717	hsa-miR-624	CLIP-seq
MIRT2518718	hsa-miR-629	CLIP-seq
MIRT2518717	hsa-miR-624	CLIP-seq
MIRT2518718	hsa-miR-629	CLIP-seq

Show/Hide all(3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 20565848, 25416956, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0007411	Process	Axon guidance	TAS

MIM	HGNC	e!Ensembl
611402	28301	ENSG00000206052

Protein

UniProt ID

Q6PKX4

Protein name

Docking protein 6 (Downstream of tyrosine kinase 6)

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02174	IRS	135 → 232	PTB domain (IRS-1 type)	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. {ECO:0000269|PubMed:15286081}.

Sequence

MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVT
ELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDIS
LGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWP
LSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLE
MEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTF
PSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ

Sequence length

331

Interactions

View interactions

	Reactome
			RET signaling

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	21931561
Osteoporosis	Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	20548944

Show/Hide Unknown Diseases (5)

Disease term	Disease name	Evidence	Source
Unknown
Myocardial Infarction	Myocardial Infarction		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Dementia	Dementia		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Ischemic Stroke	Ischemic Stroke		GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	31486300
Hirschsprung Disease	Associate	34545688
Leukemia Myeloid Acute	Associate	31486300
Leukemia Promyelocytic Acute	Associate	31486300
Stomach Neoplasms	Associate	31486300

DOK6 (docking protein 6)