Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
192669
Gene name Gene Name - the full gene name approved by the HGNC.
Argonaute RISC catalytic component 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AGO3
Synonyms (NCBI Gene) Gene synonyms aliases
EIF2C3
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001954 hsa-miR-129-5p Luciferase reporter assay 18189265
MIRT005037 hsa-let-7b-5p Microarray 17699775
MIRT633179 hsa-miR-4686 HITS-CLIP 23824327
MIRT633178 hsa-miR-1306-5p HITS-CLIP 23824327
MIRT633177 hsa-miR-125a-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000794 Component Condensed nuclear chromosome IEA
GO:0000932 Component P-body IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003725 Function Double-stranded RNA binding IDA 19966796
GO:0003727 Function Single-stranded RNA binding IDA 19966796
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607355 18421 ENSG00000126070
Protein
UniProt ID Q9H9G7
Protein name Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Protein function Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) deriv
PDB 5VM9 , 8VAJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16486 ArgoN 28 167 N-terminal domain of argonaute Domain
PF08699 ArgoL1 177 227 Argonaute linker 1 domain Domain
PF02170 PAZ 232 366 PAZ domain Domain
PF16488 ArgoL2 375 421 Argonaute linker 2 domain Family
PF16487 ArgoMid 430 512 Mid domain of argonaute Domain
PF02171 Piwi 518 819 Piwi domain Family
Sequence
MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPR
RVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRP
FKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVL
RHLPSMKYTPVGR
SFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYK
AQPVIQFMCEVLD
IHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLE
NGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDN
QTSTMI
KATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQ
Y
GGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISK
DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNT
YSGLQLIIVILPGKTPVYAEVKRVGDTL
LGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVT
HPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRF
KPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCAD
RTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEL
QLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV
DKEHDSAEGSHVSGQSNGRDP
QALAKAVQIHQDTLRTMYFA
Sequence length 860
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Transcriptional Regulation by VENTX
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Transcriptional Regulation by MECP2
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Barrett esophagus Barrett Esophagus 29551738 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 23398123
Developmental Disabilities Associate 25271087
Muscle Hypotonia Associate 25271087
Neoplasms Associate 24100239
Neurodegenerative Diseases Associate 36508664
Neurologic Manifestations Associate 25271087
Ovarian Neoplasms Associate 22174824