ALCAM (activated leukocyte cell adhesion molecule)

Gene

• Entrez ID: 214
• Gene name: Activated leukocyte cell adhesion molecule
• Gene symbol: ALCAM
• Synonyms (NCBI Gene): CD166, MEMD
• Chromosome: 3
• Chromosome location: 3q13.11
• Summary: This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004163	hsa-miR-192-5p	Microarray	16822819
MIRT024327	hsa-miR-215-5p	Microarray	19074876
MIRT004163	hsa-miR-192-5p	Microarray	19074876
MIRT053167	hsa-miR-148b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23667173
MIRT053167	hsa-miR-148b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23667173
MIRT053167	hsa-miR-148b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23667173
MIRT004163	hsa-miR-192-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT004163	hsa-miR-192-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT024327	hsa-miR-215-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT024327	hsa-miR-215-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT441237	hsa-miR-323a-5p	HITS-CLIP	24374217
MIRT441237	hsa-miR-323a-5p	HITS-CLIP	24374217
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay, Western blotting, Microarray, Immunohistochemistry (IHC), qRT-PCR, In situ hybridization, in vivo gain/loss-of-function experiments	24710410
MIRT004163	hsa-miR-192-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	38717494
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT776871	hsa-miR-205	CLIP-seq
MIRT776872	hsa-miR-2277-3p	CLIP-seq
MIRT776873	hsa-miR-342-3p	CLIP-seq
MIRT776874	hsa-miR-3660	CLIP-seq
MIRT776875	hsa-miR-377	CLIP-seq
MIRT776876	hsa-miR-3940-5p	CLIP-seq
MIRT776877	hsa-miR-4256	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT776879	hsa-miR-4297	CLIP-seq
MIRT776880	hsa-miR-4317	CLIP-seq
MIRT776881	hsa-miR-4507	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT776883	hsa-miR-4526	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT776885	hsa-miR-4643	CLIP-seq
MIRT776886	hsa-miR-4659a-3p	CLIP-seq
MIRT776887	hsa-miR-4659b-3p	CLIP-seq
MIRT776888	hsa-miR-4715-3p	CLIP-seq
MIRT776889	hsa-miR-4778-3p	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT776892	hsa-miR-548g	CLIP-seq
MIRT776893	hsa-miR-593	CLIP-seq
MIRT776894	hsa-miR-629	CLIP-seq
MIRT1555906	hsa-miR-297	CLIP-seq
MIRT1555907	hsa-miR-3924	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT1555908	hsa-miR-4677-3p	CLIP-seq
MIRT1555909	hsa-miR-4679	CLIP-seq
MIRT1555910	hsa-miR-4711-3p	CLIP-seq
MIRT1555911	hsa-miR-4796-5p	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT1555913	hsa-miR-567	CLIP-seq
MIRT1555914	hsa-miR-586	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT1929413	hsa-miR-1273e	CLIP-seq
MIRT1929414	hsa-miR-1276	CLIP-seq
MIRT1929415	hsa-miR-1321	CLIP-seq
MIRT1929416	hsa-miR-148a	CLIP-seq
MIRT1929417	hsa-miR-148b	CLIP-seq
MIRT1929418	hsa-miR-152	CLIP-seq
MIRT1929419	hsa-miR-223	CLIP-seq
MIRT1929420	hsa-miR-3162-5p	CLIP-seq
MIRT1929421	hsa-miR-3166	CLIP-seq
MIRT1929422	hsa-miR-34b	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT1929423	hsa-miR-4328	CLIP-seq
MIRT1929424	hsa-miR-4697-3p	CLIP-seq
MIRT1929425	hsa-miR-4739	CLIP-seq
MIRT1929426	hsa-miR-4756-5p	CLIP-seq
MIRT1929427	hsa-miR-4771	CLIP-seq
MIRT1929428	hsa-miR-4795-3p	CLIP-seq
MIRT1555911	hsa-miR-4796-5p	CLIP-seq
MIRT1929429	hsa-miR-488	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT2169967	hsa-miR-1206	CLIP-seq
MIRT2169968	hsa-miR-1234	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT2169969	hsa-miR-124	CLIP-seq
MIRT2169970	hsa-miR-1261	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT2169971	hsa-miR-1273d	CLIP-seq
MIRT1929413	hsa-miR-1273e	CLIP-seq
MIRT2169972	hsa-miR-1307	CLIP-seq
MIRT2169973	hsa-miR-1324	CLIP-seq
MIRT2169974	hsa-miR-138	CLIP-seq
MIRT1929416	hsa-miR-148a	CLIP-seq
MIRT1929417	hsa-miR-148b	CLIP-seq
MIRT1929418	hsa-miR-152	CLIP-seq
MIRT2169975	hsa-miR-1911	CLIP-seq
MIRT2169976	hsa-miR-198	CLIP-seq
MIRT2169977	hsa-miR-2053	CLIP-seq
MIRT1929419	hsa-miR-223	CLIP-seq
MIRT2169978	hsa-miR-2682	CLIP-seq
MIRT1555906	hsa-miR-297	CLIP-seq
MIRT2169979	hsa-miR-299-5p	CLIP-seq
MIRT2169980	hsa-miR-302a	CLIP-seq
MIRT2169981	hsa-miR-302b	CLIP-seq
MIRT2169982	hsa-miR-302c	CLIP-seq
MIRT2169983	hsa-miR-302d	CLIP-seq
MIRT2169984	hsa-miR-302e	CLIP-seq
MIRT2169985	hsa-miR-3120-3p	CLIP-seq
MIRT2169986	hsa-miR-3122	CLIP-seq
MIRT2169987	hsa-miR-3126-3p	CLIP-seq
MIRT2169988	hsa-miR-3137	CLIP-seq
MIRT2169989	hsa-miR-3145-5p	CLIP-seq
MIRT2169990	hsa-miR-3148	CLIP-seq
MIRT2169991	hsa-miR-3163	CLIP-seq
MIRT1929421	hsa-miR-3166	CLIP-seq
MIRT2169992	hsa-miR-338-5p	CLIP-seq
MIRT2169993	hsa-miR-345	CLIP-seq
MIRT2169994	hsa-miR-34a	CLIP-seq
MIRT2169995	hsa-miR-34c-5p	CLIP-seq
MIRT2169996	hsa-miR-3615	CLIP-seq
MIRT2169997	hsa-miR-3665	CLIP-seq
MIRT2169998	hsa-miR-3675-3p	CLIP-seq
MIRT2169999	hsa-miR-3681	CLIP-seq
MIRT2170000	hsa-miR-3689a-3p	CLIP-seq
MIRT2170001	hsa-miR-3689a-5p	CLIP-seq
MIRT2170002	hsa-miR-3689b	CLIP-seq
MIRT2170003	hsa-miR-3689c	CLIP-seq
MIRT2170004	hsa-miR-3689e	CLIP-seq
MIRT2170005	hsa-miR-3689f	CLIP-seq
MIRT2170006	hsa-miR-3714	CLIP-seq
MIRT2170007	hsa-miR-372	CLIP-seq
MIRT2170008	hsa-miR-373	CLIP-seq
MIRT2170009	hsa-miR-3910	CLIP-seq
MIRT2170010	hsa-miR-3913-5p	CLIP-seq
MIRT2170011	hsa-miR-3921	CLIP-seq
MIRT1555907	hsa-miR-3924	CLIP-seq
MIRT2170012	hsa-miR-3934	CLIP-seq
MIRT2170013	hsa-miR-3977	CLIP-seq
MIRT2170014	hsa-miR-4251	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT2170015	hsa-miR-4287	CLIP-seq
MIRT2170016	hsa-miR-4303	CLIP-seq
MIRT2170017	hsa-miR-4307	CLIP-seq
MIRT1929423	hsa-miR-4328	CLIP-seq
MIRT2170018	hsa-miR-4329	CLIP-seq
MIRT2170019	hsa-miR-4423-3p	CLIP-seq
MIRT2170020	hsa-miR-4456	CLIP-seq
MIRT2170021	hsa-miR-4470	CLIP-seq
MIRT2170022	hsa-miR-4477a	CLIP-seq
MIRT2170023	hsa-miR-4477b	CLIP-seq
MIRT2170024	hsa-miR-449a	CLIP-seq
MIRT2170025	hsa-miR-449b	CLIP-seq
MIRT2170026	hsa-miR-449c	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT2170027	hsa-miR-4522	CLIP-seq
MIRT2170028	hsa-miR-4524	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT2170029	hsa-miR-4638-5p	CLIP-seq
MIRT2170030	hsa-miR-4645-3p	CLIP-seq
MIRT2170031	hsa-miR-4652-3p	CLIP-seq
MIRT2170032	hsa-miR-4653-5p	CLIP-seq
MIRT2170033	hsa-miR-4666-3p	CLIP-seq
MIRT1555908	hsa-miR-4677-3p	CLIP-seq
MIRT1555909	hsa-miR-4679	CLIP-seq
MIRT2170034	hsa-miR-4682	CLIP-seq
MIRT2170035	hsa-miR-4685-3p	CLIP-seq
MIRT2170036	hsa-miR-4690-5p	CLIP-seq
MIRT2170037	hsa-miR-4693-3p	CLIP-seq
MIRT2170038	hsa-miR-4694-3p	CLIP-seq
MIRT1929424	hsa-miR-4697-3p	CLIP-seq
MIRT1555910	hsa-miR-4711-3p	CLIP-seq
MIRT2170039	hsa-miR-4732-5p	CLIP-seq
MIRT2170040	hsa-miR-4746-5p	CLIP-seq
MIRT2170041	hsa-miR-4762-3p	CLIP-seq
MIRT1929427	hsa-miR-4771	CLIP-seq
MIRT2170042	hsa-miR-4775	CLIP-seq
MIRT2170043	hsa-miR-4778-5p	CLIP-seq
MIRT2170044	hsa-miR-4780	CLIP-seq
MIRT2170045	hsa-miR-4785	CLIP-seq
MIRT2170046	hsa-miR-4788	CLIP-seq
MIRT2170047	hsa-miR-4789-5p	CLIP-seq
MIRT1929428	hsa-miR-4795-3p	CLIP-seq
MIRT1555911	hsa-miR-4796-5p	CLIP-seq
MIRT2170048	hsa-miR-491-3p	CLIP-seq
MIRT2170049	hsa-miR-499-3p	CLIP-seq
MIRT2170050	hsa-miR-499a-3p	CLIP-seq
MIRT2170051	hsa-miR-506	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT2170052	hsa-miR-519a	CLIP-seq
MIRT2170053	hsa-miR-519b-3p	CLIP-seq
MIRT2170054	hsa-miR-519c-3p	CLIP-seq
MIRT2170055	hsa-miR-520a-3p	CLIP-seq
MIRT2170056	hsa-miR-520a-5p	CLIP-seq
MIRT2170057	hsa-miR-520b	CLIP-seq
MIRT2170058	hsa-miR-520c-3p	CLIP-seq
MIRT2170059	hsa-miR-520d-3p	CLIP-seq
MIRT2170060	hsa-miR-520d-5p	CLIP-seq
MIRT2170061	hsa-miR-520e	CLIP-seq
MIRT2170062	hsa-miR-522	CLIP-seq
MIRT2170063	hsa-miR-524-5p	CLIP-seq
MIRT2170064	hsa-miR-525-5p	CLIP-seq
MIRT2170065	hsa-miR-544	CLIP-seq
MIRT2170066	hsa-miR-548ac	CLIP-seq
MIRT2170067	hsa-miR-548ae	CLIP-seq
MIRT2170068	hsa-miR-548aj	CLIP-seq
MIRT2170069	hsa-miR-548am	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT2170070	hsa-miR-548d-3p	CLIP-seq
MIRT2170071	hsa-miR-548x	CLIP-seq
MIRT2170072	hsa-miR-548z	CLIP-seq
MIRT2170073	hsa-miR-553	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT1555913	hsa-miR-567	CLIP-seq
MIRT2170074	hsa-miR-568	CLIP-seq
MIRT2170075	hsa-miR-569	CLIP-seq
MIRT2170076	hsa-miR-582-5p	CLIP-seq
MIRT1555914	hsa-miR-586	CLIP-seq
MIRT2170077	hsa-miR-590-3p	CLIP-seq
MIRT2170078	hsa-miR-600	CLIP-seq
MIRT2170079	hsa-miR-601	CLIP-seq
MIRT2170080	hsa-miR-622	CLIP-seq
MIRT2170081	hsa-miR-623	CLIP-seq
MIRT2170082	hsa-miR-639	CLIP-seq
MIRT2170083	hsa-miR-654-3p	CLIP-seq
MIRT2384062	hsa-miR-767-3p	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT2472857	hsa-miR-1256	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT2472858	hsa-miR-2276	CLIP-seq
MIRT776872	hsa-miR-2277-3p	CLIP-seq
MIRT776873	hsa-miR-342-3p	CLIP-seq
MIRT776875	hsa-miR-377	CLIP-seq
MIRT2472859	hsa-miR-3908	CLIP-seq
MIRT776876	hsa-miR-3940-5p	CLIP-seq
MIRT2472860	hsa-miR-3942-5p	CLIP-seq
MIRT2170013	hsa-miR-3977	CLIP-seq
MIRT2472861	hsa-miR-4260	CLIP-seq
MIRT2472862	hsa-miR-4261	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT776881	hsa-miR-4507	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT776885	hsa-miR-4643	CLIP-seq
MIRT2472863	hsa-miR-4703-5p	CLIP-seq
MIRT2472864	hsa-miR-4712-3p	CLIP-seq
MIRT776888	hsa-miR-4715-3p	CLIP-seq
MIRT2472865	hsa-miR-4766-3p	CLIP-seq
MIRT2472866	hsa-miR-4772-3p	CLIP-seq
MIRT2472867	hsa-miR-486-3p	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT2472868	hsa-miR-539	CLIP-seq
MIRT2170065	hsa-miR-544	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT2472869	hsa-miR-618	CLIP-seq
MIRT2472870	hsa-miR-628-5p	CLIP-seq
MIRT776894	hsa-miR-629	CLIP-seq
MIRT2674884	hsa-miR-1	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT2674885	hsa-miR-206	CLIP-seq
MIRT776872	hsa-miR-2277-3p	CLIP-seq
MIRT2674886	hsa-miR-323-3p	CLIP-seq
MIRT776873	hsa-miR-342-3p	CLIP-seq
MIRT2674887	hsa-miR-3647-3p	CLIP-seq
MIRT776875	hsa-miR-377	CLIP-seq
MIRT776876	hsa-miR-3940-5p	CLIP-seq
MIRT2674888	hsa-miR-409-3p	CLIP-seq
MIRT2472862	hsa-miR-4261	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT2674889	hsa-miR-4289	CLIP-seq
MIRT776881	hsa-miR-4507	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT776885	hsa-miR-4643	CLIP-seq
MIRT2472864	hsa-miR-4712-3p	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT2674890	hsa-miR-514	CLIP-seq
MIRT2674891	hsa-miR-514b-3p	CLIP-seq
MIRT2472868	hsa-miR-539	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT776892	hsa-miR-548g	CLIP-seq
MIRT2674892	hsa-miR-581	CLIP-seq
MIRT2674893	hsa-miR-591	CLIP-seq
MIRT776893	hsa-miR-593	CLIP-seq
MIRT2674894	hsa-miR-613	CLIP-seq
MIRT2472869	hsa-miR-618	CLIP-seq
MIRT776894	hsa-miR-629	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001772	Component	Immunological synapse	IDA	15294938
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005102	Function	Signaling receptor binding	TAS	7760007
GO:0005515	Function	Protein binding	IPI	24945728, 26146185, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	15294938
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	ISS
GO:0007155	Process	Cell adhesion	TAS	7760007
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	16352806
GO:0007165	Process	Signal transduction	TAS	7760007
GO:0007411	Process	Axon guidance	IEA
GO:0008045	Process	Motor neuron axon guidance	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	ISS
GO:0042101	Component	T cell receptor complex	IDA	15294938
GO:0042802	Function	Identical protein binding	IPI	26146185
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0048846	Process	Axon extension involved in axon guidance	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:1990138	Process	Neuron projection extension	ISS

Other IDs

• MIM: 601662
• HGNC: 400
• e!Ensembl: ENSG00000170017

Protein

• UniProt ID: Q13740
• Protein name: CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
• Protein function: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007).
• PDB: 5A2F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08205	C2-set_2	137 → 231	CD80-like C2-set immunoglobulin domain	Domain
  PF13927	Ig_3	249 → 316		Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected
• Sequence:

  MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEK
  PDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDN
  VFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPL
  EGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVF
  DIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTL
  TDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASR
  NATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKM
  TKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEEN
  VTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAA
  LVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA

• Sequence length: 583

Pathways

KEGG:

Cell adhesion molecules