UNC5B (unc-5 netrin receptor B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 219699 |
| Gene name | Unc-5 netrin receptor B |
| Gene symbol | UNC5B |
| Synonyms (NCBI Gene) |
UNC5H2p53RDL1
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| Chromosome | 10 |
| Chromosome location | 10q22.1 |
| Summary | This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which |
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miRNA
miRNA information provided by mirtarbase database.
656
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8IZJ1 | |||||||||||||||||||||||||||||||||||
| Protein name | Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1) | |||||||||||||||||||||||||||||||||||
| Protein function | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger sign | |||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. {ECO:0000269|PubMed:12359238}. | |||||||||||||||||||||||||||||||||||
| Sequence |
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| Sequence length | 945 | |||||||||||||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
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