Gene Gene information from NCBI Gene database.
Entrez ID 1977
Gene name Eukaryotic translation initiation factor 4E
Gene symbol EIF4E
Synonyms (NCBI Gene)
AUTS19CBPEIF4E1EIF4EL1EIF4FeIF-4E
Chromosome 4
Chromosome location 4q23
Summary The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5` end of messenger RNAs. The encoded protein aids in translation initiation by recruit
miRNA miRNA information provided by mirtarbase database.
607
miRTarBase ID miRNA Experiments Reference
MIRT001469 hsa-miR-16-5p pSILAC 18668040
MIRT005479 hsa-miR-141-3p Luciferase reporter assayNorthern blotqRT-PCRWestern blot 21238947
MIRT005878 hsa-miR-145-5p Luciferase reporter assayqRT-PCRWestern blot 21092188
MIRT022728 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023809 hsa-miR-1-3p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
62
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IMP 14673156
GO:0000339 Function RNA cap binding TAS 3469651
GO:0000340 Function RNA 7-methylguanosine cap binding IBA
GO:0000340 Function RNA 7-methylguanosine cap binding IDA 19750007
GO:0000932 Component P-body IDA 16157702, 20616046, 24335285
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
133440 3287 ENSG00000151247
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P06730
Protein name Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
Protein function Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606
PDB 1IPB , 1IPC , 1WKW , 2GPQ , 2V8W , 2V8X , 2V8Y , 2W97 , 3AM7 , 3TF2 , 3U7X , 4AZA , 4BEA , 4DT6 , 4DUM , 4TPW , 4TQB , 4TQC , 4UED , 5EHC , 5EI3 , 5EIR , 5EKV , 5GW6 , 5T46 , 5ZJY , 5ZJZ , 5ZK5 , 5ZK7 , 5ZK9 , 5ZML , 7D6Y , 7D8B , 7EZW , 7F07 , 7MEU , 7XTP , 8QM4 , 8QM5 , 8QM6 , 8QM7 , 8QM8 , 8QM9 , 8SX4 , 9DON
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01652 IF4E 38 197 Eukaryotic initiation factor 4E Domain
Sequence
Sequence length 217
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  EGFR tyrosine kinase inhibitor resistance
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Longevity regulating pathway
Insulin signaling pathway
  ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
mTORC1-mediated signalling
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autism, susceptibility to, 19 risk factor rs142990298 RCV000033167
EIF4E-related disorder Benign; Likely benign rs62323192, rs11723037, rs777025316 RCV003979614
RCV003982526
RCV003974003
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 30297141
Adenocarcinoma Associate 22767218, 35737644
Adenocarcinoma of Lung Associate 26498338, 32023262
Asthma Associate 35751199
Autism Spectrum Disorder Associate 30705255, 33076578
Biliary Tract Neoplasms Associate 12819026
Brain Neoplasms Associate 19188486
Breast Neoplasms Associate 16633004, 17010208, 18644990, 19134194, 19367274, 20655307, 21320304, 21415224, 23667251, 24504069, 24970821, 25273840, 25986608, 27280636, 27926520
View all (6 more)
Breast Neoplasms Stimulate 34876062
Breast Neoplasms Male Associate 27280636, 27986751