Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2044
Gene name Gene Name - the full gene name approved by the HGNC.	EPH receptor A5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EPHA5
Synonyms (NCBI Gene) Gene synonyms aliases	CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q13.1-q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically ha

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1057520012	C>T	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(198)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006576	hsa-miR-34a-5p	Luciferase reporter assay, Western blot	22079638
MIRT025144	hsa-miR-181a-5p	Microarray	17612493
MIRT542992	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523889	hsa-miR-567	PAR-CLIP	21572407
MIRT523888	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523885	hsa-miR-297	PAR-CLIP	21572407
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT523883	hsa-miR-147a	PAR-CLIP	21572407
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523880	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT542992	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523889	hsa-miR-567	PAR-CLIP	21572407
MIRT523888	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523885	hsa-miR-297	PAR-CLIP	21572407
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT523883	hsa-miR-147a	PAR-CLIP	21572407
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523880	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT542992	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523889	hsa-miR-567	PAR-CLIP	21572407
MIRT523888	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523885	hsa-miR-297	PAR-CLIP	21572407
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT523883	hsa-miR-147a	PAR-CLIP	21572407
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523880	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT523889	hsa-miR-567	PAR-CLIP	23446348
MIRT523888	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT523885	hsa-miR-297	PAR-CLIP	23446348
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT523883	hsa-miR-147a	PAR-CLIP	23446348
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT523880	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT542992	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523889	hsa-miR-567	PAR-CLIP	21572407
MIRT523888	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523885	hsa-miR-297	PAR-CLIP	21572407
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT523883	hsa-miR-147a	PAR-CLIP	21572407
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523880	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT542992	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523889	hsa-miR-567	PAR-CLIP	21572407
MIRT523888	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523885	hsa-miR-297	PAR-CLIP	21572407
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT523883	hsa-miR-147a	PAR-CLIP	21572407
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523880	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT542992	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT523889	hsa-miR-567	PAR-CLIP	21572407
MIRT523888	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT523885	hsa-miR-297	PAR-CLIP	21572407
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT523883	hsa-miR-147a	PAR-CLIP	21572407
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	21572407
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT523880	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT523890	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT523889	hsa-miR-567	PAR-CLIP	23446348
MIRT523888	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT523887	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT523886	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT523885	hsa-miR-297	PAR-CLIP	23446348
MIRT523884	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT523883	hsa-miR-147a	PAR-CLIP	23446348
MIRT523882	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT523881	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT523880	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT966547	hsa-miR-137	CLIP-seq
MIRT966548	hsa-miR-147	CLIP-seq
MIRT966549	hsa-miR-193a-3p	CLIP-seq
MIRT966550	hsa-miR-193b	CLIP-seq
MIRT966551	hsa-miR-200b	CLIP-seq
MIRT966552	hsa-miR-200c	CLIP-seq
MIRT966553	hsa-miR-3128	CLIP-seq
MIRT966554	hsa-miR-338-5p	CLIP-seq
MIRT966555	hsa-miR-4275	CLIP-seq
MIRT966556	hsa-miR-429	CLIP-seq
MIRT966557	hsa-miR-4729	CLIP-seq
MIRT966558	hsa-miR-548ag	CLIP-seq
MIRT966559	hsa-miR-548ai	CLIP-seq
MIRT966560	hsa-miR-556-5p	CLIP-seq
MIRT966561	hsa-miR-599	CLIP-seq
MIRT966562	hsa-miR-892b	CLIP-seq
MIRT966563	hsa-miR-106a	CLIP-seq
MIRT966564	hsa-miR-106b	CLIP-seq
MIRT966565	hsa-miR-1299	CLIP-seq
MIRT966566	hsa-miR-146a	CLIP-seq
MIRT966567	hsa-miR-146b-5p	CLIP-seq
MIRT966548	hsa-miR-147	CLIP-seq
MIRT966568	hsa-miR-17	CLIP-seq
MIRT966569	hsa-miR-20a	CLIP-seq
MIRT966570	hsa-miR-20b	CLIP-seq
MIRT966571	hsa-miR-218	CLIP-seq
MIRT966572	hsa-miR-23a	CLIP-seq
MIRT966573	hsa-miR-23b	CLIP-seq
MIRT966574	hsa-miR-23c	CLIP-seq
MIRT966575	hsa-miR-302a	CLIP-seq
MIRT966576	hsa-miR-302b	CLIP-seq
MIRT966577	hsa-miR-302c	CLIP-seq
MIRT966578	hsa-miR-302d	CLIP-seq
MIRT966579	hsa-miR-302e	CLIP-seq
MIRT966580	hsa-miR-3163	CLIP-seq
MIRT966581	hsa-miR-326	CLIP-seq
MIRT966582	hsa-miR-330-5p	CLIP-seq
MIRT966583	hsa-miR-372	CLIP-seq
MIRT966584	hsa-miR-373	CLIP-seq
MIRT966585	hsa-miR-410	CLIP-seq
MIRT966586	hsa-miR-4251	CLIP-seq
MIRT966587	hsa-miR-4303	CLIP-seq
MIRT966588	hsa-miR-4329	CLIP-seq
MIRT966589	hsa-miR-4796-5p	CLIP-seq
MIRT966590	hsa-miR-519d	CLIP-seq
MIRT966591	hsa-miR-520a-3p	CLIP-seq
MIRT966592	hsa-miR-520b	CLIP-seq
MIRT966593	hsa-miR-520c-3p	CLIP-seq
MIRT966594	hsa-miR-520d-3p	CLIP-seq
MIRT966595	hsa-miR-520e	CLIP-seq
MIRT966596	hsa-miR-548n	CLIP-seq
MIRT966597	hsa-miR-548t	CLIP-seq
MIRT966598	hsa-miR-589	CLIP-seq
MIRT966599	hsa-miR-590-3p	CLIP-seq
MIRT966561	hsa-miR-599	CLIP-seq
MIRT966600	hsa-miR-636	CLIP-seq
MIRT966601	hsa-miR-654-3p	CLIP-seq
MIRT966602	hsa-miR-875-3p	CLIP-seq
MIRT966603	hsa-miR-93	CLIP-seq
MIRT966604	hsa-miR-944	CLIP-seq
MIRT966557	hsa-miR-4729	CLIP-seq
MIRT966557	hsa-miR-4729	CLIP-seq
MIRT966557	hsa-miR-4729	CLIP-seq
MIRT1986283	hsa-miR-204	CLIP-seq
MIRT1986284	hsa-miR-211	CLIP-seq
MIRT1986285	hsa-miR-3646	CLIP-seq
MIRT1986286	hsa-miR-3662	CLIP-seq
MIRT1986287	hsa-miR-4282	CLIP-seq
MIRT1986288	hsa-miR-548a-3p	CLIP-seq
MIRT1986289	hsa-miR-548e	CLIP-seq
MIRT1986290	hsa-miR-548f	CLIP-seq
MIRT966560	hsa-miR-556-5p	CLIP-seq
MIRT1986291	hsa-miR-562	CLIP-seq
MIRT2220865	hsa-miR-1254	CLIP-seq
MIRT2220866	hsa-miR-1290	CLIP-seq
MIRT2220867	hsa-miR-142-5p	CLIP-seq
MIRT2220868	hsa-miR-3116	CLIP-seq
MIRT2220869	hsa-miR-3167	CLIP-seq
MIRT2220870	hsa-miR-4427	CLIP-seq
MIRT2220871	hsa-miR-4698	CLIP-seq
MIRT966557	hsa-miR-4729	CLIP-seq
MIRT2220872	hsa-miR-4789-5p	CLIP-seq
MIRT2220873	hsa-miR-661	CLIP-seq
MIRT2220874	hsa-miR-876-5p	CLIP-seq
MIRT966604	hsa-miR-944	CLIP-seq
MIRT966548	hsa-miR-147	CLIP-seq
MIRT966548	hsa-miR-147	CLIP-seq
MIRT2465230	hsa-miR-3138	CLIP-seq
MIRT2465231	hsa-miR-3911	CLIP-seq
MIRT2465232	hsa-miR-4800-5p	CLIP-seq
MIRT966561	hsa-miR-599	CLIP-seq
MIRT2465233	hsa-miR-644	CLIP-seq
MIRT2465234	hsa-miR-711	CLIP-seq
MIRT966580	hsa-miR-3163	CLIP-seq
MIRT2524579	hsa-miR-4760-5p	CLIP-seq
MIRT2524580	hsa-miR-577	CLIP-seq
MIRT966555	hsa-miR-4275	CLIP-seq
MIRT1986288	hsa-miR-548a-3p	CLIP-seq
MIRT2680192	hsa-miR-548c-3p	CLIP-seq
MIRT1986289	hsa-miR-548e	CLIP-seq
MIRT1986290	hsa-miR-548f	CLIP-seq
MIRT2680193	hsa-miR-885-5p	CLIP-seq

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IEA
GO:0005003	Function	Ephrin receptor activity	IEA
GO:0005003	Function	Ephrin receptor activity	ISS
GO:0005004	Function	GPI-linked ephrin receptor activity	ISS
GO:0005005	Function	Transmembrane-ephrin receptor activity	IBA
GO:0005005	Function	Transmembrane-ephrin receptor activity	NAS	7898931
GO:0005515	Function	Protein binding	IPI	35384245
GO:0005524	Function	ATP binding	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IDA	10375373
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10375373
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	ISS
GO:0009897	Component	External side of plasma membrane	IDA	10064801
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0021766	Process	Hippocampus development	ISS
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	IDA	9191074, 10375373
GO:0030425	Component	Dendrite	IEA
GO:0032793	Process	Positive regulation of CREB transcription factor activity	ISS
GO:0032956	Process	Regulation of actin cytoskeleton organization	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IDA	10375373
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0048013	Process	Ephrin receptor signaling pathway	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	10375373
GO:0048666	Process	Neuron development	IEP	10375373
GO:0061178	Process	Regulation of insulin secretion involved in cellular response to glucose stimulus	ISS

MIM	HGNC	e!Ensembl
600004	3389	ENSG00000145242

Protein

UniProt ID

P54756

Protein name

Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)

Protein function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is

PDB

2R2P , 4ET7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01404	Ephrin_lbd	61 → 233	Ephrin receptor ligand binding domain	Domain
PF00041	fn3	359 → 453	Fibronectin type III domain	Domain
PF00041	fn3	470 → 552	Fibronectin type III domain	Domain
PF14575	EphA2_TM	574 → 672	Ephrin type-A receptor 2 transmembrane domain	Domain
PF07714	PK_Tyr_Ser-Thr	675 → 932	Protein tyrosine and serine/threonine kinase	Domain
PF00536	SAM_1	964 → 1027	SAM domain (Sterile alpha motif)	Domain

Tissue specificity

TISSUE SPECIFICITY: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and

Sequence

MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNE
VNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISN
EGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAAD
ESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHL
AVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNG
TCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSA
PRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSG
LKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKI
AKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQI
RARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCE
CGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPN
QAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD
FLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGM
LRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKI
PIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSP
MDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHS
PLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIM
NSLQEMKVQLVNGMVPL

Sequence length

1037

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		EPH-Ephrin signaling EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Astrocytoma	astrocytoma	N/A	N/A	ClinVar
Pelvic Organ Prolapse	Pelvic organ prolapse	N/A	N/A	GWAS
Pemphigus Vulgaris	Pemphigus vulgaris	N/A	N/A	GWAS

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33288738
Anxiety	Associate	31181069
Attention Deficit Disorder with Hyperactivity	Associate	34109382
Barrett Esophagus	Associate	32251017
Breast Neoplasms	Associate	23496902, 33977106
Carcinogenesis	Associate	25609195
Carcinoma Non Small Cell Lung	Associate	25634010, 34761594, 36123678
Carcinoma Ovarian Epithelial	Associate	26909918, 27887627
Carcinoma Renal Cell	Associate	28421649
Carcinoma Renal Cell	Stimulate	34331411
Colorectal Neoplasms	Associate	36745477
Depressive Disorder	Associate	31181069
Helicobacter Infections	Associate	36164608
Hematologic Diseases	Associate	31023863
Hereditary Breast and Ovarian Cancer Syndrome	Associate	33210795
Hyperplasia	Inhibit	25609195
Infections	Associate	29899108
Lymphatic Metastasis	Stimulate	39925800
Melanoma	Associate	35181301
Neoplasms	Associate	18717013, 19949912, 23496902, 27225414, 28421649, 32251017, 33288738, 35860812, 36745477, 36911742, 39925800
Nervous System Diseases	Associate	27582484
Ovarian Neoplasms	Associate	27887627, 36345952, 39925800
Pancreatic Neoplasms	Associate	19949912
Peripheral Nervous System Diseases	Associate	22843789, 31823378
Pigmentation Disorders	Associate	35181301
Prostatic Neoplasms	Inhibit	25609195
Prostatitis	Inhibit	25609195
Pulmonary Disease Chronic Obstructive	Associate	35860812
Stomach Neoplasms	Associate	26769141, 36164608

EPHA5 (EPH receptor A5)