Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1845
Gene name Gene Name - the full gene name approved by the HGNC.
Dual specificity phosphatase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DUSP3
Synonyms (NCBI Gene) Gene synonyms aliases
VHR
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020096 hsa-miR-361-5p Sequencing 20371350
MIRT021310 hsa-miR-125a-5p Sequencing 20371350
MIRT025606 hsa-miR-10a-5p Sequencing 20371350
MIRT039365 hsa-miR-421 CLASH 23622248
MIRT715189 hsa-miR-6872-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000188 Process Inactivation of MAPK activity IMP 16604064
GO:0001772 Component Immunological synapse IDA 12447358
GO:0004725 Function Protein tyrosine phosphatase activity IDA 11863439
GO:0004725 Function Protein tyrosine phosphatase activity IMP 28759036
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600183 3069 ENSG00000108861
Protein
UniProt ID P51452
Protein name Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)
Protein function Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:102
PDB 1J4X , 1VHR , 3F81 , 8TK2 , 8TK3 , 8TK4 , 8TK5 , 8TK6 , 9DJ9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 37 176 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway   ERKs are inactivated
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
15496427
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 39954561
Colorectal Neoplasms Associate 36171645
Laryngitis Associate 23071866
Medulloblastoma Associate 28481393
Melanoma Associate 35999349
Neoplasms Associate 28389334
Nevus Pigmented Associate 27377700
Seizures Associate 40591616
Tuberculosis Associate 34193258