Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2047
Gene name	EPH receptor B1
Gene symbol	EPHB1
Synonyms (NCBI Gene)	ELKEPHT2Hek6NET
Chromosome	3
Chromosome location	3q22.2
Summary	Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to

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miRTarBase ID	miRNA	Experiments	Reference
MIRT438671	hsa-miR-128-3p	Luciferase reporter assayqRT-PCRWestern blot	23835497
MIRT438671	hsa-miR-128-3p	Luciferase reporter assayqRT-PCRWestern blot	23835497
MIRT438671	hsa-miR-128-3p	Luciferase reporter assayqRT-PCRWestern blot	23835497
MIRT438671	hsa-miR-128-3p	Luciferase reporter assayqRT-PCRWestern blot	23835497
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT658587	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT658586	hsa-miR-1248	HITS-CLIP	23824327
MIRT658585	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT658584	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT658583	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT658582	hsa-miR-4279	HITS-CLIP	23824327
MIRT658581	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT658580	hsa-miR-578	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT638750	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT658587	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT658586	hsa-miR-1248	HITS-CLIP	23824327
MIRT658585	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT658584	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT658583	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT658582	hsa-miR-4279	HITS-CLIP	23824327
MIRT658581	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT658580	hsa-miR-578	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT638750	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT624017	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT624016	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT624015	hsa-miR-5696	HITS-CLIP	23824327
MIRT624014	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT624013	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT624012	hsa-miR-548aw	HITS-CLIP	23824327
MIRT624011	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT624010	hsa-miR-527	HITS-CLIP	23824327
MIRT966665	hsa-miR-1273g	CLIP-seq
MIRT966666	hsa-miR-1914	CLIP-seq
MIRT966667	hsa-miR-3074-5p	CLIP-seq
MIRT966668	hsa-miR-3120-5p	CLIP-seq
MIRT966669	hsa-miR-3147	CLIP-seq
MIRT966670	hsa-miR-4418	CLIP-seq
MIRT966671	hsa-miR-4421	CLIP-seq
MIRT966672	hsa-miR-4427	CLIP-seq
MIRT966673	hsa-miR-4659a-3p	CLIP-seq
MIRT966674	hsa-miR-4659b-3p	CLIP-seq
MIRT966675	hsa-miR-4680-3p	CLIP-seq
MIRT966676	hsa-miR-509-3-5p	CLIP-seq
MIRT966677	hsa-miR-509-5p	CLIP-seq
MIRT1986309	hsa-miR-526b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001525	Process	Angiogenesis	IDA	9499402
GO:0001771	Process	Immunological synapse formation	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IEA
GO:0005003	Function	Ephrin receptor activity	IEA
GO:0005005	Function	Transmembrane-ephrin receptor activity	IBA
GO:0005005	Function	Transmembrane-ephrin receptor activity	IDA	18034775
GO:0005515	Function	Protein binding	IPI	8798570, 9499402, 12223469, 12925710, 18034775
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18034775
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	ISS
GO:0008046	Function	Axon guidance receptor activity	IEA
GO:0014719	Process	Skeletal muscle satellite cell activation	IEA
GO:0014719	Process	Skeletal muscle satellite cell activation	ISS
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016477	Process	Cell migration	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0021545	Process	Cranial nerve development	IEA
GO:0021631	Process	Optic nerve morphogenesis	IEA
GO:0021934	Process	Hindbrain tangential cell migration	IEA
GO:0021952	Process	Central nervous system projection neuron axonogenesis	IEA
GO:0021952	Process	Central nervous system projection neuron axonogenesis	ISS
GO:0022008	Process	Neurogenesis	IEA
GO:0022008	Process	Neurogenesis	ISS
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030010	Process	Establishment of cell polarity	ISS
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	ISS
GO:0031589	Process	Cell-substrate adhesion	IDA	9430661
GO:0031589	Process	Cell-substrate adhesion	IEA
GO:0031901	Component	Early endosome membrane	IDA	18034775
GO:0031901	Component	Early endosome membrane	IEA
GO:0032433	Component	Filopodium tip	IEA
GO:0042995	Component	Cell projection	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0046328	Process	Regulation of JNK cascade	IDA	9430661
GO:0046777	Process	Protein autophosphorylation	IDA	18034775
GO:0048013	Process	Ephrin receptor signaling pathway	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	IDA	12925710, 18034775
GO:0048013	Process	Ephrin receptor signaling pathway	IEA
GO:0048593	Process	Camera-type eye morphogenesis	IEA
GO:0048731	Process	System development	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	ISS
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0051965	Process	Positive regulation of synapse assembly	ISS
GO:0060326	Process	Cell chemotaxis	IDA	12925710
GO:0060326	Process	Cell chemotaxis	IEA
GO:0060996	Process	Dendritic spine development	IEA
GO:0060996	Process	Dendritic spine development	IEA
GO:0060996	Process	Dendritic spine development	ISS
GO:0060997	Process	Dendritic spine morphogenesis	IEA
GO:0060997	Process	Dendritic spine morphogenesis	ISS
GO:0061351	Process	Neural precursor cell proliferation	IEA
GO:0061351	Process	Neural precursor cell proliferation	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IDA	12925710, 18034775
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1902723	Process	Negative regulation of skeletal muscle satellite cell proliferation	IEA
GO:1902723	Process	Negative regulation of skeletal muscle satellite cell proliferation	ISS
GO:1902725	Process	Negative regulation of satellite cell differentiation	IEA
GO:1902725	Process	Negative regulation of satellite cell differentiation	ISS

MIM	HGNC	e!Ensembl
600600	3392	ENSG00000154928

P54762

Protein name

Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is

PDB

2DJS , 2EAO , 3ZFX , 5MJA , 5MJB , 6UMW , 7KPL , 7KPM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01404	Ephrin_lbd	20 → 196	Ephrin receptor ligand binding domain	Domain
PF00041	fn3	324 → 418	Fibronectin type III domain	Domain
PF00041	fn3	434 → 518	Fibronectin type III domain	Domain
PF14575	EphA2_TM	542 → 616	Ephrin type-A receptor 2 transmembrane domain	Domain
PF07714	PK_Tyr_Ser-Thr	619 → 878	Protein tyrosine and serine/threonine kinase	Domain
PF00536	SAM_1	909 → 973	SAM domain (Sterile alpha motif)	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially expressed in brain.

Sequence

MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQV
CNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSV
IATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDY
GACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYC
NGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPI
CTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIIC
KKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPP
QHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFN
SSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLP
LIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTY
EDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK
QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ
LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS
SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD
YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQ
PLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAG
HQKKILNSIHSMRVQISQSPTAMA

Sequence length

984

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		EPH-Ephrin signaling EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells

EPHB1 (EPH receptor B1)