Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
219699
Gene name Gene Name - the full gene name approved by the HGNC.
Unc-5 netrin receptor B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UNC5B
Synonyms (NCBI Gene) Gene synonyms aliases
UNC5H2, p53RDL1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022434 hsa-miR-124-3p Microarray 18668037
MIRT041519 hsa-miR-193b-3p CLASH 23622248
MIRT040612 hsa-miR-92b-3p CLASH 23622248
MIRT614686 hsa-miR-8485 HITS-CLIP 23313552
MIRT614685 hsa-miR-6768-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0005042 Function Netrin receptor activity IBA 21873635
GO:0005515 Function Protein binding IPI 18469807, 26235030
GO:0005886 Component Plasma membrane IEA
GO:0006915 Process Apoptotic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607870 12568 ENSG00000107731
Protein
UniProt ID Q8IZJ1
Protein name Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Protein function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger sign
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 153 243 Immunoglobulin I-set domain Domain
PF00090 TSP_1 250 299 Thrombospondin type 1 domain Domain
PF00090 TSP_1 306 353 Thrombospondin type 1 domain Domain
PF00791 ZU5 544 641 ZU5 domain Family
PF17217 UPA 691 830 UPA domain Domain
PF00531 Death 863 941 Death domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}.
Sequence
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV
KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL
FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV
PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT
VIV
YVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP
VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL
SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG
FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL
KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD
PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV
LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQA
HQGHWEEVVTLDEETLNTP
CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT
PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY
HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAE
TPAGSLDTLC
SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA
SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVAT
DGDC
Sequence length 945
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Axon guidance  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Seborrheic dermatitis Seborrheic dermatitis GWAS
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder GWAS
Oligodendroglioma Oligodendroglioma GWAS
Restless Legs Syndrome Restless Legs Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Stimulate 19822088
Carcinoma Renal Cell Associate 23526078
Colorectal Neoplasms Associate 31852293, 32271416
Coronary Artery Disease Stimulate 27727089
Diabetes Gestational Inhibit 30897795
Diabetes Mellitus Type 2 Associate 29690638
Eczema Associate 36804406
Inflammation Associate 23055195, 24528886
Kidney Neoplasms Associate 23526078
Leukemia Biphenotypic Acute Associate 35974411