FABP5 (fatty acid binding protein 5)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2171
Gene name Gene Name - the full gene name approved by the HGNC.
Fatty acid binding protein 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FABP5
Synonyms (NCBI Gene) Gene synonyms aliases
E-FABP, EFABP, KFABP, PA-FABP, PAFABP
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fa
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
KLF2 Repression 20424164
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(51)
GO ID Ontology Definition Evidence Reference
GO:0001972 Function Retinoic acid binding IEA
GO:0005324 Function Long-chain fatty acid transmembrane transporter activity IMP 21395585
GO:0005504 Function Fatty acid binding IBA
GO:0005504 Function Fatty acid binding IDA 8092987
GO:0005504 Function Fatty acid binding TAS 8092987
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605168 3560 ENSG00000164687
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q01469
Protein name Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)
Protein function Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty
PDB 1B56 , 1JJJ , 4AZM , 4AZR , 4LKP , 4LKT , 5HZ5 , 5UR9 , 7FWI , 7FXD , 7FY0 , 7FYD , 7G01 , 7G04 , 7G0B , 7G0E , 7G1Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 8 → 134 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Keratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585). {ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:8092987}.
Sequence
Sequence length 135
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  PPAR signaling pathway   Triglyceride catabolism
Signaling by Retinoic Acid
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (72)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Aniridia Associate 40570009
Arteriosclerosis Associate 30142969
Arthritis Rheumatoid Associate 29880835
Asthma Associate 26020772
Astrocytoma Associate 25797252
Bacterial Infections Stimulate 23349676
Bacterial Infections Associate 28542209
Blood Coagulation Disorders Associate 36136292
Breast Neoplasms Associate 20424164, 21356353, 26142905, 29731607, 37021816
Carcinogenesis Associate 20424164, 26592976, 31646566, 37438449