Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2042
Gene name Gene Name - the full gene name approved by the HGNC.
EPH receptor A3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
EPHA3
Synonyms (NCBI Gene) Gene synonyms aliases
EK4, ETK, ETK1, HEK, HEK4, TYRO4
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p11.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically ha
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT966382 hsa-miR-1322 CLIP-seq
MIRT966383 hsa-miR-135a CLIP-seq
MIRT966384 hsa-miR-135b CLIP-seq
MIRT966385 hsa-miR-23a CLIP-seq
MIRT966386 hsa-miR-23b CLIP-seq
Transcription factors
Transcription factor Regulation Reference
AES Unknown 20676368
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004714 Function Transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005003 Function Ephrin receptor activity IDA 11519828
GO:0005004 Function GPI-linked ephrin receptor activity IDA 11870224
GO:0005005 Function Transmembrane-ephrin receptor activity IBA 21873635
GO:0005515 Function Protein binding IPI 11519828, 11870224, 21135139
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179611 3387 ENSG00000044524
Protein
UniProt ID P29320
Protein name Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Protein function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is
PDB 2GSF , 2QO2 , 2QO7 , 2QO9 , 2QOB , 2QOC , 2QOD , 2QOF , 2QOI , 2QOK , 2QOL , 2QON , 2QOO , 2QOQ , 3DZQ , 3FXX , 3FY2 , 4G2F , 4GK2 , 4GK3 , 4GK4 , 4L0P , 4P4C , 4P5Q , 4P5Z , 4TWN , 4TWO , 6IN0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01404 Ephrin_lbd 30 202 Ephrin receptor ligand binding domain Domain
PF07699 Ephrin_rec_like 263 306 Putative ephrin-receptor like Family
PF00041 fn3 327 422 Fibronectin type III domain Domain
PF00041 fn3 437 521 Fibronectin type III domain Domain
PF14575 EphA2_TM 542 618 Ephrin type-A receptor 2 transmembrane domain Domain
PF07714 PK_Tyr_Ser-Thr 621 878 Protein tyrosine and serine/threonine kinase Domain
PF07647 SAM_2 908 973 SAM domain (Sterile alpha motif) Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highest level in placenta.
Sequence
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDE
HYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETF
NLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFY
LAFQDVGACVALVSVRVYFKKC
PFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPP
RMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDG
SMNCRC
ENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFN
IICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSS
PP
RQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQ
ETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNS
RKFEFETSPDSFSISGESS
QVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPH
TYEDPTQAVHEFAKELDA
TNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT
EKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTV
IQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT
TRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG
YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL
DKLIRNPGSLKIITSAAARPSN
LLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVG
PQKKIISSIKALE
TQSKNGPVPV
Sequence length 983
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Axon guidance   EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
30061737, 29892015
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Lung carcinoma Squamous cell carcinoma of lung, Carcinoma of lung, Large cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
Unknown
Disease term Disease name Evidence References Source
Pancreatic adenocarcinoma Pancreatic Ductal Adenocarcinoma PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate. ClinVar, CBGDA
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 29892015, 30061737 ClinVar
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 18948947
Amyotrophic Lateral Sclerosis Inhibit 23991104
Amyotrophic lateral sclerosis 1 Associate 23991104
Autism Spectrum Disorder Associate 21996756
Breast Neoplasms Associate 19678838, 21124932, 33977106, 36936167
Carcinogenesis Associate 20027224, 23324396
Carcinogenesis Inhibit 20657180
Carcinoma Large Cell Associate 30793508
Carcinoma Merkel Cell Associate 36736454
Carcinoma Non Small Cell Lung Associate 25634010