Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1880
Gene name	G protein-coupled receptor 183
Gene symbol	GPR183
Synonyms (NCBI Gene)	EBI2hEBI2
Chromosome	13
Chromosome location	13q32.3
Summary	This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029809	hsa-miR-26b-5p	Microarray	19088304
MIRT709767	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT709766	hsa-miR-4330	HITS-CLIP	19536157
MIRT709765	hsa-miR-1303	HITS-CLIP	19536157
MIRT709767	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT709766	hsa-miR-4330	HITS-CLIP	19536157
MIRT709765	hsa-miR-1303	HITS-CLIP	19536157
MIRT1031155	hsa-miR-101	CLIP-seq
MIRT1031156	hsa-miR-144	CLIP-seq
MIRT1031157	hsa-miR-3143	CLIP-seq
MIRT1031158	hsa-miR-4477a	CLIP-seq
MIRT1031159	hsa-miR-495	CLIP-seq
MIRT1031160	hsa-miR-513a-3p	CLIP-seq
MIRT1031161	hsa-miR-548l	CLIP-seq
MIRT1031162	hsa-miR-548n	CLIP-seq
MIRT1031163	hsa-miR-561	CLIP-seq
MIRT1031164	hsa-miR-567	CLIP-seq
MIRT1031165	hsa-miR-582-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	ISS
GO:0002312	Process	B cell activation involved in immune response	IBA
GO:0002313	Process	Mature B cell differentiation involved in immune response	IEA
GO:0002313	Process	Mature B cell differentiation involved in immune response	ISS
GO:0002376	Process	Immune system process	IEA
GO:0002407	Process	Dendritic cell chemotaxis	IEA
GO:0002407	Process	Dendritic cell chemotaxis	ISS
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	18628402, 22875855, 22930711
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8383238
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	18628402, 21673108, 22930711
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8383238
GO:0006955	Process	Immune response	TAS	8383238
GO:0006959	Process	Humoral immune response	IEA
GO:0006959	Process	Humoral immune response	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	18628402, 21673108, 22875855, 22930711
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8383238
GO:0008142	Function	Oxysterol binding	IDA	21796212, 22875855, 22930711
GO:0008142	Function	Oxysterol binding	IEA
GO:0008142	Function	Oxysterol binding	IMP	24678947
GO:0010818	Process	T cell chemotaxis	IEA
GO:0010818	Process	T cell chemotaxis	ISS
GO:0016020	Component	Membrane	IEA
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0030595	Process	Leukocyte chemotaxis	IEA
GO:0030595	Process	Leukocyte chemotaxis	IMP	24678947
GO:0030890	Process	Positive regulation of B cell proliferation	IDA	21673108
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0036145	Process	Dendritic cell homeostasis	IEA
GO:0036145	Process	Dendritic cell homeostasis	ISS
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061470	Process	T follicular helper cell differentiation	IEA
GO:0061470	Process	T follicular helper cell differentiation	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	21673108, 25297897
GO:2000458	Process	Regulation of astrocyte chemotaxis	IDA	25297897

MIM	HGNC	e!Ensembl
605741	3128	ENSG00000169508

P32249

Protein name

G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)

Protein function

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (

PDB

7TUY , 7TUZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	48 → 308	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogeni

Sequence

MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K

Sequence length

361

Interactions

View interactions

	Reactome
			Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

GPR183 (G protein-coupled receptor 183)