Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
214
Gene name Gene Name - the full gene name approved by the HGNC.
Activated leukocyte cell adhesion molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ALCAM
Synonyms (NCBI Gene) Gene synonyms aliases
CD166, MEMD
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004163 hsa-miR-192-5p Microarray 16822819
MIRT024327 hsa-miR-215-5p Microarray 19074876
MIRT004163 hsa-miR-192-5p Microarray 19074876
MIRT053167 hsa-miR-148b-3p Luciferase reporter assay, qRT-PCR, Western blot 23667173
MIRT053167 hsa-miR-148b-3p Luciferase reporter assay, qRT-PCR, Western blot 23667173
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001772 Component Immunological synapse IDA 15294938
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0005102 Function Signaling receptor binding TAS 7760007
GO:0005515 Function Protein binding IPI 24945728, 26146185, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601662 400 ENSG00000170017
Protein
UniProt ID Q13740
Protein name CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
Protein function Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007).
PDB 5A2F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08205 C2-set_2 137 231 CD80-like C2-set immunoglobulin domain Domain
PF13927 Ig_3 249 316 Domain
Tissue specificity TISSUE SPECIFICITY: Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected
Sequence
MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEK
PDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDN
VFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPL
EGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQK
TIHSEQAVF
DIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTL
TDVRRNATGDYKCSLI
DKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASR
NATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKM
TKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEEN
VTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAA
LVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
Sequence length 583
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Cell adhesion molecules  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast cancer Breast cancer N/A N/A GWAS
Coronary artery disease Coronary artery disease N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 24346092
Adenoma Pleomorphic Associate 25472586
Adenomatous Polyps Stimulate 19010307, 32647988
AIDS Associated Nephropathy Associate 29066542
Arthritis Rheumatoid Associate 10693872
Asthma Associate 24311777
Bone Diseases Associate 32321465
Breast Neoplasms Associate 15318930, 16484444, 20364042, 22791584, 22983139, 26923994, 28754978, 29315254, 31757997
Breast Neoplasms Inhibit 18202807, 25255861
Breast Neoplasms Stimulate 34641959