ADGRE1 (adhesion G protein-coupled receptor E1)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2015
Gene name Gene Name - the full gene name approved by the HGNC.
Adhesion G protein-coupled receptor E1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADGRE1
Synonyms (NCBI Gene) Gene synonyms aliases
EMR1, TM7LN3
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.3-p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments b
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0005509 Function Calcium ion binding IEA
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007155 Process Cell adhesion TAS 7601460
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600493 3336 ENSG00000174837
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q14246
Protein name Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor)
Protein function Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12662 cEGF 53 → 83 Complement Clr-like EGF-like Domain
PF07645 EGF_CA 132 → 170 Calcium-binding EGF domain Domain
PF07645 EGF_CA 172 → 213 Calcium-binding EGF domain Domain
PF12662 cEGF 241 → 271 Complement Clr-like EGF-like Domain
PF01825 GPS 548 → 590 GPCR proteolysis site, GPS, motif Motif
PF00002 7tm_2 599 → 840 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: Expression is restricted to eosinophils. {ECO:0000269|PubMed:17823986, ECO:0000269|PubMed:24530099}.
Sequence 
MRGFNLLLFWGCCVMHSWEGHIRPTRKPNTKGNNCRDSTLCPAYATCTNTVDSYYCACKQ
GFLSSNGQNHFKDPGVRCKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDW
VPGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFISRNSTCEDVDECADPR
ACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEMCPINSTCTNTPG
SYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGF
HPNPEGSQKDGNFSCQRVLFKCKEDVIPDNKQIQQCQEGTAVKPAYVSFCAQINNIFSVL
DKVCENKTTVVSLKNTTESFVPVLKQISTWTKFTKEETSSLATVFLESVESMTLASFWKP
SANITPAVRTEYLDIESKVINKECSEENVTLDLVAKGDKMKIGCSTIEESESTETTGVAF
VSFVGMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQ
PKQKFERPICVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTMDF
SLYIISHVGIIISLVCLVLAIATFLLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTD
NKMGCAIIAGFLHYLFLACFFWMLVEAVILFLMVRNLKVVNYFSSRNIKMLHICAFGYGL
PMLVVVISASVQPQGYGMHNRCWLNTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRL
SSVNAEVSTLKDTRLLTFKAFAQLFILGCSWVLGIFQIGPVAGVMAYLFTIINSLQGAFI
FLIHCLLNGQVREEYKRWITGKTKPSSQSQTSRILLSSMPSASKTG
Sequence length 886
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Class B/2 (Secretin family receptors)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Periodontitis Periodontitis rs28937571, rs104894211, rs587777534 23459936
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Biliary Atresia Biliary Atresia GWAS
Show/Hide Text Mining Associations (20)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 27220887
Chronic Periodontitis Associate 23459936, 25056994
Colorectal Neoplasms Associate 34486997
Coma Associate 23614351
HAIR AN syndrome Stimulate 18825363
Hypereosinophilic Syndrome Associate 24530099
Hyperplasia Associate 35586138
Idiopathic Pulmonary Fibrosis Associate 21309737
Inflammation Stimulate 20930711
Inflammation Associate 33737203