Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	196743
Gene name Gene Name - the full gene name approved by the HGNC.	Polyamine oxidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PAOX
Synonyms (NCBI Gene) Gene synonyms aliases	PAO
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q26.3

Show/Hide all(176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT667068	hsa-miR-1245a	HITS-CLIP	23824327
MIRT667067	hsa-miR-8079	HITS-CLIP	23824327
MIRT667066	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT667065	hsa-miR-4421	HITS-CLIP	23824327
MIRT667063	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT667064	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT667062	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667061	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667060	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT667068	hsa-miR-1245a	HITS-CLIP	23824327
MIRT667067	hsa-miR-8079	HITS-CLIP	23824327
MIRT667066	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT667065	hsa-miR-4421	HITS-CLIP	23824327
MIRT667063	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT667064	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT667062	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667061	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667060	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006596	Process	Polyamine biosynthetic process	TAS
GO:0006625	Process	Protein targeting to peroxisome	TAS
GO:0009446	Process	Putrescine biosynthetic process	IDA	16354669
GO:0009447	Process	Putrescine catabolic process	IDA	16354669
GO:0016491	Function	Oxidoreductase activity	IBA	21873635
GO:0046203	Process	Spermidine catabolic process	IDA	16354669
GO:0046208	Process	Spermine catabolic process	IDA	16354669
GO:0046592	Function	Polyamine oxidase activity	IBA	21873635
GO:0046592	Function	Polyamine oxidase activity	IDA	16354669
GO:0052899	Function	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	IEA
GO:0052901	Function	Spermine:oxygen oxidoreductase (spermidine-forming) activity	IEA
GO:0052902	Function	Spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity	IEA
GO:0052903	Function	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	IEA
GO:0052904	Function	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	IEA
GO:1901307	Process	Positive regulation of spermidine biosynthetic process	IDA	16354669

MIM	HGNC	e!Ensembl
615853	20837	ENSG00000148832

Protein

UniProt ID

Q6QHF9

Protein name

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)

Protein function

Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylsperm

Family and domains

Pfam

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Accession	ID	Position in sequence	Description	Type
PF01593	Amino_oxidase	23 → 168	Flavin containing amine oxidoreductase	Domain
PF01593	Amino_oxidase	168 → 635	Flavin containing amine oxidoreductase	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO:0000269|PubMed:12477380}.

Sequence

MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCF
GGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGA
SVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLK
LAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNCMMAALPEDT
VVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFF
DPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAW
FRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPK
SVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAGAQLQILFAGEATHRTFYS
TTHGALLSGWREADRLLSLWAPQVQQPRPRL

Sequence length

511

Interactions

View interactions

	KEGG		Reactome
	Peroxisome		PAOs oxidise polyamines to amines Interconversion of polyamines Peroxisomal protein import

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Ischemic Stroke	Ischemic Stroke			GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Azoospermia	Associate	37854191
Breast Neoplasms	Associate	35886868
Death	Associate	9326648
DNA Virus Infections	Associate	9326648
Drug Related Side Effects and Adverse Reactions	Associate	12022477, 9326648
Hereditary Angioedema Type III	Stimulate	35886868

PAOX (polyamine oxidase)