DUSP5 (dual specificity phosphatase 5)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1847
Gene name Gene Name - the full gene name approved by the HGNC.
Dual specificity phosphatase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DUSP5
Synonyms (NCBI Gene) Gene synonyms aliases
DUSP, HVH3
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively re
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(560)
miRTarBase ID miRNA Experiments Reference
MIRT006483 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000187 Process Activation of MAPK activity TAS
GO:0000188 Process Inactivation of MAPK activity IBA 21873635
GO:0001706 Process Endoderm formation IBA 21873635
GO:0004721 Function Phosphoprotein phosphatase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603069 3071 ENSG00000138166
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16690
Protein name Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3)
Protein function Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
PDB 2G6Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 8 → 135 Rhodanese-like domain Domain
PF00782 DSPc 186 → 316 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 384
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  MAPK signaling pathway
Efferocytosis 		  RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease rs13306026 25397684
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Crohn Disease Crohn Disease GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Ischemic Stroke Ischemic Stroke GWAS
Show/Hide Text Mining Associations (31)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Follicular Associate 31821724
Breast Neoplasms Associate 20554528, 29910679, 31357550
Bronchopulmonary Dysplasia Associate 31330530
Carcinogenesis Associate 23402999
Colorectal Neoplasms Associate 32096171, 36526622
Diabetes Gestational Associate 34190178
Enterocolitis Necrotizing Associate 31985475
Glioblastoma Associate 33853673
Glioma Associate 30387548
Hypertension Pulmonary Associate 31330530