Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1844
Gene name Gene Name - the full gene name approved by the HGNC.	Dual specificity phosphatase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DUSP2
Synonyms (NCBI Gene) Gene synonyms aliases	PAC-1, PAC1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively re

Show/Hide all(283)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003094	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT007102	hsa-miR-29b-3p	Luciferase reporter assay	23478036
MIRT023093	hsa-miR-124-3p	Microarray	18668037
MIRT053023	hsa-miR-20a-5p	qRT-PCR, Western blot, Reporter assay	22648654
MIRT688420	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT688419	hsa-miR-605-5p	HITS-CLIP	23313552
MIRT688418	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT688417	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT688416	hsa-miR-575	HITS-CLIP	23313552
MIRT688415	hsa-miR-188-5p	HITS-CLIP	23313552
MIRT688414	hsa-miR-6866-3p	HITS-CLIP	23313552
MIRT688413	hsa-miR-4780	HITS-CLIP	23313552
MIRT688412	hsa-miR-6780b-3p	HITS-CLIP	23313552
MIRT688411	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT688410	hsa-miR-623	HITS-CLIP	23313552
MIRT494092	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT494088	hsa-miR-302e	PAR-CLIP	22012620
MIRT494087	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT494085	hsa-miR-520b	PAR-CLIP	22012620
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT494082	hsa-miR-520e	PAR-CLIP	22012620
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT494078	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT494075	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT494072	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT494071	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT494070	hsa-miR-3609	PAR-CLIP	22012620
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	22012620
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	22012620
MIRT494066	hsa-miR-3686	PAR-CLIP	22012620
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	22012620
MIRT494064	hsa-miR-568	PAR-CLIP	22012620
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT494092	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT494088	hsa-miR-302e	PAR-CLIP	23592263
MIRT494087	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT494085	hsa-miR-520b	PAR-CLIP	23592263
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT494082	hsa-miR-520e	PAR-CLIP	23592263
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT494078	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT494075	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT494072	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT494071	hsa-miR-340-5p	PAR-CLIP	23592263
MIRT494070	hsa-miR-3609	PAR-CLIP	23592263
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT494066	hsa-miR-3686	PAR-CLIP	23592263
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT494064	hsa-miR-568	PAR-CLIP	23592263
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	23592263
MIRT477925	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT007102	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT477924	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT477923	hsa-miR-634	PAR-CLIP	23592263
MIRT477922	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT477921	hsa-miR-6895-5p	PAR-CLIP	23592263
MIRT477920	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT477919	hsa-miR-922	PAR-CLIP	23592263
MIRT477918	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT477917	hsa-miR-1910-5p	PAR-CLIP	23592263
MIRT477916	hsa-miR-4530	PAR-CLIP	23592263
MIRT477915	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT477914	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT477913	hsa-miR-4264	PAR-CLIP	23592263
MIRT477912	hsa-miR-298	PAR-CLIP	23592263
MIRT477911	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT477910	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT477909	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT733009	hsa-miR-93-3p	Luciferase reporter assay	33660100
MIRT688420	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT688419	hsa-miR-605-5p	HITS-CLIP	23313552
MIRT688418	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT688417	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT688416	hsa-miR-575	HITS-CLIP	23313552
MIRT688415	hsa-miR-188-5p	HITS-CLIP	23313552
MIRT688414	hsa-miR-6866-3p	HITS-CLIP	23313552
MIRT688413	hsa-miR-4780	HITS-CLIP	23313552
MIRT688412	hsa-miR-6780b-3p	HITS-CLIP	23313552
MIRT688411	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT688410	hsa-miR-623	HITS-CLIP	23313552
MIRT494092	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT494088	hsa-miR-302e	PAR-CLIP	22012620
MIRT494087	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT494085	hsa-miR-520b	PAR-CLIP	22012620
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT494082	hsa-miR-520e	PAR-CLIP	22012620
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT494078	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT494075	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT494072	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT494071	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT494070	hsa-miR-3609	PAR-CLIP	22012620
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	22012620
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	22012620
MIRT494066	hsa-miR-3686	PAR-CLIP	22012620
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	22012620
MIRT494064	hsa-miR-568	PAR-CLIP	22012620
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT494092	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT494088	hsa-miR-302e	PAR-CLIP	23592263
MIRT494087	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT494085	hsa-miR-520b	PAR-CLIP	23592263
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT494082	hsa-miR-520e	PAR-CLIP	23592263
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT494078	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT494075	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT494072	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT494071	hsa-miR-340-5p	PAR-CLIP	23592263
MIRT494070	hsa-miR-3609	PAR-CLIP	23592263
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT494066	hsa-miR-3686	PAR-CLIP	23592263
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT494064	hsa-miR-568	PAR-CLIP	23592263
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	23592263
MIRT477925	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT007102	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT477924	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT477923	hsa-miR-634	PAR-CLIP	23592263
MIRT477922	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT477921	hsa-miR-6895-5p	PAR-CLIP	23592263
MIRT477920	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT477919	hsa-miR-922	PAR-CLIP	23592263
MIRT477918	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT477917	hsa-miR-1910-5p	PAR-CLIP	23592263
MIRT477916	hsa-miR-4530	PAR-CLIP	23592263
MIRT477915	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT477914	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT477913	hsa-miR-4264	PAR-CLIP	23592263
MIRT477912	hsa-miR-298	PAR-CLIP	23592263
MIRT477911	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT477910	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT477909	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT947775	hsa-miR-3158-3p	CLIP-seq
MIRT947776	hsa-miR-3165	CLIP-seq
MIRT947777	hsa-miR-3180-5p	CLIP-seq
MIRT947778	hsa-miR-323-5p	CLIP-seq
MIRT947779	hsa-miR-3619-3p	CLIP-seq
MIRT947780	hsa-miR-3934	CLIP-seq
MIRT947781	hsa-miR-421	CLIP-seq
MIRT947782	hsa-miR-4270	CLIP-seq
MIRT947783	hsa-miR-4284	CLIP-seq
MIRT947784	hsa-miR-4441	CLIP-seq
MIRT947785	hsa-miR-4738-5p	CLIP-seq
MIRT947786	hsa-miR-4776-5p	CLIP-seq
MIRT947787	hsa-miR-4800-5p	CLIP-seq
MIRT947788	hsa-miR-488	CLIP-seq
MIRT947789	hsa-miR-552	CLIP-seq
MIRT947790	hsa-miR-876-3p	CLIP-seq
MIRT1980812	hsa-miR-2355-5p	CLIP-seq
MIRT1980813	hsa-miR-329	CLIP-seq
MIRT1980814	hsa-miR-362-3p	CLIP-seq
MIRT1980815	hsa-miR-425	CLIP-seq
MIRT1980816	hsa-miR-642b	CLIP-seq
MIRT1980817	hsa-miR-873	CLIP-seq
MIRT1980818	hsa-miR-939	CLIP-seq
MIRT2215814	hsa-let-7a	CLIP-seq
MIRT2215815	hsa-let-7b	CLIP-seq
MIRT2215816	hsa-let-7c	CLIP-seq
MIRT2215817	hsa-let-7d	CLIP-seq
MIRT2215818	hsa-let-7e	CLIP-seq
MIRT2215819	hsa-let-7f	CLIP-seq
MIRT2215820	hsa-let-7g	CLIP-seq
MIRT2215821	hsa-let-7i	CLIP-seq
MIRT2215822	hsa-miR-1207-3p	CLIP-seq
MIRT2215823	hsa-miR-1266	CLIP-seq
MIRT2215824	hsa-miR-1285	CLIP-seq
MIRT2215825	hsa-miR-1291	CLIP-seq
MIRT2215826	hsa-miR-15a	CLIP-seq
MIRT2215827	hsa-miR-15b	CLIP-seq
MIRT2215828	hsa-miR-16	CLIP-seq
MIRT2215829	hsa-miR-1910	CLIP-seq
MIRT2215830	hsa-miR-195	CLIP-seq
MIRT2215831	hsa-miR-2467-3p	CLIP-seq
MIRT2215832	hsa-miR-3136-3p	CLIP-seq
MIRT2215833	hsa-miR-3155	CLIP-seq
MIRT2215834	hsa-miR-3155b	CLIP-seq
MIRT947775	hsa-miR-3158-3p	CLIP-seq
MIRT2215835	hsa-miR-3173-5p	CLIP-seq
MIRT2215836	hsa-miR-3184	CLIP-seq
MIRT2215837	hsa-miR-3187-5p	CLIP-seq
MIRT2215838	hsa-miR-3189-3p	CLIP-seq
MIRT2215839	hsa-miR-3199	CLIP-seq
MIRT947778	hsa-miR-323-5p	CLIP-seq
MIRT1980813	hsa-miR-329	CLIP-seq
MIRT1980814	hsa-miR-362-3p	CLIP-seq
MIRT2215840	hsa-miR-3663-3p	CLIP-seq
MIRT2215841	hsa-miR-3664-3p	CLIP-seq
MIRT947781	hsa-miR-421	CLIP-seq
MIRT2215842	hsa-miR-423-5p	CLIP-seq
MIRT2215843	hsa-miR-424	CLIP-seq
MIRT1980815	hsa-miR-425	CLIP-seq
MIRT2215844	hsa-miR-4257	CLIP-seq
MIRT2215845	hsa-miR-4292	CLIP-seq
MIRT2215846	hsa-miR-432	CLIP-seq
MIRT2215847	hsa-miR-4326	CLIP-seq
MIRT2215848	hsa-miR-4458	CLIP-seq
MIRT2215849	hsa-miR-4480	CLIP-seq
MIRT2215850	hsa-miR-4500	CLIP-seq
MIRT2215851	hsa-miR-4514	CLIP-seq
MIRT2215852	hsa-miR-4518	CLIP-seq
MIRT2215853	hsa-miR-4524	CLIP-seq
MIRT2215854	hsa-miR-4633-3p	CLIP-seq
MIRT2215855	hsa-miR-4645-5p	CLIP-seq
MIRT2215856	hsa-miR-4652-5p	CLIP-seq
MIRT2215857	hsa-miR-4663	CLIP-seq
MIRT2215858	hsa-miR-4673	CLIP-seq
MIRT2215859	hsa-miR-4692	CLIP-seq
MIRT2215860	hsa-miR-4710	CLIP-seq
MIRT2215861	hsa-miR-4719	CLIP-seq
MIRT2215862	hsa-miR-4722-3p	CLIP-seq
MIRT2215863	hsa-miR-484	CLIP-seq
MIRT2215864	hsa-miR-497	CLIP-seq
MIRT2215865	hsa-miR-502-5p	CLIP-seq
MIRT2215866	hsa-miR-503	CLIP-seq
MIRT2215867	hsa-miR-612	CLIP-seq
MIRT1980816	hsa-miR-642b	CLIP-seq
MIRT2215868	hsa-miR-646	CLIP-seq
MIRT2215869	hsa-miR-659	CLIP-seq
MIRT947790	hsa-miR-876-3p	CLIP-seq
MIRT2215870	hsa-miR-940	CLIP-seq
MIRT2215871	hsa-miR-98	CLIP-seq
MIRT2215824	hsa-miR-1285	CLIP-seq
MIRT2215825	hsa-miR-1291	CLIP-seq
MIRT2215837	hsa-miR-3187-5p	CLIP-seq
MIRT2215845	hsa-miR-4292	CLIP-seq
MIRT2215855	hsa-miR-4645-5p	CLIP-seq
MIRT2215858	hsa-miR-4673	CLIP-seq
MIRT2215867	hsa-miR-612	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000188	Process	Inactivation of MAPK activity	IBA	21873635
GO:0001706	Process	Endoderm formation	IBA	21873635
GO:0004721	Function	Phosphoprotein phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	21784977
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IBA	21873635
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA	21873635
GO:0031965	Component	Nuclear membrane	IDA
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IBA	21873635
GO:0035970	Process	Peptidyl-threonine dephosphorylation	IBA	21873635
GO:0051019	Function	Mitogen-activated protein kinase binding	IBA	21873635
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA

MIM	HGNC	e!Ensembl
603068	3068	ENSG00000158050

Protein

UniProt ID

Q05923

Protein name

Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1)

Protein function

Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:8107850). Can dephosphorylate MAPK1 (By similarity). {ECO:0000250|UniProtKB:Q05

PDB

1M3G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00581	Rhodanese	15 → 138	Rhodanese-like domain	Domain
PF00782	DSPc	180 → 310	Dual specificity phosphatase, catalytic domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in hematopoietic tissues.

Sequence

MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA
GPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYL
FLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAI
GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSF
MGQLLQFETQVLCH

Sequence length

314

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Efferocytosis		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504

Show/Hide Text Mining Associations (46)

Disease Name	Relationship Type	References
Associations from Text Mining
Antiphospholipid Syndrome	Associate	11703349
Asthma	Associate	18774390
Behcet Syndrome	Associate	36857067
Bipolar Disorder	Associate	20633309
Blood Platelet Disorders	Associate	12189025, 12525806, 25466164, 26301697, 29869943, 36179652
Bone Diseases	Associate	16497877
Breast Neoplasms	Associate	25596742, 29422643
Carcinogenesis	Associate	26833217
Carcinoma Merkel Cell	Associate	26833217
Colorectal Neoplasms	Associate	23027623, 25541970, 28627973, 30011263, 40302325
COVID 19	Stimulate	34440879
Dyslipidemias	Inhibit	26083362
Fluorosis Dental	Associate	29317700
Glioma	Associate	25792385
Gout	Associate	35813414
Hodgkin Disease	Associate	30213827
Hypoxia	Inhibit	24914205
Hypoxia	Associate	25596742
Inflammation	Associate	20153702, 26083362
Kashin Beck Disease	Associate	29317700
Keratoconus	Associate	36160033
Leukemia Myeloid Acute	Associate	10339498
Leukemia Prolymphocytic T Cell	Associate	32306542
Lung Neoplasms	Inhibit	26833217
Lymphoma B Cell	Associate	30213827
Lymphoma Follicular	Associate	22473939, 35030632
Lymphoma Large B Cell Diffuse	Associate	22980495, 37032379
Lymphoma Non Hodgkin	Associate	17827388
Multiple Myeloma	Associate	16497877
Multiple Sclerosis	Stimulate	39613182
Myopathies Structural Congenital	Associate	12525806
Nasopharyngeal Carcinoma	Associate	35689852
Neoplasms	Inhibit	26833217
Neoplasms	Stimulate	30692520, 31889045
Neuronal Ceroid Lipofuscinoses	Associate	21863212
Ovarian Neoplasms	Inhibit	31889045
Ovarian Neoplasms	Associate	36707884
Peripheral Arterial Disease	Inhibit	15203712
Pneumonia Ventilator Associated	Associate	32031163
Pulmonary Embolism	Associate	17371486
Purpura Thrombocytopenic Idiopathic	Associate	24617442, 27431926
Sarcoidosis	Associate	36857067
Schizophrenia	Associate	20633309
Stomach Neoplasms	Associate	34365722, 36217165
Thrombasthenia	Associate	25607928
Venous Thromboembolism	Associate	32920367

DUSP2 (dual specificity phosphatase 2)