UNC5B (unc-5 netrin receptor B)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
219699 |
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Unc-5 netrin receptor B |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
UNC5B |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
UNC5H2, p53RDL1 |
Chromosome
Chromosome number
|
10 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
10q22.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which |
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
Protein | ||||||||||||||||||||||||||||||||||||
UniProt ID | Q8IZJ1 | |||||||||||||||||||||||||||||||||||
Protein name | Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1) | |||||||||||||||||||||||||||||||||||
Protein function | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger sign | |||||||||||||||||||||||||||||||||||
Family and domains |
Pfam
|
|||||||||||||||||||||||||||||||||||
Tissue specificity | TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}. | |||||||||||||||||||||||||||||||||||
Sequence |
|
|||||||||||||||||||||||||||||||||||
Sequence length | 945 | |||||||||||||||||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
||||||||
|
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|