AGO3 (argonaute RISC catalytic component 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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192669 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Argonaute RISC catalytic component 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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AGO3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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EIF2C3 |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p34.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||||||||||||||||||||||
UniProt ID | Q9H9G7 | |||||||||||||||||||||||||||||||||||
Protein name | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | |||||||||||||||||||||||||||||||||||
Protein function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) deriv | |||||||||||||||||||||||||||||||||||
PDB | 5VM9 , 8VAJ | |||||||||||||||||||||||||||||||||||
Family and domains |
Pfam
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Sequence | ||||||||||||||||||||||||||||||||||||
Sequence length | 860 | |||||||||||||||||||||||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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