Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	219931
Gene name Gene Name - the full gene name approved by the HGNC.	Two pore segment channel 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TPCN2
Synonyms (NCBI Gene) Gene synonyms aliases	SHEP10, TPC2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lyso

Show/Hide all(287)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022968	hsa-miR-124-3p	Microarray	18668037
MIRT719062	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT719061	hsa-miR-6086	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT719062	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT719061	hsa-miR-6086	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT714663	hsa-miR-3529-3p	HITS-CLIP	19536157
MIRT714662	hsa-miR-603	HITS-CLIP	19536157
MIRT714661	hsa-miR-549a	HITS-CLIP	19536157
MIRT714660	hsa-miR-4504	HITS-CLIP	19536157
MIRT714659	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT664480	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT648611	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648610	hsa-miR-4532	HITS-CLIP	23824327
MIRT675446	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT675445	hsa-miR-1976	HITS-CLIP	23824327
MIRT648605	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT675444	hsa-miR-4279	HITS-CLIP	23824327
MIRT664480	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT648613	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT648611	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648610	hsa-miR-4532	HITS-CLIP	23824327
MIRT648609	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT648608	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT648607	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT648606	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT648605	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT648604	hsa-miR-4284	HITS-CLIP	23824327
MIRT648613	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT648611	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648610	hsa-miR-4532	HITS-CLIP	23824327
MIRT648609	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT648608	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT648607	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT648606	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT648605	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT648604	hsa-miR-4284	HITS-CLIP	23824327
MIRT571334	hsa-miR-6871-5p	PAR-CLIP	20371350
MIRT571333	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT571332	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT571330	hsa-miR-4481	PAR-CLIP	20371350
MIRT571331	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT571329	hsa-miR-34a-5p	PAR-CLIP	20371350
MIRT571328	hsa-miR-34c-5p	PAR-CLIP	20371350
MIRT571327	hsa-miR-449a	PAR-CLIP	20371350
MIRT571326	hsa-miR-449b-5p	PAR-CLIP	20371350
MIRT571325	hsa-miR-548au-3p	PAR-CLIP	20371350
MIRT571324	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT571323	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT571322	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT571321	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT571320	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT571319	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT571318	hsa-miR-363-5p	PAR-CLIP	20371350
MIRT571317	hsa-miR-6745	PAR-CLIP	20371350
MIRT571315	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT571316	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT571314	hsa-miR-1293	PAR-CLIP	20371350
MIRT571313	hsa-miR-4483	PAR-CLIP	20371350
MIRT571312	hsa-miR-6748-5p	PAR-CLIP	20371350
MIRT571311	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT571310	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT571309	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT571308	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT571307	hsa-miR-3689c	PAR-CLIP	20371350
MIRT571306	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT571305	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT571304	hsa-miR-6127	PAR-CLIP	20371350
MIRT447287	hsa-miR-3163	PAR-CLIP	22100165
MIRT719062	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT719061	hsa-miR-6086	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT719062	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT719061	hsa-miR-6086	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT714663	hsa-miR-3529-3p	HITS-CLIP	19536157
MIRT714662	hsa-miR-603	HITS-CLIP	19536157
MIRT714661	hsa-miR-549a	HITS-CLIP	19536157
MIRT714660	hsa-miR-4504	HITS-CLIP	19536157
MIRT714659	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT711260	hsa-miR-3689a-5p	HITS-CLIP	19536157
MIRT711259	hsa-miR-3689b-5p	HITS-CLIP	19536157
MIRT711258	hsa-miR-3689e	HITS-CLIP	19536157
MIRT711257	hsa-miR-3689f	HITS-CLIP	19536157
MIRT711256	hsa-miR-3161	HITS-CLIP	19536157
MIRT711255	hsa-miR-8070	HITS-CLIP	19536157
MIRT664480	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT648611	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648610	hsa-miR-4532	HITS-CLIP	23824327
MIRT675446	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT675445	hsa-miR-1976	HITS-CLIP	23824327
MIRT648605	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT675444	hsa-miR-4279	HITS-CLIP	23824327
MIRT664480	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT648613	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT648611	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648610	hsa-miR-4532	HITS-CLIP	23824327
MIRT648609	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT648608	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT648607	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT648606	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT648605	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT648604	hsa-miR-4284	HITS-CLIP	23824327
MIRT648613	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT648611	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT648610	hsa-miR-4532	HITS-CLIP	23824327
MIRT648609	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT648608	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT648607	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT648606	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT648605	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT648604	hsa-miR-4284	HITS-CLIP	23824327
MIRT571334	hsa-miR-6871-5p	PAR-CLIP	20371350
MIRT571333	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT571332	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT571330	hsa-miR-4481	PAR-CLIP	20371350
MIRT571331	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT571329	hsa-miR-34a-5p	PAR-CLIP	20371350
MIRT571328	hsa-miR-34c-5p	PAR-CLIP	20371350
MIRT571327	hsa-miR-449a	PAR-CLIP	20371350
MIRT571326	hsa-miR-449b-5p	PAR-CLIP	20371350
MIRT571325	hsa-miR-548au-3p	PAR-CLIP	20371350
MIRT571324	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT571323	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT571322	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT571321	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT571320	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT571319	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT571318	hsa-miR-363-5p	PAR-CLIP	20371350
MIRT571317	hsa-miR-6745	PAR-CLIP	20371350
MIRT571315	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT571316	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT571314	hsa-miR-1293	PAR-CLIP	20371350
MIRT571313	hsa-miR-4483	PAR-CLIP	20371350
MIRT571312	hsa-miR-6748-5p	PAR-CLIP	20371350
MIRT571311	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT571310	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT571309	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT571308	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT571307	hsa-miR-3689c	PAR-CLIP	20371350
MIRT571306	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT571305	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT571304	hsa-miR-6127	PAR-CLIP	20371350
MIRT447287	hsa-miR-3163	PAR-CLIP	22100165
MIRT1449008	hsa-miR-1226	CLIP-seq
MIRT1449009	hsa-miR-1229	CLIP-seq
MIRT1449010	hsa-miR-125a-5p	CLIP-seq
MIRT1449011	hsa-miR-125b	CLIP-seq
MIRT1449012	hsa-miR-1279	CLIP-seq
MIRT1449013	hsa-miR-1281	CLIP-seq
MIRT1449014	hsa-miR-1291	CLIP-seq
MIRT1449015	hsa-miR-19a	CLIP-seq
MIRT1449016	hsa-miR-19b	CLIP-seq
MIRT1449017	hsa-miR-29a	CLIP-seq
MIRT1449018	hsa-miR-29b	CLIP-seq
MIRT1449019	hsa-miR-29c	CLIP-seq
MIRT1449020	hsa-miR-3137	CLIP-seq
MIRT1449021	hsa-miR-3177-3p	CLIP-seq
MIRT1449022	hsa-miR-34a	CLIP-seq
MIRT1449023	hsa-miR-361-3p	CLIP-seq
MIRT1449024	hsa-miR-3616-3p	CLIP-seq
MIRT1449025	hsa-miR-3660	CLIP-seq
MIRT1449026	hsa-miR-3686	CLIP-seq
MIRT1449027	hsa-miR-4272	CLIP-seq
MIRT1449028	hsa-miR-4311	CLIP-seq
MIRT1449029	hsa-miR-4313	CLIP-seq
MIRT1449030	hsa-miR-4319	CLIP-seq
MIRT1449031	hsa-miR-4420	CLIP-seq
MIRT1449032	hsa-miR-449b	CLIP-seq
MIRT1449033	hsa-miR-4526	CLIP-seq
MIRT1449034	hsa-miR-4530	CLIP-seq
MIRT1449035	hsa-miR-455-5p	CLIP-seq
MIRT1449036	hsa-miR-4645-3p	CLIP-seq
MIRT1449037	hsa-miR-4732-3p	CLIP-seq
MIRT1449038	hsa-miR-4795-3p	CLIP-seq
MIRT1449039	hsa-miR-548a-3p	CLIP-seq
MIRT1449040	hsa-miR-548ae	CLIP-seq
MIRT1449041	hsa-miR-548aj	CLIP-seq
MIRT1449042	hsa-miR-548am	CLIP-seq
MIRT1449043	hsa-miR-548e	CLIP-seq
MIRT1449044	hsa-miR-548f	CLIP-seq
MIRT1449045	hsa-miR-548x	CLIP-seq
MIRT1449046	hsa-miR-549	CLIP-seq
MIRT1449047	hsa-miR-564	CLIP-seq
MIRT1449048	hsa-miR-566	CLIP-seq
MIRT1449049	hsa-miR-587	CLIP-seq
MIRT1449050	hsa-miR-634	CLIP-seq
MIRT1449051	hsa-miR-646	CLIP-seq
MIRT1449052	hsa-miR-658	CLIP-seq
MIRT1449053	hsa-miR-670	CLIP-seq
MIRT1449054	hsa-miR-938	CLIP-seq
MIRT1555136	hsa-miR-3150a-3p	CLIP-seq
MIRT1555137	hsa-miR-3175	CLIP-seq
MIRT1555138	hsa-miR-939	CLIP-seq
MIRT2134334	hsa-miR-1286	CLIP-seq
MIRT2134335	hsa-miR-137	CLIP-seq
MIRT2134336	hsa-miR-3145-5p	CLIP-seq
MIRT2134337	hsa-miR-3647-3p	CLIP-seq
MIRT2134338	hsa-miR-3919	CLIP-seq
MIRT2134339	hsa-miR-450b-5p	CLIP-seq
MIRT2134340	hsa-miR-4759	CLIP-seq
MIRT2134341	hsa-miR-508-5p	CLIP-seq
MIRT2134342	hsa-miR-520a-5p	CLIP-seq
MIRT2134343	hsa-miR-525-5p	CLIP-seq
MIRT2355556	hsa-miR-1224-3p	CLIP-seq
MIRT1449008	hsa-miR-1226	CLIP-seq
MIRT2134334	hsa-miR-1286	CLIP-seq
MIRT2355557	hsa-miR-140-3p	CLIP-seq
MIRT2355558	hsa-miR-300	CLIP-seq
MIRT2355559	hsa-miR-3140-5p	CLIP-seq
MIRT2134336	hsa-miR-3145-5p	CLIP-seq
MIRT2355560	hsa-miR-3154	CLIP-seq
MIRT2355561	hsa-miR-324-5p	CLIP-seq
MIRT2355562	hsa-miR-338-3p	CLIP-seq
MIRT1449022	hsa-miR-34a	CLIP-seq
MIRT2355563	hsa-miR-3622a-3p	CLIP-seq
MIRT2355564	hsa-miR-3622b-3p	CLIP-seq
MIRT2355565	hsa-miR-365	CLIP-seq
MIRT2355566	hsa-miR-381	CLIP-seq
MIRT2134338	hsa-miR-3919	CLIP-seq
MIRT2355567	hsa-miR-3978	CLIP-seq
MIRT2355568	hsa-miR-4286	CLIP-seq
MIRT1449028	hsa-miR-4311	CLIP-seq
MIRT2355569	hsa-miR-4421	CLIP-seq
MIRT2355570	hsa-miR-4427	CLIP-seq
MIRT2355571	hsa-miR-4457	CLIP-seq
MIRT2355572	hsa-miR-4475	CLIP-seq
MIRT1449032	hsa-miR-449b	CLIP-seq
MIRT2355573	hsa-miR-4661-3p	CLIP-seq
MIRT2134340	hsa-miR-4759	CLIP-seq
MIRT2134341	hsa-miR-508-5p	CLIP-seq
MIRT2134342	hsa-miR-520a-5p	CLIP-seq
MIRT2134343	hsa-miR-525-5p	CLIP-seq
MIRT2355574	hsa-miR-552	CLIP-seq
MIRT1449050	hsa-miR-634	CLIP-seq
MIRT2355575	hsa-miR-659	CLIP-seq
MIRT2396242	hsa-miR-1257	CLIP-seq
MIRT2134334	hsa-miR-1286	CLIP-seq
MIRT2396243	hsa-miR-490-3p	CLIP-seq
MIRT2396244	hsa-miR-649	CLIP-seq
MIRT2355556	hsa-miR-1224-3p	CLIP-seq
MIRT1449008	hsa-miR-1226	CLIP-seq
MIRT2355561	hsa-miR-324-5p	CLIP-seq
MIRT2355562	hsa-miR-338-3p	CLIP-seq
MIRT2355563	hsa-miR-3622a-3p	CLIP-seq
MIRT2355564	hsa-miR-3622b-3p	CLIP-seq
MIRT2355568	hsa-miR-4286	CLIP-seq
MIRT1449050	hsa-miR-634	CLIP-seq

Show/Hide all(64)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005245	Function	Voltage-gated calcium channel activity	IDA	23063126
GO:0005245	Function	Voltage-gated calcium channel activity	ISS
GO:0005248	Function	Voltage-gated sodium channel activity	IDA	24776928
GO:0005262	Function	Calcium channel activity	IDA	27140606
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	21903581, 23394946, 24188827
GO:0005764	Component	Lysosome	IDA	22012985
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	19387438, 19620632, 20880839, 23063126
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IDA	19387438
GO:0006939	Process	Smooth muscle contraction	IEA
GO:0006939	Process	Smooth muscle contraction	ISS
GO:0007040	Process	Lysosome organization	IGI	25416817
GO:0010008	Component	Endosome membrane	IDA	19620632
GO:0010506	Process	Regulation of autophagy	IGI	22012985
GO:0015280	Function	Ligand-gated sodium channel activity	IBA
GO:0015280	Function	Ligand-gated sodium channel activity	IDA	23063126, 30860481, 32167471
GO:0015280	Function	Ligand-gated sodium channel activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0017157	Process	Regulation of exocytosis	IEA
GO:0017157	Process	Regulation of exocytosis	ISS
GO:0019065	Process	Receptor-mediated endocytosis of virus by host cell	IDA	32221306
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0019722	Process	Calcium-mediated signaling	IGI	25416817
GO:0019901	Function	Protein kinase binding	IPI	22012985
GO:0022832	Function	Voltage-gated channel activity	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0033162	Component	Melanosome membrane	IDA	27140606
GO:0033162	Component	Melanosome membrane	IEA
GO:0033280	Process	Response to vitamin D	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IDA	30860481
GO:0036020	Component	Endolysosome membrane	IDA	32167471
GO:0042802	Function	Identical protein binding	IDA	30860481
GO:0042802	Function	Identical protein binding	IPI	21903581
GO:0048086	Process	Negative regulation of developmental pigmentation	IDA	27140606
GO:0048086	Process	Negative regulation of developmental pigmentation	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IEA
GO:0051452	Process	Intracellular pH reduction	IDA	27140606
GO:0051452	Process	Intracellular pH reduction	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0072345	Function	NAADP-sensitive calcium-release channel activity	IDA	23063126
GO:0072345	Function	NAADP-sensitive calcium-release channel activity	IDA	19387438, 19620632, 20880839, 32167471
GO:0072345	Function	NAADP-sensitive calcium-release channel activity	TAS
GO:0075509	Process	Endocytosis involved in viral entry into host cell	IBA
GO:0075509	Process	Endocytosis involved in viral entry into host cell	IEA
GO:0075509	Process	Endocytosis involved in viral entry into host cell	IMP	25722412
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IDA	23063126, 30860481
GO:0090117	Process	Endosome to lysosome transport of low-density lipoprotein particle	IEA
GO:0090117	Process	Endosome to lysosome transport of low-density lipoprotein particle	ISS
GO:0097682	Function	Intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity	IBA
GO:0097682	Function	Intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity	IDA	23063126, 30860481, 32167471

MIM	HGNC	e!Ensembl
612163	20820	ENSG00000162341

Protein

UniProt ID

Q8NHX9

Protein name

Two pore channel protein 2 (Two pore calcium channel protein 2)

Protein function

Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatid

PDB

6NQ0 , 6NQ1 , 6NQ2 , 8OUO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	84 → 318	Ion transport protein	Family
PF00520	Ion_trans	431 → 699	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed:19387438}.

Sequence

MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR
SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP
PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC
HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG
GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS
LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ
NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP
FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY
LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL
FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD
AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM
TVELLFRDILEEPGEDELTERLSQHPHLWLCR

Sequence length

752

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Pancreatic secretion		Stimuli-sensing channels

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Albinism	albinism	N/A	N/A	GenCC
Breast Cancer	Breast cancer	N/A	N/A	GWAS
Diabetes	Type 2 diabetes (adjusted for BMI), Type 2 diabetes or prostate cancer (pleiotropy), Type 2 diabetes	N/A	N/A	GWAS
Duodenal Ulcer	Duodenal ulcer	N/A	N/A	GWAS
Prostate cancer	Prostate cancer (late onset), Prostate cancer	N/A	N/A	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Albinism	Associate	38279271
Bicuspid Aortic Valve Disease	Associate	36071494
Carcinoma Basal Cell	Associate	36496446
Carcinoma Squamous Cell	Associate	36496446
Diabetes Mellitus	Associate	26918892
Diabetes Mellitus Type 2	Associate	26918892
Heart Failure	Stimulate	22701570
Infections	Associate	36314791
Lupus Erythematosus Systemic	Associate	35194006
Lysosomal Storage Diseases	Associate	35915060
Melanoma	Associate	33875769, 35181301
Neoplasms	Associate	36496446
Parkinson Disease	Associate	25416817
Pigmentation Disorders	Associate	25789475, 35181301, 36496446
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	35915060

TPCN2 (two pore segment channel 2)