Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1871
Gene name Gene Name - the full gene name approved by the HGNC.
E2F transcription factor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
E2F3
Synonyms (NCBI Gene) Gene synonyms aliases
E2F-3
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003734 hsa-miR-128-3p Luciferase reporter assay 18810376
MIRT003734 hsa-miR-128-3p Luciferase reporter assay 18810376
MIRT001756 hsa-miR-34a-5p Luciferase reporter assay, Western blot 17252019
MIRT001756 hsa-miR-34a-5p Review, Luciferase reporter assay 19461653
MIRT000760 hsa-miR-34c-5p Review, Luciferase reporter assay 19461653
Transcription factors
Transcription factor Regulation Reference
BRD7 Repression 16475162
BRD7 Unknown 15137061
HIF1A Activation 20308562
RB1 Repression 20428827
TP53 Repression 20428827
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IDA 17062573
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 7739537
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600427 3115 ENSG00000112242
Protein
UniProt ID O00716
Protein name Transcription factor E2F3 (E2F-3)
Protein function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02319 E2F_TDP 179 243 E2F/DP family winged-helix DNA-binding domain Domain
PF16421 E2F_CC-MB 259 352 E2F transcription factor CC-MB domain Domain
Sequence
MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQI
LTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALG
RGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYD
TSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQ
WMG
CSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVT
YQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCP
EETETHSP
MKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEG
PFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS
Sequence length 465
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocrine resistance
Cell cycle
Cellular senescence
Cushing syndrome
Hepatitis C
Hepatitis B
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin D associated events in G1
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Focal segmental glomerulosclerosis Focal Segmental Glomerulosclerosis, Not Otherwise Specified rs267606877, rs267607183, rs267606878, rs267606879, rs267606880, rs121907909, rs74315343, rs121908415, rs121908416, rs121908417, rs1554181304, rs121434390, rs121434392, rs121434393, rs121434394
View all (39 more)
21372519
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
29754146
Mental retardation Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
21372519
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Diabetes Diabetes GWAS
Myocardial Infarction Myocardial Infarction GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 28751461, 30670912
Adenocarcinoma of Lung Associate 24830600, 32294625
Barrett Esophagus Associate 28751461, 30670912
Brain Neoplasms Associate 29110584
Brain Neoplasms Stimulate 33381564
Breast Neoplasms Associate 17572360, 19638211, 22523546, 24797070, 26934123, 37499929
Carcinogenesis Associate 29307797, 35083866
Carcinoma Hepatocellular Stimulate 12679910
Carcinoma Hepatocellular Associate 24574752, 25073510, 25142234, 33232580, 36878930
Carcinoma Non Small Cell Lung Associate 27557513, 27655285, 30396166, 34346845, 37053020