Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2029
Gene name Gene Name - the full gene name approved by the HGNC.
Endosulfine alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ENSA
Synonyms (NCBI Gene) Gene synonyms aliases
ARPP-19e
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051695 hsa-let-7e-5p CLASH 23622248
MIRT036994 hsa-miR-877-3p CLASH 23622248
MIRT676892 hsa-miR-6813-3p HITS-CLIP 23824327
MIRT676891 hsa-miR-1245a HITS-CLIP 23824327
MIRT676890 hsa-miR-8079 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle ISS
GO:0000278 Process Mitotic cell cycle ISS
GO:0004864 Function Protein phosphatase inhibitor activity IBA
GO:0004864 Function Protein phosphatase inhibitor activity IEA
GO:0005102 Function Signaling receptor binding IDA 9653196
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603061 3360 ENSG00000143420
Protein
UniProt ID O43768
Protein name Alpha-endosulfine (ARPP-19e)
Protein function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04667 Endosulfine 10 114 cAMP-regulated phosphoprotein/endosulfine conserved region Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. {ECO:0000269|PubMed:14728987, ECO:0000269|PubMed:9653196}.
Sequence
Sequence length 121
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    MASTL Facilitates Mitotic Progression
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Sarcoidosis Sarcoidosis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Lymphatic Metastasis Associate 31348270
Prostatic Neoplasms Associate 31348270