DUSP3 (dual specificity phosphatase 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1845 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Dual specificity phosphatase 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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DUSP3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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VHR |
Chromosome
Chromosome number
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17 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q21.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | P51452 | ||||||||||
Protein name | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | ||||||||||
Protein function | Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:102 | ||||||||||
PDB | 1J4X , 1VHR , 3F81 , 8TK2 , 8TK3 , 8TK4 , 8TK5 , 8TK6 , 9DJ9 | ||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 185 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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