Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1844
Gene name Gene Name - the full gene name approved by the HGNC.
Dual specificity phosphatase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DUSP2
Synonyms (NCBI Gene) Gene synonyms aliases
PAC-1, PAC1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively re
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003094 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT007102 hsa-miR-29b-3p Luciferase reporter assay 23478036
MIRT023093 hsa-miR-124-3p Microarray 18668037
MIRT053023 hsa-miR-20a-5p qRT-PCR, Western blot, Reporter assay 22648654
MIRT688420 hsa-miR-548c-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001706 Process Endoderm formation IBA
GO:0004721 Function Phosphoprotein phosphatase activity IBA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603068 3068 ENSG00000158050
Protein
UniProt ID Q05923
Protein name Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1)
Protein function Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:8107850). Can dephosphorylate MAPK1 (By similarity). {ECO:0000250|UniProtKB:Q05
PDB 1M3G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 15 138 Rhodanese-like domain Domain
PF00782 DSPc 180 310 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in hematopoietic tissues.
Sequence
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Efferocytosis
  RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
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