DUSP2 (dual specificity phosphatase 2)

Gene

• Entrez ID: 1844
• Gene name: Dual specificity phosphatase 2
• Gene symbol: DUSP2
• Synonyms (NCBI Gene): PAC-1, PAC1
• Chromosome: 2
• Chromosome location: 2q11.2
• Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively re

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003094	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT007102	hsa-miR-29b-3p	Luciferase reporter assay	23478036
MIRT023093	hsa-miR-124-3p	Microarray	18668037
MIRT053023	hsa-miR-20a-5p	qRT-PCR, Western blot, Reporter assay	22648654
MIRT688420	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT688419	hsa-miR-605-5p	HITS-CLIP	23313552
MIRT688418	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT688417	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT688416	hsa-miR-575	HITS-CLIP	23313552
MIRT688415	hsa-miR-188-5p	HITS-CLIP	23313552
MIRT688414	hsa-miR-6866-3p	HITS-CLIP	23313552
MIRT688413	hsa-miR-4780	HITS-CLIP	23313552
MIRT688412	hsa-miR-6780b-3p	HITS-CLIP	23313552
MIRT688411	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT688410	hsa-miR-623	HITS-CLIP	23313552
MIRT494092	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT494088	hsa-miR-302e	PAR-CLIP	22012620
MIRT494087	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT494085	hsa-miR-520b	PAR-CLIP	22012620
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT494082	hsa-miR-520e	PAR-CLIP	22012620
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT494078	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT494075	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT494072	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT494071	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT494070	hsa-miR-3609	PAR-CLIP	22012620
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	22012620
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	22012620
MIRT494066	hsa-miR-3686	PAR-CLIP	22012620
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	22012620
MIRT494064	hsa-miR-568	PAR-CLIP	22012620
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT494092	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT494088	hsa-miR-302e	PAR-CLIP	23592263
MIRT494087	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT494085	hsa-miR-520b	PAR-CLIP	23592263
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT494082	hsa-miR-520e	PAR-CLIP	23592263
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT494078	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT494075	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT494072	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT494071	hsa-miR-340-5p	PAR-CLIP	23592263
MIRT494070	hsa-miR-3609	PAR-CLIP	23592263
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT494066	hsa-miR-3686	PAR-CLIP	23592263
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT494064	hsa-miR-568	PAR-CLIP	23592263
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	23592263
MIRT477925	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT007102	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT477924	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT477923	hsa-miR-634	PAR-CLIP	23592263
MIRT477922	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT477921	hsa-miR-6895-5p	PAR-CLIP	23592263
MIRT477920	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT477919	hsa-miR-922	PAR-CLIP	23592263
MIRT477918	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT477917	hsa-miR-1910-5p	PAR-CLIP	23592263
MIRT477916	hsa-miR-4530	PAR-CLIP	23592263
MIRT477915	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT477914	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT477913	hsa-miR-4264	PAR-CLIP	23592263
MIRT477912	hsa-miR-298	PAR-CLIP	23592263
MIRT477911	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT477910	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT477909	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT733009	hsa-miR-93-3p	Luciferase reporter assay	33660100
MIRT688420	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT688419	hsa-miR-605-5p	HITS-CLIP	23313552
MIRT688418	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT688417	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT688416	hsa-miR-575	HITS-CLIP	23313552
MIRT688415	hsa-miR-188-5p	HITS-CLIP	23313552
MIRT688414	hsa-miR-6866-3p	HITS-CLIP	23313552
MIRT688413	hsa-miR-4780	HITS-CLIP	23313552
MIRT688412	hsa-miR-6780b-3p	HITS-CLIP	23313552
MIRT688411	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT688410	hsa-miR-623	HITS-CLIP	23313552
MIRT494092	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT494088	hsa-miR-302e	PAR-CLIP	22012620
MIRT494087	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT494085	hsa-miR-520b	PAR-CLIP	22012620
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT494082	hsa-miR-520e	PAR-CLIP	22012620
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT494078	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT494075	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT494072	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT494071	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT494070	hsa-miR-3609	PAR-CLIP	22012620
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	22012620
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	22012620
MIRT494066	hsa-miR-3686	PAR-CLIP	22012620
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	22012620
MIRT494064	hsa-miR-568	PAR-CLIP	22012620
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT494092	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT494091	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT494090	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT494089	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT494088	hsa-miR-302e	PAR-CLIP	23592263
MIRT494087	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT494086	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT494085	hsa-miR-520b	PAR-CLIP	23592263
MIRT494084	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT494083	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT494082	hsa-miR-520e	PAR-CLIP	23592263
MIRT494081	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT053023	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT494080	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT494079	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT494078	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT494077	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT494076	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT494075	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT494074	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT494073	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT494072	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT494071	hsa-miR-340-5p	PAR-CLIP	23592263
MIRT494070	hsa-miR-3609	PAR-CLIP	23592263
MIRT494069	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT494068	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT494067	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT494066	hsa-miR-3686	PAR-CLIP	23592263
MIRT494065	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT494064	hsa-miR-568	PAR-CLIP	23592263
MIRT494063	hsa-miR-6793-3p	PAR-CLIP	23592263
MIRT477925	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT007102	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT477924	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT477923	hsa-miR-634	PAR-CLIP	23592263
MIRT477922	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT477921	hsa-miR-6895-5p	PAR-CLIP	23592263
MIRT477920	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT477919	hsa-miR-922	PAR-CLIP	23592263
MIRT477918	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT477917	hsa-miR-1910-5p	PAR-CLIP	23592263
MIRT477916	hsa-miR-4530	PAR-CLIP	23592263
MIRT477915	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT477914	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT477913	hsa-miR-4264	PAR-CLIP	23592263
MIRT477912	hsa-miR-298	PAR-CLIP	23592263
MIRT477911	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT477910	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT477909	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT947775	hsa-miR-3158-3p	CLIP-seq
MIRT947776	hsa-miR-3165	CLIP-seq
MIRT947777	hsa-miR-3180-5p	CLIP-seq
MIRT947778	hsa-miR-323-5p	CLIP-seq
MIRT947779	hsa-miR-3619-3p	CLIP-seq
MIRT947780	hsa-miR-3934	CLIP-seq
MIRT947781	hsa-miR-421	CLIP-seq
MIRT947782	hsa-miR-4270	CLIP-seq
MIRT947783	hsa-miR-4284	CLIP-seq
MIRT947784	hsa-miR-4441	CLIP-seq
MIRT947785	hsa-miR-4738-5p	CLIP-seq
MIRT947786	hsa-miR-4776-5p	CLIP-seq
MIRT947787	hsa-miR-4800-5p	CLIP-seq
MIRT947788	hsa-miR-488	CLIP-seq
MIRT947789	hsa-miR-552	CLIP-seq
MIRT947790	hsa-miR-876-3p	CLIP-seq
MIRT1980812	hsa-miR-2355-5p	CLIP-seq
MIRT1980813	hsa-miR-329	CLIP-seq
MIRT1980814	hsa-miR-362-3p	CLIP-seq
MIRT1980815	hsa-miR-425	CLIP-seq
MIRT1980816	hsa-miR-642b	CLIP-seq
MIRT1980817	hsa-miR-873	CLIP-seq
MIRT1980818	hsa-miR-939	CLIP-seq
MIRT2215814	hsa-let-7a	CLIP-seq
MIRT2215815	hsa-let-7b	CLIP-seq
MIRT2215816	hsa-let-7c	CLIP-seq
MIRT2215817	hsa-let-7d	CLIP-seq
MIRT2215818	hsa-let-7e	CLIP-seq
MIRT2215819	hsa-let-7f	CLIP-seq
MIRT2215820	hsa-let-7g	CLIP-seq
MIRT2215821	hsa-let-7i	CLIP-seq
MIRT2215822	hsa-miR-1207-3p	CLIP-seq
MIRT2215823	hsa-miR-1266	CLIP-seq
MIRT2215824	hsa-miR-1285	CLIP-seq
MIRT2215825	hsa-miR-1291	CLIP-seq
MIRT2215826	hsa-miR-15a	CLIP-seq
MIRT2215827	hsa-miR-15b	CLIP-seq
MIRT2215828	hsa-miR-16	CLIP-seq
MIRT2215829	hsa-miR-1910	CLIP-seq
MIRT2215830	hsa-miR-195	CLIP-seq
MIRT2215831	hsa-miR-2467-3p	CLIP-seq
MIRT2215832	hsa-miR-3136-3p	CLIP-seq
MIRT2215833	hsa-miR-3155	CLIP-seq
MIRT2215834	hsa-miR-3155b	CLIP-seq
MIRT947775	hsa-miR-3158-3p	CLIP-seq
MIRT2215835	hsa-miR-3173-5p	CLIP-seq
MIRT2215836	hsa-miR-3184	CLIP-seq
MIRT2215837	hsa-miR-3187-5p	CLIP-seq
MIRT2215838	hsa-miR-3189-3p	CLIP-seq
MIRT2215839	hsa-miR-3199	CLIP-seq
MIRT947778	hsa-miR-323-5p	CLIP-seq
MIRT1980813	hsa-miR-329	CLIP-seq
MIRT1980814	hsa-miR-362-3p	CLIP-seq
MIRT2215840	hsa-miR-3663-3p	CLIP-seq
MIRT2215841	hsa-miR-3664-3p	CLIP-seq
MIRT947781	hsa-miR-421	CLIP-seq
MIRT2215842	hsa-miR-423-5p	CLIP-seq
MIRT2215843	hsa-miR-424	CLIP-seq
MIRT1980815	hsa-miR-425	CLIP-seq
MIRT2215844	hsa-miR-4257	CLIP-seq
MIRT2215845	hsa-miR-4292	CLIP-seq
MIRT2215846	hsa-miR-432	CLIP-seq
MIRT2215847	hsa-miR-4326	CLIP-seq
MIRT2215848	hsa-miR-4458	CLIP-seq
MIRT2215849	hsa-miR-4480	CLIP-seq
MIRT2215850	hsa-miR-4500	CLIP-seq
MIRT2215851	hsa-miR-4514	CLIP-seq
MIRT2215852	hsa-miR-4518	CLIP-seq
MIRT2215853	hsa-miR-4524	CLIP-seq
MIRT2215854	hsa-miR-4633-3p	CLIP-seq
MIRT2215855	hsa-miR-4645-5p	CLIP-seq
MIRT2215856	hsa-miR-4652-5p	CLIP-seq
MIRT2215857	hsa-miR-4663	CLIP-seq
MIRT2215858	hsa-miR-4673	CLIP-seq
MIRT2215859	hsa-miR-4692	CLIP-seq
MIRT2215860	hsa-miR-4710	CLIP-seq
MIRT2215861	hsa-miR-4719	CLIP-seq
MIRT2215862	hsa-miR-4722-3p	CLIP-seq
MIRT2215863	hsa-miR-484	CLIP-seq
MIRT2215864	hsa-miR-497	CLIP-seq
MIRT2215865	hsa-miR-502-5p	CLIP-seq
MIRT2215866	hsa-miR-503	CLIP-seq
MIRT2215867	hsa-miR-612	CLIP-seq
MIRT1980816	hsa-miR-642b	CLIP-seq
MIRT2215868	hsa-miR-646	CLIP-seq
MIRT2215869	hsa-miR-659	CLIP-seq
MIRT947790	hsa-miR-876-3p	CLIP-seq
MIRT2215870	hsa-miR-940	CLIP-seq
MIRT2215871	hsa-miR-98	CLIP-seq
MIRT2215824	hsa-miR-1285	CLIP-seq
MIRT2215825	hsa-miR-1291	CLIP-seq
MIRT2215837	hsa-miR-3187-5p	CLIP-seq
MIRT2215845	hsa-miR-4292	CLIP-seq
MIRT2215855	hsa-miR-4645-5p	CLIP-seq
MIRT2215858	hsa-miR-4673	CLIP-seq
MIRT2215867	hsa-miR-612	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001706	Process	Endoderm formation	IBA
GO:0004721	Function	Phosphoprotein phosphatase activity	IBA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	7681221
GO:0005515	Function	Protein binding	IPI	21784977
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8107850
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0006470	Process	Protein dephosphorylation	TAS	8107850
GO:0007165	Process	Signal transduction	IBA
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	TAS	8107850
GO:0016787	Function	Hydrolase activity	IEA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0043409	Process	Negative regulation of MAPK cascade	IBA
GO:0051019	Function	Mitogen-activated protein kinase binding	IEA

Other IDs

• MIM: 603068
• HGNC: 3068
• e!Ensembl: ENSG00000158050

Protein

• UniProt ID: Q05923
• Protein name: Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1)
• Protein function: Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:8107850). Can dephosphorylate MAPK1 (By similarity). {ECO:0000250|UniProtKB:Q05
• PDB: 1M3G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00581	Rhodanese	15 → 138	Rhodanese-like domain	Domain
  PF00782	DSPc	180 → 310	Dual specificity phosphatase, catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in hematopoietic tissues.
• Sequence:

  MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
  GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA
  GPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYL
  FLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAI
  GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSF
  MGQLLQFETQVLCH

• Sequence length: 314

Pathways

KEGG:

MAPK signaling pathway
Efferocytosis

Reactome:

RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway