Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
197358
Gene name Gene Name - the full gene name approved by the HGNC.
NLR family CARD domain containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NLRC3
Synonyms (NCBI Gene) Gene synonyms aliases
CLR16.2, NOD3
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT701391 hsa-miR-548c-3p HITS-CLIP 23313552
MIRT701390 hsa-miR-6771-3p HITS-CLIP 23313552
MIRT701389 hsa-miR-4293 HITS-CLIP 23313552
MIRT701388 hsa-miR-3675-3p HITS-CLIP 23313552
MIRT701387 hsa-miR-4684-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003674 Function Molecular_function ND
GO:0005515 Function Protein binding IPI 24560620, 25277106
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm IDA 15705585, 24560620, 25277106
GO:0005829 Component Cytosol IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615648 29889 ENSG00000167984
Protein
UniProt ID Q7RTR2
Protein name NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)
Protein function Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molec
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05729 NACHT 139 305 NACHT domain Domain
PF17779 NOD2_WH 395 453 NOD2 winged helix domain Domain
PF17776 NLRC4_HD2 455 582 NLRC4 helical domain HD2 Domain
PF13516 LRR_6 664 687 Leucine Rich repeat Repeat
PF13516 LRR_6 692 715 Leucine Rich repeat Repeat
PF13516 LRR_6 721 743 Leucine Rich repeat Repeat
PF13516 LRR_6 776 799 Leucine Rich repeat Repeat
PF13516 LRR_6 804 827 Leucine Rich repeat Repeat
PF13516 LRR_6 832 855 Leucine Rich repeat Repeat
PF13516 LRR_6 860 883 Leucine Rich repeat Repeat
PF13516 LRR_6 888 911 Leucine Rich repeat Repeat
PF13516 LRR_6 916 939 Leucine Rich repeat Repeat
PF13516 LRR_6 972 995 Leucine Rich repeat Repeat
PF13516 LRR_6 1000 1023 Leucine Rich repeat Repeat
PF13516 LRR_6 1028 1051 Leucine Rich repeat Repeat
Sequence
MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSND
SRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPAR
TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR
DLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPK
KEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQ
MFPED
QALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTL
CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDM
KAFGVDLALLQGAPCSCFLQREETLASSVAYCF
THLSLQEFVAAAYYYGASRRAIFDLFT
ESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQ
AYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARS
VEEAMESGALARLTGPAH
RAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSV
LSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI
NRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSL
KELMFSSNSIGDGGAKALA
EALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLS
LRENSISPEGAQAIA
HALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN
FIQAGAAQALG
QALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGA
SGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAI
CIA
TALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM
Sequence length 1065
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    IRF3-mediated induction of type I IFN
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 36808166
Alzheimer Disease Associate 35173266
Carcinogenesis Associate 36808166
Carcinoma Hepatocellular Associate 32148377
Cartilage Diseases Associate 37312878
Colorectal Neoplasms Inhibit 26378020
Common Variable Immunodeficiency Associate 32047491
Dementia Associate 35173266
Granulomatosis with Polyangiitis Associate 21412229
Inflammation Associate 26378020, 35173266, 36808166, 37312878