EPHA4 (EPH receptor A4)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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2043 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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EPH receptor A4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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EPHA4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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EK8, HEK8, SEK, TYRO1 |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q36.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically ha |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||||||||||||
| UniProt ID | P54764 | |||||||||||||||||||||||||||||||||||
| Protein name | Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) | |||||||||||||||||||||||||||||||||||
| Protein function | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as | |||||||||||||||||||||||||||||||||||
| PDB | 2LW8 , 2WO1 , 2WO2 , 2WO3 , 3CKH , 3GXU , 4BK4 , 4BK5 , 4BKA , 4BKF , 4M4P , 4M4R , 4W4Z , 4W50 , 5JR2 , 7OFV , 9CY8 | |||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:7898931}. | |||||||||||||||||||||||||||||||||||
| Sequence |
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| Sequence length | 986 | |||||||||||||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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