Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	214
Gene name Gene Name - the full gene name approved by the HGNC.	Activated leukocyte cell adhesion molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ALCAM
Synonyms (NCBI Gene) Gene synonyms aliases	CD166, MEMD
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q13.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular

Show/Hide all(289)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004163	hsa-miR-192-5p	Microarray	16822819
MIRT024327	hsa-miR-215-5p	Microarray	19074876
MIRT004163	hsa-miR-192-5p	Microarray	19074876
MIRT053167	hsa-miR-148b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23667173
MIRT053167	hsa-miR-148b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23667173
MIRT053167	hsa-miR-148b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23667173
MIRT004163	hsa-miR-192-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT004163	hsa-miR-192-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT024327	hsa-miR-215-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT024327	hsa-miR-215-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	21119604
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay	24710410
MIRT441237	hsa-miR-323a-5p	HITS-CLIP	24374217
MIRT441237	hsa-miR-323a-5p	HITS-CLIP	24374217
MIRT437958	hsa-miR-483-5p	Luciferase reporter assay, Western blotting, Microarray, Immunohistochemistry (IHC), qRT-PCR, In situ hybridization, in vivo gain/loss-of-function experiments	24710410
MIRT004163	hsa-miR-192-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	38717494
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT776871	hsa-miR-205	CLIP-seq
MIRT776872	hsa-miR-2277-3p	CLIP-seq
MIRT776873	hsa-miR-342-3p	CLIP-seq
MIRT776874	hsa-miR-3660	CLIP-seq
MIRT776875	hsa-miR-377	CLIP-seq
MIRT776876	hsa-miR-3940-5p	CLIP-seq
MIRT776877	hsa-miR-4256	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT776879	hsa-miR-4297	CLIP-seq
MIRT776880	hsa-miR-4317	CLIP-seq
MIRT776881	hsa-miR-4507	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT776883	hsa-miR-4526	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT776885	hsa-miR-4643	CLIP-seq
MIRT776886	hsa-miR-4659a-3p	CLIP-seq
MIRT776887	hsa-miR-4659b-3p	CLIP-seq
MIRT776888	hsa-miR-4715-3p	CLIP-seq
MIRT776889	hsa-miR-4778-3p	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT776892	hsa-miR-548g	CLIP-seq
MIRT776893	hsa-miR-593	CLIP-seq
MIRT776894	hsa-miR-629	CLIP-seq
MIRT1555906	hsa-miR-297	CLIP-seq
MIRT1555907	hsa-miR-3924	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT1555908	hsa-miR-4677-3p	CLIP-seq
MIRT1555909	hsa-miR-4679	CLIP-seq
MIRT1555910	hsa-miR-4711-3p	CLIP-seq
MIRT1555911	hsa-miR-4796-5p	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT1555913	hsa-miR-567	CLIP-seq
MIRT1555914	hsa-miR-586	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT1929413	hsa-miR-1273e	CLIP-seq
MIRT1929414	hsa-miR-1276	CLIP-seq
MIRT1929415	hsa-miR-1321	CLIP-seq
MIRT1929416	hsa-miR-148a	CLIP-seq
MIRT1929417	hsa-miR-148b	CLIP-seq
MIRT1929418	hsa-miR-152	CLIP-seq
MIRT1929419	hsa-miR-223	CLIP-seq
MIRT1929420	hsa-miR-3162-5p	CLIP-seq
MIRT1929421	hsa-miR-3166	CLIP-seq
MIRT1929422	hsa-miR-34b	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT1929423	hsa-miR-4328	CLIP-seq
MIRT1929424	hsa-miR-4697-3p	CLIP-seq
MIRT1929425	hsa-miR-4739	CLIP-seq
MIRT1929426	hsa-miR-4756-5p	CLIP-seq
MIRT1929427	hsa-miR-4771	CLIP-seq
MIRT1929428	hsa-miR-4795-3p	CLIP-seq
MIRT1555911	hsa-miR-4796-5p	CLIP-seq
MIRT1929429	hsa-miR-488	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT2169967	hsa-miR-1206	CLIP-seq
MIRT2169968	hsa-miR-1234	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT2169969	hsa-miR-124	CLIP-seq
MIRT2169970	hsa-miR-1261	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT2169971	hsa-miR-1273d	CLIP-seq
MIRT1929413	hsa-miR-1273e	CLIP-seq
MIRT2169972	hsa-miR-1307	CLIP-seq
MIRT2169973	hsa-miR-1324	CLIP-seq
MIRT2169974	hsa-miR-138	CLIP-seq
MIRT1929416	hsa-miR-148a	CLIP-seq
MIRT1929417	hsa-miR-148b	CLIP-seq
MIRT1929418	hsa-miR-152	CLIP-seq
MIRT2169975	hsa-miR-1911	CLIP-seq
MIRT2169976	hsa-miR-198	CLIP-seq
MIRT2169977	hsa-miR-2053	CLIP-seq
MIRT1929419	hsa-miR-223	CLIP-seq
MIRT2169978	hsa-miR-2682	CLIP-seq
MIRT1555906	hsa-miR-297	CLIP-seq
MIRT2169979	hsa-miR-299-5p	CLIP-seq
MIRT2169980	hsa-miR-302a	CLIP-seq
MIRT2169981	hsa-miR-302b	CLIP-seq
MIRT2169982	hsa-miR-302c	CLIP-seq
MIRT2169983	hsa-miR-302d	CLIP-seq
MIRT2169984	hsa-miR-302e	CLIP-seq
MIRT2169985	hsa-miR-3120-3p	CLIP-seq
MIRT2169986	hsa-miR-3122	CLIP-seq
MIRT2169987	hsa-miR-3126-3p	CLIP-seq
MIRT2169988	hsa-miR-3137	CLIP-seq
MIRT2169989	hsa-miR-3145-5p	CLIP-seq
MIRT2169990	hsa-miR-3148	CLIP-seq
MIRT2169991	hsa-miR-3163	CLIP-seq
MIRT1929421	hsa-miR-3166	CLIP-seq
MIRT2169992	hsa-miR-338-5p	CLIP-seq
MIRT2169993	hsa-miR-345	CLIP-seq
MIRT2169994	hsa-miR-34a	CLIP-seq
MIRT2169995	hsa-miR-34c-5p	CLIP-seq
MIRT2169996	hsa-miR-3615	CLIP-seq
MIRT2169997	hsa-miR-3665	CLIP-seq
MIRT2169998	hsa-miR-3675-3p	CLIP-seq
MIRT2169999	hsa-miR-3681	CLIP-seq
MIRT2170000	hsa-miR-3689a-3p	CLIP-seq
MIRT2170001	hsa-miR-3689a-5p	CLIP-seq
MIRT2170002	hsa-miR-3689b	CLIP-seq
MIRT2170003	hsa-miR-3689c	CLIP-seq
MIRT2170004	hsa-miR-3689e	CLIP-seq
MIRT2170005	hsa-miR-3689f	CLIP-seq
MIRT2170006	hsa-miR-3714	CLIP-seq
MIRT2170007	hsa-miR-372	CLIP-seq
MIRT2170008	hsa-miR-373	CLIP-seq
MIRT2170009	hsa-miR-3910	CLIP-seq
MIRT2170010	hsa-miR-3913-5p	CLIP-seq
MIRT2170011	hsa-miR-3921	CLIP-seq
MIRT1555907	hsa-miR-3924	CLIP-seq
MIRT2170012	hsa-miR-3934	CLIP-seq
MIRT2170013	hsa-miR-3977	CLIP-seq
MIRT2170014	hsa-miR-4251	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT2170015	hsa-miR-4287	CLIP-seq
MIRT2170016	hsa-miR-4303	CLIP-seq
MIRT2170017	hsa-miR-4307	CLIP-seq
MIRT1929423	hsa-miR-4328	CLIP-seq
MIRT2170018	hsa-miR-4329	CLIP-seq
MIRT2170019	hsa-miR-4423-3p	CLIP-seq
MIRT2170020	hsa-miR-4456	CLIP-seq
MIRT2170021	hsa-miR-4470	CLIP-seq
MIRT2170022	hsa-miR-4477a	CLIP-seq
MIRT2170023	hsa-miR-4477b	CLIP-seq
MIRT2170024	hsa-miR-449a	CLIP-seq
MIRT2170025	hsa-miR-449b	CLIP-seq
MIRT2170026	hsa-miR-449c	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT2170027	hsa-miR-4522	CLIP-seq
MIRT2170028	hsa-miR-4524	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT2170029	hsa-miR-4638-5p	CLIP-seq
MIRT2170030	hsa-miR-4645-3p	CLIP-seq
MIRT2170031	hsa-miR-4652-3p	CLIP-seq
MIRT2170032	hsa-miR-4653-5p	CLIP-seq
MIRT2170033	hsa-miR-4666-3p	CLIP-seq
MIRT1555908	hsa-miR-4677-3p	CLIP-seq
MIRT1555909	hsa-miR-4679	CLIP-seq
MIRT2170034	hsa-miR-4682	CLIP-seq
MIRT2170035	hsa-miR-4685-3p	CLIP-seq
MIRT2170036	hsa-miR-4690-5p	CLIP-seq
MIRT2170037	hsa-miR-4693-3p	CLIP-seq
MIRT2170038	hsa-miR-4694-3p	CLIP-seq
MIRT1929424	hsa-miR-4697-3p	CLIP-seq
MIRT1555910	hsa-miR-4711-3p	CLIP-seq
MIRT2170039	hsa-miR-4732-5p	CLIP-seq
MIRT2170040	hsa-miR-4746-5p	CLIP-seq
MIRT2170041	hsa-miR-4762-3p	CLIP-seq
MIRT1929427	hsa-miR-4771	CLIP-seq
MIRT2170042	hsa-miR-4775	CLIP-seq
MIRT2170043	hsa-miR-4778-5p	CLIP-seq
MIRT2170044	hsa-miR-4780	CLIP-seq
MIRT2170045	hsa-miR-4785	CLIP-seq
MIRT2170046	hsa-miR-4788	CLIP-seq
MIRT2170047	hsa-miR-4789-5p	CLIP-seq
MIRT1929428	hsa-miR-4795-3p	CLIP-seq
MIRT1555911	hsa-miR-4796-5p	CLIP-seq
MIRT2170048	hsa-miR-491-3p	CLIP-seq
MIRT2170049	hsa-miR-499-3p	CLIP-seq
MIRT2170050	hsa-miR-499a-3p	CLIP-seq
MIRT2170051	hsa-miR-506	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT2170052	hsa-miR-519a	CLIP-seq
MIRT2170053	hsa-miR-519b-3p	CLIP-seq
MIRT2170054	hsa-miR-519c-3p	CLIP-seq
MIRT2170055	hsa-miR-520a-3p	CLIP-seq
MIRT2170056	hsa-miR-520a-5p	CLIP-seq
MIRT2170057	hsa-miR-520b	CLIP-seq
MIRT2170058	hsa-miR-520c-3p	CLIP-seq
MIRT2170059	hsa-miR-520d-3p	CLIP-seq
MIRT2170060	hsa-miR-520d-5p	CLIP-seq
MIRT2170061	hsa-miR-520e	CLIP-seq
MIRT2170062	hsa-miR-522	CLIP-seq
MIRT2170063	hsa-miR-524-5p	CLIP-seq
MIRT2170064	hsa-miR-525-5p	CLIP-seq
MIRT2170065	hsa-miR-544	CLIP-seq
MIRT2170066	hsa-miR-548ac	CLIP-seq
MIRT2170067	hsa-miR-548ae	CLIP-seq
MIRT2170068	hsa-miR-548aj	CLIP-seq
MIRT2170069	hsa-miR-548am	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT2170070	hsa-miR-548d-3p	CLIP-seq
MIRT2170071	hsa-miR-548x	CLIP-seq
MIRT2170072	hsa-miR-548z	CLIP-seq
MIRT2170073	hsa-miR-553	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT1555913	hsa-miR-567	CLIP-seq
MIRT2170074	hsa-miR-568	CLIP-seq
MIRT2170075	hsa-miR-569	CLIP-seq
MIRT2170076	hsa-miR-582-5p	CLIP-seq
MIRT1555914	hsa-miR-586	CLIP-seq
MIRT2170077	hsa-miR-590-3p	CLIP-seq
MIRT2170078	hsa-miR-600	CLIP-seq
MIRT2170079	hsa-miR-601	CLIP-seq
MIRT2170080	hsa-miR-622	CLIP-seq
MIRT2170081	hsa-miR-623	CLIP-seq
MIRT2170082	hsa-miR-639	CLIP-seq
MIRT2170083	hsa-miR-654-3p	CLIP-seq
MIRT2384062	hsa-miR-767-3p	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT2472857	hsa-miR-1256	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT2472858	hsa-miR-2276	CLIP-seq
MIRT776872	hsa-miR-2277-3p	CLIP-seq
MIRT776873	hsa-miR-342-3p	CLIP-seq
MIRT776875	hsa-miR-377	CLIP-seq
MIRT2472859	hsa-miR-3908	CLIP-seq
MIRT776876	hsa-miR-3940-5p	CLIP-seq
MIRT2472860	hsa-miR-3942-5p	CLIP-seq
MIRT2170013	hsa-miR-3977	CLIP-seq
MIRT2472861	hsa-miR-4260	CLIP-seq
MIRT2472862	hsa-miR-4261	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT776881	hsa-miR-4507	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT776885	hsa-miR-4643	CLIP-seq
MIRT2472863	hsa-miR-4703-5p	CLIP-seq
MIRT2472864	hsa-miR-4712-3p	CLIP-seq
MIRT776888	hsa-miR-4715-3p	CLIP-seq
MIRT2472865	hsa-miR-4766-3p	CLIP-seq
MIRT2472866	hsa-miR-4772-3p	CLIP-seq
MIRT2472867	hsa-miR-486-3p	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT2472868	hsa-miR-539	CLIP-seq
MIRT2170065	hsa-miR-544	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT1555912	hsa-miR-561	CLIP-seq
MIRT2472869	hsa-miR-618	CLIP-seq
MIRT2472870	hsa-miR-628-5p	CLIP-seq
MIRT776894	hsa-miR-629	CLIP-seq
MIRT2674884	hsa-miR-1	CLIP-seq
MIRT776868	hsa-miR-1238	CLIP-seq
MIRT776869	hsa-miR-1269	CLIP-seq
MIRT776870	hsa-miR-1269b	CLIP-seq
MIRT2674885	hsa-miR-206	CLIP-seq
MIRT776872	hsa-miR-2277-3p	CLIP-seq
MIRT2674886	hsa-miR-323-3p	CLIP-seq
MIRT776873	hsa-miR-342-3p	CLIP-seq
MIRT2674887	hsa-miR-3647-3p	CLIP-seq
MIRT776875	hsa-miR-377	CLIP-seq
MIRT776876	hsa-miR-3940-5p	CLIP-seq
MIRT2674888	hsa-miR-409-3p	CLIP-seq
MIRT2472862	hsa-miR-4261	CLIP-seq
MIRT776878	hsa-miR-4282	CLIP-seq
MIRT2674889	hsa-miR-4289	CLIP-seq
MIRT776881	hsa-miR-4507	CLIP-seq
MIRT776882	hsa-miR-4520b-3p	CLIP-seq
MIRT776884	hsa-miR-4529-3p	CLIP-seq
MIRT776885	hsa-miR-4643	CLIP-seq
MIRT2472864	hsa-miR-4712-3p	CLIP-seq
MIRT776890	hsa-miR-513a-3p	CLIP-seq
MIRT2674890	hsa-miR-514	CLIP-seq
MIRT2674891	hsa-miR-514b-3p	CLIP-seq
MIRT2472868	hsa-miR-539	CLIP-seq
MIRT776891	hsa-miR-548c-3p	CLIP-seq
MIRT776892	hsa-miR-548g	CLIP-seq
MIRT2674892	hsa-miR-581	CLIP-seq
MIRT2674893	hsa-miR-591	CLIP-seq
MIRT776893	hsa-miR-593	CLIP-seq
MIRT2674894	hsa-miR-613	CLIP-seq
MIRT2472869	hsa-miR-618	CLIP-seq
MIRT776894	hsa-miR-629	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001772	Component	Immunological synapse	IDA	15294938
GO:0002250	Process	Adaptive immune response	IEA
GO:0005102	Function	Signaling receptor binding	TAS	7760007
GO:0005515	Function	Protein binding	IPI	24945728, 26146185
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	ISS
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	16352806
GO:0007165	Process	Signal transduction	TAS	7760007
GO:0008045	Process	Motor neuron axon guidance	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0031226	Component	Intrinsic component of plasma membrane	IDA	15294938
GO:0031290	Process	Retinal ganglion cell axon guidance	ISS
GO:0042101	Component	T cell receptor complex	IDA	15294938
GO:0042802	Function	Identical protein binding	IPI	26146185
GO:0043025	Component	Neuronal cell body	IEA
GO:0048846	Process	Axon extension involved in axon guidance	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:1990138	Process	Neuron projection extension	ISS

MIM	HGNC	e!Ensembl
601662	400	ENSG00000170017

Protein

UniProt ID

Q13740

Protein name

CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)

Protein function

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007).

PDB

5A2F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08205	C2-set_2	137 → 231	CD80-like C2-set immunoglobulin domain	Domain
PF13927	Ig_3	249 → 316		Domain

Tissue specificity

TISSUE SPECIFICITY: Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected

Sequence

MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEK
PDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDN
VFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPL
EGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVF
DIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTL
TDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASR
NATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKM
TKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEEN
VTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAA
LVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA

Sequence length

583

Interactions

View interactions

	KEGG
	Cell adhesion molecules

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942

Show/Hide Unknown Diseases (6)

Disease term	Disease name	Evidence	Source
Unknown
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Metabolic Syndrome	Metabolic Syndrome		GWAS
Oligodendroglioma	Oligodendroglioma		GWAS
Restless Legs Syndrome	Restless Legs Syndrome		GWAS
Coronary artery disease	Coronary artery disease		GWAS
Schizophrenia	Schizophrenia		GWAS

Show/Hide Text Mining Associations (96)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	24346092
Adenoma Pleomorphic	Associate	25472586
Adenomatous Polyps	Stimulate	19010307, 32647988
AIDS Associated Nephropathy	Associate	29066542
Arthritis Rheumatoid	Associate	10693872
Asthma	Associate	24311777
Bone Diseases	Associate	32321465
Breast Neoplasms	Associate	15318930, 16484444, 20364042, 22791584, 22983139, 26923994, 28754978, 29315254, 31757997
Breast Neoplasms	Inhibit	18202807, 25255861
Breast Neoplasms	Stimulate	34641959
Carcinogenesis	Associate	21430457, 22941204, 23840677, 29315254
Carcinoma Adenoid Cystic	Stimulate	25472586
Carcinoma Endometrioid	Stimulate	21430457
Carcinoma Hepatocellular	Associate	21572107, 24482231
Carcinoma Mucoepidermoid	Stimulate	25472586
Carcinoma Non Small Cell Lung	Associate	31883226, 33673439
Cardiovascular Diseases	Associate	21757661
Cartilage Diseases	Associate	15380042, 24966904
Cholangiocarcinoma	Associate	25987048
Colonic Neoplasms	Associate	27062566
Colonic Polyps	Associate	19010307
Colorectal Neoplasms	Stimulate	15509676
Colorectal Neoplasms	Associate	19010307, 20135722, 20606680, 20630067, 23539446, 24023782, 25665511, 26990997, 27062566, 27507615, 32158188, 32608200, 32647988, 35016698, 37103072
Death	Inhibit	18202807
Depressive Disorder	Associate	36634823
Diabetes Mellitus	Associate	22704111
Ectrodactyly	Associate	25420915
Fibroma	Stimulate	17559135
Frontotemporal Dementia	Associate	30292090
Gallbladder Neoplasms	Associate	26318430
Gastrointestinal Neoplasms	Associate	36614319
Hematologic Diseases	Associate	26318430
Hematuria	Stimulate	27894096
Hepatitis Autoimmune	Associate	36159854
HIV Infections	Associate	25420915
HIV Seropositivity	Associate	25420915
Hodgkin Disease	Associate	18070985
Hyperplasia	Associate	21430457
Idiopathic Pulmonary Fibrosis	Associate	28521775
Inflammation	Associate	22941204, 29315254, 36159854
Inflammation	Stimulate	29066542
Intervertebral Disc Degeneration	Stimulate	27018499
Ischemic Stroke	Associate	21757661
Liver Failure	Associate	36159854
Lung Diseases	Associate	28521775
Lupus Nephritis	Associate	35774777
Lymphatic Metastasis	Inhibit	15318930
Lymphatic Metastasis	Stimulate	35016698
Melanoma	Associate	10702391, 15509676, 17143262, 22318386, 26134500
Melanoma Cutaneous Malignant	Associate	26134500
Mesothelioma	Associate	28811252
Mesothelioma Malignant	Associate	28811252
Metabolic Syndrome	Associate	23975165
Mouth Diseases	Associate	23840677
Mouth Neoplasms	Associate	23840677
Multiple Myeloma	Associate	26755711, 32321465
Multiple Myeloma	Inhibit	34592762
Neoplasm Invasiveness	Stimulate	16484444, 21430457
Neoplasm Metastasis	Associate	10702391, 18327805, 20208136, 20364042, 23840677, 24385212, 26134500, 27062566, 27573419, 28811252, 29507910, 32608200, 36614319
Neoplasm Metastasis	Inhibit	18202807, 37103072
Neoplasm Recurrence Local	Associate	15318930
Neoplasms	Associate	10702391, 15509676, 15769845, 17559135, 18327805, 19010307, 19603023, 20208136, 20606680, 21364949, 21572107, 22475274, 22745734, 22761399, 22941204 View all (23 more)
Neoplasms	Inhibit	15318930
Neoplasms	Stimulate	32647988
Neuroblastoma	Associate	20208136, 34116676
Neuroinflammatory Diseases	Associate	21757661
Neuroinflammatory Diseases	Inhibit	25420915
Obesity	Associate	23975165
Osteoarthritis	Associate	14609532, 24819053, 29728632
Osteoarthritis	Inhibit	27155399
Osteoarthritis	Stimulate	28805694
Osteochondritis	Associate	23197301
Osteochondritis Dissecans	Associate	23197301
Pancreatic Neoplasms	Associate	19603023, 22745698, 27573419
Pancreatic Neoplasms	Stimulate	36614319
Pancreatitis Chronic	Associate	22745698, 27573419
Parkinson Disease	Associate	36634823
Peritonitis	Stimulate	36614319
Phyllodes Tumor	Associate	32675396
Plasmacytoma	Associate	32321465
Plasmacytoma anaplastic	Associate	32321465
Prostate Cancer Hereditary 7	Associate	35767366
Prostatic Hyperplasia	Associate	37705744
Prostatic Neoplasms	Associate	15509676, 16982673, 24385212, 35767366
Pulmonary Disease Chronic Obstructive	Associate	26736064
Rectal Neoplasms	Associate	24708484
Retinal Diseases	Associate	22940369
Salivary Gland Neoplasms	Associate	25472586, 35848479
Sarcoma Ewing	Associate	31140328
Squamous Cell Carcinoma of Head and Neck	Associate	23840677, 29507910
Stomach Neoplasms	Inhibit	21119604
Tertiary Lymphoid Structures	Associate	27062566
Thyroid Neoplasms	Associate	21364949
Uterine Cervical Dysplasia	Stimulate	27573419
Uterine Cervical Neoplasms	Associate	22475274
Uveal melanoma	Associate	22745734

ALCAM (activated leukocyte cell adhesion molecule)