Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1894
Gene name Gene Name - the full gene name approved by the HGNC.
Epithelial cell transforming 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ECT2
Synonyms (NCBI Gene) Gene synonyms aliases
ARHGEF31
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016363 hsa-miR-193b-3p Microarray 20304954
MIRT021839 hsa-miR-132-3p Microarray 17612493
MIRT024659 hsa-miR-215-5p Microarray 19074876
MIRT026504 hsa-miR-192-5p Microarray 19074876
MIRT027900 hsa-miR-96-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
CUX1 Unknown 21886810
E2F1 Unknown 21886810
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000281 Process Mitotic cytokinesis IBA 21873635
GO:0000281 Process Mitotic cytokinesis IMP 16236794
GO:0000902 Process Cell morphogenesis IEA
GO:0005085 Function Guanyl-nucleotide exchange factor activity IDA 15254234, 15545273
GO:0005096 Function GTPase activator activity IMP 15642749
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600586 3155 ENSG00000114346
Protein
UniProt ID Q9H8V3
Protein name Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
Protein function Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways invo
PDB 3L46 , 4N40 , 6L30
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12738 PTCB-BRCT 179 242 twin BRCT domain Family
PF00533 BRCT 266 341 BRCA1 C Terminus (BRCT) domain Family
PF00621 RhoGEF 456 639 RhoGEF domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma. {ECO:0000269|PubMed:19617897}.
Sequence
MAENSVLTSTTGRTSLADSSIFDSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAG
KQEELIKALKTIKIMEVPVIKIKESCPGKSDEKLIKSVINMDIKVGFVKMESVEEFEGLD
SPEFENVFVVTDFQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRPLYCTSMMNLV
LCFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRVAVSLGTPIMKP
EW
IYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNMEEMTEMQGGKY
LPLGDERCTHLVVEENIVKDLPFEPSKKLYVVKQEWFWGSI
QMDARAGETMYLYEKANTP
ELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPRKRPSAEHSLSIGSLLDIS
NTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQV
PLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYS
KDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRL
PSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHIN
EDKRKTEAQKQIFDVVYEVDG
CPANLLSSHRSLVQRVETISLGEHPCDRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQ
TRPPASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPK
ENWLKMLCRHVANTICKADAENLIYTADPESFEVNTKDMDSTLSRASRAIKKTSKKVTRA
FSFSKTPKRALRRALMTSHGSVEGRSPSSNDKHVMSRLSSTSSLAGIPSPSLVSLPSFFE
RRSHTLSRSTTHLI
Sequence length 914
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Stimulate 24484057
Adenocarcinoma Associate 30542068
Adenocarcinoma of Lung Associate 24484057, 29088286, 30542068, 33215807
Adenocarcinoma of Lung Stimulate 34306175
Astrocytoma Associate 27106762
Breast Neoplasms Associate 30732163
Carcinogenesis Associate 22412903, 25674238
Carcinoma Hepatocellular Associate 31822116, 33157984, 33558466, 34746301, 36002253, 36553600, 39380994
Carcinoma Non Small Cell Lung Associate 21189248, 29088286, 31775549, 32350115
Carcinoma Pancreatic Ductal Stimulate 33501895