Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1880
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 183
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR183
Synonyms (NCBI Gene) Gene synonyms aliases	EBI2, hEBI2
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q32.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of

Show/Hide all(18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029809	hsa-miR-26b-5p	Microarray	19088304
MIRT709767	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT709766	hsa-miR-4330	HITS-CLIP	19536157
MIRT709765	hsa-miR-1303	HITS-CLIP	19536157
MIRT709767	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT709766	hsa-miR-4330	HITS-CLIP	19536157
MIRT709765	hsa-miR-1303	HITS-CLIP	19536157
MIRT1031155	hsa-miR-101	CLIP-seq
MIRT1031156	hsa-miR-144	CLIP-seq
MIRT1031157	hsa-miR-3143	CLIP-seq
MIRT1031158	hsa-miR-4477a	CLIP-seq
MIRT1031159	hsa-miR-495	CLIP-seq
MIRT1031160	hsa-miR-513a-3p	CLIP-seq
MIRT1031161	hsa-miR-548l	CLIP-seq
MIRT1031162	hsa-miR-548n	CLIP-seq
MIRT1031163	hsa-miR-561	CLIP-seq
MIRT1031164	hsa-miR-567	CLIP-seq
MIRT1031165	hsa-miR-582-5p	CLIP-seq

Show/Hide all(42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	ISS
GO:0002312	Process	B cell activation involved in immune response	IBA
GO:0002313	Process	Mature B cell differentiation involved in immune response	IEA
GO:0002313	Process	Mature B cell differentiation involved in immune response	ISS
GO:0002376	Process	Immune system process	IEA
GO:0002407	Process	Dendritic cell chemotaxis	IEA
GO:0002407	Process	Dendritic cell chemotaxis	ISS
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	18628402, 22875855, 22930711
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8383238
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	18628402, 21673108, 22930711
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8383238
GO:0006955	Process	Immune response	TAS	8383238
GO:0006959	Process	Humoral immune response	IEA
GO:0006959	Process	Humoral immune response	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	18628402, 21673108, 22875855, 22930711
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8383238
GO:0008142	Function	Oxysterol binding	IDA	21796212, 22875855, 22930711
GO:0008142	Function	Oxysterol binding	IEA
GO:0008142	Function	Oxysterol binding	IMP	24678947
GO:0010818	Process	T cell chemotaxis	IEA
GO:0010818	Process	T cell chemotaxis	ISS
GO:0016020	Component	Membrane	IEA
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0030595	Process	Leukocyte chemotaxis	IEA
GO:0030595	Process	Leukocyte chemotaxis	IMP	24678947
GO:0030890	Process	Positive regulation of B cell proliferation	IDA	21673108
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0036145	Process	Dendritic cell homeostasis	IEA
GO:0036145	Process	Dendritic cell homeostasis	ISS
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061470	Process	T follicular helper cell differentiation	IEA
GO:0061470	Process	T follicular helper cell differentiation	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	21673108, 25297897
GO:2000458	Process	Regulation of astrocyte chemotaxis	IDA	25297897

MIM	HGNC	e!Ensembl
605741	3128	ENSG00000169508

Protein

UniProt ID

P32249

Protein name

G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)

Protein function

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (

PDB

7TUY , 7TUZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	48 → 308	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogeni

Sequence

MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K

Sequence length

361

Interactions

View interactions

	Reactome
			Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Carcinoma	Basal cell carcinoma	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Rheumatoid	Associate	38046263
Asthma	Associate	28125291, 34510493
Cleft Palate	Associate	32241273
COVID 19	Associate	37814484
Crohn Disease	Associate	36746519
Diabetes Mellitus Type 1	Associate	22403184
Glioblastoma	Associate	23541792
Lupus Erythematosus Systemic	Inhibit	35875859
Multiple Sclerosis	Associate	28052250
Nasal Polyps	Associate	39253973
Neoplasms	Associate	23541792
Pancreatitis	Associate	22403184
Pulmonary Eosinophilia	Associate	28125291

GPR183 (G protein-coupled receptor 183)